Tag: melatonin

News

10/04/21

Melatonin enhances the treatment effects of Adriamycin in breast cancer cells

10/12/20

Dim light at night promotes bone metastasis in ER+/PR+ mouse model

04/28/18

Exposure to blue outdoor light at night increases breast cancer risk

12/16/17

Melatonin enhances the treatment effects of Taxotere in ER+/PR+ BC

10/09/16

Melatonin reduces the viability of both ER+ and ER- BC stem cells

05/09/16

Melatonin favorably alters tumor microenvironment

01/04/16

Walnut compounds have chemopreventive actions

12/13/15

Sleeping short hours or in the presence of light linked to BC risk

10/05/14

Walnut compounds impair BC energy supply and induce cell death

08/24/14

Exposure to light at night reduces tamoxifen effectiveness

11/10/13

Disrupted sleep may be associated with worse breast cancer survival

11/12/11

Resveratrol plus melatonin reduces mammary tumor development

07/21/11

Organically grown tomatoes have more chemopreventive compounds

Foods

• • cherries
  • corn
  • cranberries
  • mustard
  • peanuts
  • pistachio nuts
  • tomatoes

Studies

• Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer Cite
  Yan J, Chen D, Ye Z, Zhu X, Li X, Jiao H, et al. Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer. Molecular Cancer. Springer Science and Business Media LLC; 2024; 23 10.1186/s12943-024-02164-y
• Circadian Rhythm Disruption in Cancer Survivors: From Oncogenesis to Quality of Life Cite
  Kisamore C, Kisamore C, Walker W. Circadian Rhythm Disruption in Cancer Survivors: From Oncogenesis to Quality of Life. Cancer Medicine. Wiley; 2024; 13 10.1002/cam4.70353
• Polyphenols Regulate the Activity of Endocrine-Disrupting Chemicals, Having Both Positive and Negative Effects Cite
  Leti Maggio E, Zucca C, Grande M, Carrano R, Infante A, Bei R, et al. Polyphenols Regulate the Activity of Endocrine-Disrupting Chemicals, Having Both Positive and Negative Effects. Journal of Xenobiotics. MDPI AG; 2024; 14:1378-1405 10.3390/jox14040077
• Melatonin mitigates doxorubicin induced chemo brain in a rat model in a NRF2/p53–SIRT1 dependent pathway Cite
  Ebrahim NA, Elnagar MR, El-Gamal R, Habotta OA, Albadawi EA, Albadrani M, et al. Melatonin mitigates doxorubicin induced chemo brain in a rat model in a NRF2/p53–SIRT1 dependent pathway. Heliyon. Elsevier BV; 2024; 10:e38081 10.1016/j.heliyon.2024.e38081
• Melatonin effect on breast and ovarian cancers by targeting the PI3K/Akt/mTOR pathway Cite
  Pourbarkhordar V, Rahmani S, Roohbakhsh A, Hayes AW, Karimi G. Melatonin effect on breast and ovarian cancers by targeting the PI3K/Akt/mTOR pathway. IUBMB Life. Wiley; 2024; 10.1002/iub.2900
• Apoptotic effect of melatonin on ER-positive breast cancer cell lines: ADGRL4 gene expression and promoter methylation Cite
  Rajabi A, Safaralizadeh R, Saber A, Pourmahdi M, Teimourian S, Montazeri V, et al. Apoptotic effect of melatonin on ER-positive breast cancer cell lines: ADGRL4 gene expression and promoter methylation. Naunyn-Schmiedeberg's Archives of Pharmacology. Springer Science and Business Media LLC; 2024; 10.1007/s00210-024-03383-2
• Indoor and outdoor artificial light at night (ALAN) and cancer risk: A systematic review and meta-analysis Cite
  Harding BN, Palomar Cros A, Deprato A, Papantoniou K, Straif K, Lacy P, et al. Indoor and outdoor artificial light at night (ALAN) and cancer risk: A systematic review and meta-analysis. ISEE Conference Abstracts. Environmental Health Perspectives; 2024; 2024 10.1289/isee.2024.0457
• Wavelength-resolved measures of outdoor artificial light-at-night and risks of breast, prostate, and colorectal cancer Cite
  Bhatti P, Parks J, Quinn E, Vena J, Shen Tu G, Aube M. Wavelength-resolved measures of outdoor artificial light-at-night and risks of breast, prostate, and colorectal cancer. ISEE Conference Abstracts. Environmental Health Perspectives; 2024; 2024 10.1289/isee.2024.0658
• Presence of melatonin in foods of daily consumption: The benefit of this hormone for health Cite
  Muñoz-Jurado A, Escribano BM. Presence of melatonin in foods of daily consumption: The benefit of this hormone for health. Food Chemistry. Elsevier BV; 2024; 458:140172 10.1016/j.foodchem.2024.140172
• Disruption of central and peripheral circadian clocks and circadian controlled estrogen receptor rhythms in night shift nurses in working environments Cite
  Yang Z, Black K, Ohman‐Strickland P, Graber J, Kipen HM, Fang M, et al. Disruption of central and peripheral circadian clocks and circadian controlled estrogen receptor rhythms in night shift nurses in working environments. The FASEB Journal. Wiley; 2024; 38 10.1096/fj.202302261rr
• The role of melatonin as an adjuvant therapeutic strategy in the modulation of carcinogenesis. A narrative review Cite
  Fernández-Lázaro D, Celorrio San Miguel AM, Roche E. The role of melatonin as an adjuvant therapeutic strategy in the modulation of carcinogenesis. A narrative review. Journal of Cancer Metastasis and Treatment. OAE Publishing Inc.; 2024; 10.20517/2394-4722.2024.05
