Tag: doxorubicin
Doxorubicin: Trade name Adriamycin. An anthracycline chemotherapy drug. Anthracyclines work primarily by inhibiting DNA replication in rapidly growing cancer cells.
Articles
News
06/12/19
Resveratrol increases effectiveness of Adriamycin chemotherapy in breast cancer cells 05/06/19
Metformin reduces resistance to Adriamycin chemotherapy in breast cancer cells 04/21/18
Quercetin can reverse chemotherapy resistance in ER+/PR+ breast cancer cells 03/11/18
Flaxseed lignans increase the treatment effects of Adriamycin and Taxotere in triple negative and HER2+ breast cancer cells 09/26/17
Black cumin compound thymoquinone enhances toxicity of Adriamycin while reducing heart damage in mice 08/09/16
Quercetin protects heart from Adriamycin but could interfere with treatment effects 04/08/16
Genistein could reduce treatment effects of Adriamycin chemotherapy in ER+/PR+ disease 02/08/16
Resveratrol enhances the treatment effects of Adriamycin in ER+/PR+ and triple negative cells 11/10/15
Black cumin increases the effectiveness of many types of breast cancer treatment 09/19/15
Ferritin can protect breast cancer cells from treatment by Adriamycin 09/21/13
Trans fat consumption during Adriamycin chemotherapy could increase heart damage 06/16/13
Resveratrol enhances the effectiveness of Adriamycin in ER+/PR+ breast cancer cells 05/31/13
Black pepper compound increases effectiveness of Taxol against HER2+ breast cancer 10/14/12
Fatty fish compound DHA increases Adriamycin efficacy in triple negative breast cancer cells 05/30/12
Fish oil does not prevent Adriamycin-induced heart damage and might promote it 02/15/12
Grapes and other foods might help protect against Adriamycin-induced heart damage 12/15/11
Kaempferol protects against Adriamycin-induced heart damage 12/07/11
Modern chemotherapy reduces breast cancer death by about a third compared to no chemotherapy 12/01/11
Herceptin plus anthracycline chemotherapy greatly increases risk of heart damage 11/09/11
Curcumin reduces breast cancer resistance to treatment with Adriamycin (doxorubicin) chemotherapy 09/24/11
Caffeine may reduce the effectiveness of Adriamycin (doxorubicin) chemotherapy 08/11/11
Black pepper may help prevent resistance to Adriamycin (doxorubicin) chemotherapy 07/11/11
Taking Celebrex might reduce the effectiveness of chemotherapy for breast cancer 11/03/10
Chemotherapy resistance is accompanied by increase in number of breast cancer stem cells 05/06/10
Fasting protects normal cells and sensitizes cancer cells to chemotherapy
Studies
Fucoxanthin attenuates doxorubicin-induced cardiotoxicity via anti-oxidant and anti-apoptotic mechanisms associated with p38, JNK and p53 pathways Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models Coenzyme Q10 Cardioprotective Effects Against Doxorubicin-Induced Cardiotoxicity in Wistar Rat Preventing chemotherapy-induced alopecia: a prospective clinical trial on the efficacy and safety of a scalp-cooling system in early breast cancer patients treated with anthracyclines Resveratrol chemosensitizes adriamycin‐resistant breast cancer cells by modulating miR‐122‐5p Obesity: an heavyweight player in breast cancer’s chemoresistance Cardioprotective Effect of Marine Astaxanthin on Doxorubicin-Induced Cardiotoxicity in Normal Rats Metformin prevention of doxorubicin resistance in MCF-7 and MDA-MB-231 involves oxidative stress generation and modulation of cell adaptation genes Effect of Omega-3 Supplementation on Ki-67 and VEGF Expression Levels and Clinical Outcomes of Locally Advanced Breast Cancer Patients Treated with Neoadjuvant CAF Chemotherapy: A Randomized Controlled Trial Report Apoptosis induced by luteolin in breast cancer: Mechanistic and therapeutic perspectives Concurrent exercise and chemotherapy in preclinical breast cancer models Ferulic acid ameliorates doxorubicin-induced cardiac toxicity in rats Crocin, a carotenoid, suppresses spindle microtubule dynamics and activates the mitotic checkpoint by binding to tubulin Milk and kefir maintain aspects of health during doxorubicin treatment in rats Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP) In the triple-negative breast cancer MDA-MB-231 cell line, sulforaphane enhances the intracellular accumulation and anticancer action of doxorubicin encapsulated