Tag: ursolicAcid

News

01/25/21

Ursolic acid enhances Adriamycin treatment in TN breast cancer

02/26/17

Ursolic acid causes death of various types of breast cancer cells

10/06/15

Pink Lady apple peel inhibits ER+/PR+ breast cancer growth

10/17/12

Pomegranate juice inhibits metastatic processes in BC cells

Foods

• • apples
  • basil
  • blueberries
  • cherries
  • cranberries
  • holy basil
  • oregano
  • pears
  • plums
  • sage
  • thyme

Studies

• Ursolic acid inhibits the proliferation of triple‑negative breast cancer stem‑like cells through NRF2‑mediated ferroptosis Cite
  Yang X, Liang B, Zhang L, Zhang M, Ma M, Qing L, et al. Ursolic acid inhibits the proliferation of triple‑negative breast cancer stem‑like cells through NRF2‑mediated ferroptosis. Oncology Reports. Spandidos Publications; 2024; 52 10.3892/or.2024.8753
• Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy Cite
  Khan F, Pandey P, Verma M, Ramniwas S, Lee D, Moon S, et al. Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy. Biomedicine & Pharmacotherapy. Elsevier BV; 2024; 173:116363 10.1016/j.biopha.2024.116363
• Ursolic acid regulates key EMT transcription factors, induces cell cycle arrest and apoptosis in MDA‐MB‐231 and MCF‐7 breast cancer cells, an in‐vitro and in silico studies Cite
  Mallepogu V, Sankaran KR, Pasala C, Bandi LR, Maram R, Amineni UM, et al. Ursolic acid regulates key EMT transcription factors, induces cell cycle arrest and apoptosis in MDA‐MB‐231 and MCF‐7 breast cancer cells, an in‐vitro and in silico studies. Journal of Cellular Biochemistry. Wiley; 2023; 10.1002/jcb.30496
• Ursolic acid: a pentacyclic triterpenoid that exhibits anticancer therapeutic potential by modulating multiple oncogenic targets Cite
  Sandhu SS, Rouz SK, Kumar S, Swamy N, Deshmukh L, Hussain A, et al. Ursolic acid: a pentacyclic triterpenoid that exhibits anticancer therapeutic potential by modulating multiple oncogenic targets. Biotechnology and Genetic Engineering Reviews. Informa UK Limited; 2023;:1-31 10.1080/02648725.2022.2162257
• Fractionation and Characterization of Triterpenoids from Vaccinium vitis-idaea L. Cuticular Waxes and Their Potential as Anticancer Agents Cite
  Vilkickyte G, Petrikaite V, Marksa M, Ivanauskas L, Jakstas V, Raudone L. Fractionation and Characterization of Triterpenoids from Vaccinium vitis-idaea L. Cuticular Waxes and Their Potential as Anticancer Agents. Antioxidants. MDPI AG; 2023; 12:465 10.3390/antiox12020465
• Inhibitory Effects of Ursolic Acid on the Stemness and Progression of Human Breast Cancer Cells by Modulating Argonaute-2 Cite
  Liao W, Liu Y, Ying T, Shieh J, Hung Y, Lee H, et al. Inhibitory Effects of Ursolic Acid on the Stemness and Progression of Human Breast Cancer Cells by Modulating Argonaute-2. International Journal of Molecular Sciences. MDPI AG; 2022; 24:366 10.3390/ijms24010366
• Ursolic acid: a natural modulator of signaling networks in different cancers Cite
  Zafar S, Khan K, Hafeez A, Irfan M, Armaghan M, Rahman Au, et al. Ursolic acid: a natural modulator of signaling networks in different cancers. Cancer Cell International. Springer Science and Business Media LLC; 2022; 22 10.1186/s12935-022-02804-7
• Ursolic acid augments the chemosensitivity of drug-resistant breast cancer cells to doxorubicin by AMPK-mediated mitochondrial dysfunction Cite
  Luo F, Zhao J, Liu S, Xue Y, Tang D, Yang J, et al. Ursolic acid augments the chemosensitivity of drug-resistant breast cancer cells to doxorubicin by AMPK-mediated mitochondrial dysfunction. Biochemical Pharmacology. Elsevier BV; 2022; 205:115278 10.1016/j.bcp.2022.115278
• Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review Cite
  Kamran S, Sinniah A, Abdulghani MAM, Alshawsh MA. Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review. Cancers. MDPI AG; 2022; 14:1100 10.3390/cancers14051100
• Antiangiogenic Phytochemicals Constituent of Diet as Promising Candidates for Chemoprevention of Cancer Cite
