Tag: isothiocyanates

News

11/23/20

Blueberries linked to better, apple juice linked to worse, survival

09/10/19

Watercress compound PEITC inhibits progression of HER2+ BC

07/10/16

Cabbage compound BITC reduces breast cancer cell division

05/23/15

Sulforaphane inhibits HER2+ and triple negative breast cancer

06/29/14

Arugula compound erucin inhibits proliferation of ER+ BC cells

07/07/13

Watercress compound can inhibit metastasis to brain

11/05/12

Frozen broccoli has less bioavailable sulforaphane than fresh broccoli

02/20/12

Cruciferous vegetable consumption linked to reduced risk of cancer

12/18/11

Isothiocyanates have genotoxic potential at concentrated doses

09/15/10

Watercress reduces breast cancer growth by inhibiting angiogenesis

04/18/10

Broccoli compound sulforaphane reduces BC stem cell survival

Foods

• • brussels sprouts
  • cauliflower
  • greens
  • horseradish
  • mustard
  • papaya
  • turnips and turnip greens
  • watercress

Studies

• The Role of MicroRNA-124-3p in Breast Cancer Stem Cell Inhibition by Benzyl Isothiocyanate Cite
  Kim S, Singh SV. The Role of MicroRNA-124-3p in Breast Cancer Stem Cell Inhibition by Benzyl Isothiocyanate. Pharmaceutical Research. Springer Science and Business Media LLC; 2024; 10.1007/s11095-024-03775-2
• Immunomodulatory Effects and Regulatory Mechanisms of (R)-6-HITC, an Isothiocyanate from Wasabi (Eutrema japonicum, in an Ex Vivo Mouse Model of LPS-Induced Inflammation Cite
  Alcarranza M, Alarcón-de-la-Lastra C, Recio Jiménez R, Fernández I, Castejón Martínez ML, Villegas I. Immunomodulatory Effects and Regulatory Mechanisms of (R)-6-HITC, an Isothiocyanate from Wasabi (Eutrema japonicum, in an Ex Vivo Mouse Model of LPS-Induced Inflammation. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2024; 10.1021/acs.jafc.4c02943
• Effects of Different Combinations of Phytochemical-Rich Fruits and Vegetables on Chronic Disease Risk Markers and Gene Expression Changes: Insights from the MiBLEND Study, a Randomized Trial Cite
  DeBenedictis JN, Murrell C, Hauser D, van Herwijnen M, Elen B, de Kok TM, et al. Effects of Different Combinations of Phytochemical-Rich Fruits and Vegetables on Chronic Disease Risk Markers and Gene Expression Changes: Insights from the MiBLEND Study, a Randomized Trial. Antioxidants. MDPI AG; 2024; 13:915 10.3390/antiox13080915
• Anti-Inflammatory Therapeutic Mechanisms of Isothiocyanates: Insights from Sulforaphane Cite
  Habtemariam S. Anti-Inflammatory Therapeutic Mechanisms of Isothiocyanates: Insights from Sulforaphane. Biomedicines. MDPI AG; 2024; 12:1169 10.3390/biomedicines12061169
• Isothiocyanates in Medicine: A Comprehensive Review on Phenylethyl-, Allyl-, and Benzyl-Isothiocyanates Cite
  Hoch CC, Shoykhet M, Weiser T, Griesbaum L, Petry J, Hachani K, et al. Isothiocyanates in Medicine: A Comprehensive Review on Phenylethyl-, Allyl-, and Benzyl-Isothiocyanates. Pharmacological Research. Elsevier BV; 2024;:107107 10.1016/j.phrs.2024.107107
• Synergistic Anti-Cancer Potential of Phenethyl Isothiocyanate and Curcumin Induces Apoptosis and G2/M Cell Cycle Arrest in HER2-Positive Breast Cancer Cells Cite
  Sirigiripeta S, Dokala A, Anupalli R. Synergistic Anti-Cancer Potential of Phenethyl Isothiocyanate and Curcumin Induces Apoptosis and G2/M Cell Cycle Arrest in HER2-Positive Breast Cancer Cells. Cytology and Genetics. Allerton Press; 2023; 57:611-624 10.3103/s0095452723060087
