Tag: orange

News

05/16/16

Fruit consumption in adolescence linked to lower BC risk

07/09/12

Orange flavonoid hesperidin could interfere with cyclophosphamide

07/19/11

Citrus flavonoid naringenin inhibits metastasis in mice

Foods

• • oranges

Studies

• Citrus wastewater as a source of value‐added products: Quali‐quantitative analysis and in vitro screening on breast cancer cell lines Cite
  Raimondi MV, Rigogliuso S, Saiano F, Poma P, Labbozzetta M, Barreca M, et al. Citrus wastewater as a source of value‐added products: Quali‐quantitative analysis and in vitro screening on breast cancer cell lines. Archiv der Pharmazie. Wiley; 2024; 10.1002/ardp.202400530
• Bioactivities and Applications of Fruit Byproducts and Their Phytochemicals: A Mini Review Cite
  Balogun O, Kang HW. Bioactivities and Applications of Fruit Byproducts and Their Phytochemicals: A Mini Review. Food Reviews International. Informa UK Limited; 2024;:1-41 10.1080/87559129.2024.2383429
• Citrus polymethoxyflavones degrade estrogen receptor-alpha (ERα) and combine with tamoxifen for the treatment of estrogen receptor-positive breast cancer Cite
  Wang Y, Sun M, He Z, Han Y, Song Y, Liang J, et al. Citrus polymethoxyflavones degrade estrogen receptor-alpha (ERα) and combine with tamoxifen for the treatment of estrogen receptor-positive breast cancer. Heliyon. Elsevier BV; 2024; 10:e33104 10.1016/j.heliyon.2024.e33104
• Navel orange peel essential oil inhibits the growth and progression of triple negative breast cancer Cite
  Yang C, Zhang W, Xiang S, Chen L, Chun J, Chen H. Navel orange peel essential oil inhibits the growth and progression of triple negative breast cancer. BMC Complementary Medicine and Therapies. Springer Science and Business Media LLC; 2024; 24 10.1186/s12906-024-04525-y
• The Pharmacological Effects and Potential Applications of Limonene From Citrus Plants: A Review Cite
  Chen X, Ding Y, Guan H, Zhou C, He X, Shao Y, et al. The Pharmacological Effects and Potential Applications of Limonene From Citrus Plants: A Review. Natural Product Communications. SAGE Publications; 2024; 19 10.1177/1934578x241254229
• Nobiletin Inhibits Breast Cancer Stem Cell by Regulating the Cell Cycle: A Comprehensive Bioinformatics Analysis and In Vitro Experiments Cite
  Hermawan A, Ikawati M, Putri DDP, Fatimah N, Prasetio HH. Nobiletin Inhibits Breast Cancer Stem Cell by Regulating the Cell Cycle: A Comprehensive Bioinformatics Analysis and In Vitro Experiments. Nutrition and Cancer. Informa UK Limited; 2024;:1-18 10.1080/01635581.2024.2348217
• Possible interactions between selected food processing and medications Cite
  Poli G, Bologna E, Saguy IS. Possible interactions between selected food processing and medications. Frontiers in Nutrition. Frontiers Media SA; 2024; 11 10.3389/fnut.2024.1380010
• Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy Cite
  Khan F, Pandey P, Verma M, Ramniwas S, Lee D, Moon S, et al. Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy. Biomedicine & Pharmacotherapy. Elsevier BV; 2024; 173:116363 10.1016/j.biopha.2024.116363
• Exploring Citrus sinensis Phytochemicals as Potential Inhibitors for Breast Cancer Genes BRCA1 and BRCA2 Using Pharmacophore Modeling, Molecular Docking, MD Simulations, and DFT Analysis Cite
  Zia M, Parveen S, Shafiq N, Rashid M, Farooq A, Dauelbait M, et al. Exploring Citrus sinensis Phytochemicals as Potential Inhibitors for Breast Cancer Genes BRCA1 and BRCA2 Using Pharmacophore Modeling, Molecular Docking, MD Simulations, and DFT Analysis. ACS Omega. American Chemical Society (ACS); 2024; 10.1021/acsomega.3c05098
