Ginger is recommended for breast cancer

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Ginger is recommended for breast cancer
Ginger refers to the fresh or dried rhizome (underground stem) of the ginger plant (Zingiber officinale). Ginger contains numerous compounds that have been shown to have antioxidant, anti-inflammatory, antimicrobial, antiviral, antifungal, anti-arthritic, hypotensive, antiatherogenic, radioprotective and antiemetic properties.
Ginger is believed to affect serotonin receptors in the digestive tract and it has been traditionally used to aid digestion and treat stomach upset and nausea (including pregnancy-related "morning sickness"). Ginger may assist in prevention of the progression of type 2 diabetes through its hypoglycemic effects and by increasing insulin sensitivity.
Ginger also contains components shown to have anti-cancer effects, including various gingerols, gingerdione, shogaols, and paradols, as well as caffeic acid, β-elemene and zingerone. Ginger has been shown to have protective effect in cell and animal prostate cancer models and to suppress colorectal, skin and lung carcinogenesis in laboratory animals. Ginger has also been shown to inhibit the growth of leukemia cells, as well as gastric, pancreatic, liver and ovarian cancer cells in the laboratory.
Ginger has been found to significantly inhibit mammary tumorigenesis and tumor growth in laboratory mice when fed in drinking water. Ginger components 6-Shogaol and [6]-gingerol have been shown to inhibit cell adhesion, invasion, and motility in both hormone receptor positive (ER+/PR+) and triple negative (ER-/PR-/HER2-) human breast cancer cells in the laboratory. 6-shogaol has also been shown to induce breast cancer cell death and inhibit the formation of breast cancer stem cell-like spheroids.
Ginger has been found to be effective in treating chemotherapy-induced nausea and vomiting, although not all studies agree. The key appears to be to take the ginger before undergoing a chemotherapy treatment as well as afterwards. It has been shown that 6-shogaol increases the cytotoxic effects of Taxol (paclitaxel). In addition, ginger appears to increase the effectiveness of Adriamycin (doxorubicin) chemotherapy.
On the other hand, ginger should be avoided during radiation treatment since it has been shown to help protect cells against the cytotoxic effects of radiation.
Edible tropical ginger (Zingiber zerumbet Smith), also known as subtropical ginger, contains compounds such as zerumbone and 1'-acetoxychavicol acetate, which have been shown to have anti-breast cancer effects in the laboratory. However, note that this ginger is typically not sold in the U.S. and many "tropical gingers" are inedible ornamental plants.
Wild ginger (Asarum canadense), which is used in some weight loss and Chinese herbal preparations, should be avoided. Wild ginger incorporates aristolochic acid, which has been shown to be toxic to the kidneys and is a suspected human carcinogen.
Ginger ale or ginger beer is a soft drink that, as formulated commercially, typically contains high amounts of sugar and low or nonexistent amounts of ginger. For example Canada Dry regular ginger ale contains the following ingredients: carbonated water, high fructose syrup and/or sugar, citric acid, natural flavors, sodium benzoate and caramel color.
Below are links to recent studies concerning this food. For a more complete list of studies, please click on ginger.

  • Efficacy based ginger fingerprinting reveals potential antiproliferative analytes for triple negative breast cancer Cite
    Zhao L, Rupji M, Choudhary I, Osan R, Kapoor S, Zhang H, et al. Efficacy based ginger fingerprinting reveals potential antiproliferative analytes for triple negative breast cancer. Scientific Reports. Springer Science and Business Media LLC; 2020; 10 10.1038/s41598-020-75707-0
  • Effect of ginger (Zingiber officinale) on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials Cite
    Morvaridzadeh M, Fazelian S, Agah S, Khazdouz M, Rahimlou M, Agh F, et al. Effect of ginger (Zingiber officinale) on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials. Cytokine. Elsevier BV; 2020; 135:155224 10.1016/j.cyto.2020.155224
  • [10]-Gingerol improves doxorubicin anticancer activity and decreases its side effects in triple negative breast cancer models Cite
    Baptista Moreno Martin AC, Tomasin R, Luna-Dulcey L, Graminha AE, Araújo Naves M, Teles RHG, et al. [10]-Gingerol improves doxorubicin anticancer activity and decreases its side effects in triple negative breast cancer models. Cellular Oncology. Springer Science and Business Media LLC; 2020; 43:915-929 10.1007/s13402-020-00539-z
  • 6-Shogaol suppresses the growth of breast cancer cells by inducing apoptosis and suppressing autophagy via targeting notch signaling pathway Cite
    Bawadood AS, Al-Abbasi FA, Anwar F, El-Halawany AM, Al-Abd AM. 6-Shogaol suppresses the growth of breast cancer cells by inducing apoptosis and suppressing autophagy via targeting notch signaling pathway. Biomedicine & Pharmacotherapy. Elsevier BV; 2020; 128:110302 10.1016/j.biopha.2020.110302
  • Ginger and its active compounds in cancer therapy: From folk uses to nano-therapeutic applications Cite
    Mahomoodally M, Aumeeruddy M, Rengasamy KR, Roshan S, Hammad S, Pandohee J, et al. Ginger and its active compounds in cancer therapy: From folk uses to nano-therapeutic applications. Seminars in Cancer Biology. Elsevier BV; 2019; 10.1016/j.semcancer.2019.08.009