• Allyl isothiocyanate regulates oxidative stress, inflammation, cell proliferation, cell cycle arrest, apoptosis, angiogenesis, invasion and metastasis via interaction with multiple cell signaling pathways Cite
  Rajakumar T, Pugalendhi P. Allyl isothiocyanate regulates oxidative stress, inflammation, cell proliferation, cell cycle arrest, apoptosis, angiogenesis, invasion and metastasis via interaction with multiple cell signaling pathways. Histochemistry and Cell Biology. Springer Science and Business Media LLC; 2023; 10.1007/s00418-023-02255-9
• Glucosinolates in cancer prevention and treatment: experimental and clinical evidence Cite
  Orouji N, Asl SK, Taghipour Z, Habtemariam S, Nabavi SM, Rahimi R. Glucosinolates in cancer prevention and treatment: experimental and clinical evidence. Medical Oncology. Springer Science and Business Media LLC; 2023; 40 10.1007/s12032-023-02211-6
• Mechanism of synergistic inhibitory effect of benzyl isothiocyanate and zoledronic acid combination on breast cancer induction of osteoclast differentiation Cite
  Hahm E, Kim S, Pore SK, Mathan SV, Singh RP, Singh SV. Mechanism of synergistic inhibitory effect of benzyl isothiocyanate and zoledronic acid combination on breast cancer induction of osteoclast differentiation. Molecular Carcinogenesis. Wiley; 2023; 10.1002/mc.23653
• Preparation, characterization, and in vitro cytotoxicity activity of allyl-isothiocyanate-embedded polymeric nanoparticles for potential breast cancer targeting Cite
  Patil PB, Patel JK. Preparation, characterization, and in vitro cytotoxicity activity of allyl-isothiocyanate-embedded polymeric nanoparticles for potential breast cancer targeting. Breast Cancer. Springer Science and Business Media LLC; 2023; 10.1007/s12282-023-01501-1
• Allyl isothiocyanate inhibits invasion and angiogenesis in breast cancer via EGFR-mediated JAK-1/STAT-3 signaling pathway Cite
  Rajakumar T, Pugalendhi P. Allyl isothiocyanate inhibits invasion and angiogenesis in breast cancer via EGFR-mediated JAK-1/STAT-3 signaling pathway. Amino Acids. Springer Science and Business Media LLC; 2023; 10.1007/s00726-023-03285-2
• Erucin, an H2S-Releasing Isothiocyanate, Exerts Anticancer Effects in Human Triple-Negative Breast Cancer Cells Triggering Autophagy-Dependent Apoptotic Cell Death Cite
  Bello I, Smimmo M, d’Emmanuele di Villa Bianca R, Bucci M, Cirino G, Panza E, et al. Erucin, an H2S-Releasing Isothiocyanate, Exerts Anticancer Effects in Human Triple-Negative Breast Cancer Cells Triggering Autophagy-Dependent Apoptotic Cell Death. International Journal of Molecular Sciences. MDPI AG; 2023; 24:6764 10.3390/ijms24076764
• 2,2-Diphenethyl Isothiocyanate Enhances Topoisomerase Inhibitor-Induced Cell Death and Suppresses Multi-Drug Resistance 1 in Breast Cancer Cells Cite
  Aggarwal M. 2,2-Diphenethyl Isothiocyanate Enhances Topoisomerase Inhibitor-Induced Cell Death and Suppresses Multi-Drug Resistance 1 in Breast Cancer Cells. Cancers. MDPI AG; 2023; 15:928 10.3390/cancers15030928
• A Presurgical‐Window Intervention Trial of Isothiocyanate‐Rich Broccoli Sprout Extract in Patients with Breast Cancer Cite
  Wang Z, Tu C, Pratt R, Khoury T, Qu J, Fahey JW, et al. A Presurgical‐Window Intervention Trial of Isothiocyanate‐Rich Broccoli Sprout Extract in Patients with Breast Cancer. Molecular Nutrition & Food Research. Wiley; 2022;:2101094 10.1002/mnfr.202101094
• Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care Cite