in liposomes Co-delivery of Adriamycin and P-gp inhibitor Quercetin using PEGylated liposomes to overcome cancer resistance Treatment with DHA Modifies the Response of MDA-MB-231 Breast Cancer Cells and Tumors from nu/nu Mice to Doxorubicin through Apoptosis and Cell Cycle Arrest Reversal of multidrug resistance in breast cancer cells by a combination of ursolic acid with doxorubicin Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats Fabrication of 6-gingerol, doxorubicin and alginate hydroxyapatite into a bio-compatible formulation: enhanced anti-proliferative effect on breast and liver cancer cells Expression profiling of genes modulated by rosmarinic acid (RA) in MCF-7 breast cancer cells Wild edible onions - Allium flavum and Allium carinatum - successfully prevent adverse effects of chemotherapeutic drug doxorubicin Sulforaphane induces autophagy by inhibition of HDAC6-mediated PTEN activation in triple negative breast cancer cells Fisetin, a plant flavonoid ameliorates doxorubicin -induced cardiotoxicity in experimental rats: the decisive role of caspase -3, COX -II, cTn -I, iNOs and TNF -α Antiproliferative activity of the combination of doxorubicin/ quercetin on MCF7 breast cancer cell line: A combined study using colorimetric assay and synchrotron infrared microspectroscopy Expression of genes modulated by epigallocatechin-3-gallate in breast cancer cells Improved chemotherapy against breast cancer through immunotherapeutic activity of fucoidan decorated electrostatically assembled nanoparticles bearing doxorubicin Silymarin increases the sensitivity of breast cancer cells to doxorubicin in doxorubicin-induced MCF-7 cells by inhibiting breast cancer resistance protein expression Melatonin improves cardiac and mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin activity Low-dose doxorubicin with carotenoids selectively alters redox status and upregulates oxidative stress-mediated apoptosis in breast cancer cells Nicotine reduces effectiveness of doxorubicin chemotherapy and promotes CD44+CD24‑ cancer stem cells in MCF‑7 cell populations Indole-3-Carbinol (I3C) enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin (DOX) through inhibition of NF-κβ, blocking angiogenesis and regulation of mitochondrial apoptotic pathway Loading of doxorubicin and thymoquinone with F2 gel nanofibers improves the antitumor activity and ameliorates doxorubicin-associated nephrotoxicity Quercetin reversed MDR in breast cancer cells through down‐regulating P‐gp expression and eliminating cancer stem cells mediated by YB‐1 nuclear translocation Effect of resveratrol on doxorubicin resistance in breast neoplasm cells by modulating PI3K/Akt signaling pathway Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model Physical exercise prevents cognitive impairment by enhancing hippocampal neuroplasticity and mitochondrial function in doxorubicin-induced chemobrain Capsaicin and Piperine Can Overcome Multidrug Resistance in Cancer Cells to Doxorubicin Flaxseed Lignans Enhance the Cytotoxicity of Chemotherapeutic Agents against Breast Cancer Cell Lines MDA-MB-231 and SKBR3 Quercetin enhances chemotherapeutic effect of doxorubicin against human breast cancer cells while reducing toxic side effects of it Effects of polyphenols on doxorubicin-induced oral keratinocyte cytotoxicity and anticancer potency against oral cancer cells The effect of an aerobic exercise bout 24 h prior to each doxorubicin treatment for breast cancer on markers of cardiotoxicity and treatment symptoms: a RCT Enhanced anticancer effect and reduced toxicity of doxorubicin in combination with thymoquinone released from poly-N-acetyl glucosamine nanomatrix in mice bearing solid Ehrlish carcinoma Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin-induced neurotoxicity in rats Protective effects of acute exercise prior to doxorubicin on cardiac function of breast cancer patients: A proof-of-concept RCT Improved survival for sequentially as opposed to concurrently delivered neoadjuvant chemotherapy in non-metastatic breast cancer Synergistic Anti-Breast-Cancer Effects of Combined Treatment With Oleuropein and Doxorubicin In Vivo Metformin augments doxorubicin cytotoxicity in mammary carcinoma through activation of adenosine monophosphate protein kinase pathway Liposomal