• Beyond Insoluble Dietary Fiber: Bioactive Compounds in Plant Foods Cite
  Timm M, Offringa LC, Van Klinken BJ, Slavin J. Beyond Insoluble Dietary Fiber: Bioactive Compounds in Plant Foods. Nutrients. MDPI AG; 2023; 15:4138 10.3390/nu15194138
• Phytochemistry and biological activities of Citrus sinensis and Citrus limon: An update Cite
  Zahr S, Zahr R, El Hajj R, Khalil M. Phytochemistry and biological activities of Citrus sinensis and Citrus limon: An update. Journal of Herbal Medicine. Elsevier BV; 2023;:100737 10.1016/j.hermed.2023.100737
• Nobiletin inhibits breast cancer cell migration and invasion by suppressing the IL-6-induced ERK-STAT and JNK-c-JUN pathways Cite
  Wu Y, Li Q, Lv L, Chen J, Ying H, Ruan M, et al. Nobiletin inhibits breast cancer cell migration and invasion by suppressing the IL-6-induced ERK-STAT and JNK-c-JUN pathways. Phytomedicine. Elsevier BV; 2023; 110:154610 10.1016/j.phymed.2022.154610
• Transcriptomics, molecular docking, and cross-resistance profiling of nobiletin in cancer cells and synergistic interaction with doxorubicin upon SOX5 transfection Cite
  Adham AN, Abdelfatah S, Naqishbandi A, Sugimoto Y, Fleischer E, Efferth T. Transcriptomics, molecular docking, and cross-resistance profiling of nobiletin in cancer cells and synergistic interaction with doxorubicin upon SOX5 transfection. Phytomedicine. Elsevier BV; 2022; 100:154064 10.1016/j.phymed.2022.154064
• Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms Cite
  Slika H, Mansour H, Wehbe N, Nasser SA, Iratni R, Nasrallah G, et al. Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms. Biomedicine & Pharmacotherapy. Elsevier BV; 2022; 146:112442 10.1016/j.biopha.2021.112442
• Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention Cite
  Pandey P, Khan F, Qari HA, Oves M. Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention. Pharmaceuticals. MDPI AG; 2021; 14:1069 10.3390/ph14111069
• The Orange Peel: An Outstanding Source of Chemical Resources Cite
  Fontana G. The Orange Peel: An Outstanding Source of Chemical Resources. Citrus - Research, Development and Biotechnology [Working Title]. IntechOpen; 2021; 10.5772/intechopen.96298
• Incipient citrus polymethoxylated flavone Tangeretin as anticancer drug candidate: Mechanistic insights, limitations and possible solutions Cite
  Boye A, Ahmad I, Fakhri S, Hussain Y, Khan H. Incipient citrus polymethoxylated flavone Tangeretin as anticancer drug candidate: Mechanistic insights, limitations and possible solutions. Advances in Cancer Biology - Metastasis. Elsevier BV; 2021; 3:100010 10.1016/j.adcanc.2021.100010
• Anticancer activity of limonene: A systematic review of target signaling pathways Cite
  Araújo‐Filho HGd, Santos JF, Carvalho MTB, Picot L, Fruitier‐Arnaudin I, Groult H, et al. Anticancer activity of limonene: A systematic review of target signaling pathways. Phytotherapy Research. Wiley; 2021; 10.1002/ptr.7125
• Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents Cite
  Feng S, Zhou H, Wu D, Zheng D, Qu B, Liu R, et al. Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents. Acta Pharmaceutica Sinica B. Elsevier BV; 2020; 10:327-343 10.1016/j.apsb.2019.07.007
• Nobiletin Attenuates Cell Proliferation by Modulating the Activating Protein-1 Signaling Pathway in 7,12-Dimethylbenz[a]anthracene-Induced Mammary Carcinogenesis Cite
