Tag: pterostilbene

News

06/20/25

Pterostilbene plus resveratrol inhibits ER-/PR-/HER2- and ER-/PR-/HER2+ disease in mice

09/02/20

Blueberry compound pterostilbene inhibits mutant p53 breast cancer

11/05/17

Blueberry compound pterostilbene reduces proliferation of TN disease

06/12/16

Compounds in blueberries and grapes can restore some ER expression

02/22/15

Blueberry and ginger compounds enhance paclitaxel treatment effects

03/29/13

Blueberry compound inhibits BC stem cell generation and activities

05/15/12

Blueberries and raspberries both reduce mammary tumor development

11/14/10

Blueberry compound pterostilbene increases effectiveness of tamoxifen

Foods

• • blueberries
  • grapes

Studies

• Pterostilbene induces pyroptosis in mouse breast cancer cells through the caspase-3/Gasdermin E signaling pathway and reshapes the tumor immune microenvironment Cite
  Huang X, Yang W, Hu X, Peng L, Dong J, Li L. Pterostilbene induces pyroptosis in mouse breast cancer cells through the caspase-3/Gasdermin E signaling pathway and reshapes the tumor immune microenvironment. Translational Oncology. Elsevier BV; 2025; 59:102454 10.1016/j.tranon.2025.102454
• Abstract P5-01-21: Epigenetic changes induced by combinatorial pterostilbene and resveratrol in Her2-positive and triple-negative mammary cancer via gut microbiome-metabolome axis modulation Cite
  Ganguly S, Tollefsbol TO. Abstract P5-01-21: Epigenetic changes induced by combinatorial pterostilbene and resveratrol in Her2-positive and triple-negative mammary cancer via gut microbiome-metabolome axis modulation. Clinical Cancer Research. American Association for Cancer Research (AACR); 2025; 31:P5-01-21-P5-01-21 10.1158/1557-3265.sabcs24-p5-01-21
• Pterostilbene as a Multifaceted Anticancer Agent: Molecular Mechanisms, Therapeutic Potential and Future Directions Cite
  Ali MA, Kaleem N, Ali A, Khan N, Khaliq M, Arif N, et al. Pterostilbene as a Multifaceted Anticancer Agent: Molecular Mechanisms, Therapeutic Potential and Future Directions. Medical Oncology. Springer Science and Business Media LLC; 2025; 42 10.1007/s12032-025-02721-5
• Anticancer efficacy of dual-loaded SLNs with Doxorubicin (DOX) and Pterostilbene (PTS): formulation, characterization, and evaluation for breast cancer Cite
  Marwah H, Pant J, Shah K, Alam P, Dewangan HK. Anticancer efficacy of dual-loaded SLNs with Doxorubicin (DOX) and Pterostilbene (PTS): formulation, characterization, and evaluation for breast cancer. Nanomedicine. Informa UK Limited; 2025; 20:1249-1265 10.1080/17435889.2025.2501526
• Pterostilbene as a Multifaceted Anticancer Agent: Molecular Mechanisms, Therapeutic Potential and Future Directions Cite
  Ali MA, Kaleem N, Ali A, Khan N, Khaliq M, Arif N, et al. Pterostilbene as a Multifaceted Anticancer Agent: Molecular Mechanisms, Therapeutic Potential and Future Directions. Medical Oncology. Springer Science and Business Media LLC; 2025; 42 10.1007/s12032-025-02721-5
• Pterostilbene as a potent ESR-1 in breast cancer therapy: insights from network pharmacology, molecular docking, dynamics simulations, ADMET, and in vitro analysis Cite
  Marwah H, Dewangan HK. Pterostilbene as a potent ESR-1 in breast cancer therapy: insights from network pharmacology, molecular docking, dynamics simulations, ADMET, and in vitro analysis. Molecular Diversity. Springer Science and Business Media LLC; 2025; 10.1007/s11030-025-11144-3
• Advances in antitumor effects of pterostilbene and its derivatives Cite
  Yu X, Xu M, Gao Z, Guan H, Zhu Q. Advances in antitumor effects of pterostilbene and its derivatives. Future Medicinal Chemistry. Informa UK Limited; 2024;:1-16 10.1080/17568919.2024.2435251
• Blueberries in focus: Exploring the phytochemical potentials and therapeutic applications Cite
  Ashique S, Mukherjee T, Mohanty S, Garg A, Mishra N, Kaushik M, et al. Blueberries in focus: Exploring the phytochemical potentials and therapeutic applications. Journal of Agriculture and Food Research. Elsevier BV; 2024; 18:101300 10.1016/j.jafr.2024.101300
• A Structure‐Activity Relationship Study of Amino Acid Derivatives of Pterostilbene Analogues Toward Human Breast Cancer Cite
