Tag: linoleicAcid

News

03/27/25

How linoleic acid promotes triple negative tumor growth

12/08/20

Linoleic acid furthers angiogenesis of triple negative breast cancer

05/07/17

Vegetable oil linoleic acid promotes migration & invasion of TN cells

06/27/15

High corn oil diet promotes mammary tumor development in animal model

03/24/14

Common omega-6 fat promotes metastasis of TN breast cancer cells

Foods

• • canola oil
  • corn oil
  • safflower oil
  • soybean oil
  • sunflower oil

Studies

• Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling Cite
  Koundouros N, Nagiec MJ, Bullen N, Noch EK, Burgos-Barragan G, Li Z, et al. Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling. Science. American Association for the Advancement of Science (AAAS); 2025; 387 10.1126/science.adm9805
• Differential effects of docosahexaenoic acid (DHA) and linoleic acid (LA) on miR-101 and miR-342 tumor suppressor microRNAs in Taxol-treated HER2-positive breast cancer cells Cite
  Aslan C, Maralbashi S, Shekari N, Javadian M, Shomali N, Kazemi T. Differential effects of docosahexaenoic acid (DHA) and linoleic acid (LA) on miR-101 and miR-342 tumor suppressor microRNAs in Taxol-treated HER2-positive breast cancer cells. Clinical Nutrition ESPEN. Elsevier BV; 2024; 63:502-507 10.1016/j.clnesp.2024.07.007
• Red Blood Cell Polyunsaturated Fatty Acids and Mortality Following Breast Cancer Cite
  Parada H, Wu T, Hoh E, Rock CL, Martinez ME. Red Blood Cell Polyunsaturated Fatty Acids and Mortality Following Breast Cancer. Cancer Epidemiology, Biomarkers & Prevention. American Association for Cancer Research (AACR); 2024; 10.1158/1055-9965.epi-24-0074
• High linoleic acid levels in red blood cells predict a poor response to neoadjuvant chemotherapy in HER2-positive breast cancer patients Cite
  Valenzuela R, Walbaum B, Farias C, Acevedo F, Vargas C, Bennett JT, et al. High linoleic acid levels in red blood cells predict a poor response to neoadjuvant chemotherapy in HER2-positive breast cancer patients. Nutrition. Elsevier BV; 2024;:112357 10.1016/j.nut.2024.112357
• Gut microbial fatty acid isomerization modulates intraepithelial T cells Cite
  Song X, Zhang H, Zhang Y, Goh B, Bao B, Mello SS, et al. Gut microbial fatty acid isomerization modulates intraepithelial T cells. Nature. Springer Science and Business Media LLC; 2023; 10.1038/s41586-023-06265-4
• Fatty acids and their lipid mediators in the induction of cellular apoptosis in cancer cells Cite
  Biswas P, Datta C, Rathi P, Bhattacharjee A. Fatty acids and their lipid mediators in the induction of cellular apoptosis in cancer cells. Prostaglandins & Other Lipid Mediators. Elsevier BV; 2022;:106637 10.1016/j.prostaglandins.2022.106637
• Dietary palmitic acid promotes a prometastatic memory via Schwann cells Cite
  Pascual G, Domínguez D, Elosúa-Bayes M, Beckedorff F, Laudanna C, Bigas C, et al. Dietary palmitic acid promotes a prometastatic memory via Schwann cells. Nature. Springer Science and Business Media LLC; 2021; 10.1038/s41586-021-04075-0
• Docosahexaenoic acid (DHA) and linoleic acid (LA) modulate the expression of breast cancer involved miRNAs in MDA-MB-231 cell line Cite
  Elieh Ali Komi D, Shekari N, Soofian-kordkandi P, Javadian M, Shanehbandi D, Baradaran B, et al. Docosahexaenoic acid (DHA) and linoleic acid (LA) modulate the expression of breast cancer involved miRNAs in MDA-MB-231 cell line. Clinical Nutrition ESPEN. Elsevier BV; 2021; 10.1016/j.clnesp.2021.09.006
• Role of Src/FAK in migration and invasion mediated by extracellular vesicles from MDA-MB-231 cells stimulated with linoleic acid Cite
  Ramirez-Ricardo J, Leal-Orta E, Garcia-Hernandez A, Diaz-Aragon R, Cortes-Reynosa P, Thompson-Bonilla R, et al. Role of Src/FAK in migration and invasion mediated by extracellular vesicles from MDA-MB-231 cells stimulated with linoleic acid. Medical Oncology. Springer Science and Business Media LLC; 2021; 38 10.1007/s12032-021-01485-y
