Tag: isoflavones

Articles

• Supplements with warnings for breast cancer

News

05/27/20

Genistein promotes proliferation and metastasis in IBC animal model

04/08/16

Genistein could reduce treatment effects of Adriamycin in ER+/PR+ BC

09/14/14

Soy supplement promotes BC proliferation

02/06/12

Soy supplements do not reduce breast cancer risk and could be harmful

01/18/12

High intake of soy isoflavones increases risk of HER2+ recurrence

12/06/11

Red clover compound biochanin A reduces potency of tamoxifen in rats

08/17/11

Genistein stimulates aromatase activity and ER+ BC cell growth

10/02/10

Soy protein isolate may increase PR expression & tumor aggressiveness

Foods

• • genistein and daidzein
  • soy protein isolate
  • soybean paste
  • soybeans
  • tofu

Studies

• Equol: a metabolite of gut microbiota with potential antitumor effects Cite
  Lv J, Jin S, Zhang Y, Zhou Y, Li M, Feng N. Equol: a metabolite of gut microbiota with potential antitumor effects. Gut Pathogens. Springer Science and Business Media LLC; 2024; 16 10.1186/s13099-024-00625-9
• Traditional and Domestic Cooking Dramatically Reduce Estrogenic Isoflavones in Soy-Foods Cite
  Bensaada S, Peruzzi G, Cubizolles L, Denayrolles M, Bennetau-Pelissero C. Traditional and Domestic Cooking Dramatically Reduce Estrogenic Isoflavones in Soy-Foods. MDPI AG; 2024; 10.20944/preprints202403.0708.v1
• Perspective: Observational studies involving low soy intake populations have limited ability for providing insight into the health effects of soybean isoflavones Cite
  Messina M, Messina V, Nagata C. Perspective: Observational studies involving low soy intake populations have limited ability for providing insight into the health effects of soybean isoflavones. Advances in Nutrition. Elsevier BV; 2024;:100210 10.1016/j.advnut.2024.100210
• Phytonutrients and outcomes following breast cancer: a systematic review and meta-analysis of observational studies Cite
  van Die MD, Bone KM, Visvanathan K, Kyrø C, Aune D, Ee C, et al. Phytonutrients and outcomes following breast cancer: a systematic review and meta-analysis of observational studies. JNCI Cancer Spectrum. Oxford University Press (OUP); 2023; 10.1093/jncics/pkad104
• Dietary Isoflavone Intake and Breast Cancer Prognosis: A Prospective Analysis and Meta-Analysis Cite
  Song S, Cheun J, Moon H, Noh D, Jung S, Lee ES, et al. Dietary Isoflavone Intake and Breast Cancer Prognosis: A Prospective Analysis and Meta-Analysis. Nutrition and Cancer. Informa UK Limited; 2023;:1-13 10.1080/01635581.2023.2279220
• Structure-Based Multi-Targeted Molecular Docking and Dynamic Simulation of Soybean-Derived Isoflavone Genistin as a Potential Breast Cancer Signaling Proteins Inhibitor Cite
  Elkhalifa AEO, Al-Shammari E, Kuddus M, Adnan M, Sachidanandan M, Awadelkareem AM, et al. Structure-Based Multi-Targeted Molecular Docking and Dynamic Simulation of Soybean-Derived Isoflavone Genistin as a Potential Breast Cancer Signaling Proteins Inhibitor. Life. MDPI AG; 2023; 13:1739 10.3390/life13081739
• Soy protein, bioactive peptides, and isoflavones: A review of their safety and health benefits Cite
  Tan ST, Tan SS, Tan CX. Soy protein, bioactive peptides, and isoflavones: A review of their safety and health benefits. PharmaNutrition. Elsevier BV; 2023; 25:100352 10.1016/j.phanu.2023.100352
• The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer Cite
  Pejčić T, Zeković M, Bumbaširević U, Kalaba M, Vovk I, Bensa M, et al. The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer. Antioxidants. MDPI AG; 2023; 12:368 10.3390/antiox12020368
• Understanding the phytoestrogen genistein actions on breast cancer: Insights on estrogen receptor equivalence, pleiotropic essence and emerging paradigms in bioavailability modulation Cite
  Mukherjee TK, Malik P, Singh R, Kumar M, Malik A. Understanding the phytoestrogen genistein actions on breast cancer: Insights on estrogen receptor equivalence, pleiotropic essence and emerging paradigms in bioavailability modulation. Current Topics in Medicinal Chemistry. Bentham Science Publishers Ltd.; 2023; 23 10.2174/1568026623666230103163023
• Soy Isoflavones Induce Feminization of Japanese Eel (Anguilla japonica) Cite
  Inaba H, Iwata Y, Suzuki T, Horiuchi M, Surugaya R, Ijiri S, et al. Soy Isoflavones Induce Feminization of Japanese Eel (Anguilla japonica). International Journal of Molecular Sciences. MDPI AG; 2022; 24:396 10.3390/ijms24010396
• Association of urinary phytoestrogens with hormone-related cancers and cancer biomarkers: NHANES 1999-2010 Cite
  Liu F, Peng Y, Qiao Y, Wang P, Si C, Wang X, et al. Association of urinary phytoestrogens with hormone-related cancers and cancer biomarkers: NHANES 1999-2010. British Journal of Nutrition. Cambridge University Press (CUP); 2022;:1-37 10.1017/s0007114522003877
• Soy isoflavones decrease fibroglandular breast tissue measured by magnetic resonance imaging in premenopausal women: a 2-year randomized double-blind placebo controlled clinical trial Cite
