Ginger has been found to significantly inhibit mammary tumor development and growth in laboratory mice when fed in drinking water. Ginger contains a variety of compounds with anti-cancer effects, including various gingerols. [6]-gingerol has been shown to inhibit cell adhesion, invasion, and motility in both hormone receptor positive (ER+/PR+) and triple negative (ER-/PR-/HER2-) breast cancer cells. In addition, [6]-gingerol has been shown to selectively induce the death of ER+/PR+ breast cancer stem cells. Ginger appears to increase the effectiveness of Adriamycin (doxorubicin) chemotherapy and may reduce chemotherapy-associated nausea. However, ginger should be avoided during radiotherapy since it has been shown to help protect cells against the cytotoxic effects of radiation. Now a new study has reported that [10]-gingerol is especially effective in inducing triple negative breast cancer cell death.

Latest research finds [10]-gingerol reduces breast cancer growth

The study referenced above was designed to compare the effectiveness of [10]-gingerol with [8]-gingerol and [6]-gingerol in inhibiting the growth of human breast cancer and mouse mammary tumor cells. Ginger contains several bioactive gingerols, however most cancer-related research has focused on [6]-gingerol. The authors first determined that [10]-gingerol was more powerful than [6]-gingerol and at least as potent as [8]-gingerol in inhibiting triple-negative human (MDA-MB-231 and MDA-MB-468 cell lines) and mouse mammary carcinoma (4T1, E0771) cell growth. [10]-gingerol-gingerol was also found to suppress the growth of ER+/PR+ (MCF-7, T47D) and HER2+ (SKBR3) breast cancer cells.

Further experimentation demonstrated that [10]-gingerol's growth inhibitory effect on triple negative cells was associated with reduced cell division and increased apoptosis (programmed cell death). Surprisingly, the cytotoxic effect of [10]-gingerol did not appear to depend on accumulation of reactive oxygen species. The authors conclude that further investigation of [10]-gingerol for possible use in breast cancer treatment is justified.

Please see our article on triple negative diet for more information.