Tag: fisetin

News

02/04/20

Quercetin and fisetin inhibit TN cell migration

02/04/17

Fisetin inhibits formation of a cancer-causing compound from estrogen

10/06/15

Pink Lady apple peel inhibits ER+/PR+ breast cancer growth

Foods

• • apples
  • kiwifruit
  • onions
  • strawberries

Studies

• Triple Negative Breast Cancer (TNBC): Signalling pathways-Role of plant-based inhibitors Cite
  Ravindra B. Malabadi , Sadiya MR , Kiran P. Kolkar , Simuzar S. Mammadova , Raju K. Chalannavar , Himansu Baijnath , et al. Triple Negative Breast Cancer (TNBC): Signalling pathways-Role of plant-based inhibitors. Open Access Research Journal of Biology and Pharmacy. Open Access Research Journals Publication; 2024; 10:028-071 10.53022/oarjbp.2024.10.2.0013
• Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling Cite
  Kubatka P, Koklesova L, Mazurakova A, Brockmueller A, Büsselberg D, Kello M, et al. Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling. Cancer and Metastasis Reviews. Springer Science and Business Media LLC; 2023; 10.1007/s10555-023-10134-x
• A Systematic Review on Chemical Actives from Plant Sources, Targets and Chemotherapy for Triple-Negative Breast Cancer Cite
  Varne AA, Bhatia MS, Ashtek SS. A Systematic Review on Chemical Actives from Plant Sources, Targets and Chemotherapy for Triple-Negative Breast Cancer. Pharmaceutical Chemistry Journal. Springer Science and Business Media LLC; 2023; 57:694-702 10.1007/s11094-023-02940-y
• Novel PEGylated cholephytosomes for targeting fisetin to breast cancer: in vitro appraisal and in vivo antitumoral studies Cite
  Talaat SM, Elnaggar YSR, Gowayed MA, El-Ganainy SO, Allam M, Abdallah OY. Novel PEGylated cholephytosomes for targeting fisetin to breast cancer: in vitro appraisal and in vivo antitumoral studies. Drug Delivery and Translational Research. Springer Science and Business Media LLC; 2023; 10.1007/s13346-023-01409-5
• Naringenin in combination with quercetin/fisetin shows synergistic anti-proliferative and migration reduction effects in breast cancer cell lines Cite
  Jalalpour Choupanan M, Shahbazi S, Reiisi S. Naringenin in combination with quercetin/fisetin shows synergistic anti-proliferative and migration reduction effects in breast cancer cell lines. Molecular Biology Reports. Springer Science and Business Media LLC; 2023; 10.1007/s11033-023-08664-2
• The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC) Cite
  Farghadani R, Naidu R. The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC). Biomedicine & Pharmacotherapy. Elsevier BV; 2023; 165:115170 10.1016/j.biopha.2023.115170
• Insights on the Role of Polyphenols in Combating Cancer Drug Resistance Cite
  Farhan M. Insights on the Role of Polyphenols in Combating Cancer Drug Resistance. Biomedicines. MDPI AG; 2023; 11:1709 10.3390/biomedicines11061709
• Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics Cite
  Kumar RM, Kumar H, Bhatt T, Jain R, Panchal K, Chaurasiya A, et al. Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics. Pharmaceuticals. MDPI AG; 2023; 16:196 10.3390/ph16020196
• Fisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells Cite
  Khozooei S, Lettau K, Barletta F, Jost T, Rebholz S, Veerappan S, et al. Fisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells. Journal of Experimental & Clinical Cancer Research. Springer Science and Business Media LLC; 2022; 41 10.1186/s13046-022-02442-x
• Regulation of micro-RNA, epigenetic factor by natural products for the treatment of cancers: Mechanistic insight and translational Association Cite
  Javaid A, Zahra D, Rashid F, Mashraqi M, Alzamami A, Khurshid M, et al. Regulation of micro-RNA, epigenetic factor by natural products for the treatment of cancers: Mechanistic insight and translational Association. Saudi Journal of Biological Sciences. Elsevier BV; 2022; 10.1016/j.sjbs.2022.03.005
• Natural Products Targeting Cancer Stem Cells for Augmenting Cancer Therapeutics Cite