  • The effect of ginger ( Zingiber officinale ) on chemotherapy‐induced nausea and vomiting in breast cancer patients: A systematic literature review of randomized controlled trials Cite
    Saneei Totmaj A, Emamat H, Jarrahi F, Zarrati M. The effect of ginger ( Zingiber officinale ) on chemotherapy‐induced nausea and vomiting in breast cancer patients: A systematic literature review of randomized controlled trials. Phytotherapy Research. Wiley; 2019; 33:1957-1965 10.1002/ptr.6377
  • Fabrication of 6-gingerol, doxorubicin and alginate hydroxyapatite into a bio-compatible formulation: enhanced anti-proliferative effect on breast and liver cancer cells Cite
    Manatunga DC, de Silva RM, de Silva KMN, Wijeratne DT, Malavige GN, Williams G. Fabrication of 6-gingerol, doxorubicin and alginate hydroxyapatite into a bio-compatible formulation: enhanced anti-proliferative effect on breast and liver cancer cells. Chemistry Central Journal. Springer Science and Business Media LLC; 2018; 12 10.1186/s13065-018-0482-6
  • [10]-Gingerol Affects Multiple Metastatic Processes and Induces Apoptosis in MDAMB- 231 Breast Tumor Cells Cite
    Fuzer AM, Martin AC, Becceneri AB, da Silva JA, Vieira PC, Cominetti MR. [10]-Gingerol Affects Multiple Metastatic Processes and Induces Apoptosis in MDAMB- 231 Breast Tumor Cells. Anti-Cancer Agents in Medicinal Chemistry. Bentham Science Publishers Ltd.; 2018; 19:645-654 10.2174/1871520618666181029125607
  • Anti-cancer potential of a mix of natural extracts of turmeric, ginger and garlic: A cell-based study Cite
    Vemuri SK, Banala RR, Subbaiah G, Srivastava SK, Reddy AG, Malarvili T. Anti-cancer potential of a mix of natural extracts of turmeric, ginger and garlic: A cell-based study. Egyptian Journal of Basic and Applied Sciences. Informa UK Limited; 2017; 4:332-344 10.1016/j.ejbas.2017.07.005
  • Zerumbone modulates CD1d expression and lipid antigen presentation pathway in breast cancer cells Cite
    Shyanti RK, Sehrawat A, Singh SV, Mishra J, Singh RP. Zerumbone modulates CD1d expression and lipid antigen presentation pathway in breast cancer cells. Toxicology in Vitro. Elsevier BV; 2017; 44:74-84 10.1016/j.tiv.2017.06.016
  • Abstract B40: [10]-gingerol as a pro-apoptotic molecule in triple negative breast cancer Cite
    Martin ACBM, Tomasin R, Becceneri AB, Fuzer A, Vieira PC, Cominetti MR. Abstract B40: [10]-gingerol as a pro-apoptotic molecule in triple negative breast cancer. Exploiting Repair Defects in the Tumor Microenvironment. American Association for Cancer Research; 2017; 10.1158/1557-3125.dnarepair16-b40
  • [10]-Gingerol, a major phenolic constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative breast cancer cells Cite
    Bernard MM, McConnery JR, Hoskin DW. [10]-Gingerol, a major phenolic constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative breast cancer cells. Experimental and Molecular Pathology. Elsevier BV; 2017; 102:370-376 10.1016/j.yexmp.2017.03.006
  • Ginger extract adjuvant to doxorubicin in mammary carcinoma: study of some molecular mechanisms Cite
    El-Ashmawy NE, Khedr NF, El-Bahrawy HA, Abo Mansour HE. Ginger extract adjuvant to doxorubicin in mammary carcinoma: study of some molecular mechanisms. European Journal of Nutrition. Springer Science and Business Media LLC; 2017; 57:981-989 10.1007/s00394-017-1382-6
  • Antioxidant activity of ginger extract as a daily supplement in cancer patients receiving adjuvant chemotherapy: a pilot study Cite
    Danwilai K, Konmun J, Sripanidkulchai B, Subongkot S. Antioxidant activity of ginger extract as a daily supplement in cancer patients receiving adjuvant chemotherapy: a pilot study. Cancer Management and Research. Informa UK Limited; 2017; Volume 9:11-18 10.2147/cmar.s124016
  • [10]-Gingerol Reverts Malignant Phenotype of Breast Cancer Cells in 3D Culture Cite
    Fuzer AM, Lee S, Mott JD, Cominetti MR. [10]-Gingerol Reverts Malignant Phenotype of Breast Cancer Cells in 3D Culture. Journal of Cellular Biochemistry. Wiley; 2017; 118:2693-2699 10.1002/jcb.25906
  • The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis Cite
    Mazidi M, Gao H, Rezaie P, Ferns GA. The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis. Food & Nutrition Research. SNF Swedish Nutrition Foundation; 2016; 60:32613 10.3402/fnr.v60.32613
  • Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study Cite
    Thamlikitkul L, Srimuninnimit V, Akewanlop C, Ithimakin S, Techawathanawanna S, Korphaisarn K, et al. Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study. Supportive Care in Cancer. Springer Science and Business Media LLC; 2016; 25:459-464 10.1007/s00520-016-3423-8
  • Elevated IL-1β expression induces invasiveness of triple negative breast cancer cells and is suppressed by zerumbone Cite
    Jeon M, Han J, Nam SJ, Lee JE, Kim S. Elevated IL-1β expression induces invasiveness of triple negative breast cancer cells and is suppressed by zerumbone. Chemico-Biological Interactions. Elsevier BV; 2016; 258:126-133 10.1016/j.cbi.2016.08.021
  • The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting Cite
    Salihah N, Mazlan N, Lua PL. The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting. Focus on Alternative and Complementary Therapies. Wiley; 2016; 21:8-16 10.1111/fct.12236