  Mazurakova A, Koklesova L, Samec M, Kudela E, Kajo K, Skuciova V, et al. Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care. EPMA Journal. Springer Science and Business Media LLC; 2022; 10.1007/s13167-022-00277-2
• Antinutrients: Lectins, goitrogens, phytates and oxalates, friends or foe? Cite
  López-Moreno M, Garcés-Rimón M, Miguel M. Antinutrients: Lectins, goitrogens, phytates and oxalates, friends or foe?. Journal of Functional Foods. Elsevier BV; 2022; 89:104938 10.1016/j.jff.2022.104938
• Influence of isolation techniques on the composition of glucosinolate breakdown products, their antiproliferative activity and gastrointestinal stability of allyl isothiocyanate Cite
  Vrca I, Šćurla J, Kević N, Burčul F, Čulić VČ, Bočina I, et al. Influence of isolation techniques on the composition of glucosinolate breakdown products, their antiproliferative activity and gastrointestinal stability of allyl isothiocyanate. European Food Research and Technology. Springer Science and Business Media LLC; 2021; 10.1007/s00217-021-03903-x
• Cardioprotective effect of allyl isothiocyanate in a rat model of doxorubicin acute toxicity Cite
  Waz S, Matouk AI. Cardioprotective effect of allyl isothiocyanate in a rat model of doxorubicin acute toxicity. Toxicology Mechanisms and Methods. Informa UK Limited; 2021;:1-25 10.1080/15376516.2021.1992064
• Allyl Isothiocyanate Induces DNA Damage and Impairs DNA Repair in Human Breast Cancer MCF-7 Cells Cite
  LIAO C, PENG S, CHEN J, CHEN P, HUANG A, LIEN J, et al. Allyl Isothiocyanate Induces DNA Damage and Impairs DNA Repair in Human Breast Cancer MCF-7 Cells. Anticancer Research. Anticancer Research USA Inc.; 2021; 41:4343-4351 10.21873/anticanres.15239
• Modulatory Effect of 4-(methylthio)butyl Isothiocyanate Isolated From Eruca Sativa Thell. on DMBA Induced Overexpression of Hypoxia and Glycolytic Pathway in Sprague-Dawley Female Rats Cite
  Singh D, Thakur S, Singh D, Buttar HS, Singh B, Arora S. Modulatory Effect of 4-(methylthio)butyl Isothiocyanate Isolated From Eruca Sativa Thell. on DMBA Induced Overexpression of Hypoxia and Glycolytic Pathway in Sprague-Dawley Female Rats. Frontiers in Pharmacology. Frontiers Media SA; 2021; 12 10.3389/fphar.2021.728296
• Pterostilbene-isothiocyanate inhibits breast cancer metastasis by selectively blocking IKK-β/NEMO interaction in cancer cells Cite
  Kumar V, Haldar S, Das NS, Ghosh S, Dhankhar P, Sircar D, et al. Pterostilbene-isothiocyanate inhibits breast cancer metastasis by selectively blocking IKK-β/NEMO interaction in cancer cells. Biochemical Pharmacology. Elsevier BV; 2021;:114717 10.1016/j.bcp.2021.114717
• Dietary Isothiocyanates Inhibit Cancer Progression by Modulation of Epigenome Cite
  Sundaram MK, R P, Haque S, Akhter N, Khan S, Ahmed S, et al. Dietary Isothiocyanates Inhibit Cancer Progression by Modulation of Epigenome. Seminars in Cancer Biology. Elsevier BV; 2021; 10.1016/j.semcancer.2020.12.021
• Phenethyl isothiocyanate reduces breast cancer stem cell-like properties by epigenetic reactivation of CDH1 Cite
  Zhang T, Zhang W, Hao M. Phenethyl isothiocyanate reduces breast cancer stem cell-like properties by epigenetic reactivation of CDH1. Oncology Reports. Spandidos Publications; 2020; 45:337-348 10.3892/or.2020.7860
• Phenethyl Isothiocyanate Suppresses Stemness in the Chemo- and Radio-Resistant Triple-Negative Breast Cancer Cell Line MDA-MB-231/IR Via Downregulation of Metadherin Cite
  Nguyen YT, Moon JY, Ediriweera MK, Cho SK. Phenethyl Isothiocyanate Suppresses Stemness in the Chemo- and Radio-Resistant Triple-Negative Breast Cancer Cell Line MDA-MB-231/IR Via Downregulation of Metadherin. Cancers. MDPI AG; 2020; 12:268 10.3390/cancers12020268