  Cordella F, Dragone N, D'Orsi R, Saponaro C, Vergara D, Lessi M, et al. A Structure‐Activity Relationship Study of Amino Acid Derivatives of Pterostilbene Analogues Toward Human Breast Cancer. ChemMedChem. Wiley; 2024; 10.1002/cmdc.202300727
• Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer Cite
  da Silva FC, Brandão DC, Ferreira EA, Siqueira RP, Ferreira HSV, Da Silva Filho AA, et al. Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer. Pharmaceuticals. MDPI AG; 2023; 16:1466 10.3390/ph16101466
• Chondroitin/Lactoferrin-dual functionalized pterostilbene-solid lipid nanoparticles as targeted breast cancer therapy Cite
  Aly S, El-Kamel AH, Sheta E, El-Habashy SE. Chondroitin/Lactoferrin-dual functionalized pterostilbene-solid lipid nanoparticles as targeted breast cancer therapy. International Journal of Pharmaceutics. Elsevier BV; 2023;:123163 10.1016/j.ijpharm.2023.123163
• Pterostilbene–isothiocyanate reduces miR-21 level by impeding Dicer-mediated processing of pre-miR-21 in 5-fluorouracil and tamoxifen-resistant human breast cancer cell lines Cite
  Kumar V, Haldar S, Saini S, Ghosh S, Dhankhar P, Roy P. Pterostilbene–isothiocyanate reduces miR-21 level by impeding Dicer-mediated processing of pre-miR-21 in 5-fluorouracil and tamoxifen-resistant human breast cancer cell lines. 3 Biotech. Springer Science and Business Media LLC; 2023; 13 10.1007/s13205-023-03582-3
• Pterostilbene antagonizes homocysteine-induced oxidative stress, apoptosis and lipid deposition in vascular endothelial cells Cite
  Jiang Q, Wang L, Si X, Bian Y, Zhang W, Cui H, et al. Pterostilbene antagonizes homocysteine-induced oxidative stress, apoptosis and lipid deposition in vascular endothelial cells. Food Science and Human Wellness. Elsevier BV; 2023; 12:1683-1692 10.1016/j.fshw.2023.02.029
• Pterostilbene inhibits the metastasis of TNBC via suppression of β-catenin-mediated epithelial to mesenchymal transition and stemness Cite
  Ma K, Chen H, Wang K, Han X, Zhang Y, Wang H, et al. Pterostilbene inhibits the metastasis of TNBC via suppression of β-catenin-mediated epithelial to mesenchymal transition and stemness. Journal of Functional Foods. Elsevier BV; 2022; 96:105219 10.1016/j.jff.2022.105219
• Pterostilbene inhibits the metastasis of TNBC via suppression of β-catenin-mediated epithelial to mesenchymal transition and stemness Cite
  Ma K, Chen H, Wang K, Han X, Zhang Y, Wang H, et al. Pterostilbene inhibits the metastasis of TNBC via suppression of β-catenin-mediated epithelial to mesenchymal transition and stemness. Journal of Functional Foods. Elsevier BV; 2022; 96:105219 10.1016/j.jff.2022.105219
• Pterostilbene in Cancer Therapy Cite
  Obrador E, Salvador-Palmer R, Jihad-Jebbar A, López-Blanch R, Dellinger TH, Dellinger RW, et al. Pterostilbene in Cancer Therapy. Antioxidants. MDPI AG; 2021; 10:492 10.3390/antiox10030492
• Recent advances in nuclear receptors-mediated health benefits of blueberry Cite
  Zou H, Ye H, Zhang J, Ren L. Recent advances in nuclear receptors-mediated health benefits of blueberry. Phytomedicine. Elsevier BV; 2022; 100:154063 10.1016/j.phymed.2022.154063
• Dietary Intake of Polyphenols or Polyunsaturated Fatty Acids and Its Relationship with Metabolic and Inflammatory State in Patients with Type 2 Diabetes Mellitus Cite
  Kosmalski M, Pękala-Wojciechowska A, Sut A, Pietras T, Luzak B. Dietary Intake of Polyphenols or Polyunsaturated Fatty Acids and Its Relationship with Metabolic and Inflammatory State in Patients with Type 2 Diabetes Mellitus. Nutrients. MDPI AG; 2022; 14:1083 10.3390/nu14051083
• Pterostilbene-isothiocyanate inhibits breast cancer metastasis by selectively blocking IKK-β/NEMO interaction in cancer cells Cite
  Kumar V, Haldar S, Das NS, Ghosh S, Dhankhar P, Sircar D, et al. Pterostilbene-isothiocyanate inhibits breast cancer metastasis by selectively blocking IKK-β/NEMO interaction in cancer cells. Biochemical Pharmacology. Elsevier BV; 2021;:114717 10.1016/j.bcp.2021.114717
• Pterostilbene Changes Epigenetic Marks at Enhancer Regions of Oncogenes in Breast Cancer Cells Cite