• Melatonin: Current evidence on protective and therapeutic roles in gynecological diseases Cite
  Hosseinzadeh A, Alinaghian N, Sheibani M, Seirafianpour F, Naeini AJ, Mehrzadi S. Melatonin: Current evidence on protective and therapeutic roles in gynecological diseases. Life Sciences. Elsevier BV; 2024; 344:122557 10.1016/j.lfs.2024.122557
• Melatonin and Its Role in the Epithelial-to-Mesenchymal Transition (EMT) in Cancer Cite
  Martínez-Campa C, Álvarez-García V, Alonso-González C, González A, Cos S. Melatonin and Its Role in the Epithelial-to-Mesenchymal Transition (EMT) in Cancer. Cancers. MDPI AG; 2024; 16:956 10.3390/cancers16050956
• Intra-tumor ROS amplification by melatonin interferes in the apoptosis-autophagy-inflammation-EMT collusion in the breast tumor microenvironment Cite
  Das N, Mukherjee S, Das A, Gupta P, Bandyopadhyay A, Chattopadhyay S. Intra-tumor ROS amplification by melatonin interferes in the apoptosis-autophagy-inflammation-EMT collusion in the breast tumor microenvironment. Heliyon. Elsevier BV; 2024; 10:e23870 10.1016/j.heliyon.2023.e23870
• Potential Protective Role of Melatonin in Benign Mammary Cells Reprogrammed by Extracellular Vesicles from Malignant Cells Cite
  Procópio de Oliveira C, Frigieri BM, Fukumasu H, Chuffa LGdA, Novais AA, Zuccari DAPdC. Potential Protective Role of Melatonin in Benign Mammary Cells Reprogrammed by Extracellular Vesicles from Malignant Cells. Biomedicines. MDPI AG; 2023; 11:2837 10.3390/biomedicines11102837
• The dark side of light at night: assessing breast cancer risk with a dose-response meta-analysis Cite
  Urbano T, Vinceti M, Wise LA, Filippini T. The dark side of light at night: assessing breast cancer risk with a dose-response meta-analysis. European Journal of Public Health. Oxford University Press (OUP); 2023; 33 10.1093/eurpub/ckad160.572
• Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer Cite
  Wichert K, Hoppe R, Ickstadt K, Behrens T, Winter S, Herold R, et al. Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer. European Journal of Epidemiology. Springer Science and Business Media LLC; 2023; 38:1053-1068 10.1007/s10654-023-01048-7
• Exposure to outdoor artificial light at night and breast cancer risk: a population-based case-control study in two French departments (the CECILE study) Cite
  Prajapati N, Cordina-Duverger E, Boileau A, Faure E, Guénel P. Exposure to outdoor artificial light at night and breast cancer risk: a population-based case-control study in two French departments (the CECILE study). Frontiers in Environmental Health. Frontiers Media SA; 2023; 2 10.3389/fenvh.2023.1268828
• Dietary Supplements in Cancer Prevention and Therapy Cite
  Tomer R, Sharma I, Sobti RC. Dietary Supplements in Cancer Prevention and Therapy. Handbook of Oncobiology: From Basic to Clinical Sciences. Springer Nature Singapore; 2023;:1-16 10.1007/978-981-99-2196-6_31-1
• Fucoidan/chitosan layered PLGA nanoparticles with melatonin loading for inducing intestinal absorption and addressing triple-negative breast cancer progression Cite
  Yen Y, Lee Y, Yu L, Li C, Shueng P, Chiu H, et al. Fucoidan/chitosan layered PLGA nanoparticles with melatonin loading for inducing intestinal absorption and addressing triple-negative breast cancer progression. International Journal of Biological Macromolecules. Elsevier BV; 2023; 250:126211 10.1016/j.ijbiomac.2023.126211
• Codelivery of resveratrol melatonin utilizing pH responsive sericin based nanocarriers inhibits the proliferation of breast cancer cell line at the different pH Cite
  Aghaz F, Asadi Z, Sajadimajd S, Kashfi K, Arkan E, Rahimi Z. Codelivery of resveratrol melatonin utilizing pH responsive sericin based nanocarriers inhibits the proliferation of breast cancer cell line at the different pH. Scientific Reports. Springer Science and Business Media LLC; 2023; 13 10.1038/s41598-023-37668-y
• Melatonin: A Potential Regulator of DNA Methylation Cite
  Linowiecka K, Slominski AT, Reiter RJ, Böhm M, Steinbrink K, Paus R, et al. Melatonin: A Potential Regulator of DNA Methylation. Antioxidants. MDPI AG; 2023; 12:1155 10.3390/antiox12061155
• Artificial light at night and breast cancer risk: the findings from CECILE study, France Cite
  Prajapati N, Boileau A, Cordina-Duverger E, Faure E, Guénel P. Artificial light at night and breast cancer risk: the findings from CECILE study, France. Population Medicine. E.U. European Publishing; 2023; 5 10.18332/popmed/165524
• The Complex Effects of Light on Metabolism in Humans Cite
  Ishihara A, Courville AB, Chen KY. The Complex Effects of Light on Metabolism in Humans. Nutrients. MDPI AG; 2023; 15:1391 10.3390/nu15061391
• Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism Cite
  Meléndez-Fernández OH, Liu JA, Nelson RJ. Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism. International Journal of Molecular Sciences. MDPI AG; 2023; 24:3392 10.3390/ijms24043392
• Interactions of melatonin with various signaling pathways: implications for cancer therapy Cite