  Lu LW, Chen N, Brunder DG, Nayeem F, Nagamani M, Nishino TK, et al. Soy isoflavones decrease fibroglandular breast tissue measured by magnetic resonance imaging in premenopausal women: a 2-year randomized double-blind placebo controlled clinical trial. Clinical Nutrition ESPEN. Elsevier BV; 2022; 10.1016/j.clnesp.2022.10.007
• Biochanin A as a modulator of the inflammatory response: An updated overview and therapeutic potential Cite
  Felix FB, Vago JP, Beltrami VA, Araújo JMD, Grespan R, Teixeira MM, et al. Biochanin A as a modulator of the inflammatory response: An updated overview and therapeutic potential. Pharmacological Research. Elsevier BV; 2022; 180:106246 10.1016/j.phrs.2022.106246
• Habitual Phytoestrogen Intake is Associated with Breast Composition in Girls at 2 Years after Menarche Onset Cite
  Lesser C, Mericq V, Reyes M, GARMENDIA ML, Shepherd JA, Michels KB, et al. Habitual Phytoestrogen Intake is Associated with Breast Composition in Girls at 2 Years after Menarche Onset. Cancer Epidemiology, Biomarkers & Prevention. American Association for Cancer Research (AACR); 2022; 10.1158/1055-9965.epi-22-0016
• Isoflavones in Soybean as a Daily Nutrient: The Mechanisms of Action and How They Alter the Pharmacokinetics of Drugs Cite
  SOYATA A, HASANAH AN, RUSDIANA T. Isoflavones in Soybean as a Daily Nutrient: The Mechanisms of Action and How They Alter the Pharmacokinetics of Drugs. Turkish Journal of Pharmaceutical Sciences. Galenos Yayinevi; 2021; 18:799-810 10.4274/tjps.galenos.2020.79106
• Isoflavones in Animals: Metabolism and Effects in Livestock and Occurrence in Feed Cite
  Grgic D, Varga E, Novak B, Müller A, Marko D. Isoflavones in Animals: Metabolism and Effects in Livestock and Occurrence in Feed. Toxins. MDPI AG; 2021; 13:836 10.3390/toxins13120836
• Developmental exposure to phytoestrogens found in soy: New findings and clinical implications Cite
  Suen AA, Kenan AC, Williams CJ. Developmental exposure to phytoestrogens found in soy: New findings and clinical implications. Biochemical Pharmacology. Elsevier BV; 2021;:114848 10.1016/j.bcp.2021.114848
• Alternative and Non-Hormonal treatments to symptoms of Menopause Cite
  Djapardy V, Panay N. Alternative and Non-Hormonal treatments to symptoms of Menopause. Best Practice & Research Clinical Obstetrics & Gynaecology. Elsevier BV; 2021; 10.1016/j.bpobgyn.2021.09.012
• A Meta-Analysis of Randomized Controlled Trials of the Effects of Soy Intake on Inflammatory Markers in Postmenopausal Women Cite
  Bajerska J, Łagowska K, Mori M, Reguła J, Skoczek-Rubińska A, Toda T, et al. A Meta-Analysis of Randomized Controlled Trials of the Effects of Soy Intake on Inflammatory Markers in Postmenopausal Women. The Journal of Nutrition. Oxford University Press (OUP); 2021; 10.1093/jn/nxab325
• Endocrine disruptors on and in fruits and vegetables: estimation of the potential exposure of the French population Cite
  Lee A, Bensaada S, Lamothe V, Lacoste M, Bennetau-Pelissero C. Endocrine disruptors on and in fruits and vegetables: estimation of the potential exposure of the French population. Food Chemistry. Elsevier BV; 2021;:131513 10.1016/j.foodchem.2021.131513
• Urinary equol levels are positively associated with urinary estradiol excretion in women Cite
  Fujitani T, Fujii Y, Lyu Z, Harada Sassa M, Harada KH. Urinary equol levels are positively associated with urinary estradiol excretion in women. Scientific Reports. Springer Science and Business Media LLC; 2021; 11 10.1038/s41598-021-98872-2
• Isoflavones alter male and female fertility in different development windows Cite
  Sleiman HK, de Oliveira JM, Langoni de Freitas GB. Isoflavones alter male and female fertility in different development windows. Biomedicine & Pharmacotherapy. Elsevier BV; 2021; 140:111448 10.1016/j.biopha.2021.111448
• Therapeutic effects of polyphenols in fermented soybean and black soybean products Cite
  Khosravi A, Razavi SH. Therapeutic effects of polyphenols in fermented soybean and black soybean products. Journal of Functional Foods; 2021; 81:104467 https://doi.org/10.1016/j.jff.2021.104467
• Daidzein Induces Intrinsic Pathway of Apoptosis along with ER α/β Ratio Alteration and ROS Production Cite
  Kumar V, Chauhan S. Daidzein Induces Intrinsic Pathway of Apoptosis along with ER α/β Ratio Alteration and ROS Production. Asian Pacific Journal of Cancer Prevention. EpiSmart Science Vector Ltd; 2021; 22:603-610 10.31557/apjcp.2021.22.2.603
• Abstract PS5-31: Molecular markers of response to s-equol, a novel oral estrogen receptor (ER) beta agonist for triple negative breast cancer Cite
  Lathrop K, Kaklamani V, Brenner A, Li R, Nazarullah A, Hackman S, et al. Abstract PS5-31: Molecular markers of response to s-equol, a novel oral estrogen receptor (ER) beta agonist for triple negative breast cancer. Poster Session Abstracts. American Association for Cancer Research; 2021; 10.1158/1538-7445.sabcs20-ps5-31
• A Systematic Review of the Effects of Equol (Soy Metabolite) on Breast Cancer Cite
  Hod R, Maniam S, Mohd Nor NH. A Systematic Review of the Effects of Equol (Soy Metabolite) on Breast Cancer. Molecules. MDPI AG; 2021; 26:1105 10.3390/molecules26041105
• From Proteomics to Personalized Medicine: The Importance of Isoflavone Dose and Estrogen Receptor Status in Breast Cancer Cells Cite