• Biomedical application of Indole-3-carbinol: A mini-review Cite
  Singh AA, Patil MP, Kang M, Niyonizigiye I, Kim G. Biomedical application of Indole-3-carbinol: A mini-review. Phytochemistry Letters. Elsevier BV; 2020; 41:49-54 10.1016/j.phytol.2020.09.024
• Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models Cite
  Gupta P, Srivastava SK. Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models. BMC Medicine. Springer Science and Business Media LLC; 2012; 10 10.1186/1741-7015-10-80
• Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment Cite
  Koschorke A, Faraci S, Giani D, Chiodoni C, Iorio E, Canese R, et al. Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment. Cellular Oncology. Springer Science and Business Media LLC; 2019; 42:815-828 10.1007/s13402-019-00464-w
• Anti-Estrogenic and Anti-Cell Proliferative Effect of Allyl Isothiocyanate in Chemoprevention of Chemically Induced Mammary Carcinogenesis in Rats Cite
  Thangarasu R, Pachaiappan P, Subbaiyan T. Anti-Estrogenic and Anti-Cell Proliferative Effect of Allyl Isothiocyanate in Chemoprevention of Chemically Induced Mammary Carcinogenesis in Rats. Pathology & Oncology Research. Springer Science and Business Media LLC; 2019; 26:913-925 10.1007/s12253-019-00638-9
• Temporal Efficacy of a Sulforaphane-Based Broccoli Sprout Diet in Prevention of Breast Cancer through Modulation of Epigenetic Mechanisms Cite
  Li Y, Buckhaults P, Li S, Tollefsbol T. Temporal Efficacy of a Sulforaphane-Based Broccoli Sprout Diet in Prevention of Breast Cancer through Modulation of Epigenetic Mechanisms. Cancer Prevention Research. American Association for Cancer Research (AACR); 2018; 11:451-464 10.1158/1940-6207.capr-17-0423
• Metabolic targets of watercress and PEITC in MCF-7 and MCF-10A cells explain differential sensitisation responses to ionising radiation Cite
  Giallourou NS, Rowland IR, Rothwell SD, Packham G, Commane DM, Swann JR. Metabolic targets of watercress and PEITC in MCF-7 and MCF-10A cells explain differential sensitisation responses to ionising radiation. European Journal of Nutrition. Springer Science and Business Media LLC; 2018; 58:2377-2391 10.1007/s00394-018-1789-8
• Glucosinolate and isothiocyanate intakes are inversely associated with breast cancer risk: a case–control study in China Cite
  Zhang N, Ho SC, Mo X, Lin F, Huang W, Luo H, et al. Glucosinolate and isothiocyanate intakes are inversely associated with breast cancer risk: a case–control study in China. British Journal of Nutrition. Cambridge University Press (CUP); 2018; 119:957-964 10.1017/s0007114518000600
• Allyl Isothiocyanate Exhibits No Anticancer Activity in MDA-MB-231 Breast Cancer Cells Cite
  Sayeed M, Bracci M, Ciarapica V, Malavolta M, Provinciali M, Pieragostini E, et al. Allyl Isothiocyanate Exhibits No Anticancer Activity in MDA-MB-231 Breast Cancer Cells. International Journal of Molecular Sciences. MDPI AG; 2018; 19:145 10.3390/ijms19010145
• High-Pressure Processing of Broccoli Sprouts: Influence on Bioactivation of Glucosinolates to Isothiocyanates Cite
  Westphal A, Riedl KM, Cooperstone JL, Kamat S, Balasubramaniam VM, Schwartz SJ, et al. High-Pressure Processing of Broccoli Sprouts: Influence on Bioactivation of Glucosinolates to Isothiocyanates. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2017; 65:8578-8585 10.1021/acs.jafc.7b01380