curcumin alters chemosensitivity of breast cancer cells to Adriamycin via regulating microRNA expression Rutin Protects against Neuronal Damage in Vitro and Ameliorates Doxorubicin-induced Memory Deficits in Vivo in Wistar Rats Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy Interventions for preventing cardiomyopathy due to anthracyclines: a Bayesian network meta-analysis Inhibitory effect of fruit juices on the doxorubicin metabolizing activity of carbonyl reductase 1 Silymarin decreases the expression of VEGF-A, iNOS and caspase-3 and preserves the ultrastructure of cardiac cells in doxorubicin induced cardiotoxicity in rats: a possible protective role Ginger extract adjuvant to doxorubicin in mammary carcinoma: study of some molecular mechanisms Time-of-Day Dictates Transcriptional Inflammatory Responses to Cytotoxic Chemotherapy Ursolic Acid Enhances Doxorubicin Cytotoxicity on MCF-7 Cells Mediated by G2/M Arrest Rutin attenuates doxorubicin-induced cardiotoxicity via regulating autophagy and apoptosis Combining doxorubicin with a phenolic extract from flaxseed oil: Evaluation of the effect on two breast cancer cell lines (−)-Epigallocatechin-3-gallate alleviates doxorubicin-induced cardiotoxicity in sarcoma 180 tumor-bearing mice Effect of crocin and doxorubicin / radiation on the breast cancer cell line, Michigan Cancer Foundation-7 Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells Gamma-tocotrienol reverses multidrug resistance of breast cancer cells with a mechanism distinct from that of atorvastatin Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin-cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study Morphine enhances doxorubicin uptake in an in vitro model of blood-brain barrier Cardioprotective Effect of Grape Seed Extract on Chronic Doxorubicin-Induced Cardiac Toxicity in Wistar Rats Anthocyanin Attenuates Doxorubicin-Induced Cardiomyotoxicity via Estrogen Receptor-α/β and Stabilizes HSF1 to Inhibit the IGF-IIR Apoptotic Pathway Proteomic analysis of the vitamin C effect on the doxorubicin cytotoxicity in the MCF-7 breast cancer cell line Obesity As a Risk Factor for Anthracyclines and Trastuzumab Cardiotoxicity in Breast Cancer: A Systematic Review and Meta-Analysis Diverse Effects of the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Combination with Tamoxifen Citrate and Doxorubicin in MCF-7 Breast Cancer Cells Beet root juice protects against doxorubicin toxicity in cardiomyocytes while enhancing apoptosis in breast cancer cells Ameliorative Influence of Dietary Dates on Doxorubicin-Induced Cardiac Toxicity Quercetin attenuates doxorubicin cardiotoxicity by modulating Bmi-1 expression Quercetin protects from doxorubicin induced vascular toxicity but impairs its cytotoxic profile in breast cancer cells In vitro modulation of P-glycoprotein, MRP-1 and BCRP expression by mangiferin in doxorubicin-treated MCF-7 cells The Effect of Caffeine and chk2 Inhibitor on Doxorubicin-Induced Cellular Senescence in MCF-7 Cells Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice Mangiferin and Cancer: Mechanisms of Action Novel triterpenoids isolated from raisins exert potent antiproliferative activities by targeting mitochondrial and Ras/Raf/ERK signaling in human breast cancer cells Consumption of Fresh Yellow Onion Ameliorates Hyperglycemia and Insulin Resistance in Breast Cancer Patients During Doxorubicin-Based Chemotherapy Crocin treatment prevents doxorubicin-induced cardiotoxicity in rats Influence of doxorubicin on apoptosis and oxidative stress in breast cancer cell lines Doxorubicin cytotoxicity in combination with soy isoflavone daidzein on MCF-7 breast cancer cells Protective effect of Co-enzyme Q10 On doxorubicin-induced cardiomyopathy of rat hearts The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters Resveratrol improves the anticancer effects of Doxorubicin in vitro and in vivo models Chemotherapy Agents Alter Plasma Lipids in Breast Cancer Patients and Show Differential Effects on Lipid Metabolism Genes in Liver Cells Co-delivery with nano-quercetin enhances doxorubicin-mediated cytotoxicity against MCF-7 cells Effects of Administered Cardioprotective Drugs on Treatment Response of Breast Cancer Cells Evaluation of the effect of crocetin on antitumor activity of