  Mihanfar A, Yousefi B, Azizzadeh B, Majidinia M. Interactions of melatonin with various signaling pathways: implications for cancer therapy. Cancer Cell International. Springer Science and Business Media LLC; 2022; 22 10.1186/s12935-022-02825-2
• Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy Cite
  Arinno A, Maneechote C, Khuanjing T, Prathumsap N, Chunchai T, Arunsak B, et al. Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. Elsevier BV; 2023; 1869:166618 10.1016/j.bbadis.2022.166618
• The Self-Administered Use of Complementary and Alternative Medicine (CAM) Supplements and Antioxidants in Cancer Therapy and the Critical Role of Nrf-2—A Systematic Review Cite
  Krejbich P, Birringer M. The Self-Administered Use of Complementary and Alternative Medicine (CAM) Supplements and Antioxidants in Cancer Therapy and the Critical Role of Nrf-2—A Systematic Review. Antioxidants. MDPI AG; 2022; 11:2149 10.3390/antiox11112149
• The metastatic spread of breast cancer accelerates during sleep Cite
  Diamantopoulou Z, Castro-Giner F, Schwab FD, Foerster C, Saini M, Budinjas S, et al. The metastatic spread of breast cancer accelerates during sleep. Nature. Springer Science and Business Media LLC; 2022; 10.1038/s41586-022-04875-y
• Melatonin as an adjuvant treatment modality with doxorubicin Cite
  Dana PM, Sadoughi F, Reiter RJ, Mohammadi S, Heidar Z, Mirzamoradi M, et al. Melatonin as an adjuvant treatment modality with doxorubicin. Biochimie. Elsevier BV; 2022; 10.1016/j.biochi.2022.05.005
• Melatonin Modulation of Radiation-Induced Molecular Changes in MCF-7 Human Breast Cancer Cells Cite
  Alonso-González C, González-Abalde C, Menéndez-Menéndez J, González-González A, Álvarez-García V, González-Cabeza A, et al. Melatonin Modulation of Radiation-Induced Molecular Changes in MCF-7 Human Breast Cancer Cells. Biomedicines. MDPI AG; 2022; 10:1088 10.3390/biomedicines10051088
• Melatonin as an Adjuvant to Antiangiogenic Cancer Treatments Cite
  González A, Alonso-González C, González-González A, Menéndez-Menéndez J, Cos S, Martínez-Campa C. Melatonin as an Adjuvant to Antiangiogenic Cancer Treatments. Cancers. MDPI AG; 2021; 13:3263 10.3390/cancers13133263
• Circadian rhythms and cancers: the intrinsic links and therapeutic potentials Cite
  Zhou L, Zhang Z, Nice E, Huang C, Zhang W, Tang Y. Circadian rhythms and cancers: the intrinsic links and therapeutic potentials. Journal of Hematology & Oncology. Springer Science and Business Media LLC; 2022; 15 10.1186/s13045-022-01238-y
• Effect of astaxanthin and melatonin on cell viability and DNA damage in human breast cancer cell lines Cite
  Karimian A, Mir Mohammadrezaei F, Hajizadeh Moghadam A, Bahadori MH, Ghorbani-Anarkooli M, Asadi A, et al. Effect of astaxanthin and melatonin on cell viability and DNA damage in human breast cancer cell lines. Acta Histochemica. Elsevier BV; 2022; 124:151832 10.1016/j.acthis.2021.151832
• Protective role of melatonin in breast cancer: what we can learn from women with blindness Cite
  Minella C, Coliat P, Amé S, Neuberger K, Stora A, Mathelin C, et al. Protective role of melatonin in breast cancer: what we can learn from women with blindness. Cancer Causes & Control. Springer Science and Business Media LLC; 2021; 10.1007/s10552-021-01502-5
• Melatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells Cite
  Tran QH, Hoang DH, Song M, Choe W, Kang I, Kim SS, et al. Melatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells. Experimental & Molecular Medicine. Springer Science and Business Media LLC; 2021; 10.1038/s12276-021-00675-y
• Melatonin—A New Prospect in Prostate and Breast Cancer Management Cite
  Anim-Koranteng C, Shah HE, Bhawnani N, Ethirajulu A, Alkasabera A, Onyali CB, et al. Melatonin—A New Prospect in Prostate and Breast Cancer Management. Cureus. Cureus, Inc.; 2021; 10.7759/cureus.18124
• Melatonin rescues the mice brain against cisplatin-induced neurodegeneration, an insight into antioxidant and anti-inflammatory effects Cite
  Zakria M, Ahmad N, Al Kury LT, Alattar A, Uddin Z, Siraj S, et al. Melatonin rescues the mice brain against cisplatin-induced neurodegeneration, an insight into antioxidant and anti-inflammatory effects. NeuroToxicology. Elsevier BV; 2021; 10.1016/j.neuro.2021.08.010
• Melatonin inhibits triple-negative breast cancer progression through the Lnc049808-FUNDC1 pathway Cite
  Yang A, Peng F, Zhu L, Li X, Ou S, Huang Z, et al. Melatonin inhibits triple-negative breast cancer progression through the Lnc049808-FUNDC1 pathway. Cell Death & Disease. Springer Science and Business Media LLC; 2021; 12 10.1038/s41419-021-04006-x
• Melatonin Suppresses ADGRL4 Expression and Induces Promoter Methylation in Estrogen‐Responsive Breast Cancer Cells Cite
  Rajabi A, Maydanchi M, Saber A, Bakhshi M, Baniardalan F, Sobhkhizy A, et al. Melatonin Suppresses ADGRL4 Expression and Induces Promoter Methylation in Estrogen‐Responsive Breast Cancer Cells. The FASEB Journal. Wiley; 2021; 35 10.1096/fasebj.2021.35.s1.05095
• Part-time cancers and role of melatonin in determining their metabolic phenotype Cite