• Isothiocyanates, Nitriles, and Epithionitriles from Glucosinolates Are Affected by Genotype and Developmental Stage in Brassica oleracea Varieties Cite
  Hanschen FS, Schreiner M. Isothiocyanates, Nitriles, and Epithionitriles from Glucosinolates Are Affected by Genotype and Developmental Stage in Brassica oleracea Varieties. Frontiers in Plant Science. Frontiers Media SA; 2017; 8 10.3389/fpls.2017.01095
• Sulforaphene, an isothiocyanate present in radish plants, inhibits proliferation of human breast cancer cells Cite
  Pawlik A, Wała M, Hać A, Felczykowska A, Herman-Antosiewicz A. Sulforaphene, an isothiocyanate present in radish plants, inhibits proliferation of human breast cancer cells. Phytomedicine. Elsevier BV; 2017; 29:1-10 10.1016/j.phymed.2017.03.007
• Sulforaphene inhibits triple negative breast cancer through activating tumor suppressor Egr1 Cite
  Yang M, Teng W, Qu Y, Wang H, Yuan Q. Sulforaphene inhibits triple negative breast cancer through activating tumor suppressor Egr1. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2016; 158:277-286 10.1007/s10549-016-3888-7
• Combination of lapatinib with isothiocyanates overcomes drug resistance and inhibits migration of HER2 positive breast cancer cells Cite
  Kaczyńska A, Herman-Antosiewicz A. Combination of lapatinib with isothiocyanates overcomes drug resistance and inhibits migration of HER2 positive breast cancer cells. Breast Cancer. Springer Science and Business Media LLC; 2016; 24:271-280 10.1007/s12282-016-0700-9
• Allyl Isothiocyanate Induces Cell Toxicity by Multiple Pathways in Human Breast Cancer Cells Cite
  Bo P, Lien J, Chen Y, Yu F, Lu H, Yu C, et al. Allyl Isothiocyanate Induces Cell Toxicity by Multiple Pathways in Human Breast Cancer Cells. The American Journal of Chinese Medicine. World Scientific Pub Co Pte Lt; 2016; 44:415-437 10.1142/s0192415x16500245
• Phenethyl isothiocyanate, by virtue of its antioxidant activity, inhibits invasiveness and metastatic potential of breast cancer cells: HIF-1α as a putative target Cite
  Sarkar R, Mukherjee S, Biswas J, Roy M. Phenethyl isothiocyanate, by virtue of its antioxidant activity, inhibits invasiveness and metastatic potential of breast cancer cells: HIF-1α as a putative target. Free Radical Research. Informa UK Limited; 2015; 50:84-100 10.3109/10715762.2015.1108520
• Abstract 913: Natural product sulforaphane selectively inhibits breast cancer stem cells in basal and trastuzumab resistant Her2+ breast cancer. Cite
  Burnett J, Korkaya H, Newman B, Conley S, Connarn J, Sun L, et al. Abstract 913: Natural product sulforaphane selectively inhibits breast cancer stem cells in basal and trastuzumab resistant Her2+ breast cancer.. Experimental and Molecular Therapeutics. American Association for Cancer Research; 2013; 10.1158/1538-7445.am2013-913
• Dose response chemopreventive potential of allyl isothiocyanate against 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats Cite
  Rajakumar T, Pugalendhi P, Thilagavathi S. Dose response chemopreventive potential of allyl isothiocyanate against 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats. Chemico-Biological Interactions. Elsevier BV; 2015; 231:35-43 10.1016/j.cbi.2015.02.015
• The role of polycomb group protein Bmi-1 and Notch4 in breast cancer stem cell inhibition by benzyl isothiocyanate Cite
  Kim S, Singh SV. The role of polycomb group protein Bmi-1 and Notch4 in breast cancer stem cell inhibition by benzyl isothiocyanate. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2015; 149:681-692 10.1007/s10549-015-3279-5
