Tag: phloretin

Phloretin: A dihydrochalcone flavonoid found primarily in apples and, to a lesser extent, pears.

News

08/06/24: Apple flavonoid phloretin enhances anti-cancer effects of Herceptin

Foods

- apples
- pears

Studies

Apple polyphenol phloretin inhibits type II glucose transporter and enhances anti-HER2 antibody drug binding as an adjuvant treatment for HER2-positive breast cancer Cite
Chang H, Cheng T, Tu S, Liao P, Lee Y, Ho C, et al. Apple polyphenol phloretin inhibits type II glucose transporter and enhances anti-HER2 antibody drug binding as an adjuvant treatment for HER2-positive breast cancer. Food Science and Human Wellness. Tsinghua University Press; 2024; 10.26599/fshw.2024.9250251
Exploring the chemotherapeutic potential and therapeutic insight of phloretin against human malignancies: a systematic review Cite
Sohel M, Nity NU, Sarker MR, Hossain MR, Islam KMT, Rahman A, et al. Exploring the chemotherapeutic potential and therapeutic insight of phloretin against human malignancies: a systematic review. Phytochemistry Reviews. Springer Science and Business Media LLC; 2024; 10.1007/s11101-024-09938-8
Phloretin Inhibits the Proliferation of Breast Cancer Cells Through the Down-regulation of Estrogen Receptor α Cite
JANG SY, KIM J, HONG E, YANG YJ, NA Y, YEOM C, et al. Phloretin Inhibits the Proliferation of Breast Cancer Cells Through the Down-regulation of Estrogen Receptor α. Anticancer Research. Anticancer Research USA Inc.; 2024; 44:1109-1120 10.21873/anticanres.16906
Phloretin-induced suppression of oxidative and nitrosative stress attenuates doxorubicin-induced cardiotoxicity in rats Cite
Patil C, Wagh S, Patil K, Mahajan U, Bagal P, Wadkar A, et al. Phloretin-induced suppression of oxidative and nitrosative stress attenuates doxorubicin-induced cardiotoxicity in rats. Asian Pacific Journal of Tropical Biomedicine. Medknow; 2022; 12:124 10.4103/2221-1691.338921
Apple polyphenol phloretin complexed with ruthenium is capable of reprogramming the breast cancer microenvironment through modulation of PI3K/Akt/mTOR/VEGF pathways Cite
Roy S, Mondru AK, Chakraborty T, Das A, Dasgupta S. Apple polyphenol phloretin complexed with ruthenium is capable of reprogramming the breast cancer microenvironment through modulation of PI3K/Akt/mTOR/VEGF pathways. Toxicology and Applied Pharmacology. Elsevier BV; 2022; 434:115822 10.1016/j.taap.2021.115822
Phloretin, as a Potent Anticancer Compound: From Chemistry to Cellular Interactions Cite
Tuli HS, Rath P, Chauhan A, Ramniwas S, Vashishth K, Varol M, et al. Phloretin, as a Potent Anticancer Compound: From Chemistry to Cellular Interactions. Molecules. MDPI AG; 2022; 27:8819 10.3390/molecules27248819
In Silico Studies towards Enhancing the Anticancer Activity of Phytochemical Phloretin Against Cancer Drug Targets Cite
Anand Mariadoss AV, Krishnan Dhanabalan A, Munusamy H, Gunasekaran K, David E. In Silico Studies towards Enhancing the Anticancer Activity of Phytochemical Phloretin Against Cancer Drug Targets. Current Drug Therapy. Bentham Science Publishers Ltd.; 2018; 13:174-188 10.2174/1574885513666180402134054
Biochemical Basis of Anti-Cancer-Effects of Phloretin—A Natural Dihydrochalcone Cite
Choi BY. Biochemical Basis of Anti-Cancer-Effects of Phloretin—A Natural Dihydrochalcone. Molecules. MDPI AG; 2019; 24:278 10.3390/molecules24020278
The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter Cite
Wu K, Ho C, Chen Z, Chen L, Whang-Peng J, Lin T, et al. The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter. Journal of Food and Drug Analysis. The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA); 2018; 26:221-231 10.1016/j.jfda.2017.03.009
Evaluation of antioxidative and antitumor activities of extracted flavonoids from Pink Lady apples in human colon and breast cancer cell lines Cite
Yang S, Zhang H, Yang X, Zhu Y, Zhang M. Evaluation of antioxidative and antitumor activities of extracted flavonoids from Pink Lady apples in human colon and breast cancer cell lines. Food & Function. Royal Society of Chemistry (RSC); 2015; 6:3789-3798 10.1039/c5fo00570a
Effects of the Flavonoids Biochanin A, Morin, Phloretin, and Silymarin on P-Glycoprotein-Mediated Transport Cite
Zhang S, Morris ME. Effects of the Flavonoids Biochanin A, Morin, Phloretin, and Silymarin on P-Glycoprotein-Mediated Transport. Journal of Pharmacology and Experimental Therapeutics. American Society for Pharmacology & Experimental Therapeutics (ASPET); 2002; 304:1258-1267 10.1124/jpet.102.044412
Apple polyphenol phloretin potentiates the anticancer actions of paclitaxel through induction of apoptosis in human hep G2 cells Cite
Yang K, Tsai C, Wang Y, Wei P, Lee C, Chen J, et al. Apple polyphenol phloretin potentiates the anticancer actions of paclitaxel through induction of apoptosis in human hep G2 cells. Molecular Carcinogenesis. Wiley; 2009; 48:420-431 10.1002/mc.20480
Phloretin Induces Apoptosis in H-Ras MCF10A Human Breast Tumor Cells through the Activation of p53 via JNK and p38 Mitogen-Activated Protein Kinase Signaling Cite
Kim M, Kwon JY, Kang NJ, Lee KW, Lee HJ. Phloretin Induces Apoptosis in H-Ras MCF10A Human Breast Tumor Cells through the Activation of p53 via JNK and p38 Mitogen-Activated Protein Kinase Signaling. Annals of the New York Academy of Sciences. Wiley; 2009; 1171:479-483 10.1111/j.1749-6632.2009.04692.x
Polyphenolic Profiles in Eight Apple Cultivars Using High-Performance Liquid Chromatography (HPLC) Cite
Tsao R, Yang R, Young JC, Zhu H. Polyphenolic Profiles in Eight Apple Cultivars Using High-Performance Liquid Chromatography (HPLC). Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2003; 51:6347-6353 10.1021/jf0346298