• Abstract PS8-27: Consumption of a high-fat diet rich in linoleic acid promotes mammary tumor growth Cite
  Jin R, Jiaqing J, Yin D, Yi Y, Yuan H, Edward S, et al. Abstract PS8-27: Consumption of a high-fat diet rich in linoleic acid promotes mammary tumor growth. Poster Session Abstracts. American Association for Cancer Research; 2021; 10.1158/1538-7445.sabcs20-ps8-27
• Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells Cite
  Diaz-Aragon R, Ramirez-Ricardo J, Cortes-Reynosa P, Simoni-Nieves A, Gomez-Quiroz L, Perez Salazar E. Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells. Molecular and Cellular Biochemistry. Springer Science and Business Media LLC; 2019; 457:119-132 10.1007/s11010-019-03517-8
• Linoleic acid induces secretion of extracellular vesicles from MDA-MB-231 breast cancer cells that mediate cellular processes involved with angiogenesis in HUVECs Cite
  Garcia-Hernandez A, Leal-Orta E, Ramirez-Ricardo J, Cortes-Reynosa P, Thompson-Bonilla R, Salazar EP. Linoleic acid induces secretion of extracellular vesicles from MDA-MB-231 breast cancer cells that mediate cellular processes involved with angiogenesis in HUVECs. Prostaglandins & Other Lipid Mediators. Elsevier BV; 2020; 153:106519 10.1016/j.prostaglandins.2020.106519
• Altered Levels of Desaturation and ω-6 Fatty Acids in Breast Cancer Patients’ Red Blood Cell Membranes Cite
  Amézaga J, Ugartemendia G, Larraioz A, Bretaña N, Iruretagoyena A, Camba J, et al. Altered Levels of Desaturation and ω-6 Fatty Acids in Breast Cancer Patients’ Red Blood Cell Membranes. Metabolites. MDPI AG; 2020; 10:469 10.3390/metabo10110469
• Cold-pressed rapeseed (Brassica napus) oil: Chemistry and functionality Cite
  Chew SC. Cold-pressed rapeseed (Brassica napus) oil: Chemistry and functionality. Food Research International. Elsevier BV; 2020; 131:108997 10.1016/j.foodres.2020.108997
• Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease Cite
  Burns JL, Nakamura MT, Ma DW. Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease. Prostaglandins, Leukotrienes and Essential Fatty Acids. Elsevier BV; 2018; 135:1-4 10.1016/j.plefa.2018.05.004
• Linoleic acid induces an increased response to insulin in MDA‐MB‐231 breast cancer cells Cite
  Rodriguez‐Monterrosas C, Diaz‐Aragon R, Cortes‐Reynosa P, Salazar EP. Linoleic acid induces an increased response to insulin in MDA‐MB‐231 breast cancer cells. Journal of Cellular Biochemistry. Wiley; 2018; 119:5413-5425 10.1002/jcb.26694
• Abstract 5374: Polyunsaturated fatty acids (PUFAs) alter the epigenetic landscape in MDA-MB-231 triple negative breast carcinoma (TNBC) Cite
  Chattin AM, O'Brien M, Pardini RS. Abstract 5374: Polyunsaturated fatty acids (PUFAs) alter the epigenetic landscape in MDA-MB-231 triple negative breast carcinoma (TNBC). Molecular and Cellular Biology, Genetics. American Association for Cancer Research; 2017; 10.1158/1538-7445.am2017-5374
• The ratio of 1/3 linoleic acid to alpha linolenic acid is optimal for oligodendrogenesis of embryonic neural stem cells Cite
  Hejr H, Ghareghani M, Zibara K, Ghafari M, Sadri F, Salehpour Z, et al. The ratio of 1/3 linoleic acid to alpha linolenic acid is optimal for oligodendrogenesis of embryonic neural stem cells. Neuroscience Letters. Elsevier BV; 2017; 651:216-225 10.1016/j.neulet.2017.05.020
• Linoleic acid induces migration and invasion through FFAR4- and PI3K-/Akt-dependent pathway in MDA-MB-231 breast cancer cells Cite
  Serna-Marquez N, Diaz-Aragon R, Reyes-Uribe E, Cortes-Reynosa P, Salazar EP. Linoleic acid induces migration and invasion through FFAR4- and PI3K-/Akt-dependent pathway in MDA-MB-231 breast cancer cells. Medical Oncology. Springer Science and Business Media LLC; 2017; 34 10.1007/s12032-017-0969-3
• Fatty acid intake and erythrocyte fatty acid profile in women with breast, ovarian and cervical cancers Cite