  Harandi-Zadeh S, Boycott C, Beetch M, Yang T, Martin BJE, Ren K, et al. Pterostilbene Changes Epigenetic Marks at Enhancer Regions of Oncogenes in Breast Cancer Cells. Antioxidants. MDPI AG; 2021; 10:1232 10.3390/antiox10081232
• Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy Cite
  Sabo AA, Dudau M, Constantin GL, Pop TC, Geilfus C, Naccarati A, et al. Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy. Frontiers in Pharmacology. Frontiers Media SA; 2021; 12 10.3389/fphar.2021.652074
• Targeting Breast Cancer-Derived Stem Cells by Dietary Phytochemicals: A Strategy for Cancer Prevention and Treatment Cite
  Prajapati KS, Gupta S, Kumar S. Targeting Breast Cancer-Derived Stem Cells by Dietary Phytochemicals: A Strategy for Cancer Prevention and Treatment. Cancers. MDPI AG; 2022; 14:2864 10.3390/cancers14122864
• Amelioration of Pterostilbene Antiproliferative, Proapoptotic, and Oxidant Potentials in Human Breast Cancer MCF7 Cells Using Zein Nanocomposites Cite
  Kutbi HI, Kammoun AK, Farag El-Telbany D. Amelioration of Pterostilbene Antiproliferative, Proapoptotic, and Oxidant Potentials in Human Breast Cancer MCF7 Cells Using Zein Nanocomposites. International Journal of Nanomedicine. Informa UK Limited; 2021; Volume 16:3059-3071 10.2147/ijn.s303975
• Pterostilbene in Cancer Therapy Cite
  Obrador E, Salvador-Palmer R, Jihad-Jebbar A, López-Blanch R, Dellinger TH, Dellinger RW, et al. Pterostilbene in Cancer Therapy. Antioxidants. MDPI AG; 2021; 10:492 10.3390/antiox10030492
• Modulation of Autophagy in Cancer Cells by Dietary Polyphenols Cite
  Musial C, Siedlecka-Kroplewska K, Kmiec Z, Gorska-Ponikowska M. Modulation of Autophagy in Cancer Cells by Dietary Polyphenols. Antioxidants. MDPI AG; 2021; 10:123 10.3390/antiox10010123
• Pterostilbene as a Phytochemical Compound Induces Signaling Pathways Involved in the Apoptosis and Death of Mutant P53-Breast Cancer Cell Lines Cite
  Elsherbini AM, Sheweita SA, Sultan AS. Pterostilbene as a Phytochemical Compound Induces Signaling Pathways Involved in the Apoptosis and Death of Mutant P53-Breast Cancer Cell Lines. Nutrition and Cancer. Informa UK Limited; 2020;:1-9 10.1080/01635581.2020.1817513
• PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades Cite
  Liu D, Ma Z, Xu L, Zhang X, Qiao S, Yuan J. PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades. Aging. Impact Journals, LLC; 2019; 11:10061-10073 10.18632/aging.102418
• Synergistic Action of Stilbenes in Muscadine Grape Berry Extract Shows Better Cytotoxic Potential Against Cancer Cells Than Resveratrol Alone Cite
  Balasubramani SP, Rahman MA, Basha SM. Synergistic Action of Stilbenes in Muscadine Grape Berry Extract Shows Better Cytotoxic Potential Against Cancer Cells Than Resveratrol Alone. Biomedicines. MDPI AG; 2019; 7:96 10.3390/biomedicines7040096
• Stilbenoid‐Mediated Epigenetic Activation of Semaphorin 3A in Breast Cancer Cells Involves Changes in Dynamic Interactions of DNA with DNMT3A and NF1C Transcription Factor Cite
  Beetch M, Lubecka K, Shen K, Flower K, Harandi‐Zadeh S, Suderman M, et al. Stilbenoid‐Mediated Epigenetic Activation of Semaphorin 3A in Breast Cancer Cells Involves Changes in Dynamic Interactions of DNA with DNMT3A and NF1C Transcription Factor. Molecular Nutrition & Food Research. Wiley; 2019; 63:1801386 10.1002/mnfr.201801386
• Resveratrol analogues surprisingly effective against triple‑negative breast cancer, independent of ERα Cite
  Horgan X, Tatum H, Brannan E, Paull D, Rhodes L. Resveratrol analogues surprisingly effective against triple‑negative breast cancer, independent of ERα. Oncology Reports. Spandidos Publications; 2019; 10.3892/or.2019.7122
• Differential Anticancer Activity of Pterostilbene Against Three Subtypes of Human Breast Cancer Cells Cite
  . Differential Anticancer Activity of Pterostilbene Against Three Subtypes of Human Breast Cancer Cells. Anticancer Research. Anticancer Research USA Inc.; 2017; 37 10.21873/anticanres.12064
• A Novel Combinatorial Epigenetic Therapy Using Resveratrol and Pterostilbene for Restoring Estrogen Receptor-α (ERα) Expression in ERα-Negative Breast Cancer Cells Cite
