Tag: EGFR
EGFR (epidermal growth factor receptor): A cell surface protein that binds to members of the epidermal growth factor family of extracellular protein ligands. Binding of the protein to an EGF ligand leads to cell proliferation.
Articles
- ER+/PR- breast cancer characteristics
- Foods to eat and avoid for ER+/PR- patients and survivors
- Foods to eat and avoid for inflammatory breast cancer (IBC)
- HER2+ breast cancer characteristics
- Inflammatory breast cancer characteristics
News
- 04/22/24
- EGFR inhibition enhances treatment effects of Adriamycin
- 05/03/22
- EGFR inhibition reduces resistance to tamoxifen treatment
- 03/10/19
- Delphinidin inhibits angiogenesis and migration of TN cells
- 05/07/17
- Vegetable oil linoleic acid promotes migration & invasion of TN cells
- 10/03/16
- Anthocyanin found primarily in red & black fruits inhibits TN BC
- 04/28/12
- Ki67 proliferation index predicts progression of LCIS
- 03/30/11
- Although similar, ER+/PR- BC is more aggressive than ER+/PR+
Studies
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Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway
Cite
Ganesan K, Xu C, Wu J, Du B, Liu Q, Sui Y, et al. Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway. Science China Life Sciences. Springer Science and Business Media LLC; 2024; 10.1007/s11427-023-2499-2
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Abstract PO4-24-09: Grape seed extract inhibits EGFR signaling pathway as a main factor of tamoxifen resistant in hormone receptor positive breast cancer
Cite
Jung SP, Lee E, You JY, Chun JH, Kim H. Abstract PO4-24-09: Grape seed extract inhibits EGFR signaling pathway as a main factor of tamoxifen resistant in hormone receptor positive breast cancer. Cancer Research. American Association for Cancer Research (AACR); 2024; 84:PO4-24-09-PO4-24-09 10.1158/1538-7445.sabcs23-po4-24-09
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Molecular docking of ferulic acid analogue compounds against epidermal growth factor receptor as a potential therapy for breast cancer
Cite
Ainurrizma DA, Ekowati J, Pebrianti D, Diyah NW, Adrianto MF, Deevi RK, et al. Molecular docking of ferulic acid analogue compounds against epidermal growth factor receptor as a potential therapy for breast cancer. Pharmacy Education. International Pharmaceutical Federation (FIP); 2024; 24:185-190 10.46542/pe.2024.243.185190
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Active substance and mechanisms of Actinidia chinensis Planch for the treatment of breast cancer was explored based on network pharmacology and in silico study
Cite
Xu Y, Yang J, Han X, Gan C, Wei X. Active substance and mechanisms of Actinidia chinensis Planch for the treatment of breast cancer was explored based on network pharmacology and in silico study. Medicine. Ovid Technologies (Wolters Kluwer Health); 2024; 103:e37829 10.1097/md.0000000000037829
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Epidermal growth factor receptor inhibition potentiates chemotherapeutics‐mediated sensitization of metastatic breast cancer stem cells
Cite
Kar T, Dugam P, Shivhare S, Shetty SR, Choudhury S, Sen D, et al. Epidermal growth factor receptor inhibition potentiates chemotherapeutics‐mediated sensitization of metastatic breast cancer stem cells. Cancer Reports. Wiley; 2024; 7 10.1002/cnr2.2049
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Combination Treatment with EGFR Inhibitor and Doxorubicin Synergistically Inhibits Proliferation of MCF-7 Cells and MDA-MB-231 Triple-Negative Breast Cancer Cells In Vitro
Cite
Abrahams B, Gerber A, Hiss DC. Combination Treatment with EGFR Inhibitor and Doxorubicin Synergistically Inhibits Proliferation of MCF-7 Cells and MDA-MB-231 Triple-Negative Breast Cancer Cells In Vitro. International Journal of Molecular Sciences. MDPI AG; 2024; 25:3066 10.3390/ijms25053066