  Ilieș M, Uifălean A, Pașca S, Dhople VM, Lalk M, Iuga CA, et al. From Proteomics to Personalized Medicine: The Importance of Isoflavone Dose and Estrogen Receptor Status in Breast Cancer Cells. Journal of Personalized Medicine. MDPI AG; 2020; 10:292 10.3390/jpm10040292
• Isoflavones from black chickpea (Cicer arietinum L) sprouts with antioxidant and antiproliferative activity Cite
  Dulce-María D, Adrián C, Cuauhtémoc R, Ada-Keila M, Jorge M, Erika A, et al. Isoflavones from black chickpea (Cicer arietinum L) sprouts with antioxidant and antiproliferative activity. Saudi Journal of Biological Sciences. Elsevier BV; 2021; 28:1141-1146 10.1016/j.sjbs.2020.11.048
• Isoflavone intake on the risk of overall breast cancer and molecular subtypes in women at high risk for hereditary breast cancer Cite
  Sim EJ, Ko K, Ahn C, Park SM, Surh Y, An S, et al. Isoflavone intake on the risk of overall breast cancer and molecular subtypes in women at high risk for hereditary breast cancer. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2020; 184:615-626 10.1007/s10549-020-05875-0
• Effect of isoflavones on breast cancer cell development and their impact on breast cancer treatments Cite
  Hatono M, Ikeda H, Suzuki Y, Kajiwara Y, Kawada K, Tsukioki T, et al. Effect of isoflavones on breast cancer cell development and their impact on breast cancer treatments. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2020; 10.1007/s10549-020-05957-z
• Dietary Intake and Plasma Levels of Isoflavones Among Breast Cancer Survivors Cite
  Song S, Moon H, Noh D, Jung S, Lee ES, Kim Z, et al. Dietary Intake and Plasma Levels of Isoflavones Among Breast Cancer Survivors. Current Developments in Nutrition. Oxford University Press (OUP); 2020; 4:1490-1490 10.1093/cdn/nzaa061_118
• Changes in steroid hormone profile and tumour progression after genistein treatment of canine inflammatory mammary cancer xenotransplanted mice Cite
  Martín-Ruiz A, Peña L, González-Gil A, Silvan G, Caceres S, Illera J. Changes in steroid hormone profile and tumour progression after genistein treatment of canine inflammatory mammary cancer xenotransplanted mice. Research in Veterinary Science. Elsevier BV; 2020; 131:87-91 10.1016/j.rvsc.2020.04.013
• (±)-Equol does not interact with genistein on estrogen-dependent breast tumor growth Cite
  Song H, Hughes JR, Turner RT, Iwaniec UT, Doerge DR, Helferich WG. (±)-Equol does not interact with genistein on estrogen-dependent breast tumor growth. Food and Chemical Toxicology. Elsevier BV; 2020; 136:110979 10.1016/j.fct.2019.110979
• Association between flavonoids, flavonoid subclasses intake and breast cancer risk: a case-control study in China Cite
  Feng X, Ho SC, Mo X, Lin F, Zhang N, Luo H, et al. Association between flavonoids, flavonoid subclasses intake and breast cancer risk: a case-control study in China. European Journal of Cancer Prevention. Ovid Technologies (Wolters Kluwer Health); 2019; 29:493-500 10.1097/cej.0000000000000561
• Rodent Models Assessing Mammary Tumor Prevention by Soy or Soy Isoflavones Cite
  Moorehead . Rodent Models Assessing Mammary Tumor Prevention by Soy or Soy Isoflavones. Genes. MDPI AG; 2019; 10:566 10.3390/genes10080566
• Abstract 4390: Dietary soy isoflavone equol promotes breast cancer progression via regulation of protein synthesis initiation Cite
  Cruz-Collazo AM, Parra CDl, Schneider R, Dharmawardhane S. Abstract 4390: Dietary soy isoflavone equol promotes breast cancer progression via regulation of protein synthesis initiation. Molecular and Cellular Biology / Genetics. American Association for Cancer Research; 2019; 10.1158/1538-7445.am2019-4390
• Use of dietary supplements containing soy isoflavones and breast cancer risk among women aged >50 y: a prospective study Cite
  Touillaud M, Gelot A, Mesrine S, Bennetau-Pelissero C, Clavel-Chapelon F, Arveux P, et al. Use of dietary supplements containing soy isoflavones and breast cancer risk among women aged >50 y: a prospective study. The American Journal of Clinical Nutrition. Oxford University Press (OUP); 2019; 109:597-605 10.1093/ajcn/nqy313
• Abstract P2-05-06: Effects of a soy isoflavone in breast cancer treatment Cite
  Hatono M, Ikeda H, Taira N, Suzuki Y, Kajiwara Y, Kawata K, et al. Abstract P2-05-06: Effects of a soy isoflavone in breast cancer treatment. Poster Session Abstracts. American Association for Cancer Research; 2019; 10.1158/1538-7445.sabcs18-p2-05-06
• The association of urinary estrogen levels with urinary isoflavone levels: Difference between premenopausal women and postmenopausal women Cite
  Yasui T, Ideno Y, Onizuka Y, Nakajima-Shimada J, Lee J, Shinozaki H, et al. The association of urinary estrogen levels with urinary isoflavone levels: Difference between premenopausal women and postmenopausal women. Maturitas. Elsevier BV; 2019; 121:41-47 10.1016/j.maturitas.2018.12.010
• Phytoestrogens and breast cancer: In vitro anticancer activities of isoflavones, lignans, coumestans, stilbenes and their analogs and derivatives Cite