  Marrero AD, Quesada AR, Martínez-Poveda B, Medina MÁ. Antiangiogenic Phytochemicals Constituent of Diet as Promising Candidates for Chemoprevention of Cancer. Antioxidants. MDPI AG; 2022; 11:302 10.3390/antiox11020302
• Inhibitory Effect of Ursolic Acid on the Migration and Invasion of Doxorubicin-Resistant Breast Cancer Cite
  Zong L, Cheng G, Zhao J, Zhuang X, Zheng Z, Liu Z, et al. Inhibitory Effect of Ursolic Acid on the Migration and Invasion of Doxorubicin-Resistant Breast Cancer. Molecules. MDPI AG; 2022; 27:1282 10.3390/molecules27041282
• Screening of Phytochemicals as Potential Inhibitors of Breast Cancer using Structure Based Multitargeted Molecular Docking Analysis Cite
  Jha V, Devkar S, Gharat K, Kasbe S, Matharoo DK, Pendse S, et al. Screening of Phytochemicals as Potential Inhibitors of Breast Cancer using Structure Based Multitargeted Molecular Docking Analysis. Phytomedicine Plus. Elsevier BV; 2022; 2:100227 10.1016/j.phyplu.2022.100227
• Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer Cite
  Al-Bari MAA, Ito Y, Ahmed S, Radwan N, Ahmed HS, Eid N. Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer. International Journal of Molecular Sciences. MDPI AG; 2021; 22:9807 10.3390/ijms22189807
• Ursolic Acid Reverses the Chemoresistance of Breast Cancer Cells to Paclitaxel by Targeting MiRNA-149-5p/MyD88 Cite
  Xiang F, Fan Y, Ni Z, Liu Q, Zhu Z, Chen Z, et al. Ursolic Acid Reverses the Chemoresistance of Breast Cancer Cells to Paclitaxel by Targeting MiRNA-149-5p/MyD88. Frontiers in Oncology. Frontiers Media SA; 2019; 9 10.3389/fonc.2019.00501
• Ursolic Acid Enhances Cytotoxicity of Doxorubicin-Resistant Triple-Negative Breast Cancer Cells via ZEB1-AS1/miR-186-5p/ABCC1 Axis Cite
  Lu Q, Chen W, Ji Y, Liu Y, Xue X. Ursolic Acid Enhances Cytotoxicity of Doxorubicin-Resistant Triple-Negative Breast Cancer Cells via ZEB1-AS1/miR-186-5p/ABCC1 Axis. Cancer Biotherapy and Radiopharmaceuticals. Mary Ann Liebert Inc; 2021; 10.1089/cbr.2020.4147
• Inhibition of breast cancer stem-like cells by a triterpenoid, ursolic acid, via activation of Wnt antagonist, sFRP4 and suppression of miRNA-499a-5p Cite
  Mandal S, Gamit N, Varier L, Dharmarajan A, Warrier S. Inhibition of breast cancer stem-like cells by a triterpenoid, ursolic acid, via activation of Wnt antagonist, sFRP4 and suppression of miRNA-499a-5p. Life Sciences. Elsevier BV; 2020; 265:118854 10.1016/j.lfs.2020.118854
• Antiproliferative Effects of Ocimum basilicum Methanolic Extract and Fractions, Oleanolic Acid and 3-epi-Ursolic Acid Cite
  Qamar KA, Farooq AD, Siddiqui BS, Kabir N, Begum S. Antiproliferative Effects of Ocimum basilicum Methanolic Extract and Fractions, Oleanolic Acid and 3-epi-Ursolic Acid. Current Traditional Medicine. Bentham Science Publishers Ltd.; 2020; 6:134-146 10.2174/2215083805666191010152439
• Antiproliferative Activity of Ursolic Acid in MDA-MB-231 Human Breast Cancer Cells through Nrf2 Pathway Regulation Cite
  Zhang X, Li T, Gong ES, Liu RH. Antiproliferative Activity of Ursolic Acid in MDA-MB-231 Human Breast Cancer Cells through Nrf2 Pathway Regulation. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2020; 68:7404-7415 10.1021/acs.jafc.0c03202
• Ursolic Acid Promotes the Sensitization of rhTRAIL-resistant Triple-negative Breast Cancer Cite
  MANOUCHEHRI JM, KALAFATIS M. Ursolic Acid Promotes the Sensitization of rhTRAIL-resistant Triple-negative Breast Cancer. Anticancer Research. Anticancer Research USA Inc.; 2018; 38:6789-6795 10.21873/anticanres.13050
• Reversal of multidrug resistance in breast cancer cells by a combination of ursolic acid with doxorubicin Cite
  Zong L, Cheng G, Liu S, Pi Z, Liu Z, Song F. Reversal of multidrug resistance in breast cancer cells by a combination of ursolic acid with doxorubicin. Journal of Pharmaceutical and Biomedical Analysis. Elsevier BV; 2019; 165:268-275 10.1016/j.jpba.2018.11.057
• Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells Cite
  Lewinska A, Adamczyk-Grochala J, Kwasniewicz E, Deregowska A, Wnuk M. Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells. Apoptosis. Springer Science and Business Media LLC; 2017; 22:800-815 10.1007/s10495-017-1353-7
• Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway Cite
  Wu S, Zhang T, Du J. Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway. Drug Design, Development and Therapy. Informa UK Limited; 2016; Volume 10:3471-3481 10.2147/dddt.s110505
• A novel co-drug of aspirin and ursolic acid interrupts adhesion, invasion and migration of cancer cells to vascular endothelium via regulating EMT and EGFR-mediated signaling pathways: multiple targets for cancer metastasis prevention and treatment Cite
  Tang Q, Liu Y, Li T, Yang X, Zheng G, Chen H, et al. A novel co-drug of aspirin and ursolic acid interrupts adhesion, invasion and migration of cancer cells to vascular endothelium via regulating EMT and EGFR-mediated signaling pathways: multiple targets for cancer metastasis prevention and treatment. Oncotarget. Impact Journals, LLC; 2016; 7:73114-73129 10.18632/oncotarget.12232
• Effect of ursolic acid in attenuating chronic constriction injury-induced neuropathic pain in rats Cite
  Bhat RA, Lingaraju MC, Pathak NN, Kalra J, Kumar D, Kumar D, et al. Effect of ursolic acid in attenuating chronic constriction injury-induced neuropathic pain in rats. Fundamental & Clinical Pharmacology. Wiley; 2016; 30:517-528 10.1111/fcp.12223
• 2α-Hydroxyursolic Acid Inhibited Cell Proliferation and Induced Apoptosis in MDA-MB-231 Human Breast Cancer Cells through the p38/MAPK Signal Transduction Pathway Cite
  Jiang X, Li T, Liu RH. 2α-Hydroxyursolic Acid Inhibited Cell Proliferation and Induced Apoptosis in MDA-MB-231 Human Breast Cancer Cells through the p38/MAPK Signal Transduction Pathway. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2016; 64:1806-1816 10.1021/acs.jafc.5b04852
• Review on anti-tumor effect of triterpene acid compounds Cite
  Lei P, Zhang W, Men X. Review on anti-tumor effect of triterpene acid compounds. Journal of Cancer Research and Therapeutics. Medknow; 2014; 10:14 10.4103/0973-1482.139746
• EFFECTS OF EXTRACTS OF APPLE PEEL FROM ORGANICALLY AND INTEGRATED PRODUCTION CULTIVATED APPLES AND URSOLIC ACID ON CANCER CELL PROLIFERATION Cite
  Olsson M, Andersson S, Johansson D, Oredsson S, Gustavsson K. EFFECTS OF EXTRACTS OF APPLE PEEL FROM ORGANICALLY AND INTEGRATED PRODUCTION CULTIVATED APPLES AND URSOLIC ACID ON CANCER CELL PROLIFERATION. Acta Horticulturae. International Society for Horticultural Science (ISHS); 2014;:227-230 10.17660/actahortic.2014.1040.31
• Inhibition of breast tumor growth and angiogenesis by a medicinal herb:Ocimum gratissimum Cite
  Nangia-Makker P, Tait L, Shekhar MP, Palomino E, Hogan V, Piechocki MP, et al. Inhibition of breast tumor growth and angiogenesis by a medicinal herb:Ocimum gratissimum. International Journal of Cancer. Wiley; 2007; 121:884-894 10.1002/ijc.22733
• Ursolic acid promotes cancer cell death by inducing Atg5-dependent autophagy Cite
  Leng S, Hao Y, Du D, Xie S, Hong L, Gu H, et al. Ursolic acid promotes cancer cell death by inducing Atg5-dependent autophagy. International Journal of Cancer. Wiley; 2013;:n/a-n/a 10.1002/ijc.28301
• Triterpenoid Content of Berries and Leaves of Bilberry Vaccinium myrtillus from Finland and Poland Cite
  Szakiel A, Pączkowski C, Huttunen S. Triterpenoid Content of Berries and Leaves of Bilberry Vaccinium myrtillus from Finland and Poland. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2012; 60:11839-11849 10.1021/jf3046895
• Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells Cite
  Kim KH, Seo HS, Choi HS, Choi I, Shin YC, Ko S. Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells. Archives of Pharmacal Research. Springer Science and Business Media LLC; 2011; 34:1363-1372 10.1007/s12272-011-0817-5
• Effect of 2α-Hydroxyursolic Acid on NF-κB Activation Induced by TNF-α in Human Breast Cancer MCF-7 Cells Cite
  Yoon H, Liu RH. Effect of 2α-Hydroxyursolic Acid on NF-κB Activation Induced by TNF-α in Human Breast Cancer MCF-7 Cells. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2008; 56:8412-8417 10.1021/jf8012844