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Activation of epidermal growth factor receptors in triple-negative breast cancer cells by morphine; analysis through Raman spectroscopy and machine learning
Cite
Sezer G, Sahin F, Onses MS, Cumaoglu A. Activation of epidermal growth factor receptors in triple-negative breast cancer cells by morphine; analysis through Raman spectroscopy and machine learning. Talanta. Elsevier BV; 2024;:125827 10.1016/j.talanta.2024.125827
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Role of EGFR and FASN in breast cancer progression
Cite
Chaturvedi S, Biswas M, Sadhukhan S, Sonawane A. Role of EGFR and FASN in breast cancer progression. Journal of Cell Communication and Signaling. Springer Science and Business Media LLC; 2023; 10.1007/s12079-023-00771-w
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Identification of potential edible spices as EGFR and EGFR mutant T790M/L858R inhibitors by structure-based virtual screening and molecular dynamics
Cite
Ahmad Ansari I, Debnath B, Kar S, Patel HM, Debnath S, Zaki ME, et al. Identification of potential edible spices as EGFR and EGFR mutant T790M/L858R inhibitors by structure-based virtual screening and molecular dynamics. Journal of Biomolecular Structure and Dynamics. Informa UK Limited; 2023;:1-18 10.1080/07391102.2023.2223661
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Exploring the mechanism by which quercetin re-sensitizes breast cancer to paclitaxel: network pharmacology, molecular docking, and experimental verification
Cite
Yang Y, Yan J, Huang J, Wu X, Yuan Y, Yuan Y, et al. Exploring the mechanism by which quercetin re-sensitizes breast cancer to paclitaxel: network pharmacology, molecular docking, and experimental verification. Naunyn-Schmiedeberg's Archives of Pharmacology. Springer Science and Business Media LLC; 2023; 10.1007/s00210-023-02510-9
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Biological Activity of Oleanolic Acid Derivatives HIMOXOL and Br-HIMOLID in Breast Cancer Cells Is Mediated by ER and EGFR
Cite
Lisiak N, Dzikowska P, Wisniewska U, Kaczmarek M, Bednarczyk-Cwynar B, Zaprutko L, et al. Biological Activity of Oleanolic Acid Derivatives HIMOXOL and Br-HIMOLID in Breast Cancer Cells Is Mediated by ER and EGFR. International Journal of Molecular Sciences. MDPI AG; 2023; 24:5099 10.3390/ijms24065099
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Prognostic and Predictive Biomarkers in Familial Breast Cancer
Cite
Deb S, Chakrabarti A, Fox SB. Prognostic and Predictive Biomarkers in Familial Breast Cancer. Cancers. MDPI AG; 2023; 15:1346 10.3390/cancers15041346
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EGFR inhibition reverses epithelial‑mesenchymal transition, and decreases tamoxifen resistance via Snail and Twist downregulation in breast cancer cells
Cite
Takeda T, Tsubaki M, Matsuda T, Kimura A, Jinushi M, Obana T, et al. EGFR inhibition reverses epithelial‑mesenchymal transition, and decreases tamoxifen resistance via Snail and Twist downregulation in breast cancer cells. Oncology Reports. Spandidos Publications; 2022; 47 10.3892/or.2022.8320
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Screening of Phytochemicals as Potential Inhibitors of Breast Cancer using Structure Based Multitargeted Molecular Docking Analysis
Cite
Jha V, Devkar S, Gharat K, Kasbe S, Matharoo DK, Pendse S, et al. Screening of Phytochemicals as Potential Inhibitors of Breast Cancer using Structure Based Multitargeted Molecular Docking Analysis. Phytomedicine Plus. Elsevier BV; 2022; 2:100227 10.1016/j.phyplu.2022.100227
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A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer
Cite
Subramaniyan V, Fuloria S, Gupta G, Kumar DH, Sekar M, Sathasivam KV, et al. A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer. Chemico-Biological Interactions. Elsevier BV; 2022; 351:109735 10.1016/j.cbi.2021.109735
