Tag: EGFR

Articles

• ER+/PR- breast cancer characteristics
• Foods to eat and avoid for ER+/PR- patients and survivors
• Foods to eat and avoid for inflammatory breast cancer (IBC)
• HER2+ breast cancer characteristics
• Inflammatory breast cancer characteristics

News

04/22/24

EGFR inhibition enhances treatment effects of Adriamycin

05/03/22

EGFR inhibition reduces resistance to tamoxifen treatment

03/10/19

Delphinidin inhibits angiogenesis and migration of TN cells

05/07/17

Vegetable oil linoleic acid promotes migration & invasion of TN cells

10/03/16

Anthocyanin found primarily in red & black fruits inhibits TN BC

04/28/12

Ki67 proliferation index predicts progression of LCIS

03/30/11

Although similar, ER+/PR- BC is more aggressive than ER+/PR+

Studies

• Targeting the EGFR pathway in chemotherapy-resistant triple-negative breast cancer - a phase II study Cite
  Yam C, Patel M, Hill HA, Sun R, Bassett RL, Kong E, et al. Targeting the EGFR pathway in chemotherapy-resistant triple-negative breast cancer - a phase II study. Cancer Research Communications. American Association for Cancer Research (AACR); 2024; 10.1158/2767-9764.crc-24-0255
• Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway Cite
  Ganesan K, Xu C, Wu J, Du B, Liu Q, Sui Y, et al. Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway. Science China Life Sciences. Springer Science and Business Media LLC; 2024; 10.1007/s11427-023-2499-2
• Abstract PO4-24-09: Grape seed extract inhibits EGFR signaling pathway as a main factor of tamoxifen resistant in hormone receptor positive breast cancer Cite
  Jung SP, Lee E, You JY, Chun JH, Kim H. Abstract PO4-24-09: Grape seed extract inhibits EGFR signaling pathway as a main factor of tamoxifen resistant in hormone receptor positive breast cancer. Cancer Research. American Association for Cancer Research (AACR); 2024; 84:PO4-24-09-PO4-24-09 10.1158/1538-7445.sabcs23-po4-24-09
• Molecular docking of ferulic acid analogue compounds against epidermal growth factor receptor as a potential therapy for breast cancer Cite
  Ainurrizma DA, Ekowati J, Pebrianti D, Diyah NW, Adrianto MF, Deevi RK, et al. Molecular docking of ferulic acid analogue compounds against epidermal growth factor receptor as a potential therapy for breast cancer. Pharmacy Education. International Pharmaceutical Federation (FIP); 2024; 24:185-190 10.46542/pe.2024.243.185190
• Active substance and mechanisms of Actinidia chinensis Planch for the treatment of breast cancer was explored based on network pharmacology and in silico study Cite
  Xu Y, Yang J, Han X, Gan C, Wei X. Active substance and mechanisms of Actinidia chinensis Planch for the treatment of breast cancer was explored based on network pharmacology and in silico study. Medicine. Ovid Technologies (Wolters Kluwer Health); 2024; 103:e37829 10.1097/md.0000000000037829
• Epidermal growth factor receptor inhibition potentiates chemotherapeutics‐mediated sensitization of metastatic breast cancer stem cells Cite
  Kar T, Dugam P, Shivhare S, Shetty SR, Choudhury S, Sen D, et al. Epidermal growth factor receptor inhibition potentiates chemotherapeutics‐mediated sensitization of metastatic breast cancer stem cells. Cancer Reports. Wiley; 2024; 7 10.1002/cnr2.2049
• Combination Treatment with EGFR Inhibitor and Doxorubicin Synergistically Inhibits Proliferation of MCF-7 Cells and MDA-MB-231 Triple-Negative Breast Cancer Cells In Vitro Cite