doxorubicin encapsulated in PLGA nanoparticles Anti-cancer and cardioprotective effects of indol-3-carbinol in doxorubicin-treated mice Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-γ pathway Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS Ameliorative effect of naringin against doxorubicin-induced acute cardiac toxicity in rats Circadian/melatonin disruption by dim light at night drive chemotherapy resistance in breast cancer The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study Benzyl butyl phthalate increases the chemoresistance to doxorubicin/cyclophosphamide by increasing breast cancer-associated dendritic cell-derived CXCL1/GROα and S100A8/A9 Cytoprotective effects of ferritin on doxorubicin-induced breast cancer cell death Comparative Effectiveness of Chemotherapy Regimens in Prolonging Survival for Two Large Population-Based Cohorts of Elderly Adults with Breast and Colon Cancer in 1992-2009 Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells Resveratrol, a polyphenol phytoalexin, protects against doxorubicin-induced cardiotoxicity Body Mass Index, PAM50 Subtype, and Outcomes in Node-Positive Breast Cancer: CALGB 9741 (Alliance) Effect of hesperidin on mice bearing Ehrlich solid carcinoma maintained on doxorubicin Doxorubicin and cyclophosphamide treatment produces anxiety-like behavior and spatial cognition impairment in rats: Possible involvement of hippocampal neurogenesis via brain-derived neurotrophic factor and cyclin D1 regulation Pegylated liposomal doxorubicin plus cyclophosphamide followed by paclitaxel as primary chemotherapy in elderly or cardiotoxicity-prone patients with high-risk breast cancer: results of the phase II CAPRICE study Saffron extracts alleviate cardiomyocytes injury induced by doxorubicin and ischemia-reperfusion in vitro Efficacy of Antioxidants as a Complementary and Alternative Medicine (CAM) in Combination With the Chemotherapeutic Agent Doxorubicin The flavonoid quercetin: Possible solution for anthracycline-induced cardiotoxicity and multidrug resistance Can short-term fasting protect against doxorubicin-induced cardiotoxicity? Risk of Hospitalization According to Chemotherapy Regimen in Early-Stage Breast Cancer Curcumin as a cancer chemotherapy sensitizing agent Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1) Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation Resveratrol enhances chemosensitivity of doxorubicin in multidrug-resistant human breast cancer cells via increased cellular influx of doxorubicin Metformin reverses multidrug resistance and epithelial-mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells DHA is a more potent inhibitor of breast cancer metastasis to bone and related osteolysis than EPA Dietary Trans Fats Enhance Doxorubicin-Induced Cardiotoxicity in Mice Protective effect of saffron extract against doxorubicin cardiotoxicity in isolated rabbit heart Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin Protective effect of melatonin against Adriamycin-induced cardiotoxicity Proteomic Profiling Reveals That Resveratrol Inhibits HSP27 Expression and Sensitizes Breast Cancer Cells to Doxorubicin Therapy Both Aerobic Exercise and Resveratrol Supplementation Attenuate Doxorubicin-Induced Cardiac Injury in Mice The anticancer activity of alpha-tomatine against mammary adenocarcinoma in mice The Indole-3-carbinol Cyclic Tetrameric Derivative CTet Synergizes with Cisplatin and Doxorubicin in Triple-negative Breast Cancer Cell Lines Sesamol prevents doxorubicin-induced oxidative damage and toxicity on H9c2 cardiomyoblasts 3,3′-Diindolymethane ameliorates adriamycin-induced cardiac fibrosis via activation of a BRCA1-dependent anti-oxidant pathway Docosahexanoic Acid Improves Chemotherapy Efficacy by Inducing CD95 Translocation to Lipid Rafts in ER− Breast Cancer Cells Risk of heart failure in breast cancer patients after anthracycline and trastuzumab treatment: a retrospective cohort study Tissue retention of doxorubicin and its effects on cardiac, smooth, and skeletal muscle function The Effect of Quercetin On Doxorubicin Cytotoxicity in Human Breast Cancer Cells Diindolilmethane (DIM) selectively inhibits cancer stem cells Metformin and the mTOR Inhibitor Everolimus (RAD001) Sensitize Breast Cancer Cells to the Cytotoxic Effect