  Kala R, Tollefsbol TO. A Novel Combinatorial Epigenetic Therapy Using Resveratrol and Pterostilbene for Restoring Estrogen Receptor-α (ERα) Expression in ERα-Negative Breast Cancer Cells. PLOS ONE. Public Library of Science (PLoS); 2016; 11:e0155057 10.1371/journal.pone.0155057
• Abstract A32: Targeting c-Met by Pterostilbene (PTER) suppresses breast cancer brain metastasis Cite
  Xing F, Sharma S, Liu Y, Wu K, Watabe K. Abstract A32: Targeting c-Met by Pterostilbene (PTER) suppresses breast cancer brain metastasis. Tumor Dormancy and Resistance. American Association for Cancer Research; 2016; 10.1158/1538-7445.tummet15-a32
• Abstract B17: Epigenetic regulation of NOTCH oncogenic signaling in breast cancer Cite
  Lubecka K, Kurzava L, Flower K, Buvala H, Teegarden D, Camarillo I, et al. Abstract B17: Epigenetic regulation of NOTCH oncogenic signaling in breast cancer. Cancer Genomics and Epigenomics. American Association for Cancer Research; 2016; 10.1158/1538-7445.chromepi15-b17
• Plant stilbenes induce endoplasmic reticulum stress and their anti-cancer activity can be enhanced by inhibitors of autophagy Cite
  Papandreou I, Verras M, McNeil B, Koong AC, Denko NC. Plant stilbenes induce endoplasmic reticulum stress and their anti-cancer activity can be enhanced by inhibitors of autophagy. Experimental Cell Research. Elsevier BV; 2015; 339:147-153 10.1016/j.yexcr.2015.10.014
• Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition Cite
  Su C, Lee W, Wu AT, Lin Y, Wang L, Wu C, et al. Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition. The Journal of Nutritional Biochemistry. Elsevier BV; 2015; 26:675-685 10.1016/j.jnutbio.2015.01.005
• Targeting Cancer Stem Cells in Breast Cancer: Potential Anticancer Properties of 6-Shogaol and Pterostilbene Cite
  Wu C, Hong B, Ho C, Yen G. Targeting Cancer Stem Cells in Breast Cancer: Potential Anticancer Properties of 6-Shogaol and Pterostilbene. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2015; 63:2432-2441 10.1021/acs.jafc.5b00002
• Resveratrol and pterostilbene regulate MED28 (magicin/EG1) expression and cell growth in MCF7 human breast cancer cells Cite
  Huang C, Hsieh N, Pan M, Li C, Chou Y, Chiou Y, et al. Resveratrol and pterostilbene regulate MED28 (magicin/EG1) expression and cell growth in MCF7 human breast cancer cells. Journal of Functional Foods. Elsevier BV; 2015; 12:158-167 10.1016/j.jff.2014.11.006
• Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit Cite
  Mak K, Wu ATH, Lee W, Chang T, Chiou J, Wang L, et al. Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit. Molecular Nutrition & Food Research. Wiley; 2013; 57:1123-1134 10.1002/mnfr.201200549
• Invadopodia-associated proteins blockade as a novel mechanism for 6-shogaol and pterostilbene to reduce breast cancer cell motility and invasion Cite
  Hong B, Wu C, Yeh C, Yen G. Invadopodia-associated proteins blockade as a novel mechanism for 6-shogaol and pterostilbene to reduce breast cancer cell motility and invasion. Molecular Nutrition & Food Research. Wiley; 2013; 57:886-895 10.1002/mnfr.201200715
• Resveratrol Modulates MED28 (Magicin/EG-1) Expression and Inhibits Epidermal Growth Factor (EGF)-Induced Migration in MDA-MB-231 Human Breast Cancer Cells Cite
  Lee M, Pan M, Chiou Y, Cheng A, Huang H. Resveratrol Modulates MED28 (Magicin/EG-1) Expression and Inhibits Epidermal Growth Factor (EGF)-Induced Migration in MDA-MB-231 Human Breast Cancer Cells. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2011; 59:11853-11861 10.1021/jf202426k
• The antiproliferative effects of pterostilbene on breast cancer in vitro are via inhibition of constitutive and leptin-induced Janus kinase/signal transducer and activator of transcription activation Cite
  McCormack D, Schneider J, McDonald D, McFadden D. The antiproliferative effects of pterostilbene on breast cancer in vitro are via inhibition of constitutive and leptin-induced Janus kinase/signal transducer and activator of transcription activation. The American Journal of Surgery. Elsevier BV; 2011; 202:541-544 10.1016/j.amjsurg.2011.06.020