  Bannikoppa P, Dhayanand J, Madhukumar R, Padmanabhan A, Bafna U, Vijayakumar M, et al. Fatty acid intake and erythrocyte fatty acid profile in women with breast, ovarian and cervical cancers. Clinical Nutrition ESPEN. Elsevier BV; 2017; 19:59-63 10.1016/j.clnesp.2017.03.001
• Abstract 4536: Polyunsaturated fatty acids alter the epigenetic landscape in triple-negative breast cancer (TNBC) Cite
  Chattin AM, O’Brien M, Pardini RS. Abstract 4536: Polyunsaturated fatty acids alter the epigenetic landscape in triple-negative breast cancer (TNBC). Molecular and Cellular Biology, Genetics. American Association for Cancer Research; 2016; 10.1158/1538-7445.am2016-4536
• Abstract PR13: Circadian/melatonin disruption by dim light at night drive chemotherapy resistance in breast cancer Cite
  Hill SM, Xiang S, Dauchy RT, Mao L, Hauch A, Brimmer S, et al. Abstract PR13: Circadian/melatonin disruption by dim light at night drive chemotherapy resistance in breast cancer. Chemoprevention and Biological Therapies. American Association for Cancer Research; 2015; 10.1158/1940-6215.prev-14-pr13
• Heating of vegetable oils influences the activity of enzymes participating in arachidonic acid formation in Wistar rats Cite
  Stawarska A, Białek A, Tokarz A. Heating of vegetable oils influences the activity of enzymes participating in arachidonic acid formation in Wistar rats. Nutrition Research. Elsevier BV; 2015; 35:930-938 10.1016/j.nutres.2015.05.022
• Impact of grass/forage feeding versus grain finishing on beef nutrients and sensory quality: The U.S. experience Cite
  Van Elswyk ME, McNeill SH. Impact of grass/forage feeding versus grain finishing on beef nutrients and sensory quality: The U.S. experience. Meat Science. Elsevier BV; 2014; 96:535-540 10.1016/j.meatsci.2013.08.010
• Prospective Associations between Plasma Saturated, Monounsaturated and Polyunsaturated Fatty Acids and Overall and Breast Cancer Risk – Modulation by Antioxidants: A Nested Case-Control Study Cite
  Pouchieu C, Chajès V, Laporte F, Kesse-Guyot E, Galan P, Hercberg S, et al. Prospective Associations between Plasma Saturated, Monounsaturated and Polyunsaturated Fatty Acids and Overall and Breast Cancer Risk – Modulation by Antioxidants: A Nested Case-Control Study. PLoS ONE. Public Library of Science (PLoS); 2014; 9:e90442 10.1371/journal.pone.0090442
• Plasma Fatty Acid Ratios Affect Blood Gene Expression Profiles - A Cross-Sectional Study of the Norwegian Women and Cancer Post-Genome Cohort Cite
  Olsen KS, Fenton C, Frøyland L, Waaseth M, Paulssen RH, Lund E. Plasma Fatty Acid Ratios Affect Blood Gene Expression Profiles - A Cross-Sectional Study of the Norwegian Women and Cancer Post-Genome Cohort. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e67270 10.1371/journal.pone.0067270
• Delta-6-desaturase activity and arachidonic acid synthesis are increased in human breast cancer tissue Cite
  Pender-Cudlip MC, Krag KJ, Martini D, Yu J, Guidi A, Skinner SS, et al. Delta-6-desaturase activity and arachidonic acid synthesis are increased in human breast cancer tissue. Cancer Science. Wiley; 2013; 104:760-764 10.1111/cas.12129
• Role of LOXs and COX-2 on FAK activation and cell migration induced by linoleic acid in MDA-MB-231 breast cancer cells Cite
  Serna-Marquez N, Villegas-Comonfort S, Galindo-Hernandez O, Navarro-Tito N, Millan A, Salazar EP. Role of LOXs and COX-2 on FAK activation and cell migration induced by linoleic acid in MDA-MB-231 breast cancer cells. Cellular Oncology. Springer Science and Business Media LLC; 2012; 36:65-77 10.1007/s13402-012-0114-4
• Influence of fatty acid-free diet on mammary tumor development and growth rate in HER-2/neu transgenic mice Cite
  Rossini A, Zanobbio L, Sfondrini L, Cavalleri A, Secreto G, Morelli D, et al. Influence of fatty acid-free diet on mammary tumor development and growth rate in HER-2/neu transgenic mice. Journal of Cellular Physiology. Wiley; 2012; 228:242-249 10.1002/jcp.24130
• Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids Cite