  Meerson A, Khatib S, Mahajna J. Natural Products Targeting Cancer Stem Cells for Augmenting Cancer Therapeutics. International Journal of Molecular Sciences. MDPI AG; 2021; 22:13044 10.3390/ijms222313044
• Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy Cite
  Fatima N, Baqri SSR, Bhattacharya A, Koney NK, Husain K, Abbas A, et al. Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy. Frontiers in Genetics. Frontiers Media SA; 2021; 12 10.3389/fgene.2021.758733
• Flavonoids in Cancer Metastasis Cite
  Liskova A, Koklesova L, Samec M, Smejkal K, Samuel SM, Varghese E, et al. Flavonoids in Cancer Metastasis. Cancers. MDPI AG; 2020; 12:1498 10.3390/cancers12061498
• Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling Cite
  Shahi Thakuri P, Gupta M, Singh S, Joshi R, Glasgow E, Lekan A, et al. Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling. BMC Cancer. Springer Science and Business Media LLC; 2020; 20 10.1186/s12885-019-6479-2
• Association between flavonoids, flavonoid subclasses intake and breast cancer risk: a case-control study in China Cite
  Feng X, Ho SC, Mo X, Lin F, Zhang N, Luo H, et al. Association between flavonoids, flavonoid subclasses intake and breast cancer risk: a case-control study in China. European Journal of Cancer Prevention. Ovid Technologies (Wolters Kluwer Health); 2019; 29:493-500 10.1097/cej.0000000000000561
• Fisetin induces apoptosis in breast cancer MDA‐MB‐453 cells through degradation of HER2/neu and via the PI3K/Akt pathway Cite
  Guo G, Zhang W, Dang M, Yan M, Chen Z. Fisetin induces apoptosis in breast cancer MDA‐MB‐453 cells through degradation of HER2/neu and via the PI3K/Akt pathway. Journal of Biochemical and Molecular Toxicology. Wiley; 2018; 33:e22268 10.1002/jbt.22268
• Fisetin, a plant flavonoid ameliorates doxorubicin-induced cardiotoxicity in experimental rats: the decisive role of caspase-3, COX-II, cTn-I, iNOs and TNF-α Cite
  Ma T, Kandhare AD, Mukherjee-Kandhare AA, Bodhankar SL. Fisetin, a plant flavonoid ameliorates doxorubicin-induced cardiotoxicity in experimental rats: the decisive role of caspase-3, COX-II, cTn-I, iNOs and TNF-α. Molecular Biology Reports. Springer Science and Business Media LLC; 2018; 46:105-118 10.1007/s11033-018-4450-y
• Fisetin inhibits cell migration via inducing HO-1 and reducing MMPs expression in breast cancer cell lines Cite
  Tsai C, Chen J, Chang C, Lu D, Chang P, Wang S, et al. Fisetin inhibits cell migration via inducing HO-1 and reducing MMPs expression in breast cancer cell lines. Food and Chemical Toxicology. Elsevier BV; 2018; 120:528-535 10.1016/j.fct.2018.07.059
• Fisetin Inhibited Growth and Metastasis of Triple-Negative Breast Cancer by Reversing Epithelial-to-Mesenchymal Transition via PTEN/Akt/GSK3β Signal Pathway Cite
  Li J, Gong X, Jiang R, Lin D, Zhou T, Zhang A, et al. Fisetin Inhibited Growth and Metastasis of Triple-Negative Breast Cancer by Reversing Epithelial-to-Mesenchymal Transition via PTEN/Akt/GSK3β Signal Pathway. Frontiers in Pharmacology. Frontiers Media SA; 2018; 9 10.3389/fphar.2018.00772
• Anti‑cancer effects of fisetin on mammary carcinoma cells via regulation of the PI3K/Akt/mTOR pathway: In�vitro and in�vivo studies Cite
  Sun X, Ma X, Li Q, Yang Y, Xu X, Sun J, et al. Anti‑cancer effects of fisetin on mammary carcinoma cells via regulation of the PI3K/Akt/mTOR pathway: In�vitro and in�vivo studies. International Journal of Molecular Medicine. Spandidos Publications; 2018; 10.3892/ijmm.2018.3654
• A hydroxylated flavonol, fisetin inhibits the formation of a carcinogenic estrogen metabolite Cite
  Meng X, Sun H, Yang L, Yin R, Qi L. A hydroxylated flavonol, fisetin inhibits the formation of a carcinogenic estrogen metabolite. Steroids. Elsevier BV; 2017; 119:53-56 10.1016/j.steroids.2017.01.002
• The flavonoid fisetin as an anticancer agent targeting the growth signaling pathways Cite