  Zhang H, Lv P, Xiao Z, Jothi EA, Yang J. Nobiletin Attenuates Cell Proliferation by Modulating the Activating Protein-1 Signaling Pathway in 7,12-Dimethylbenz[a]anthracene-Induced Mammary Carcinogenesis. Journal of Environmental Pathology, Toxicology and Oncology. Begell House; 2020; 39:13-21 10.1615/jenvironpatholtoxicoloncol.2019031445
• Inhibitory Effects of Tangeretin, a Citrus Peel-Derived Flavonoid, on Breast Cancer Stem Cell Formation through Suppression of Stat3 Signaling Cite
  Ko Y, Choi HS, Liu R, Kim J, Kim S, Yun B, et al. Inhibitory Effects of Tangeretin, a Citrus Peel-Derived Flavonoid, on Breast Cancer Stem Cell Formation through Suppression of Stat3 Signaling. Molecules. MDPI AG; 2020; 25:2599 10.3390/molecules25112599
• Postdiagnostic Fruit and Vegetable Consumption and Breast Cancer Survival: Prospective Analyses in the Nurses' Health Studies Cite
  Farvid MS, Holmes MD, Chen WY, Rosner BA, Tamimi RM, Willett WC, et al. Postdiagnostic Fruit and Vegetable Consumption and Breast Cancer Survival: Prospective Analyses in the Nurses' Health Studies. Cancer Research. American Association for Cancer Research (AACR); 2020; 80:5134-5143 10.1158/0008-5472.can-18-3515
• Acute and sub-chronic oral toxicity studies of hesperidin isolated from orange peel extract in Sprague Dawley rats Cite
  Li Y, Kandhare AD, Mukherjee AA, Bodhankar SL. Acute and sub-chronic oral toxicity studies of hesperidin isolated from orange peel extract in Sprague Dawley rats. Regulatory Toxicology and Pharmacology. Elsevier BV; 2019; 105:77-85 10.1016/j.yrtph.2019.04.001
• A follow-up report on potential drug interactions with clementines: Two single case experiments show no effect on CYP3A-dependent midazolam clearance Cite
  Hohmann N, Mikus G, Haefeli WE, Schwenger V, Gattuso G, Barreca D, et al. A follow-up report on potential drug interactions with clementines: Two single case experiments show no effect on CYP3A-dependent midazolam clearance. European Journal of Pharmaceutical Sciences. Elsevier BV; 2019; 133:54-58 10.1016/j.ejps.2019.03.013
• Anticancer Potential of Citrus Juices and Their Extracts: A Systematic Review of Both Preclinical and Clinical Studies Cite
  Cirmi S, Maugeri A, Ferlazzo N, Gangemi S, Calapai G, Schumacher U, et al. Anticancer Potential of Citrus Juices and Their Extracts: A Systematic Review of Both Preclinical and Clinical Studies. Frontiers in Pharmacology. Frontiers Media SA; 2017; 8 10.3389/fphar.2017.00420
• Tangeretin attenuates cisplatin-induced renal injury in rats: Impact on the inflammatory cascade and oxidative perturbations Cite
  Arab HH, Mohamed WR, Barakat BM, Arafa EA. Tangeretin attenuates cisplatin-induced renal injury in rats: Impact on the inflammatory cascade and oxidative perturbations. Chemico-Biological Interactions. Elsevier BV; 2016; 258:205-213 10.1016/j.cbi.2016.09.008
• Fruit and vegetable consumption in adolescence and early adulthood and risk of breast cancer: population based cohort study Cite
  Farvid MS, Chen WY, Michels KB, Cho E, Willett WC, Eliassen AH. Fruit and vegetable consumption in adolescence and early adulthood and risk of breast cancer: population based cohort study. BMJ. BMJ; 2016;:i2343 10.1136/bmj.i2343
• Antioxidant activity of Citrus fruits Cite
  Zou Z, Xi W, Hu Y, Nie C, Zhou Z. Antioxidant activity of Citrus fruits. Food Chemistry. Elsevier BV; 2016; 196:885-896 10.1016/j.foodchem.2015.09.072
• HPLC-DAD Phenolic Characterization and Antioxidant Activities of Ripe and Unripe Sweet Orange Peels Cite
  Omoba O, Obafaye R, Salawu S, Boligon A, Athayde M. HPLC-DAD Phenolic Characterization and Antioxidant Activities of Ripe and Unripe Sweet Orange Peels. Antioxidants. MDPI AG; 2015; 4:498-512 10.3390/antiox4030498