  Abrahams B, Gerber A, Hiss DC. Combination Treatment with EGFR Inhibitor and Doxorubicin Synergistically Inhibits Proliferation of MCF-7 Cells and MDA-MB-231 Triple-Negative Breast Cancer Cells In Vitro. International Journal of Molecular Sciences. MDPI AG; 2024; 25:3066 10.3390/ijms25053066
• Activation of epidermal growth factor receptors in triple-negative breast cancer cells by morphine; analysis through Raman spectroscopy and machine learning Cite
  Sezer G, Sahin F, Onses MS, Cumaoglu A. Activation of epidermal growth factor receptors in triple-negative breast cancer cells by morphine; analysis through Raman spectroscopy and machine learning. Talanta. Elsevier BV; 2024;:125827 10.1016/j.talanta.2024.125827
• Role of EGFR and FASN in breast cancer progression Cite
  Chaturvedi S, Biswas M, Sadhukhan S, Sonawane A. Role of EGFR and FASN in breast cancer progression. Journal of Cell Communication and Signaling. Springer Science and Business Media LLC; 2023; 10.1007/s12079-023-00771-w
• Identification of potential edible spices as EGFR and EGFR mutant T790M/L858R inhibitors by structure-based virtual screening and molecular dynamics Cite
  Ahmad Ansari I, Debnath B, Kar S, Patel HM, Debnath S, Zaki ME, et al. Identification of potential edible spices as EGFR and EGFR mutant T790M/L858R inhibitors by structure-based virtual screening and molecular dynamics. Journal of Biomolecular Structure and Dynamics. Informa UK Limited; 2023;:1-18 10.1080/07391102.2023.2223661
• Exploring the mechanism by which quercetin re-sensitizes breast cancer to paclitaxel: network pharmacology, molecular docking, and experimental verification Cite
  Yang Y, Yan J, Huang J, Wu X, Yuan Y, Yuan Y, et al. Exploring the mechanism by which quercetin re-sensitizes breast cancer to paclitaxel: network pharmacology, molecular docking, and experimental verification. Naunyn-Schmiedeberg's Archives of Pharmacology. Springer Science and Business Media LLC; 2023; 10.1007/s00210-023-02510-9
• Biological Activity of Oleanolic Acid Derivatives HIMOXOL and Br-HIMOLID in Breast Cancer Cells Is Mediated by ER and EGFR Cite
  Lisiak N, Dzikowska P, Wisniewska U, Kaczmarek M, Bednarczyk-Cwynar B, Zaprutko L, et al. Biological Activity of Oleanolic Acid Derivatives HIMOXOL and Br-HIMOLID in Breast Cancer Cells Is Mediated by ER and EGFR. International Journal of Molecular Sciences. MDPI AG; 2023; 24:5099 10.3390/ijms24065099
• Prognostic and Predictive Biomarkers in Familial Breast Cancer Cite
  Deb S, Chakrabarti A, Fox SB. Prognostic and Predictive Biomarkers in Familial Breast Cancer. Cancers. MDPI AG; 2023; 15:1346 10.3390/cancers15041346
• EGFR inhibition reverses epithelial‑mesenchymal transition, and decreases tamoxifen resistance via Snail and Twist downregulation in breast cancer cells Cite
  Takeda T, Tsubaki M, Matsuda T, Kimura A, Jinushi M, Obana T, et al. EGFR inhibition reverses epithelial‑mesenchymal transition, and decreases tamoxifen resistance via Snail and Twist downregulation in breast cancer cells. Oncology Reports. Spandidos Publications; 2022; 47 10.3892/or.2022.8320
• Screening of Phytochemicals as Potential Inhibitors of Breast Cancer using Structure Based Multitargeted Molecular Docking Analysis Cite
  Jha V, Devkar S, Gharat K, Kasbe S, Matharoo DK, Pendse S, et al. Screening of Phytochemicals as Potential Inhibitors of Breast Cancer using Structure Based Multitargeted Molecular Docking Analysis. Phytomedicine Plus. Elsevier BV; 2022; 2:100227 10.1016/j.phyplu.2022.100227
• A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer Cite