  Basu P, Maier C. Phytoestrogens and breast cancer: In vitro anticancer activities of isoflavones, lignans, coumestans, stilbenes and their analogs and derivatives. Biomedicine & Pharmacotherapy. Elsevier BV; 2018; 107:1648-1666 10.1016/j.biopha.2018.08.100
• Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation Cite
  Hüser S, Guth S, Joost HG, Soukup ST, Köhrle J, Kreienbrock L, et al. Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation. Archives of Toxicology. Springer Science and Business Media LLC; 2018; 92:2703-2748 10.1007/s00204-018-2279-8
• 6,7,4′-Trihydroxyisoflavone suppressed the estrogen receptor negative breast cancer growth via regulating glycogen synthase kinase-3β/β-catenin signaling Cite
  Chen J, Lee J, Bao C, Kim JT, Lee HJ. 6,7,4′-Trihydroxyisoflavone suppressed the estrogen receptor negative breast cancer growth via regulating glycogen synthase kinase-3β/β-catenin signaling. Journal of Functional Foods. Elsevier BV; 2018; 48:498-506 10.1016/j.jff.2018.07.044
• Dietary isoflavones or isoflavone-rich food intake and breast cancer risk: A meta-analysis of prospective cohort studies Cite
  Zhao T, Jin F, Li J, Xu Y, Dong H, Liu Q, et al. Dietary isoflavones or isoflavone-rich food intake and breast cancer risk: A meta-analysis of prospective cohort studies. Clinical Nutrition. Elsevier BV; 2019; 38:136-145 10.1016/j.clnu.2017.12.006
• Equol Enhances Apoptosis-inducing Activity of Genistein by Increasing Bax/Bcl-xL Expression Ratio in MCF-7 Human Breast Cancer Cells Cite
  Ono M, Ejima K, Higuchi T, Takeshima M, Wakimoto R, Nakano S. Equol Enhances Apoptosis-inducing Activity of Genistein by Increasing Bax/Bcl-xL Expression Ratio in MCF-7 Human Breast Cancer Cells. Nutrition and Cancer. Informa UK Limited; 2017; 69:1300-1307 10.1080/01635581.2017.1367945
• Is vegetarian diet associated with a lower risk of breast cancer in Taiwanese women? Cite
  Chang Y, Hou Y, Chen L, Wu J, Wu C, Chang Y, et al. Is vegetarian diet associated with a lower risk of breast cancer in Taiwanese women?. BMC Public Health. Springer Science and Business Media LLC; 2017; 17 10.1186/s12889-017-4819-1
• Evaluation of estrogenic activity of red clover (Trifolium pratense L.) sprouts cultivated under different conditions by content of isoflavones, calorimetric study and molecular modelling Cite
  Budryn G, Gałązka-Czarnecka I, Brzozowska E, Grzelczyk J, Mostowski R, Żyżelewicz D, et al. Evaluation of estrogenic activity of red clover (Trifolium pratense L.) sprouts cultivated under different conditions by content of isoflavones, calorimetric study and molecular modelling. Food Chemistry. Elsevier BV; 2018; 245:324-336 10.1016/j.foodchem.2017.10.100
• The Impacts of Genistein and Daidzein on Estrogen Conjugations in Human Breast Cancer Cells: A Targeted Metabolomics Approach Cite
  Poschner S, Maier-Salamon A, Zehl M, Wackerlig J, Dobusch D, Pachmann B, et al. The Impacts of Genistein and Daidzein on Estrogen Conjugations in Human Breast Cancer Cells: A Targeted Metabolomics Approach. Frontiers in Pharmacology. Frontiers Media SA; 2017; 8 10.3389/fphar.2017.00699
• State of the evidence 2017: an update on the connection between breast cancer and the environment Cite
  Gray JM, Rasanayagam S, Engel C, Rizzo J. State of the evidence 2017: an update on the connection between breast cancer and the environment. Environmental Health. Springer Science and Business Media LLC; 2017; 16 10.1186/s12940-017-0287-4
• Dietary Isoflavones and Breast Cancer Risk Cite
  Ziaei S, Halaby R. Dietary Isoflavones and Breast Cancer Risk. Medicines. MDPI AG; 2017; 4:18 10.3390/medicines4020018
• Dietary isoflavone intake and all-cause mortality in breast cancer survivors: The Breast Cancer Family Registry Cite
  Zhang FF, Haslam DE, Terry MB, Knight JA, Andrulis IL, Daly MB, et al. Dietary isoflavone intake and all-cause mortality in breast cancer survivors: The Breast Cancer Family Registry. Cancer. Wiley; 2017; 123:2070-2079 10.1002/cncr.30615
• Estrogen receptor-α and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells Cite
  Gong P, Madak-Erdogan Z, Flaws JA, Shapiro DJ, Katzenellenbogen JA, Katzenellenbogen BS. Estrogen receptor-α and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells. Molecular and Cellular Endocrinology. Elsevier BV; 2016; 437:190-200 10.1016/j.mce.2016.08.025
• Isoflavone Content in Subterranean Clover Germplasm from Sardinia Cite
  Tava A, Stochmal A, Pecetti L. Isoflavone Content in Subterranean Clover Germplasm from Sardinia. Chemistry & Biodiversity. Wiley; 2016; 13:1038-1045 10.1002/cbdv.201500360
• Glycone-rich Soy Isoflavone Extracts Promote Estrogen Receptor Positive Breast Cancer Cell Growth Cite
  Johnson KA, Vemuri S, Alsahafi S, Castillo R, Cheriyath V. Glycone-rich Soy Isoflavone Extracts Promote Estrogen Receptor Positive Breast Cancer Cell Growth. Nutrition and Cancer. Informa UK Limited; 2016; 68:622-633 10.1080/01635581.2016.1154578
• The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters Cite
  Rigalli JP, Tocchetti GN, Arana MR, Villanueva SSM, Catania VA, Theile D, et al. The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Letters. Elsevier BV; 2016; 376:165-172 10.1016/j.canlet.2016.03.040