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Role of calcium in hormone independent and resistant breast cancer
Cite
Cyrus K, Wang Q, Sharawi Z, Noguchi G, Kaushal M, Chang T, et al. Role of calcium in hormone independent and resistant breast cancer. International Journal of Cancer. Wiley; 2021; 10.1002/ijc.33745
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Tamoxifen overcomes the trastuzumab-resistance of SK-BR-3 tumorspheres by targeting crosstalk between cytoplasmic estrogen receptor α and the EGFR/HER2 signaling pathway
Cite
Kwon Y, Nam K, Kim S. Tamoxifen overcomes the trastuzumab-resistance of SK-BR-3 tumorspheres by targeting crosstalk between cytoplasmic estrogen receptor α and the EGFR/HER2 signaling pathway. Biochemical Pharmacology. Elsevier BV; 2021;:114635 10.1016/j.bcp.2021.114635
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Using dynamic cell communication improves treatment strategies of breast cancer
Cite
Liu Z, Hu S, Yun Z, Hu W, Zhang S, Luo D. Using dynamic cell communication improves treatment strategies of breast cancer. Cancer Cell International. Springer Science and Business Media LLC; 2021; 21 10.1186/s12935-021-01979-9
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EGFR inhibition blocks cancer stem cell clustering and lung metastasis of triple negative breast cancer
Cite
Liu X, Adorno-Cruz V, Chang Y, Jia Y, Kawaguchi M, Dashzeveg NK, et al. EGFR inhibition blocks cancer stem cell clustering and lung metastasis of triple negative breast cancer. Theranostics. Ivyspring International Publisher; 2021; 11:6632-6643 10.7150/thno.57706
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Grape Seed Procyanidins Inhibit the Growth of Breast Cancer MCF-7 Cells by Down-Regulating the EGFR/VEGF/MMP9 Pathway
Cite
Kong F, He C, Kong F, Han S, Kong X, Han W, et al. Grape Seed Procyanidins Inhibit the Growth of Breast Cancer MCF-7 Cells by Down-Regulating the EGFR/VEGF/MMP9 Pathway. Natural Product Communications. SAGE Publications; 2021; 16:1934578X2199169 10.1177/1934578x21991691
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Abstract P3-11-17: Statins suppress the aggressive phenotype of triple negative breast cancer cells via modulation of EGFR signalling
Cite
Smith C, Alim S, Kadi A, Lawati RA, Miles M, Hiscox S. Abstract P3-11-17: Statins suppress the aggressive phenotype of triple negative breast cancer cells via modulation of EGFR signalling. Poster Session Abstracts. American Association for Cancer Research; 2020; 10.1158/1538-7445.sabcs19-p3-11-17
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Quadruple negative breast cancer
Cite
Huang M, Wu J, Ling R, Li N. Quadruple negative breast cancer. Breast Cancer. Springer Science and Business Media LLC; 2020; 27:527-533 10.1007/s12282-020-01047-6
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Short-Term Environmental Conditioning Enhances Tumorigenic Potential of Triple-Negative Breast Cancer Cells
Cite
. Short-Term Environmental Conditioning Enhances Tumorigenic Potential of Triple-Negative Breast Cancer Cells. Tomography. Grapho, LLC; 2019; 5:346-357 10.18383/j.tom.2019.00019
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High glucose levels promote the proliferation of breast cancer cells through GTPases
Cite
Hou Y, Zhou M, Xie J, Chao P, Feng Q, Wu J. High glucose levels promote the proliferation of breast cancer cells through GTPases. Breast Cancer: Targets and Therapy. Informa UK Limited; 2017; Volume 9:429-436 10.2147/bctt.s135665
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EGFR signaling promotes inflammation and cancer stem-like activity in inflammatory breast cancer
Cite
Wang X, Reyes ME, Zhang D, Funakoshi Y, Trape AP, Gong Y, et al. EGFR signaling promotes inflammation and cancer stem-like activity in inflammatory breast cancer. Oncotarget. Impact Journals, LLC; 2017; 8:67904-67917 10.18632/oncotarget.18958
