The current webpage is designed to make additional research available concerning how certain fruits can enhance the treatment effects of Adriamycin (doxorubicin). These are fruits with significant levels of compounds that act as Adriamycin sensitizers or protect against Adriamycin-induced toxic side effects. Below are links to studies relating to the beneficial fruits in Foods to eat and avoid during Adriamycin.
The following fruits or their extracts have been tested and found specifically to enhance the treatment effects of Adriamycin and/or protect normal tissues (but not tumors) from Adriamycin-induced cardiomyopathy and other toxic side effects:
Fruit consumption heightens the cytotoxic effects of Adriamycin on breast cancer cells or protects from its toxic side effects mainly through the actions of various phytonutrients, among them:
as well as melatonin (cherries).
Fruit phytonutrients should be obtained by eating whole fruit rather than taking supplements. When a beneficial nutrient is administered at low doses by consuming food, it is likely to have subtle chemopreventive effects, whereas the same compound administered at high doses is more likely to have pharmacological effects, with possible unwanted outcomes. For example, resveratrol has been reported to promote proliferation of ER+/PR+ cells under some circumstances. In fact, while resveratrol has been shown to reduce ER+ cell growth at the earlier stages of cancer development, it can promote ER+ proliferation during later stages.