• Plasma equol concentration is not associated with breast cancer and fibrocystic breast conditions among women in Shanghai, China Cite
  Atkinson C, Ray RM, Li W, Lin M, Gao DL, Shannon J, et al. Plasma equol concentration is not associated with breast cancer and fibrocystic breast conditions among women in Shanghai, China. Nutrition Research. Elsevier BV; 2016; 36:863-871 10.1016/j.nutres.2016.03.008
• Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques Cite
  Dewi FN, Wood CE, Willson CJ, Register TC, Lees CJ, Howard TD, et al. Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques. Cancer Prevention Research. American Association for Cancer Research (AACR); 2016; 9:385-395 10.1158/1940-6207.capr-15-0165
• Abstract P3-09-03: Combined effects of soy isoflavones and a high fat diet on the mammary gland in an animal model of diet-induced obesity Cite
  Kurrat A, Diel P, Blei T, Kluxen F, Mueller D, Pichotta M, et al. Abstract P3-09-03: Combined effects of soy isoflavones and a high fat diet on the mammary gland in an animal model of diet-induced obesity. Poster Session Abstracts. American Association for Cancer Research; 2016; 10.1158/1538-7445.sabcs15-p3-09-03
• Soy isoflavone exposure through all life stages accelerates 17β-estradiol-induced mammary tumor onset and growth, yet reduces tumor burden, in ACI rats Cite
  Möller FJ, Pemp D, Soukup ST, Wende K, Zhang X, Zierau O, et al. Soy isoflavone exposure through all life stages accelerates 17β-estradiol-induced mammary tumor onset and growth, yet reduces tumor burden, in ACI rats. Archives of Toxicology. Springer Science and Business Media LLC; 2016; 90:1907-1916 10.1007/s00204-016-1674-2
• Quantitative phosphoproteomics reveals genistein as a modulator of cell cycle and DNA damage response pathways in triple-negative breast cancer cells Cite
  FANG Y, ZHANG Q, WANG X, YANG X, WANG X, HUANG Z, et al. Quantitative phosphoproteomics reveals genistein as a modulator of cell cycle and DNA damage response pathways in triple-negative breast cancer cells. International Journal of Oncology. Spandidos Publications; 2016; 48:1016-1028 10.3892/ijo.2016.3327
• Genistein-induced differentiation of breast cancer stem/progenitor cells through a paracrine mechanism Cite
  LIU Y, ZOU T, WANG S, CHEN H, SU D, FU X, et al. Genistein-induced differentiation of breast cancer stem/progenitor cells through a paracrine mechanism. International Journal of Oncology. Spandidos Publications; 2016; 48:1063-1072 10.3892/ijo.2016.3351
• Soy and Breast Cancer, have we Analyzed all the Risks? Cite
  J K, L S. Soy and Breast Cancer, have we Analyzed all the Risks?. Journal of Carcinogenesis & Mutagenesis. OMICS Publishing Group; 2015; 06 10.4172/2157-2518.1000e117
• Environmental phenols and pubertal development in girls Cite
  Wolff MS, Teitelbaum SL, McGovern K, Pinney SM, Windham GC, Galvez M, et al. Environmental phenols and pubertal development in girls. Environment International. Elsevier BV; 2015; 84:174-180 10.1016/j.envint.2015.08.008
• Epigenetic activities of flavonoids in the prevention and treatment of cancer Cite
  Busch C, Burkard M, Leischner C, Lauer UM, Frank J, Venturelli S. Epigenetic activities of flavonoids in the prevention and treatment of cancer. Clinical Epigenetics. Springer Science and Business Media LLC; 2015; 7 10.1186/s13148-015-0095-z
• Genistein inhibits MDA-MB-231 triple-negative breast cancer cell growth by inhibiting NF-κB activity via the Notch-1 pathway Cite
  PAN H, ZHOU W, HE W, LIU X, DING Q, LING L, et al. Genistein inhibits MDA-MB-231 triple-negative breast cancer cell growth by inhibiting NF-κB activity via the Notch-1 pathway. International Journal of Molecular Medicine. Spandidos Publications; 2012; 30:337-343 10.3892/ijmm.2012.990
• The Effects of Soy Supplementation on Gene Expression in Breast Cancer: A Randomized Placebo-Controlled Study Cite
  Shike M, Doane AS, Russo L, Cabal R, Reis-Filo J, Gerald W, et al. The Effects of Soy Supplementation on Gene Expression in Breast Cancer: A Randomized Placebo-Controlled Study. JNCI Journal of the National Cancer Institute. Oxford University Press (OUP); 2014; 106:dju189-dju189 10.1093/jnci/dju189
• Genistein isoflavone glycoconjugates in sour cherry (Prunus cerasus L.) cultivars Cite
  Abrankó L, Nagy Á, Szilvássy B, Stefanovits-Bányai É, Hegedűs A. Genistein isoflavone glycoconjugates in sour cherry (Prunus cerasus L.) cultivars. Food Chemistry. Elsevier BV; 2015; 166:215-222 10.1016/j.foodchem.2014.06.007
• Cell proliferation and apoptosis in rat mammary glands following combinational exposure to bisphenol A and genistein Cite
  Wang J, Jenkins S, Lamartiniere CA. Cell proliferation and apoptosis in rat mammary glands following combinational exposure to bisphenol A and genistein. BMC Cancer. Springer Science and Business Media LLC; 2014; 14 10.1186/1471-2407-14-379
• Association between Soy Isoflavone Intake and Breast Cancer Risk for Pre- and Post-Menopausal Women: A Meta-Analysis of Epidemiological Studies Cite
  Chen M, Rao Y, Zheng Y, Wei S, Li Y, Guo T, et al. Association between Soy Isoflavone Intake and Breast Cancer Risk for Pre- and Post-Menopausal Women: A Meta-Analysis of Epidemiological Studies. PLoS ONE. Public Library of Science (PLoS); 2014; 9:e89288 10.1371/journal.pone.0089288