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Abstract 1077: Extra-virgin olive oil Met inhibitor oleocanthal-lapatinib: a novel synergistic combination for HER2-dependent breast malignancies
Cite
Siddique AB, Ebrahim HY, Akl MR, Mohyeldin MM, Sayed KAE. Abstract 1077: Extra-virgin olive oil Met inhibitor oleocanthal-lapatinib: a novel synergistic combination for HER2-dependent breast malignancies. Cancer Chemistry. American Association for Cancer Research; 2017; 10.1158/1538-7445.am2017-1077
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Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells
Cite
Sauer SJ, Tarpley M, Shah I, Save AV, Lyerly H, Patierno SR, et al. Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells. Carcinogenesis. Oxford University Press (OUP); 2017; 38 10.1093/carcin/bgx003
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Cellular and molecular mechanisms underlying alcohol-induced aggressiveness of breast cancer
Cite
Wang Y, Xu M, Ke Z, Luo J. Cellular and molecular mechanisms underlying alcohol-induced aggressiveness of breast cancer. Pharmacological Research. Elsevier BV; 2017; 115:299-308 10.1016/j.phrs.2016.12.005
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Cyanidin-3-o-glucoside directly binds to ERα36 and inhibits EGFR-positive triple-negative breast cancer
Cite
Wang L, Li H, Yang S, Ma W, Liu M, Guo S, et al. Cyanidin-3-o-glucoside directly binds to ERα36 and inhibits EGFR-positive triple-negative breast cancer. Oncotarget. Impact Journals, LLC; 2016; 7:68864-68882 10.18632/oncotarget.12025
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CD44 correlates with clinicopathological characteristics and is upregulated by EGFR in breast cancer
Cite
Xu H, Wu K, Tian Y, Liu Q, Han N, Yuan X, et al. CD44 correlates with clinicopathological characteristics and is upregulated by EGFR in breast cancer. International Journal of Oncology. Spandidos Publications; 2016; 49:1343-1350 10.3892/ijo.2016.3639
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Combination of lapatinib with isothiocyanates overcomes drug resistance and inhibits migration of HER2 positive breast cancer cells
Cite
Kaczyńska A, Herman-Antosiewicz A. Combination of lapatinib with isothiocyanates overcomes drug resistance and inhibits migration of HER2 positive breast cancer cells. Breast Cancer. Springer Science and Business Media LLC; 2016; 24:271-280 10.1007/s12282-016-0700-9
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Effects of Estrogen Receptor and Human Epidermal Growth Factor Receptor-2 Levels on the Efficacy of Trastuzumab
Cite
Loi S, Dafni U, Karlis D, Polydoropoulou V, Young BM, Willis S, et al. Effects of Estrogen Receptor and Human Epidermal Growth Factor Receptor-2 Levels on the Efficacy of Trastuzumab. JAMA Oncology. American Medical Association (AMA); 2016; 2:1040 10.1001/jamaoncol.2016.0339
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Gallic acid abolishes the EGFR/Src/Akt/Erk-mediated expression of matrix metalloproteinase-9 in MCF-7 breast cancer cells
Cite
Chen Y, Lin K, Jhang L, Huang C, Lee Y, Chang L. Gallic acid abolishes the EGFR/Src/Akt/Erk-mediated expression of matrix metalloproteinase-9 in MCF-7 breast cancer cells. Chemico-Biological Interactions. Elsevier BV; 2016; 252:131-140 10.1016/j.cbi.2016.04.025
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Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors
Cite
Goel S, Wang Q, Watt AC, Tolaney SM, Dillon DA, Li W, et al. Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors. Cancer Cell. Elsevier BV; 2016; 29:255-269 10.1016/j.ccell.2016.02.006
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Abstract B20: Combination ofGanoderma lucidumextract and erlotinib decreases IBC progression
Cite
Rios-Fuller TJ, Suarez-Arroyo IJ, Lacourt-Ventura M, Maldonado G, Cubano LA, Martinez-Montemayor MM. Abstract B20: Combination ofGanoderma lucidumextract and erlotinib decreases IBC progression. Targeted Therapies. American Association for Cancer Research; 2016; 10.1158/1557-3125.advbc15-b20
