Delphinidin inhibits malignant transformation and inhibits TN growth

Posted: July 17, 2016

Study:	Delphinidin-3-glucoside suppresses breast carcinogenesis by inactivating the Akt/HOTAIR signaling pathway Cite Yang X, Luo E, Liu X, Han B, Yu X, Peng X. Delphinidin-3-glucoside suppresses breast carcinogenesis by inactivating the Akt/HOTAIR signaling pathway. BMC Cancer. Springer Science and Business Media LLC; 2016; 16 10.1186/s12885-016-2465-0
Publication:	BMC Cancer, July 2016

Delphinidin inhibits triple negative BC growth

Delphinidin is an anthocyanin pigment found in a variety of blue, red and purple fruits, especially berries such as blueberries, black currants, and cranberries. Delphinidin has previously been reported to suppress the growth of hormone receptor positive (ER+/PR+), HER2+ and triple negative (ER-/PR-/HER2-) breast cancer cells.

Now a new study has reported that delphinidin inhibits carcinogen-induced transformation of normal cells into breast cancer cells and also inhibits tumor growth in a mouse model of triple negative breast cancer.

Latest research finds delphinidin inhibits BC development

The study referenced at the beginning of this new story was designed to investigate the mechanism of action by which delphinidin-3-glucoside reduces breast carcinogenesis and growth, including the role of the Akt/HOTAIR signaling pathway. Activation of the Akt gene is frequently observed in human cancer cells. In particular, long non-coding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) plays an important part in cancer progression. This is regulated by the interferon regulatory factor-1 (IRF1) and up-streaming Akt activation. Therefore, down-regulation of Akt/HOTAIR signaling is one possible strategy for breast cancer prevention.

To conduct the study, the authors first treated non-cancerous MCF-10A human breast cells either with two carcinogens or with the carcinogens plus delphinidin for 30 days. The cells were then evaluated for cancer-associated properties using a variety of tests. Exposure to the carcinogens was found to induce malignant transformation in breast cells. This transformation was effectively suppressed in cells co-treated with delphinidin through inactivation of the Akt/HOTAIR signaling pathway.

In a second experiment, the authors implanted bioluminescent MDA-MB-231-Luc-GFP triple negative breast cancer cells in mice to generate tumors in them. Delphinidin was found to inhibit the growth of these xenografted breast tumors, again by decreasing HOTAIR. The authors conclude that the findings suggest that delphinidin is effective in inhibiting breast carcinogenesis, in part through down-regulation of HOTAIR.

Selected breast cancer studies

Delphinidin Suppresses PMA-Induced MMP-9 Expression by Blocking the NF-κB Activation Through MAPK Signaling Pathways in MCF-7 Human Breast Carcinoma Cells Cite
Im N, Jang WJ, Jeong C, Jeong G. Delphinidin Suppresses PMA-Induced MMP-9 Expression by Blocking the NF-κB Activation Through MAPK Signaling Pathways in MCF-7 Human Breast Carcinoma Cells. Journal of Medicinal Food. Mary Ann Liebert Inc; 2014; 17:855-861 10.1089/jmf.2013.3077
Delphinidin inhibits cell proliferation and induces apoptosis in MDA-MB-231 human breast cancer cell lines Cite
Seo EY. Delphinidin inhibits cell proliferation and induces apoptosis in MDA-MB-231 human breast cancer cell lines. Journal of Nutrition and Health. The Korean Nutrition Society; 2013; 46:503 10.4163/jnh.2013.46.6.503
Inhibition of Estrogen-Mediated Mammary Tumorigenesis by Blueberry and Black Raspberry Cite
Ravoori S, Vadhanam MV, Aqil F, Gupta RC. Inhibition of Estrogen-Mediated Mammary Tumorigenesis by Blueberry and Black Raspberry. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2012; 60:5547-5555 10.1021/jf205325p
The health benefits of blackcurrants Cite
Gopalan A, Reuben SC, Ahmed S, Darvesh AS, Hohmann J, Bishayee A. The health benefits of blackcurrants. Food & Function. Royal Society of Chemistry (RSC); 2012; 3:795 10.1039/c2fo30058c
Influence of Berry Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention Cite
Aiyer HS, Warri AM, Woode DR, Hilakivi-Clarke L, Clarke R. Influence of Berry Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2012; 60:5693-5708 10.1021/jf204084f
Delphinidin Inhibits HER2 and Erk1/2 Signaling and Suppresses Growth of HER2-Overexpressing and Triple Negative Breast Cancer Cell Lines Cite
Ozbay T, Nahta R. Delphinidin Inhibits HER2 and Erk1/2 Signaling and Suppresses Growth of HER2-Overexpressing and Triple Negative Breast Cancer Cell Lines. Breast Cancer: Basic and Clinical Research. SAGE Publications; 2011; 5:BCBCR.S7156 10.4137/bcbcr.s7156
Characterization of Anthocyanins and Proanthocyanidins in Some Cultivars ofRibes,Aronia, andSambucusand Their Antioxidant Capacity Cite
Wu X, Gu L, Prior RL, McKay S. Characterization of Anthocyanins and Proanthocyanidins in Some Cultivars ofRibes,Aronia, andSambucusand Their Antioxidant Capacity. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2004; 52:7846-7856 10.1021/jf0486850

Latest research finds delphinidin inhibits BC development

Selected breast cancer studies

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