  Rengarajan T, Yaacob NS. The flavonoid fisetin as an anticancer agent targeting the growth signaling pathways. European Journal of Pharmacology. Elsevier BV; 2016; 789:8-16 10.1016/j.ejphar.2016.07.001
• Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells Cite
  Klimaszewska-Wisniewska A, Halas-Wisniewska M, Tadrowski T, Gagat M, Grzanka D, Grzanka A. Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells. Cancer Cell International. Springer Science and Business Media LLC; 2016; 16 10.1186/s12935-016-0288-3
• The Dietary Flavonoid Fisetin Causes Cell Cycle Arrest, Caspase-Dependent Apoptosis, and Enhanced Cytotoxicity of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells Cite
  Smith ML, Murphy K, Doucette CD, Greenshields AL, Hoskin DW. The Dietary Flavonoid Fisetin Causes Cell Cycle Arrest, Caspase-Dependent Apoptosis, and Enhanced Cytotoxicity of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells. Journal of Cellular Biochemistry. Wiley; 2016; 117:1913-1925 10.1002/jcb.25490
• Epigenetic activities of flavonoids in the prevention and treatment of cancer Cite
  Busch C, Burkard M, Leischner C, Lauer UM, Frank J, Venturelli S. Epigenetic activities of flavonoids in the prevention and treatment of cancer. Clinical Epigenetics. Springer Science and Business Media LLC; 2015; 7 10.1186/s13148-015-0095-z
• Fisetin regulates TPA-induced breast cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways Cite
  Noh E, Park Y, Kim J, Kim M, Kim H, Song H, et al. Fisetin regulates TPA-induced breast cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways. European Journal of Pharmacology. Elsevier BV; 2015; 764:79-86 10.1016/j.ejphar.2015.06.038
• Fisetin regulates obesity by targeting mTORC1 signaling Cite
  Jung CH, Kim H, Ahn J, Jeon T, Lee D, Ha T. Fisetin regulates obesity by targeting mTORC1 signaling. The Journal of Nutritional Biochemistry. Elsevier BV; 2013; 24:1547-1554 10.1016/j.jnutbio.2013.01.003
• Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB Cite
  Goh FY, Upton N, Guan S, Cheng C, Shanmugam MK, Sethi G, et al. Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB. European Journal of Pharmacology. Elsevier BV; 2012; 679:109-116 10.1016/j.ejphar.2012.01.002
• New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals Cite
  Souček P, Kondrová E, Heřmánek J, Stopka P, Boumendjel A, Ueng Y, et al. New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals. Anti-Cancer Drugs. Ovid Technologies (Wolters Kluwer Health); 2011; 22:176-184 10.1097/cad.0b013e328341a17b
• Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy Cite
  Chiu S. Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy. International Journal of Oncology. Spandidos Publications; 2011; 10.3892/ijo.2011.1203
• Flavonoids, Proanthocyanidins, and Cancer Risk: A Network of Case-Control Studies From Italy Cite
  Rossi M, Bosetti C, Negri E, Lagiou P, Vecchia CL. Flavonoids, Proanthocyanidins, and Cancer Risk: A Network of Case-Control Studies From Italy. Nutrition and Cancer. Informa UK Limited; 2010; 62:871-877 10.1080/01635581.2010.509534
• Low Concentrations of Flavonoids Are Protective in Rat H4IIE Cells Whereas High Concentrations Cause DNA Damage and Apoptosis Cite
  Wätjen W, Michels G, Steffan B, Niering P, Chovolou Y, Kampkötter A, et al. Low Concentrations of Flavonoids Are Protective in Rat H4IIE Cells Whereas High Concentrations Cause DNA Damage and Apoptosis. The Journal of Nutrition. Oxford University Press (OUP); 2005; 135:525-531 10.1093/jn/135.3.525
• A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF- B-signaling pathways Cite
  Suh Y, Afaq F, Johnson JJ, Mukhtar H. A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF- B-signaling pathways. Carcinogenesis. Oxford University Press (OUP); 2008; 30:300-307 10.1093/carcin/bgn269
• Flavonoids and Breast Cancer Risk in Italy Cite
  Bosetti C. Flavonoids and Breast Cancer Risk in Italy. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2005; 14:805-808 10.1158/1055-9965.epi-04-0838