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EGFR Regulates the Development and Microarchitecture of Intratumoral Angiogenic Vasculature Capable of Sustaining Cancer Cell Intravasation
Cite
Minder P, Zajac E, Quigley JP, Deryugina EI. EGFR Regulates the Development and Microarchitecture of Intratumoral Angiogenic Vasculature Capable of Sustaining Cancer Cell Intravasation. Neoplasia. Elsevier BV; 2015; 17:634-649 10.1016/j.neo.2015.08.002
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Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells
Cite
KIM S, LEE J, OH SJ, NAM SJ, LEE JE. Differential effect of EGFR inhibitors on tamoxifen-resistant breast cancer cells. Oncology Reports. Spandidos Publications; 2015; 34:1613-1619 10.3892/or.2015.4116
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Abstract 3212: Ganoderma lucidum (Reishi) chemosensitizes EGFR-overexpressing inflammatory breast cancer cells to erlotinib
Cite
Suárez-Arroyo I, Moraskie M, Cubano LA, Martínez-Montemayor MM. Abstract 3212: Ganoderma lucidum (Reishi) chemosensitizes EGFR-overexpressing inflammatory breast cancer cells to erlotinib. Cancer Chemistry. American Association for Cancer Research; 2014; 10.1158/1538-7445.am2014-3212
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Management of dermatological toxicities in patients receiving EGFR inhibitors
Cite
Lynch K. Management of dermatological toxicities in patients receiving EGFR inhibitors. Community Oncology. Elsevier BV; 2012; 9:315-323 10.1016/j.cmonc.2012.09.008
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Grape Polyphenols Inhibit Akt/Mammalian Target of Rapamycin Signaling and Potentiate the Effects of Gefitinib in Breast Cancer
Cite
Castillo-Pichardo L, Dharmawardhane SF. Grape Polyphenols Inhibit Akt/Mammalian Target of Rapamycin Signaling and Potentiate the Effects of Gefitinib in Breast Cancer. Nutrition and Cancer. Informa UK Limited; 2012; 64:1058-1069 10.1080/01635581.2012.716898
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Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression
Cite
SUN X, LIU X, HUANG D. Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression. Molecular Medicine Reports. Spandidos Publications; 2012; 6:1267-1270 10.3892/mmr.2012.1103
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Luteolin exerts anti-tumor activity through the suppression of epidermal growth factor receptor-mediated pathway in MDA-MB-231 ER-negative breast cancer cells
Cite
Lee E, Oh S, Sung M. Luteolin exerts anti-tumor activity through the suppression of epidermal growth factor receptor-mediated pathway in MDA-MB-231 ER-negative breast cancer cells. Food and Chemical Toxicology. Elsevier BV; 2012; 50:4136-4143 10.1016/j.fct.2012.08.025
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Tumour characteristics among women with very low-risk breast cancer
Cite
Narod SA, Valentini A, Nofech-Mozes S, Sun P, Hanna W. Tumour characteristics among women with very low-risk breast cancer. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2012; 134:1241-1246 10.1007/s10549-012-2065-x
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High Ki67 expression is a risk marker of invasive relapse for classical lobular carcinoma in situ patients
Cite
Vincent-Salomon A, Hajage D, Rouquette A, Cédenot A, Gruel N, Alran S, et al. High Ki67 expression is a risk marker of invasive relapse for classical lobular carcinoma in situ patients. The Breast. Elsevier BV; 2012; 21:380-383 10.1016/j.breast.2012.03.005
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Influence of Berry Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention
Cite
Aiyer HS, Warri AM, Woode DR, Hilakivi-Clarke L, Clarke R. Influence of Berry Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2012; 60:5693-5708 10.1021/jf204084f