• Isoflavone content and estrogenic activity of different batches of red clover (Trifolium pratense L.) extracts: An in vitro study in MCF-7 cells Cite
  Spagnuolo P, Rasini E, Luini A, Legnaro M, Luzzani M, Casareto E, et al. Isoflavone content and estrogenic activity of different batches of red clover (Trifolium pratense L.) extracts: An in vitro study in MCF-7 cells. Fitoterapia. Elsevier BV; 2014; 94:62-69 10.1016/j.fitote.2014.01.027
• Genistein modulates the anti-tumor activity of cisplatin in MCF-7 breast and HT-29 colon cancer cells Cite
  Hu X, Xie M, Kluxen FM, Diel P. Genistein modulates the anti-tumor activity of cisplatin in MCF-7 breast and HT-29 colon cancer cells. Archives of Toxicology. Springer Science and Business Media LLC; 2014; 10.1007/s00204-013-1184-4
• Genistein Exposure During the Early Postnatal Period Favors the Development of Obesity in Female, But Not Male Rats Cite
  Strakovsky RS, Lezmi S, Flaws JA, Schantz SL, Pan Y, Helferich WG. Genistein Exposure During the Early Postnatal Period Favors the Development of Obesity in Female, But Not Male Rats. Toxicological Sciences. Oxford University Press (OUP); 2013; 138:161-174 10.1093/toxsci/kft331
• S-(−)equol producing status not associated with breast cancer risk among low isoflavone-consuming US postmenopausal women undergoing a physician-recommended breast biopsy Cite
  Virk-Baker MK, Barnes S, Krontiras H, Nagy TR. S-(−)equol producing status not associated with breast cancer risk among low isoflavone-consuming US postmenopausal women undergoing a physician-recommended breast biopsy. Nutrition Research. Elsevier BV; 2014; 34:116-125 10.1016/j.nutres.2013.12.002
• Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review Cite
  Fritz H, Seely D, Flower G, Skidmore B, Fernandes R, Vadeboncoeur S, et al. Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e81968 10.1371/journal.pone.0081968
• Coexposure to Phytoestrogens and Bisphenol A Mimics Estrogenic Effects in an Additive Manner Cite
  Katchy A, Pinto C, Jonsson P, Nguyen-Vu T, Pandelova M, Riu A, et al. Coexposure to Phytoestrogens and Bisphenol A Mimics Estrogenic Effects in an Additive Manner. Toxicological Sciences. Oxford University Press (OUP); 2013; 138:21-35 10.1093/toxsci/kft271
• Commercial processed food may have endocrine-disrupting potential: soy-based ingredients making the difference Cite
  Omoruyi IM, Kabiersch G, Pohjanvirta R. Commercial processed food may have endocrine-disrupting potential: soy-based ingredients making the difference. Food Additives & Contaminants: Part A. Informa UK Limited; 2013; 30:1722-1727 10.1080/19440049.2013.817025
• Phytoestrogens in menopausal supplements induce ER-dependent cell proliferation and overcome breast cancer treatment in an in vitro breast cancer model Cite
  van Duursen MB, Smeets EE, Rijk JC, Nijmeijer SM, van den Berg M. Phytoestrogens in menopausal supplements induce ER-dependent cell proliferation and overcome breast cancer treatment in an in vitro breast cancer model. Toxicology and Applied Pharmacology. Elsevier BV; 2013; 269:132-140 10.1016/j.taap.2013.03.014
• The Estrogenic Activity of Isoflavones Extracted from ChickpeaCicer arietinum LSproutsin Vitro Cite
  HaiRong M, HuaBo W, Zhen C, Yi Y, ZhengHua W, Madina H, et al. The Estrogenic Activity of Isoflavones Extracted from ChickpeaCicer arietinum LSproutsin Vitro. Phytotherapy Research. Wiley; 2012; 27:1237-1242 10.1002/ptr.4858
• A diet containing the soy phytoestrogen genistein causes infertility in female rats partially deficient in UDP glucuronyltransferase Cite
  Seppen J. A diet containing the soy phytoestrogen genistein causes infertility in female rats partially deficient in UDP glucuronyltransferase. Toxicology and Applied Pharmacology. Elsevier BV; 2012; 264:335-342 10.1016/j.taap.2012.09.013
• Acute genistein treatment mimics the effects of estradiol by enhancing place learning and impairing response learning in young adult female rats Cite
  Pisani SL, Neese SL, Doerge DR, Helferich WG, Schantz SL, Korol DL. Acute genistein treatment mimics the effects of estradiol by enhancing place learning and impairing response learning in young adult female rats. Hormones and Behavior. Elsevier BV; 2012; 62:491-499 10.1016/j.yhbeh.2012.08.006
• Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women Cite
  Nechuta SJ, Caan BJ, Chen WY, Lu W, Chen Z, Kwan ML, et al. Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women. The American Journal of Clinical Nutrition. Oxford University Press (OUP); 2012; 96:123-132 10.3945/ajcn.112.035972
• Soy isoflavone extracts stimulate the growth of nude mouse xenografts bearing estrogen-dependent human breast cancer cells (MCF-7) Cite
  Wu Q, Yang Y, Yu J, Jin N. Soy isoflavone extracts stimulate the growth of nude mouse xenografts bearing estrogen-dependent human breast cancer cells (MCF-7). Journal of Biomedical Research. Elsevier BV; 2012; 26:44-52 10.1016/s1674-8301(12)60006-2
• Tumor Angiogenesis as a Target for Dietary Cancer Prevention Cite