  Reiter RJ, Sharma R, Rodriguez C, Martin V, Rosales-Corral S, de Campos Zuccari DAP, et al. Part-time cancers and role of melatonin in determining their metabolic phenotype. Life Sciences. Elsevier BV; 2021;:119597 10.1016/j.lfs.2021.119597
• An updated review of mechanistic potentials of melatonin against cancer: pivotal roles in angiogenesis, apoptosis, autophagy, endoplasmic reticulum stress and oxidative stress Cite
  Mehrzadi S, Pourhanifeh MH, Mirzaei A, Moradian F, Hosseinzadeh A. An updated review of mechanistic potentials of melatonin against cancer: pivotal roles in angiogenesis, apoptosis, autophagy, endoplasmic reticulum stress and oxidative stress. Cancer Cell International. Springer Science and Business Media LLC; 2021; 21 10.1186/s12935-021-01892-1
• Melatonin inhibits cell proliferation in a rat model of breast hyperplasia by mediating the PTEN/AKT pathway Cite
  Zhang X, Niu Y, Huang Y. Melatonin inhibits cell proliferation in a rat model of breast hyperplasia by mediating the PTEN/AKT pathway. Oncology Reports. Spandidos Publications; 2021; 45 10.3892/or.2021.8017
• Antioxidants for the Treatment of Breast Cancer: Are We There Yet? Cite
  Griñan-Lison C, Blaya-Cánovas JL, López-Tejada A, Ávalos-Moreno M, Navarro-Ocón A, Cara FE, et al. Antioxidants for the Treatment of Breast Cancer: Are We There Yet?. Antioxidants. MDPI AG; 2021; 10:205 10.3390/antiox10020205
• Melatonin downregulates TRPC6, impairing store-operated calcium entry in triple negative breast cancer cells. Cite
  Jardin I, Diez-Bello R, Falcon D, Alvarado S, Regodon S, Salido GM, et al. Melatonin downregulates TRPC6, impairing store-operated calcium entry in triple negative breast cancer cells.. Journal of Biological Chemistry. Elsevier BV; 2020;:jbc.RA120.015769 10.1074/jbc.ra120.015769
• Melatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPKα2-dependent mitochondrial damage Cite
  Yang G, Song M, Hoang DH, Tran QH, Choe W, Kang I, et al. Melatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPKα2-dependent mitochondrial damage. Experimental & Molecular Medicine. Springer Science and Business Media LLC; 2020; 10.1038/s12276-020-00541-3
• Urinary Melatonin in Relation to Breast Cancer Risk: Nested Case–Control Analysis in the DOM Study and Meta-analysis of Prospective Studies Cite
  Wong AT, Fensom GK, Key TJ, Onland-Moret NC, Tong TY, Travis RC. Urinary Melatonin in Relation to Breast Cancer Risk: Nested Case–Control Analysis in the DOM Study and Meta-analysis of Prospective Studies. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2020; 10.1158/1055-9965.epi-20-0822
• Circadian rhythm and concentration of melatonin in breast cancer patients Cite
  Ahabrach H, El Mlili N, Errami M, Cauli O. Circadian rhythm and concentration of melatonin in breast cancer patients. Endocrine, Metabolic & Immune Disorders - Drug Targets. Bentham Science Publishers Ltd.; 2020; 20 10.2174/1871530320666201201110807
• Abstract LB-212: Circadian melatonin signal disruption by exposure to artificial light at night promotes bone lytic breast cancer metastases Cite
  Anbalagan M. Abstract LB-212: Circadian melatonin signal disruption by exposure to artificial light at night promotes bone lytic breast cancer metastases. Bioinformatics, Convergence Science, and Systems Biology. American Association for Cancer Research; 2020; 10.1158/1538-7445.am2020-lb-212
• Melatonin as a Radio-Sensitizer in Cancer Cite
  Alonso-González C, González A, Menéndez-Menéndez J, Martínez-Campa C, Cos S. Melatonin as a Radio-Sensitizer in Cancer. Biomedicines. MDPI AG; 2020; 8:247 10.3390/biomedicines8080247
• The Effect of Zinc and Melatonin Administration on Lipid Peroxidation, IL-6 Levels, and Element Metabolism in DMBA-Induced Breast Cancer in Rats Cite
  Gulbahce-Mutlu E, Baltaci SB, Menevse E, Mogulkoc R, Baltaci AK. The Effect of Zinc and Melatonin Administration on Lipid Peroxidation, IL-6 Levels, and Element Metabolism in DMBA-Induced Breast Cancer in Rats. Biological Trace Element Research. Springer Science and Business Media LLC; 2020; 10.1007/s12011-020-02238-0
• Inhibitory effect of melatonin on hypoxia-induced vasculogenic mimicry via suppressing epithelial-mesenchymal transition (EMT) in breast cancer stem cells. Cite
  Maroufi NF, Amiri M, Dizaji BF, Vahedian V, Akbarzadeh M, Roshanravan N, et al. Inhibitory effect of melatonin on hypoxia-induced vasculogenic mimicry via suppressing epithelial-mesenchymal transition (EMT) in breast cancer stem cells.. European Journal of Pharmacology. Elsevier BV; 2020; 881:173282 10.1016/j.ejphar.2020.173282
• Clinical impact of melatonin on breast cancer patients undergoing chemotherapy; effects on cognition, sleep and depressive symptoms: A randomized, double-blind, placebo-controlled trial Cite
  Palmer ACS, Zortea M, Souza A, Santos V, Biazús JV, Torres ILS, et al. Clinical impact of melatonin on breast cancer patients undergoing chemotherapy; effects on cognition, sleep and depressive symptoms: A randomized, double-blind, placebo-controlled trial. PLOS ONE. Public Library of Science (PLoS); 2020; 15:e0231379 10.1371/journal.pone.0231379