• Epigenetic activities of flavonoids in the prevention and treatment of cancer Cite
  Busch C, Burkard M, Leischner C, Lauer UM, Frank J, Venturelli S. Epigenetic activities of flavonoids in the prevention and treatment of cancer. Clinical Epigenetics. Springer Science and Business Media LLC; 2015; 7 10.1186/s13148-015-0095-z
• Citrus Consumption and Risk of Cutaneous Malignant Melanoma Cite
  Wu S, Han J, Feskanich D, Cho E, Stampfer MJ, Willett WC, et al. Citrus Consumption and Risk of Cutaneous Malignant Melanoma. Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2015; 33:2500-2508 10.1200/jco.2014.57.4111
• Tangeretin, a citrus pentamethoxyflavone, exerts cytostatic effect via p53/p21 up-regulation and suppresses metastasis in 7,12-dimethylbenz(α)anthracene-induced rat mammary carcinoma Cite
  Arivazhagan L, Sorimuthu Pillai S. Tangeretin, a citrus pentamethoxyflavone, exerts cytostatic effect via p53/p21 up-regulation and suppresses metastasis in 7,12-dimethylbenz(α)anthracene-induced rat mammary carcinoma. The Journal of Nutritional Biochemistry. Elsevier BV; 2014; 25:1140-1153 10.1016/j.jnutbio.2014.06.007
• Clementine juice has the potential for drug interactions – In vitro comparison with grapefruit and mandarin juice Cite
  Theile D, Hohmann N, Kiemel D, Gattuso G, Barreca D, Mikus G, et al. Clementine juice has the potential for drug interactions – In vitro comparison with grapefruit and mandarin juice. European Journal of Pharmaceutical Sciences. Elsevier BV; 2017; 97:247-256 10.1016/j.ejps.2016.11.021
• Comparison of phenolic compounds of orange juice processed by pulsed electric fields (PEF) and conventional thermal pasteurisation Cite
  Agcam E, Akyıldız A, Akdemir Evrendilek G. Comparison of phenolic compounds of orange juice processed by pulsed electric fields (PEF) and conventional thermal pasteurisation. Food Chemistry. Elsevier BV; 2014; 143:354-361 10.1016/j.foodchem.2013.07.115
• Antiproliferative activity of peels, pulps and seeds of 61 fruits Cite
  Li F, Li S, Li H, Deng G, Ling W, Wu S, et al. Antiproliferative activity of peels, pulps and seeds of 61 fruits. Journal of Functional Foods. Elsevier BV; 2013; 5:1298-1309 10.1016/j.jff.2013.04.016
• Citrus Fruit Intake and Breast Cancer Risk: A Quantitative Systematic Review Cite
  Song J, Bae J. Citrus Fruit Intake and Breast Cancer Risk: A Quantitative Systematic Review. Journal of Breast Cancer. Korean Breast Cancer Society; 2013; 16:72 10.4048/jbc.2013.16.1.72
• Grapefruit–medication interactions: Forbidden fruit or avoidable consequences? Cite
  Bailey DG, Dresser G, Arnold JMO. Grapefruit–medication interactions: Forbidden fruit or avoidable consequences?. Canadian Medical Association Journal. CMA Joule Inc.; 2012; 185:309-316 10.1503/cmaj.120951
• Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells Cite
  Surichan S, Androutsopoulos VP, Sifakis S, Koutala E, Tsatsakis A, Arroo RR, et al. Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells. Food and Chemical Toxicology. Elsevier BV; 2012; 50:3320-3328 10.1016/j.fct.2012.06.030
• Undesirable Effects of Citrus Juice on the Pharmacokinetics of Drugs Cite
  Saito M, Hirata-Koizumi M, Matsumoto M, Urano T, Hasegawa R. Undesirable Effects of Citrus Juice on the Pharmacokinetics of Drugs. Drug Safety. Springer Science and Business Media LLC; 2012; 28:677-694 10.2165/00002018-200528080-00003
• The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice Cite