  Li WW, Li VW, Hutnik M, Chiou AS. Tumor Angiogenesis as a Target for Dietary Cancer Prevention. Journal of Oncology. Hindawi Limited; 2012; 2012:1-23 10.1155/2012/879623
• Embryotoxic and Teratogenic Effects of the Combination of Bisphenol A and Genistein on In Vitro Cultured Postimplantation Rat Embryos Cite
  Xing L, Xu Y, Xiao Y, Shang L, Liu R, Wei X, et al. Embryotoxic and Teratogenic Effects of the Combination of Bisphenol A and Genistein on In Vitro Cultured Postimplantation Rat Embryos. Toxicological Sciences. Oxford University Press (OUP); 2010; 115:577-588 10.1093/toxsci/kfq081
• Effects of multiple daily genistein treatments on delayed alternation and a differential reinforcement of low rates of responding task in middle-aged rats Cite
  Neese SL, Bandara SB, Doerge DR, Helferich WG, Korol DL, Schantz SL. Effects of multiple daily genistein treatments on delayed alternation and a differential reinforcement of low rates of responding task in middle-aged rats. Neurotoxicology and Teratology. Elsevier BV; 2012; 34:187-195 10.1016/j.ntt.2011.09.002
• Effects of herbal and dietary supplements on cognition in menopause: A systematic review Cite
  Clement YN, Onakpoya I, Hung SK, Ernst E. Effects of herbal and dietary supplements on cognition in menopause: A systematic review. Maturitas. Elsevier BV; 2011; 68:256-263 10.1016/j.maturitas.2010.12.005
• Hormonally Active Doses of Isoflavone Aglycones Promote Mammary and Endometrial Carcinogenesis and Alter the Molecular Tumor Environment in Donryu Rats Cite
  Kakehashi A, Tago Y, Yoshida M, Sokuza Y, Wei M, Fukushima S, et al. Hormonally Active Doses of Isoflavone Aglycones Promote Mammary and Endometrial Carcinogenesis and Alter the Molecular Tumor Environment in Donryu Rats. Toxicological Sciences. Oxford University Press (OUP); 2012; 126:39-51 10.1093/toxsci/kfs016
• Soy Isoflavone Supplementation for Breast Cancer Risk Reduction: A Randomized Phase II Trial Cite
  Khan SA, Chatterton RT, Michel N, Bryk M, Lee O, Ivancic D, et al. Soy Isoflavone Supplementation for Breast Cancer Risk Reduction: A Randomized Phase II Trial. Cancer Prevention Research. American Association for Cancer Research (AACR); 2012; 5:309-319 10.1158/1940-6207.capr-11-0251
• Determination of conjugated and free isoflavones in some legumes by LC–MS/MS Cite
  Konar N, Poyrazoğlu ES, Demir K, Artik N. Determination of conjugated and free isoflavones in some legumes by LC–MS/MS. Journal of Food Composition and Analysis. Elsevier BV; 2012; 25:173-178 10.1016/j.jfca.2011.11.004
• Differential Influence of Dietary Soy Intake on the Risk of Breast Cancer Recurrence Related to HER2 Status Cite
  Woo HD, Park K, Ro J, Kim J. Differential Influence of Dietary Soy Intake on the Risk of Breast Cancer Recurrence Related to HER2 Status. Nutrition and Cancer. Informa UK Limited; 2012; 64:198-205 10.1080/01635581.2012.635261
• The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression Cite
  Wang Y, Man Gho W, Chan FL, Chen S, Leung LK. The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression. British Journal of Nutrition. Cambridge University Press (CUP); 2008; 99:303-310 10.1017/s0007114507811974
• Early Life Exposure to Isoflavones Adversely Affects Reproductive Health in First but Not Second Generation Female CD-1 Mice Cite
  Dinsdale EC, Chen J, Ward WE. Early Life Exposure to Isoflavones Adversely Affects Reproductive Health in First but Not Second Generation Female CD-1 Mice. The Journal of Nutrition. Oxford University Press (OUP); 2011; 141:1996-2002 10.3945/jn.111.142281
• Soy Isoflavones in the Prevention of Menopausal Bone Loss and Menopausal Symptoms Cite
  Levis S. Soy Isoflavones in the Prevention of Menopausal Bone Loss and Menopausal Symptoms. Archives of Internal Medicine. American Medical Association (AMA); 2011; 171:1363 10.1001/archinternmed.2011.330
• Flavonoids, Proanthocyanidins, and Cancer Risk: A Network of Case-Control Studies From Italy Cite
  Rossi M, Bosetti C, Negri E, Lagiou P, Vecchia CL. Flavonoids, Proanthocyanidins, and Cancer Risk: A Network of Case-Control Studies From Italy. Nutrition and Cancer. Informa UK Limited; 2010; 62:871-877 10.1080/01635581.2010.509534
• Enhanced Mammary Progesterone Receptor-A Isoform Activity in the Promotion of Mammary Tumor Progression by Dietary Soy in Rats Cite
  Dave B, Wynne R, Su Y, Korourian S, Chang JC, Simmen RCM. Enhanced Mammary Progesterone Receptor-A Isoform Activity in the Promotion of Mammary Tumor Progression by Dietary Soy in Rats. Nutrition and Cancer. Informa UK Limited; 2010; 62:774-782 10.1080/01635581.2010.494334
• A vegetable-fruit-soy dietary pattern protects against breast cancer among postmenopausal Singapore Chinese women Cite
  Butler LM, Wu AH, Wang R, Koh W, Yuan J, Yu MC. A vegetable-fruit-soy dietary pattern protects against breast cancer among postmenopausal Singapore Chinese women. The American Journal of Clinical Nutrition. Oxford University Press (OUP); 2010; 91:1013-1019 10.3945/ajcn.2009.28572
• Breast, colorectal, and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition-Norfolk in relation to phytoestrogen intake derived from an improved database Cite