  Subramaniyan V, Fuloria S, Gupta G, Kumar DH, Sekar M, Sathasivam KV, et al. A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer. Chemico-Biological Interactions. Elsevier BV; 2022; 351:109735 10.1016/j.cbi.2021.109735
• Role of calcium in hormone independent and resistant breast cancer Cite
  Cyrus K, Wang Q, Sharawi Z, Noguchi G, Kaushal M, Chang T, et al. Role of calcium in hormone independent and resistant breast cancer. International Journal of Cancer. Wiley; 2021; 10.1002/ijc.33745
• Tamoxifen overcomes the trastuzumab-resistance of SK-BR-3 tumorspheres by targeting crosstalk between cytoplasmic estrogen receptor α and the EGFR/HER2 signaling pathway Cite
  Kwon Y, Nam K, Kim S. Tamoxifen overcomes the trastuzumab-resistance of SK-BR-3 tumorspheres by targeting crosstalk between cytoplasmic estrogen receptor α and the EGFR/HER2 signaling pathway. Biochemical Pharmacology. Elsevier BV; 2021;:114635 10.1016/j.bcp.2021.114635
• Using dynamic cell communication improves treatment strategies of breast cancer Cite
  Liu Z, Hu S, Yun Z, Hu W, Zhang S, Luo D. Using dynamic cell communication improves treatment strategies of breast cancer. Cancer Cell International. Springer Science and Business Media LLC; 2021; 21 10.1186/s12935-021-01979-9
• EGFR inhibition blocks cancer stem cell clustering and lung metastasis of triple negative breast cancer Cite
  Liu X, Adorno-Cruz V, Chang Y, Jia Y, Kawaguchi M, Dashzeveg NK, et al. EGFR inhibition blocks cancer stem cell clustering and lung metastasis of triple negative breast cancer. Theranostics. Ivyspring International Publisher; 2021; 11:6632-6643 10.7150/thno.57706
• Grape Seed Procyanidins Inhibit the Growth of Breast Cancer MCF-7 Cells by Down-Regulating the EGFR/VEGF/MMP9 Pathway Cite
  Kong F, He C, Kong F, Han S, Kong X, Han W, et al. Grape Seed Procyanidins Inhibit the Growth of Breast Cancer MCF-7 Cells by Down-Regulating the EGFR/VEGF/MMP9 Pathway. Natural Product Communications. SAGE Publications; 2021; 16:1934578X2199169 10.1177/1934578x21991691
• Abstract P3-11-17: Statins suppress the aggressive phenotype of triple negative breast cancer cells via modulation of EGFR signalling Cite
  Smith C, Alim S, Kadi A, Lawati RA, Miles M, Hiscox S. Abstract P3-11-17: Statins suppress the aggressive phenotype of triple negative breast cancer cells via modulation of EGFR signalling. Poster Session Abstracts. American Association for Cancer Research; 2020; 10.1158/1538-7445.sabcs19-p3-11-17
• Quadruple negative breast cancer Cite
  Huang M, Wu J, Ling R, Li N. Quadruple negative breast cancer. Breast Cancer. Springer Science and Business Media LLC; 2020; 27:527-533 10.1007/s12282-020-01047-6
• Short-Term Environmental Conditioning Enhances Tumorigenic Potential of Triple-Negative Breast Cancer Cells Cite
  . Short-Term Environmental Conditioning Enhances Tumorigenic Potential of Triple-Negative Breast Cancer Cells. Tomography. Grapho, LLC; 2019; 5:346-357 10.18383/j.tom.2019.00019
• High glucose levels promote the proliferation of breast cancer cells through GTPases Cite
  Hou Y, Zhou M, Xie J, Chao P, Feng Q, Wu J. High glucose levels promote the proliferation of breast cancer cells through GTPases. Breast Cancer: Targets and Therapy. Informa UK Limited; 2017; Volume 9:429-436 10.2147/bctt.s135665
• EGFR signaling promotes inflammation and cancer stem-like activity in inflammatory breast cancer Cite