  Ye L, Chan FL, Chen S, Leung LK. The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice. The Journal of Nutritional Biochemistry. Elsevier BV; 2012; 23:1230-1237 10.1016/j.jnutbio.2011.07.003
• Effect of flavonone hesperidin on the apoptosis of human mammary carcinoma cell line MCF-7 Cite
  Natarajan N, Thamaraiselvan R, Lingaiah H, Srinivasan P, Maruthaiveeran Periyasamy B. Effect of flavonone hesperidin on the apoptosis of human mammary carcinoma cell line MCF-7. Biomedicine & Preventive Nutrition. Elsevier BV; 2011; 1:207-215 10.1016/j.bionut.2011.07.001
• Naringenin reduces lung metastasis in a breast cancer resection model Cite
  Qin L, Jin L, Lu L, Lu X, Zhang C, Zhang F, et al. Naringenin reduces lung metastasis in a breast cancer resection model. Protein & Cell. Springer Science and Business Media LLC; 2011; 2:507-516 10.1007/s13238-011-1056-8
• Dietary flavones and flavonones display differential effects on aromatase (CYP19) transcription in the breast cancer cells MCF-7 Cite
  Li F, Ye L, Lin S, Leung LK. Dietary flavones and flavonones display differential effects on aromatase (CYP19) transcription in the breast cancer cells MCF-7. Molecular and Cellular Endocrinology. Elsevier BV; 2011; 344:51-58 10.1016/j.mce.2011.06.024
• Phenolic compound profile of selected vegetables frequently consumed by African Americans in the southeast United States Cite
  Huang Z, Wang B, Eaves DH, Shikany JM, Pace RD. Phenolic compound profile of selected vegetables frequently consumed by African Americans in the southeast United States. Food Chemistry. Elsevier BV; 2007; 103:1395-1402 10.1016/j.foodchem.2006.10.077
• Comparisons of food intake between breast cancer patients and controls in Korean women Cite
  Kim E, Hong Y, Jeon H, Sung M, Sung C. Comparisons of food intake between breast cancer patients and controls in Korean women. Nutrition Research and Practice. The Korean Nutrition Society and The Korean Society of Community Nutrition; 2007; 1:237 10.4162/nrp.2007.1.3.237
• Antioxidant and Antiproliferative Activities of Common Fruits Cite
  Sun J, Chu Y, Wu X, Liu RH. Antioxidant and Antiproliferative Activities of Common Fruits. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2002; 50:7449-7454 10.1021/jf0207530
• Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells Cite
  Lee W, Chen W, Wang C, Lin W, Tseng T. Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells. Toxicology and Applied Pharmacology. Elsevier BV; 2008; 226:178-191 10.1016/j.taap.2007.09.013
• Influence of orange juice over the genotoxicity induced by alkylating agents: an in vivo analysis Cite
  Franke SIR, Prá D, Erdtmann B, Henriques JAP, da Silva J. Influence of orange juice over the genotoxicity induced by alkylating agents: an in vivo analysis. Mutagenesis. Oxford University Press (OUP); 2005; 20:279-283 10.1093/mutage/gei034
• Naringenin Inhibits Glucose Uptake in MCF-7 Breast Cancer Cells: A Mechanism for Impaired Cellular Proliferation Cite
  Harmon AW, Patel YM. Naringenin Inhibits Glucose Uptake in MCF-7 Breast Cancer Cells: A Mechanism for Impaired Cellular Proliferation. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2004; 85:103-110 10.1023/b:brea.0000025397.56192.e2
• Comparison of Antioxidant Potency of Commonly Consumed Polyphenol-Rich Beverages in the United States Cite
  Seeram NP, Aviram M, Zhang Y, Henning SM, Feng L, Dreher M, et al. Comparison of Antioxidant Potency of Commonly Consumed Polyphenol-Rich Beverages in the United States. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2008; 56:1415-1422 10.1021/jf073035s