• Usefulness of melatonin as complementary to chemotherapeutic agents at different stages of the angiogenic process Cite
  González-González A, González A, Rueda N, Alonso-González C, Menéndez JM, Martínez-Campa C, et al. Usefulness of melatonin as complementary to chemotherapeutic agents at different stages of the angiogenic process. Scientific Reports. Springer Science and Business Media LLC; 2020; 10 10.1038/s41598-020-61622-x
• The role of melatonin on miRNAs modulation in triple-negative breast cancer cells Cite
  Ferreira LC, Orso F, Dettori D, Lacerda JZ, Borin TF, Taverna D, et al. The role of melatonin on miRNAs modulation in triple-negative breast cancer cells. PLOS ONE. Public Library of Science (PLoS); 2020; 15:e0228062 10.1371/journal.pone.0228062
• Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis Cite
  Reiter RJ, Sharma R, Ma Q, Rorsales-Corral S, de Almeida Chuffa LG. Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis. Cellular and Molecular Life Sciences. Springer Science and Business Media LLC; 2020; 77:2527-2542 10.1007/s00018-019-03438-1
• The role of melatonin on doxorubicin-induced cardiotoxicity: A systematic review Cite
  Najafi M, Hooshangi Shayesteh MR, Mortezaee K, Farhood B, Haghi-Aminjan H. The role of melatonin on doxorubicin-induced cardiotoxicity: A systematic review. Life Sciences. Elsevier BV; 2020; 241:117173 10.1016/j.lfs.2019.117173
• A ketogenic diet combined with melatonin overcomes cisplatin and vincristine drug resistance in breast carcinoma syngraft Cite
  Talib WH. A ketogenic diet combined with melatonin overcomes cisplatin and vincristine drug resistance in breast carcinoma syngraft. Nutrition. Elsevier BV; 2020; 72:110659 10.1016/j.nut.2019.110659
• SAT-337 Disruption Of The Circadian Melatonin Signal By Dim Light At Night Promotes Bone-lytic Breast Cancer Metastases Cite
  Anbalagan M, Dauchy R, Xiang S, Robling A, Blask D, Rowan B, et al. SAT-337 Disruption Of The Circadian Melatonin Signal By Dim Light At Night Promotes Bone-lytic Breast Cancer Metastases. Journal of the Endocrine Society. The Endocrine Society; 2019; 3 10.1210/js.2019-sat-337
• Association of antidiabetic medication and statins with breast cancer incidence in women with type 2 diabetes Cite
  Hosio M, Urpilainen E, Marttila M, Hautakoski A, Arffman M, Sund R, et al. Association of antidiabetic medication and statins with breast cancer incidence in women with type 2 diabetes. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2019; 175:741-748 10.1007/s10549-019-05185-0
• Epigenetic modification in 4T1 mouse breast cancer model by artificial light at night and melatonin – the role of DNA-methyltransferase Cite
  Agbaria S, Haim A, Fares F, Zubidat AE. Epigenetic modification in 4T1 mouse breast cancer model by artificial light at night and melatonin – the role of DNA-methyltransferase. Chronobiology International. Informa UK Limited; 2019; 36:629-643 10.1080/07420528.2019.1574265
• Evaluating the Association between Artificial Light-at-Night Exposure and Breast and Prostate Cancer Risk in Spain (MCC-Spain Study) Cite
  Garcia-Saenz A, Sánchez de Miguel A, Espinosa A, Valentin A, Aragonés N, Llorca J, et al. Evaluating the Association between Artificial Light-at-Night Exposure and Breast and Prostate Cancer Risk in Spain (MCC-Spain Study). Environmental Health Perspectives. Environmental Health Perspectives; 2018; 126:047011 10.1289/ehp1837
• AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis Cite
  Liu D, Ma Z, Di S, Yang Y, Yang J, Xu L, et al. AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis. Free Radical Biology and Medicine. Elsevier BV; 2018; 129:59-72 10.1016/j.freeradbiomed.2018.08.032
• Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization Cite
  Farhood B, Goradel NH, Mortezaee K, Khanlarkhani N, Salehi E, Nashtaei MS, et al. Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization. Clinical and Translational Oncology. Springer Science and Business Media LLC; 2018; 21:268-279 10.1007/s12094-018-1934-0
• Melatonin restrains angiogenic factors in triple-negative breast cancer by targeting miR-152-3p: In vivo and in vitro studies Cite
  Marques JH, Mota AL, Oliveira JG, Lacerda JZ, Stefani JP, Ferreira LC, et al. Melatonin restrains angiogenic factors in triple-negative breast cancer by targeting miR-152-3p: In vivo and in vitro studies. Life Sciences. Elsevier BV; 2018; 208:131-138 10.1016/j.lfs.2018.07.012
• Melatonin improves cardiac and mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin activity? Cite
  Govender J, Loos B, Marais E, Engelbrecht A. Melatonin improves cardiac and mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin activity?. Toxicology and Applied Pharmacology. Elsevier BV; 2018; 358:86-101 10.1016/j.taap.2018.06.031
• Melatonin Antagonizes Jasmonate-Triggered Anthocyanin Biosynthesis in Arabidopsis thaliana Cite