  Wang X, Reyes ME, Zhang D, Funakoshi Y, Trape AP, Gong Y, et al. EGFR signaling promotes inflammation and cancer stem-like activity in inflammatory breast cancer. Oncotarget. Impact Journals, LLC; 2017; 8:67904-67917 10.18632/oncotarget.18958
• Abstract 1077: Extra-virgin olive oil Met inhibitor oleocanthal-lapatinib: a novel synergistic combination for HER2-dependent breast malignancies Cite
  Siddique AB, Ebrahim HY, Akl MR, Mohyeldin MM, Sayed KAE. Abstract 1077: Extra-virgin olive oil Met inhibitor oleocanthal-lapatinib: a novel synergistic combination for HER2-dependent breast malignancies. Cancer Chemistry. American Association for Cancer Research; 2017; 10.1158/1538-7445.am2017-1077
• Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells Cite
  Sauer SJ, Tarpley M, Shah I, Save AV, Lyerly H, Patierno SR, et al. Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells. Carcinogenesis. Oxford University Press (OUP); 2017; 38 10.1093/carcin/bgx003
• Cellular and molecular mechanisms underlying alcohol-induced aggressiveness of breast cancer Cite
  Wang Y, Xu M, Ke Z, Luo J. Cellular and molecular mechanisms underlying alcohol-induced aggressiveness of breast cancer. Pharmacological Research. Elsevier BV; 2017; 115:299-308 10.1016/j.phrs.2016.12.005
• Cyanidin-3-o-glucoside directly binds to ERα36 and inhibits EGFR-positive triple-negative breast cancer Cite
  Wang L, Li H, Yang S, Ma W, Liu M, Guo S, et al. Cyanidin-3-o-glucoside directly binds to ERα36 and inhibits EGFR-positive triple-negative breast cancer. Oncotarget. Impact Journals, LLC; 2016; 7:68864-68882 10.18632/oncotarget.12025
• CD44 correlates with clinicopathological characteristics and is upregulated by EGFR in breast cancer Cite
  Xu H, Wu K, Tian Y, Liu Q, Han N, Yuan X, et al. CD44 correlates with clinicopathological characteristics and is upregulated by EGFR in breast cancer. International Journal of Oncology. Spandidos Publications; 2016; 49:1343-1350 10.3892/ijo.2016.3639
• Combination of lapatinib with isothiocyanates overcomes drug resistance and inhibits migration of HER2 positive breast cancer cells Cite
  Kaczyńska A, Herman-Antosiewicz A. Combination of lapatinib with isothiocyanates overcomes drug resistance and inhibits migration of HER2 positive breast cancer cells. Breast Cancer. Springer Science and Business Media LLC; 2016; 24:271-280 10.1007/s12282-016-0700-9
• Effects of Estrogen Receptor and Human Epidermal Growth Factor Receptor-2 Levels on the Efficacy of Trastuzumab Cite
  Loi S, Dafni U, Karlis D, Polydoropoulou V, Young BM, Willis S, et al. Effects of Estrogen Receptor and Human Epidermal Growth Factor Receptor-2 Levels on the Efficacy of Trastuzumab. JAMA Oncology. American Medical Association (AMA); 2016; 2:1040 10.1001/jamaoncol.2016.0339
• Gallic acid abolishes the EGFR/Src/Akt/Erk-mediated expression of matrix metalloproteinase-9 in MCF-7 breast cancer cells Cite
  Chen Y, Lin K, Jhang L, Huang C, Lee Y, Chang L. Gallic acid abolishes the EGFR/Src/Akt/Erk-mediated expression of matrix metalloproteinase-9 in MCF-7 breast cancer cells. Chemico-Biological Interactions. Elsevier BV; 2016; 252:131-140 10.1016/j.cbi.2016.04.025
• Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors Cite
  Goel S, Wang Q, Watt AC, Tolaney SM, Dillon DA, Li W, et al. Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors. Cancer Cell. Elsevier BV; 2016; 29:255-269 10.1016/j.ccell.2016.02.006
• Abstract B20: Combination ofGanoderma lucidumextract and erlotinib decreases IBC progression Cite