  Gibson R, Neumann M, Lien E, Boyd K, Tu W. Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. Prostaglandins, Leukotrienes and Essential Fatty Acids. Elsevier BV; 2013; 88:139-146 10.1016/j.plefa.2012.04.003
• Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A Cite
  Espinosa-Neira R, Mejia-Rangel J, Cortes-Reynosa P, Salazar EP. Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A. The International Journal of Biochemistry & Cell Biology. Elsevier BV; 2011; 43:1782-1791 10.1016/j.biocel.2011.08.017
• Arachidonic acid promotes epithelial-to-mesenchymal-like transition in mammary epithelial cells MCF10A Cite
  Martinez-Orozco R, Navarro-Tito N, Soto-Guzman A, Castro-Sanchez L, Perez Salazar E. Arachidonic acid promotes epithelial-to-mesenchymal-like transition in mammary epithelial cells MCF10A. European Journal of Cell Biology. Elsevier BV; 2010; 89:476-488 10.1016/j.ejcb.2009.12.005
• Arachidonic acid promotes FAK activation and migration in MDA-MB-231 breast cancer cells Cite
  Navarro-Tito N, Robledo T, Salazar EP. Arachidonic acid promotes FAK activation and migration in MDA-MB-231 breast cancer cells. Experimental Cell Research. Elsevier BV; 2008; 314:3340-3355 10.1016/j.yexcr.2008.08.018
• Identification of possible biomarkers for breast cancer from free fatty acid profiles determined by GC–MS and multivariate statistical analysis Cite
  Lv W, Yang T. Identification of possible biomarkers for breast cancer from free fatty acid profiles determined by GC–MS and multivariate statistical analysis. Clinical Biochemistry. Elsevier BV; 2012; 45:127-133 10.1016/j.clinbiochem.2011.10.011
• Long-Chain n-3-to-n-6 Polyunsaturated Fatty Acid Ratios in Breast Adipose Tissue From Women With and Without Breast Cancer Cite
  Bagga D, Anders KH, Wang H, Glaspy JA. Long-Chain n-3-to-n-6 Polyunsaturated Fatty Acid Ratios in Breast Adipose Tissue From Women With and Without Breast Cancer. Nutrition and Cancer. Informa UK Limited; 2002; 42:180-185 10.1207/s15327914nc422_5
• 5-Lipoxygenase and 5-Lipoxygenase-Activating Protein Gene Polymorphisms, Dietary Linoleic Acid, and Risk for Breast Cancer Cite
  Wang J, John EM, Ingles SA. 5-Lipoxygenase and 5-Lipoxygenase-Activating Protein Gene Polymorphisms, Dietary Linoleic Acid, and Risk for Breast Cancer. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2008; 17:2748-2754 10.1158/1055-9965.epi-08-0439
• Anti-Aromatase Activity of Phytochemicals in White Button Mushrooms (Agaricus bisporus) Cite
  Chen S, Oh S, Phung S, Hur G, Ye JJ, Kwok SL, et al. Anti-Aromatase Activity of Phytochemicals in White Button Mushrooms (Agaricus bisporus). Cancer Research. American Association for Cancer Research (AACR); 2006; 66:12026-12034 10.1158/0008-5472.can-06-2206
• Micellar oleic and eicosapentaenoic acid but not linoleic acid influences the β-carotene uptake and its cleavage into retinol in rats Cite
  Raju M, Lakshminarayana R, Krishnakantha TP, Baskaran V. Micellar oleic and eicosapentaenoic acid but not linoleic acid influences the β-carotene uptake and its cleavage into retinol in rats. Molecular and Cellular Biochemistry. Springer Science and Business Media LLC; 2006; 288:7-15 10.1007/s11010-005-9091-5
• Dietary Fat, Cooking Fat, and Breast Cancer Risk in a Multiethnic Population Cite
  Wang J, John EM, Horn-Ross PL, Ingles SA. Dietary Fat, Cooking Fat, and Breast Cancer Risk in a Multiethnic Population. Nutrition and Cancer. Informa UK Limited; 2008; 60:492-504 10.1080/01635580801956485
• Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines Cite
  Nakagawa H. Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines. Carcinogenesis. Oxford University Press (OUP); 2001; 22:891-897 10.1093/carcin/22.6.891
• Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells Cite
  Menéndez J, del Mar Barbacid M, Montero S, Sevilla E, Escrich E, Solanas M, et al. Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells. European Journal of Cancer. Elsevier BV; 2001; 37:402-413 10.1016/s0959-8049(00)00408-1