  Ai Y, Zhu Z. Melatonin Antagonizes Jasmonate-Triggered Anthocyanin Biosynthesis in Arabidopsis thaliana. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2018; 66:5392-5400 10.1021/acs.jafc.8b01795
• Night Shift Work Increases the Risks of Multiple Primary Cancers in Women: A Systematic Review and Meta-analysis of 61 Articles Cite
  Yuan X, Zhu C, Wang M, Mo F, Du W, Ma X. Night Shift Work Increases the Risks of Multiple Primary Cancers in Women: A Systematic Review and Meta-analysis of 61 Articles. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2018; 27:25-40 10.1158/1055-9965.epi-17-0221
• Melatonin limits paclitaxel-induced mitochondrial dysfunction in vitro and protects against paclitaxel-induced neuropathic pain in the rat Cite
  Galley HF, McCormick B, Wilson KL, Lowes DA, Colvin L, Torsney C. Melatonin limits paclitaxel-induced mitochondrial dysfunction in vitro and protects against paclitaxel-induced neuropathic pain in the rat. Journal of Pineal Research. Wiley; 2017; 63:e12444 10.1111/jpi.12444
• Melatonin-induced KiSS1 expression inhibits triple-negative breast cancer cell invasiveness Cite
  Kim T, Cho S. Melatonin-induced KiSS1 expression inhibits triple-negative breast cancer cell invasiveness. Oncology Letters. Spandidos Publications; 2017; 14:2511-2516 10.3892/ol.2017.6434
• Abstract 4897: Circadian/melatonin disruption by dim light at night drives human epithelial breast cancer to a metastatic phenotype Cite
  Hill SM, Xiang S, Dauchy RT, Wren-Dail M, Anbalagan M, Rowan B, et al. Abstract 4897: Circadian/melatonin disruption by dim light at night drives human epithelial breast cancer to a metastatic phenotype. Tumor Biology. American Association for Cancer Research; 2017; 10.1158/1538-7445.am2017-4897
• Abstract 2504: Melatonin decreases plasma arginine, its precursors and acylcarnitines in breast cancer xenograft model at specific time point during circadian rhythm Cite
  Zuccari D, Junior RP, Sonehara NM, Chammas R, Raynaud F. Abstract 2504: Melatonin decreases plasma arginine, its precursors and acylcarnitines in breast cancer xenograft model at specific time point during circadian rhythm. Molecular and Cellular Biology, Genetics. American Association for Cancer Research; 2017; 10.1158/1538-7445.am2017-2504
• Abstract 1477: Melatonin regulates the tumor suppressor miR-148a-3p involved in angiogenesis and metastasis of breast cancer Cite
  Zuccari D, Lacerda JZ, Ferreira LC, Lopes BC, Aristizábal-Pachón AF, Bajgelman MC. Abstract 1477: Melatonin regulates the tumor suppressor miR-148a-3p involved in angiogenesis and metastasis of breast cancer. Molecular and Cellular Biology, Genetics. American Association for Cancer Research; 2017; 10.1158/1538-7445.am2017-1477
• Oxidative DNA damage during night shift work Cite
  Bhatti P, Mirick DK, Randolph TW, Gong J, Buchanan DT, Zhang J(, et al. Oxidative DNA damage during night shift work. Occupational and Environmental Medicine. BMJ; 2017; 74:680-683 10.1136/oemed-2017-104414
• Efficacy of melatonin, IL-25 and siIL-17B in tumorigenesis-associated properties of breast cancer cell lines Cite
  Gelaleti GB, Borin TF, Maschio-Signorini LB, Moschetta MG, Jardim-Perassi BV, Calvinho GB, et al. Efficacy of melatonin, IL-25 and siIL-17B in tumorigenesis-associated properties of breast cancer cell lines. Life Sciences. Elsevier BV; 2017; 183:98-109 10.1016/j.lfs.2017.06.013
• Abstract P1-05-28: Melatonin treatment: A transcriptomic networks in a xenograft model of breast cancer Cite
  Jardim-Perassi B, Sonehara N, de Paula-Junior R, Chammas R, Coutinho L, Reis Júnior O, et al. Abstract P1-05-28: Melatonin treatment: A transcriptomic networks in a xenograft model of breast cancer. Poster Session Abstracts. American Association for Cancer Research; 2017; 10.1158/1538-7445.sabcs16-p1-05-28
• Melatonin as an anti-inflammatory agent in radiotherapy Cite
  Najafi M, Shirazi A, Motevaseli E, Rezaeyan AH, Salajegheh A, Rezapoor S. Melatonin as an anti-inflammatory agent in radiotherapy. Inflammopharmacology. Springer Science and Business Media LLC; 2017; 25:403-413 10.1007/s10787-017-0332-5
• Urinary Melatonin in Relation to Postmenopausal Breast Cancer Risk According to Melatonin 1 Receptor Status Cite
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• Evaluation of Melatonin Effect on Human Breast Cancer Stem Cells Using a Threedimensional Growth Method of Mammospheres Cite
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• Melatonin decreases estrogen receptor binding to estrogen response elements sites on the OCT4 gene in human breast cancer stem cells Cite
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• Light at night and breast cancer incidence in Connecticut: An ecological study of age group effects Cite
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• Melatonin as an antioxidant: under promises but over delivers Cite
  Reiter RJ, Mayo JC, Tan D, Sainz RM, Alatorre-Jimenez M, Qin L. Melatonin as an antioxidant: under promises but over delivers. Journal of Pineal Research. Wiley; 2016; 61:253-278 10.1111/jpi.12360