  Rios-Fuller TJ, Suarez-Arroyo IJ, Lacourt-Ventura M, Maldonado G, Cubano LA, Martinez-Montemayor MM. Abstract B20: Combination ofGanoderma lucidumextract and erlotinib decreases IBC progression. Targeted Therapies. American Association for Cancer Research; 2016; 10.1158/1557-3125.advbc15-b20
• EGFR Regulates the Development and Microarchitecture of Intratumoral Angiogenic Vasculature Capable of Sustaining Cancer Cell Intravasation Cite
  Minder P, Zajac E, Quigley JP, Deryugina EI. EGFR Regulates the Development and Microarchitecture of Intratumoral Angiogenic Vasculature Capable of Sustaining Cancer Cell Intravasation. Neoplasia. Elsevier BV; 2015; 17:634-649 10.1016/j.neo.2015.08.002
• Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells Cite
  KIM S, LEE J, OH SJ, NAM SJ, LEE JE. Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells. Oncology Reports. Spandidos Publications; 2015; 34:1613-1619 10.3892/or.2015.4116
• Abstract 3212: Ganoderma lucidum (Reishi) chemosensitizes EGFR-overexpressing inflammatory breast cancer cells to erlotinib Cite
  Suárez-Arroyo I, Moraskie M, Cubano LA, Martínez-Montemayor MM. Abstract 3212: Ganoderma lucidum (Reishi) chemosensitizes EGFR-overexpressing inflammatory breast cancer cells to erlotinib. Cancer Chemistry. American Association for Cancer Research; 2014; 10.1158/1538-7445.am2014-3212
• Management of dermatological toxicities in patients receiving EGFR inhibitors Cite
  Lynch K. Management of dermatological toxicities in patients receiving EGFR inhibitors. Community Oncology. Elsevier BV; 2012; 9:315-323 10.1016/j.cmonc.2012.09.008
• Grape Polyphenols Inhibit Akt/Mammalian Target of Rapamycin Signaling and Potentiate the Effects of Gefitinib in Breast Cancer Cite
  Castillo-Pichardo L, Dharmawardhane SF. Grape Polyphenols Inhibit Akt/Mammalian Target of Rapamycin Signaling and Potentiate the Effects of Gefitinib in Breast Cancer. Nutrition and Cancer. Informa UK Limited; 2012; 64:1058-1069 10.1080/01635581.2012.716898
• Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression Cite
  SUN X, LIU X, HUANG D. Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression. Molecular Medicine Reports. Spandidos Publications; 2012; 6:1267-1270 10.3892/mmr.2012.1103
• Luteolin exerts anti-tumor activity through the suppression of epidermal growth factor receptor-mediated pathway in MDA-MB-231 ER-negative breast cancer cells Cite
  Lee E, Oh S, Sung M. Luteolin exerts anti-tumor activity through the suppression of epidermal growth factor receptor-mediated pathway in MDA-MB-231 ER-negative breast cancer cells. Food and Chemical Toxicology. Elsevier BV; 2012; 50:4136-4143 10.1016/j.fct.2012.08.025
• Tumour characteristics among women with very low-risk breast cancer Cite
  Narod SA, Valentini A, Nofech-Mozes S, Sun P, Hanna W. Tumour characteristics among women with very low-risk breast cancer. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2012; 134:1241-1246 10.1007/s10549-012-2065-x
• High Ki67 expression is a risk marker of invasive relapse for classical lobular carcinoma in situ patients Cite
  Vincent-Salomon A, Hajage D, Rouquette A, Cédenot A, Gruel N, Alran S, et al. High Ki67 expression is a risk marker of invasive relapse for classical lobular carcinoma in situ patients. The Breast. Elsevier BV; 2012; 21:380-383 10.1016/j.breast.2012.03.005
• Influence of Berry Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention Cite
  Aiyer HS, Warri AM, Woode DR, Hilakivi-Clarke L, Clarke R. Influence of Berry Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2012; 60:5693-5708 10.1021/jf204084f
• Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G2 /M arrest and apoptosis Cite
  Li J, Zhu F, Lubet RA, De Luca A, Grubbs C, Ericson ME, et al. Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G2 /M arrest and apoptosis. Molecular Carcinogenesis. Wiley; 2011; 52:134-143 10.1002/mc.21839
• Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study Cite
  Sihto H, Lundin J, Lundin M, Lehtimäki T, Ristimäki A, Holli K, et al. Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study. Breast Cancer Research. Springer Science and Business Media LLC; 2011; 13 10.1186/bcr2944
• Effects of Intermittent and Chronic Calorie Restriction on Mammalian Target of Rapamycin (mTOR) and IGF-I Signaling Pathways in Mammary Fat Pad Tissues and Mammary Tumors Cite
  Dogan S, Johannsen A, Grande J, Cleary M. Effects of Intermittent and Chronic Calorie Restriction on Mammalian Target of Rapamycin (mTOR) and IGF-I Signaling Pathways in Mammary Fat Pad Tissues and Mammary Tumors. Nutrition and Cancer. Informa UK Limited; 2011; 63:389-401 10.1080/01635581.2011.535968
• A Review of an Unfavorable Subset of Breast Cancer: Estrogen Receptor Positive Progesterone Receptor Negative Cite
  Thakkar JP, Mehta DG. A Review of an Unfavorable Subset of Breast Cancer: Estrogen Receptor Positive Progesterone Receptor Negative. The Oncologist. Wiley; 2011; 16:276-285 10.1634/theoncologist.2010-0302
• Oleic acid promotes MMP-9 secretion and invasion in breast cancer cells Cite
  Soto-Guzman A, Navarro-Tito N, Castro-Sanchez L, Martinez-Orozco R, Salazar EP. Oleic acid promotes MMP-9 secretion and invasion in breast cancer cells. Clinical & Experimental Metastasis. Springer Science and Business Media LLC; 2010; 27:505-515 10.1007/s10585-010-9340-1
• Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes Cite
  Rimawi MF, Shetty PB, Weiss HL, Schiff R, Osborne CK, Chamness GC, et al. Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes. Cancer. Wiley; 2010; 116:1234-1242 10.1002/cncr.24816
• Fucoidan from Laminaria cichorioides inhibits AP-1 transactivation and cell transformation in the mouse epidermal JB6 cells Cite
  Lee NY, Ermakova SP, Choi H, Kusaykin MI, Shevchenko NM, Zvyagintseva TN, et al. Fucoidan from Laminaria cichorioides inhibits AP-1 transactivation and cell transformation in the mouse epidermal JB6 cells. Molecular Carcinogenesis. Wiley; 2008; 47:629-637 10.1002/mc.20428
• Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway Cite
  Thoennissen NH, O'Kelly J, Lu D, Iwanski GB, La DT, Abbassi S, et al. Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway. Oncogene. Springer Science and Business Media LLC; 2009; 29:285-296 10.1038/onc.2009.335
• ER+ PR- breast cancer defines a unique subtype of breast cancer that is driven by growth factor signaling and may be more likely to respond to EGFR targeted therapies Cite
  Finn RS, Dering J, Ginther C, Press M, Forbes J, Mackey J, et al. ER+ PR- breast cancer defines a unique subtype of breast cancer that is driven by growth factor signaling and may be more likely to respond to EGFR targeted therapies. Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2006; 24:514-514 10.1200/jco.2006.24.18_suppl.514
• Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment Cite
  Moiseeva EP, Fox LH, Howells LM, Temple LAF, Manson MM. Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment. Apoptosis. Springer Science and Business Media LLC; 2006; 11:799-812 10.1007/s10495-006-5877-5