• Analysis and Antioxidant Activity of Extracts from Broccoli (Brassica oleracea L.) Sprouts Cite
  Jang HW, Moon J, Shibamoto T. Analysis and Antioxidant Activity of Extracts from Broccoli (Brassica oleracea L.) Sprouts. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2015; 63:1169-1174 10.1021/jf504929m
• Erucin, the Major Isothiocyanate in Arugula (Eruca sativa), Inhibits Proliferation of MCF7 Tumor Cells by Suppressing Microtubule Dynamics Cite
  Azarenko O, Jordan MA, Wilson L. Erucin, the Major Isothiocyanate in Arugula (Eruca sativa), Inhibits Proliferation of MCF7 Tumor Cells by Suppressing Microtubule Dynamics. PLoS ONE. Public Library of Science (PLoS); 2014; 9:e100599 10.1371/journal.pone.0100599
• Effect of preliminary processing and method of preservation on the content of glucosinolates in kale (Brassica oleracea L. var. acephala) leaves Cite
  Korus A, Słupski J, Gębczyński P, Banaś A. Effect of preliminary processing and method of preservation on the content of glucosinolates in kale (Brassica oleracea L. var. acephala) leaves. LWT - Food Science and Technology. Elsevier BV; 2014; 59:1003-1008 10.1016/j.lwt.2014.06.030
• Wasabi-Derived 6-(Methylsulfinyl)Hexyl Isothiocyanate Induces Apoptosis in Human Breast Cancer by Possible Involvement of the NF-κB Pathways Cite
  Fuke Y, Hishinuma M, Namikawa M, Oishi Y, Matsuzaki T. Wasabi-Derived 6-(Methylsulfinyl)Hexyl Isothiocyanate Induces Apoptosis in Human Breast Cancer by Possible Involvement of the NF-κB Pathways. Nutrition and Cancer. Informa UK Limited; 2014; 66:879-887 10.1080/01635581.2014.916322
• Metastasis of Breast Tumor Cells to Brain Is Suppressed by Phenethyl Isothiocyanate in a Novel In Vivo Metastasis Model Cite
  Gupta P, Adkins C, Lockman P, Srivastava SK. Metastasis of Breast Tumor Cells to Brain Is Suppressed by Phenethyl Isothiocyanate in a Novel In Vivo Metastasis Model. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e67278 10.1371/journal.pone.0067278
• Epigenetic impact of dietary isothiocyanates in cancer chemoprevention Cite
  Gerhauser C. Epigenetic impact of dietary isothiocyanates in cancer chemoprevention. Current Opinion in Clinical Nutrition and Metabolic Care. Ovid Technologies (Wolters Kluwer Health); 2013; 16:405-410 10.1097/mco.0b013e328362014e
• Dietary Chemopreventative Benzyl Isothiocyanate Inhibits Breast Cancer Stem Cells In Vitro and In Vivo Cite
  Kim S, Sehrawat A, Singh SV. Dietary Chemopreventative Benzyl Isothiocyanate Inhibits Breast Cancer Stem Cells In Vitro and In Vivo. Cancer Prevention Research. American Association for Cancer Research (AACR); 2013; 6:782-790 10.1158/1940-6207.capr-13-0100
• Targeting Heat Shock Proteins by Phenethyl Isothiocyanate Results in Cell-Cycle Arrest and Apoptosis of Human Breast Cancer Cells Cite
  Sarkars R, Mukherjee S, Roy M. Targeting Heat Shock Proteins by Phenethyl Isothiocyanate Results in Cell-Cycle Arrest and Apoptosis of Human Breast Cancer Cells. Nutrition and Cancer. Informa UK Limited; 2013; 65:480-493 10.1080/01635581.2013.767366
• β-Phenylethyl isothiocyanate reverses platinum resistance by a GSH-dependent mechanism in cancer cells with epithelial-mesenchymal transition phenotype Cite
  Wu W, Zhang Y, Zeng Z, Li X, Hu K, Luo H, et al. β-Phenylethyl isothiocyanate reverses platinum resistance by a GSH-dependent mechanism in cancer cells with epithelial-mesenchymal transition phenotype. Biochemical Pharmacology. Elsevier BV; 2013; 85:486-496 10.1016/j.bcp.2012.11.017