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Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G2 /M arrest and apoptosis
Cite
Li J, Zhu F, Lubet RA, De Luca A, Grubbs C, Ericson ME, et al. Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G2 /M arrest and apoptosis. Molecular Carcinogenesis. Wiley; 2011; 52:134-143 10.1002/mc.21839
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Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study
Cite
Sihto H, Lundin J, Lundin M, Lehtimäki T, Ristimäki A, Holli K, et al. Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study. Breast Cancer Research. Springer Science and Business Media LLC; 2011; 13 10.1186/bcr2944
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Effects of Intermittent and Chronic Calorie Restriction on Mammalian Target of Rapamycin (mTOR) and IGF-I Signaling Pathways in Mammary Fat Pad Tissues and Mammary Tumors
Cite
Dogan S, Johannsen A, Grande J, Cleary M. Effects of Intermittent and Chronic Calorie Restriction on Mammalian Target of Rapamycin (mTOR) and IGF-I Signaling Pathways in Mammary Fat Pad Tissues and Mammary Tumors. Nutrition and Cancer. Informa UK Limited; 2011; 63:389-401 10.1080/01635581.2011.535968
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A Review of an Unfavorable Subset of Breast Cancer: Estrogen Receptor Positive Progesterone Receptor Negative
Cite
Thakkar JP, Mehta DG. A Review of an Unfavorable Subset of Breast Cancer: Estrogen Receptor Positive Progesterone Receptor Negative. The Oncologist. Wiley; 2011; 16:276-285 10.1634/theoncologist.2010-0302
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Oleic acid promotes MMP-9 secretion and invasion in breast cancer cells
Cite
Soto-Guzman A, Navarro-Tito N, Castro-Sanchez L, Martinez-Orozco R, Salazar EP. Oleic acid promotes MMP-9 secretion and invasion in breast cancer cells. Clinical & Experimental Metastasis. Springer Science and Business Media LLC; 2010; 27:505-515 10.1007/s10585-010-9340-1
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Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes
Cite
Rimawi MF, Shetty PB, Weiss HL, Schiff R, Osborne CK, Chamness GC, et al. Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes. Cancer. Wiley; 2010; 116:1234-1242 10.1002/cncr.24816
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Fucoidan from Laminaria cichorioides inhibits AP-1 transactivation and cell transformation in the mouse epidermal JB6 cells
Cite
Lee NY, Ermakova SP, Choi H, Kusaykin MI, Shevchenko NM, Zvyagintseva TN, et al. Fucoidan from Laminaria cichorioides inhibits AP-1 transactivation and cell transformation in the mouse epidermal JB6 cells. Molecular Carcinogenesis. Wiley; 2008; 47:629-637 10.1002/mc.20428
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Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway
Cite
Thoennissen NH, O'Kelly J, Lu D, Iwanski GB, La DT, Abbassi S, et al. Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway. Oncogene. Springer Science and Business Media LLC; 2009; 29:285-296 10.1038/onc.2009.335
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ER+ PR- breast cancer defines a unique subtype of breast cancer that is driven by growth factor signaling and may be more likely to respond to EGFR targeted therapies
Cite
Finn RS, Dering J, Ginther C, Press M, Forbes J, Mackey J, et al. ER+ PR- breast cancer defines a unique subtype of breast cancer that is driven by growth factor signaling and may be more likely to respond to EGFR targeted therapies. Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2006; 24:514-514 10.1200/jco.2006.24.18_suppl.514
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Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment
Cite
Moiseeva EP, Fox LH, Howells LM, Temple LAF, Manson MM. Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment. Apoptosis. Springer Science and Business Media LLC; 2006; 11:799-812 10.1007/s10495-006-5877-5