The current webpage is designed to make additional research available concerning how various fruits and fruit components influence lobular breast cancer risk, development, growth and prognosis. Below are links to studies relating to the beneficial fruits listed in Foods to eat and avoid for lobular breast cancer patients & survivors.
There are very few studies that directly investigate the influence of fruit or micronutrients on lobular breast cancer. Dietary, but not supplemental, beta-carotene (found, for example, in cantaloupes and passion fruit) and dietary fiber both have been reported to prevent lobular breast cancer.
However, since lobular breast cancer typically is characterized by greatly reduced expression of E-cadherin (a protein that facilitates cell-to-cell adhesion), fruit consumption can inhibit lobular disease through the actions of micronutrients that increase E-cadherin expression, among them anthocyanins such as cyanidin-3-glucoside (blackberries, boysenberries, and passion fruit), lycopene (watermelon), melatonin (cherries), phloretin (apples), pterostilbene (blueberries, grapes), quercetin (black currants, cranberries) and ursolic acid (red apple peels, plums).
Those with lobular breast cancer can also view additional studies concerning fruit that pertain to their receptor type: Fruit and ER+/PR+ breast cancer, Fruit and triple negative breast cancer, Fruit and HER2+ breast cancer.
Fruit micronutrients should be obtained by eating fruit rather than taking supplements. When a beneficial micronutrient is administered at low doses by consuming food, it is likely to have subtle chemopreventive effects, whereas the same compound administered at high doses is more likely to have pharmacological effects, with possible unwanted outcomes. For example, quercetin has been reported to contribute to the growth of estrogen-induced mammary tumors, but only once the tumors were established in female rats.