  Ward HA, Kuhnle GG, Mulligan AA, Lentjes MA, Luben RN, Khaw K. Breast, colorectal, and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition-Norfolk in relation to phytoestrogen intake derived from an improved database. American Journal of Clinical Nutrition. Oxford University Press (OUP); 2009; 91:440-448 10.3945/ajcn.2009.28282
• Dietary Seaweed Modifies Estrogen and Phytoestrogen Metabolism in Healthy Postmenopausal Women Cite
  Teas J, Hurley TG, Hebert JR, Franke AA, Sepkovic DW, Kurzer MS. Dietary Seaweed Modifies Estrogen and Phytoestrogen Metabolism in Healthy Postmenopausal Women. The Journal of Nutrition. Oxford University Press (OUP); 2009; 139:939-944 10.3945/jn.108.100834
• Soy Food Intake and Breast Cancer Survival Cite
  Shu XO. Soy Food Intake and Breast Cancer Survival. JAMA. American Medical Association (AMA); 2009; 302:2437 10.1001/jama.2009.1783
• Plasma Phytoestrogens Are Not Altered by Probiotic Consumption in Postmenopausal Women with and without a History of Breast Cancer Cite
  Nettleton JA, Greany KA, Thomas W, Wangen KE, Adlercreutz H, Kurzer MS. Plasma Phytoestrogens Are Not Altered by Probiotic Consumption in Postmenopausal Women with and without a History of Breast Cancer. The Journal of Nutrition. Oxford University Press (OUP); 2004; 134:1998-2003 10.1093/jn/134.8.1998
• The Effect of the Phytoestrogens Genistein, Daidzein, and Equol on the Growth of Tamoxifen-Resistant T47D/PKCα Cite
  Tonetti DA, Zhang Y, Zhao H, Lim S, Constantinou AI. The Effect of the Phytoestrogens Genistein, Daidzein, and Equol on the Growth of Tamoxifen-Resistant T47D/PKCα. Nutrition and Cancer. Informa UK Limited; 2007; 58:222-229 10.1080/01635580701328545
• Isoflavones in urine, saliva, and blood of infants: data from a pilot study on the estrogenic activity of soy formula Cite
  Cao Y, Calafat AM, Doerge DR, Umbach DM, Bernbaum JC, Twaddle NC, et al. Isoflavones in urine, saliva, and blood of infants: data from a pilot study on the estrogenic activity of soy formula. Journal of Exposure Science & Environmental Epidemiology. Springer Science and Business Media LLC; 2008; 19:223-234 10.1038/jes.2008.44
• Soy processing influences growth of estrogen-dependent breast cancer tumors Cite
  Allred CD. Soy processing influences growth of estrogen-dependent breast cancer tumors. Carcinogenesis. Oxford University Press (OUP); 2004; 25:1649-1657 10.1093/carcin/bgh178
• Reduced mammary tumor progression in a transgenic mouse model fed an isoflavone-poor soy protein concentrate Cite
  Chiesa G, Rigamonti E, Lovati MR, Disconzi E, Soldati S, Sacco MG, et al. Reduced mammary tumor progression in a transgenic mouse model fed an isoflavone-poor soy protein concentrate. Molecular Nutrition & Food Research. Wiley; 2008; 52:1121-1129 10.1002/mnfr.200700296
• Phytoestrogens and breast cancer: a complex story Cite
  Helferich WG, Andrade JE, Hoagland MS. Phytoestrogens and breast cancer: a complex story. Inflammopharmacology. Springer Science and Business Media LLC; 2008; 16:219-226 10.1007/s10787-008-8020-0
• A comparison of the effects of soya isoflavonoids and fish oil on cell proliferation, apoptosis and the expression of oestrogen receptors α and β in the mammary gland and colon of the rat Cite
  Kramer F, Johnson IT, Doleman JF, Lund EK. A comparison of the effects of soya isoflavonoids and fish oil on cell proliferation, apoptosis and the expression of oestrogen receptors α and β in the mammary gland and colon of the rat. British Journal of Nutrition. Cambridge University Press (CUP); 2008; 102:29-36 10.1017/s0007114508137862
• Evaluation of the Estrogenic Effects of Legume Extracts Containing Phytoestrogens Cite
  Boué SM, Wiese TE, Nehls S, Burow ME, Elliott S, Carter-Wientjes CH, et al. Evaluation of the Estrogenic Effects of Legume Extracts Containing Phytoestrogens. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2003; 51:2193-2199 10.1021/jf021114s
• Effect of Red Clover Isoflavones on Cox-2 Activity in Murine and Human Monocyte/Macrophage Cells Cite
  Lam ANC, Demasi M, James MJ, Husband AJ, Walker C. Effect of Red Clover Isoflavones on Cox-2 Activity in Murine and Human Monocyte/Macrophage Cells. Nutrition and Cancer. Informa UK Limited; 2004; 49:89-93 10.1207/s15327914nc4901_12
• Flavonoids and Breast Cancer Risk in Italy Cite
  Bosetti C. Flavonoids and Breast Cancer Risk in Italy. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2005; 14:805-808 10.1158/1055-9965.epi-04-0838
• Environmental Influences on Isoflavones and Saponins in Soybeans and Their Role in Colon Cancer Cite
  MacDonald RS, Guo J, Copeland J, Browning JD, Sleper D, Rottinghaus GE, et al. Environmental Influences on Isoflavones and Saponins in Soybeans and Their Role in Colon Cancer. The Journal of Nutrition. Oxford University Press (OUP); 2005; 135:1239-1242 10.1093/jn/135.5.1239
• Diet and Risk of Ovarian Cancer in the California Teachers Study Cohort Cite
  Chang ET, Lee VS, Canchola AJ, Clarke CA, Purdie DM, Reynolds P, et al. Diet and Risk of Ovarian Cancer in the California Teachers Study Cohort. American Journal of Epidemiology. Oxford University Press (OUP); 2007; 165:802-813 10.1093/aje/kwk065