• Abstract 874: Circadian/melatonin disruption by dim light at night drives paclitaxel resistance in breast cancer via activation of stat3 Cite
  Hill SM, Xiang S, Dauchy RT, mao L, Yuan L, Hauch A, et al. Abstract 874: Circadian/melatonin disruption by dim light at night drives paclitaxel resistance in breast cancer via activation of stat3. Experimental and Molecular Therapeutics. American Association for Cancer Research; 2016; 10.1158/1538-7445.am2016-874
• Abstract 2408: Melatonin action in xenograft model of breast cancer, comparing radiopharmaceuticals in the detection of intratumor heterogeneity by PET/CT confirmed by immunohistochemical markers Cite
  Mota AL, Jardim-Perassi BV, Borin TF, Sonehara NM, Pozzo L, Bernardes ES, et al. Abstract 2408: Melatonin action in xenograft model of breast cancer, comparing radiopharmaceuticals in the detection of intratumor heterogeneity by PET/CT confirmed by immunohistochemical markers. Tumor Biology. American Association for Cancer Research; 2016; 10.1158/1538-7445.am2016-2408
• The Use of Complementary and Alternative Medicine Supplements of Potential Concern during Breast Cancer Chemotherapy Cite
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• Decreased concentration of serum melatonin in nighttime compared with daytime female medical technologists in South Korea Cite
  Song G, Yoon K, Chi H, Roh J, Kim J. Decreased concentration of serum melatonin in nighttime compared with daytime female medical technologists in South Korea. Chronobiology International. Informa UK Limited; 2016; 33:1305-1310 10.1080/07420528.2016.1199562
• Melatonin: Antiproliferative Actions and Protection of Normal Tissue and Enhancement of Radiosensitivity of Breast Cancer Cells Cite
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• Melatonin Regulates Angiogenic and Inflammatory Proteins in MDA-MB-231 Cell Line and in Co-culture with Cancer-associated Fibroblasts Cite
  B. Maschio-Signorini L, B. Gelaleti G, G. Moschetta M, F. Borin T, V. Jardim-Perassi B, R. Lopes J, et al. Melatonin Regulates Angiogenic and Inflammatory Proteins in MDA-MB-231 Cell Line and in Co-culture with Cancer-associated Fibroblasts. Anti-Cancer Agents in Medicinal Chemistry. Bentham Science Publishers Ltd.; 2016; 16:1474-1484 10.2174/1871520616666160422105920
• Sustained release of melatonin: A novel approach in elevating efficacy of tamoxifen in breast cancer treatment Cite
  Sabzichi M, Samadi N, Mohammadian J, Hamishehkar H, Akbarzadeh M, Molavi O. Sustained release of melatonin: A novel approach in elevating efficacy of tamoxifen in breast cancer treatment. Colloids and Surfaces B: Biointerfaces. Elsevier BV; 2016; 145:64-71 10.1016/j.colsurfb.2016.04.042
• Identification of circadian-related gene expression profiles in entrained breast cancer cell lines Cite
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• Effect of Melatonin in Epithelial Mesenchymal Transition Markers and Invasive Properties of Breast Cancer Stem Cells of Canine and Human Cell Lines Cite
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• High Incidence of Breast Cancer in Light-Polluted Areas with Spatial Effects in Korea Cite
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• Abstract A91: Over-the-counter melatonin supplementation in human subjects: A potentially novel chronotherapeutic approach targeting the Warburg effect and fatty acid metabolism in breast cancer therapy/prevention Cite
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• Can Avoiding Light at Night Reduce the Risk of Breast Cancer? Cite
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• Melatonin enhancement of the radiosensitivity of human breast cancer cells is associated with the modulation of proteins involved in estrogen biosynthesis Cite
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• Abstract PR13: Circadian/melatonin disruption by dim light at night drive chemotherapy resistance in breast cancer Cite
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• Breast cancer cells: Modulation by melatonin and the ubiquitin-proteasome system – A review Cite
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• Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice Cite
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• Melatonin Regulates Angiogenic Factors under Hypoxia in Breast Cancer Cell Lines Cite
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• Night-shift work increases morbidity of breast cancer and all-cause mortality: a meta-analysis of 16 prospective cohort studies Cite
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• High prevalence of breast cancer in light polluted areas in urban and rural regions of South Korea: An ecologic study on the treatment prevalence of female cancers based on National Health Insurance data Cite
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• Abstract P6-04-01: Melatonin on angiogenesis in breast cancer Cite
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• Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin Cite