of Chemotherapeutic Drugs In Vitro Lack of Effect of Coenzyme Q10 on Doxorubicin Cytotoxicity in Breast Cancer Cell Cultures Longer Therapy, Iatrogenic Amenorrhea, and Survival in Early Breast Cancer Antioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in rats Effect of low-protein diet on anthracycline pharmacokinetics and cardiotoxicity Grape Seed and Skin Extract Protects Against Acute Chemotherapy Toxicity induced by Doxorubicin in Rat Heart Loperamide, an FDA-Approved Antidiarrhea Drug, Effectively Reverses the Resistance of Multidrug Resistant MCF-7/MDR1 Human Breast Cancer Cells to Doxorubicin-Induced Cytotoxicity Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats Reversion of multidrug resistance by co-encapsulation of doxorubicin and curcumin in chitosan/poly(butyl cyanoacrylate) nanoparticles Modulation by Melatonin of the Cardiotoxic and Antitumor Activities of Adriamycin BRCA2 deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats Trastuzumab Adjuvant Chemotherapy and Cardiotoxicity in Real-World Women With Breast Cancer Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100 000 women in 123 randomised trials Cardiotoxic Chemotherapy is Associated with Increased Heart Failure Risk Among Women with Breast Cancer in the Cancer Research Network Resveratrol enhances the cytotoxic profile of docetaxel and doxorubicin in solid tumour cell lines in vitro Curcumin enhances the efficacy of chemotherapy by tailoring p65NFκB-p300 cross-talk in favor of p53-p300 in breast cancer Adjuvant Trastuzumab in HER2-Positive Breast Cancer Efficacy of neoadjuvant therapy with trastuzumab concurrent with anthracycline- and nonanthracycline-based regimens for HER2-positive breast cancer Attenuation of Cytotoxic Natural Product DNA Intercalating Agents by Caffeine Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells Interaction of celecoxib with different anti-cancer drugs is antagonistic in breast but not in other cancer cells Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology Prolonged Drug Selection of Breast Cancer Cells and Enrichment of Cancer Stem Cell Characteristics Early identification of trastuzumab-related cardiotoxicity with speckle-tracking echocardiography Hematologic toxicity with adjuvant docetaxel and cyclophosphamide in early breast cancer Late pancreatic toxicity in patients with breast cancer after taxane-anthracycline-based neoadjuvant and adjuvant chemotherapy Hepatotoxicity in breast cancer patients post-chemotherapy with docetaxel, doxorubucin, and cyclophosphamide Luteolin as a glycolysis inhibitor offers superior efficacy and lesser toxicity of doxorubicin in breast cancer cells The Role of Curcuma longa Against Doxorubicin (Adriamycin)-Induced Toxicity in Rats Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates The effects of exercise training on antitumor efficacy of doxorubicin in MDA-MB-231 breast cancer xenografts Apigenin augments the growth inhibitory effects of doxorubicin in breast cancer cells derived from African American patients The herbal medicine black cohosh increases the cytotoxicity of doxorubicin to breast cancer cells by inhibiting doxorubicin efflux Severe dietary restriction enhances cancer treatment: Protecting normal cells and sensitizing malignant cells to chemotherapy by fasting Decrease in breast density in the contralateral normal breast of patients receiving neoadjuvant chemotherapy: MR imaging evaluation Effect of coenzyme Q10 on the disposition of doxorubicin in rats Protection against acute adriamycin-induced cardiotoxicity by garlic: Role of endogenous antioxidants and inhibition of TNF-α expression Aged Garlic Extract Protects against Doxorubicin-Induced Cardiotoxicity In Rats Patterns of Local and Distant Disease Relapse in Patients with Breast Cancer Treated with Primary Chemotherapy: Do Patients with a Complete Pathological Response Differ from Those with Residual Tumour in the Breast? Influence of palm oil on doxorubicin induced cytotoxicity in normal and tumor cell cultures Fifteen-year trends in metastatic breast cancer survival in Greece Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission Differential modulation of cisplatin and doxorubicin efficacies in leukemia cells by flavonoids
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