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• Urinary Excretion of Melatonin and Association with Breast Cancer: Meta-Analysis and Review of the Literature Cite
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• Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer Cite
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• 0359 Nighshift work and breast cancer risk–good news, bad news? Cite
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• 0200 Night shiftwork and breast cancer survival in Danish women Cite
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• Synergistic anti-tumor effects of melatonin and PUFAs from walnuts in a murine mammary adenocarcinoma model Cite
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• Anti-aromatase effect of resveratrol and melatonin on hormonal positive breast cancer cells co-cultured with breast adipose fibroblasts Cite
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• Breast cancer risk, nightwork, and circadian clock gene polymorphisms Cite
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• Urinary Levels of Melatonin and Risk of Postmenopausal Breast Cancer: Women's Health Initiative Observational Cohort Cite
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• Melatonin content of pepper and tomato fruits: Effects of cultivar and solar radiation Cite
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• Effect of Melatonin on Tumor Growth and Angiogenesis in Xenograft Model of Breast Cancer Cite
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• Breast cancer and circadian disruption from electric lighting in the modern world Cite
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• Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation Cite
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• Bedtime misalignment and progression of breast cancer Cite
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• The association between different night shiftwork factors and breast cancer: a case–control study Cite
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• A meta-analysis on dose–response relationship between night shift work and the risk of breast cancer Cite
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• Protective effect of melatonin against Adriamycin-induced cardiotoxicity Cite
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• Evaluation of the anti-angiogenic action of melatonin in breast cancer Cite
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• Melatonin modulates aromatase activity and expression in endothelial cells Cite
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• Association of sleep duration and breast cancer OncotypeDX recurrence score Cite
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• Bright Light Therapy Protects Women from Circadian Rhythm Desynchronization During Chemotherapy for Breast Cancer Cite
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• Night work and breast cancer: A population-based case-control study in France (the CECILE study) Cite
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• Cardioprotective activity of melatonin and its novel synthesized derivatives on doxorubicin-induced cardiotoxicity Cite
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• Dietary correlates of urinary 6-sulfatoxymelatonin concentrations in the Nurses’ Health Study cohorts Cite
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• Melatonin suppresses aromatase expression and activity in breast cancer associated fibroblasts Cite
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• Modulation by Melatonin of the Cardiotoxic and Antitumor Activities of Adriamycin Cite
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• A combination of resveratrol and melatonin exerts chemopreventive effects in N-methyl-N-nitrosourea-induced rat mammary carcinogenesis Cite
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• Case–control study of shift-work and breast cancer risk in Danish nurses: Impact of shift systems Cite
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• Night Work and Breast Cancer Risk Among Norwegian Nurses: Assessment by Different Exposure Metrics Cite
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• Exposure to Room Light before Bedtime Suppresses Melatonin Onset and Shortens Melatonin Duration in Humans Cite
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• Does the Modern Urbanized Sleeping Habitat Pose a Breast Cancer Risk? Cite
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• Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells Cite
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• Light-at-night, circadian disruption and breast cancer: assessment of existing evidence Cite
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• Circulating melatonin and the risk of breast and endometrial cancer in women Cite
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• Melatonin in walnuts: Influence on levels of melatonin and total antioxidant capacity of blood Cite
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