• Chemopreventive and anti-angiogenic effects of dietary phenethyl isothiocyanate in anN-methyl nitrosourea-induced breast cancer animal model Cite
  Aras U, Gandhi YA, Masso-Welch PA, Morris ME. Chemopreventive and anti-angiogenic effects of dietary phenethyl isothiocyanate in anN-methyl nitrosourea-induced breast cancer animal model. Biopharmaceutics & Drug Disposition. Wiley; 2012; 34:98-106 10.1002/bdd.1826
• Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli Cite
  Saha S, Hollands W, Teucher B, Needs PW, Narbad A, Ortori CA, et al. Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli. Molecular Nutrition & Food Research. Wiley; 2012; 56:1906-1916 10.1002/mnfr.201200225
• ERK-modulated intrinsic signaling and G2/M phase arrest contribute to the induction of apoptotic death by allyl isothiocyanate in MDA-MB-468 human breast adenocarcinoma cells Cite
  TSAI S, HUANG W, HUANG W, LU C, CHIANG J, PENG S, et al. ERK-modulated intrinsic signaling and G2/M phase arrest contribute to the induction of apoptotic death by allyl isothiocyanate in MDA-MB-468 human breast adenocarcinoma cells. International Journal of Oncology. Spandidos Publications; 2012; 41:2065-2072 10.3892/ijo.2012.1640
• Assessment of DNA damage and repair in adults consuming allyl isothiocyanate or Brassica vegetables Cite
  Charron CS, Clevidence BA, Albaugh GA, Kramer MH, Vinyard BT, Milner JA, et al. Assessment of DNA damage and repair in adults consuming allyl isothiocyanate or Brassica vegetables. The Journal of Nutritional Biochemistry. Elsevier BV; 2013; 24:894-902 10.1016/j.jnutbio.2012.06.004
• Biomarkers of Phenethyl Isothiocyanate-Mediated Mammary Cancer Chemoprevention in a Clinically Relevant Mouse Model Cite
  Singh SV, Kim S, Sehrawat A, Arlotti JA, Hahm E, Sakao K, et al. Biomarkers of Phenethyl Isothiocyanate-Mediated Mammary Cancer Chemoprevention in a Clinically Relevant Mouse Model. JNCI Journal of the National Cancer Institute. Oxford University Press (OUP); 2012; 104:1228-1239 10.1093/jnci/djs321
• Low concentrations of isothiocyanates protect mesenchymal stem cells from oxidative injuries, while high concentrations exacerbate DNA damage Cite
  Zanichelli F, Capasso S, Di Bernardo G, Cipollaro M, Pagnotta E, Cartenì M, et al. Low concentrations of isothiocyanates protect mesenchymal stem cells from oxidative injuries, while high concentrations exacerbate DNA damage. Apoptosis. Springer Science and Business Media LLC; 2012; 17:964-974 10.1007/s10495-012-0740-3
• Abstract LB-322: Cruciferous vegetable intake after diagnosis of breast cancer and survival: a report from the shanghai breast cancer survival study Cite
  Nechuta SJ, Lu W, Cai H, Zheng Y, Bao P, Zheng W, et al. Abstract LB-322: Cruciferous vegetable intake after diagnosis of breast cancer and survival: a report from the shanghai breast cancer survival study. Epidemiology. American Association for Cancer Research; 2012; 10.1158/1538-7445.am2012-lb-322
• Abstract 565: Benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells is associated with downregulation of urokinase-type plasminogen activator and its receptor Cite
  Sehrawat A, Kim S, Singh SV. Abstract 565: Benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells is associated with downregulation of urokinase-type plasminogen activator and its receptor. Prevention Research. American Association for Cancer Research; 2012; 10.1158/1538-7445.am2012-565
• Influence of fermentation conditions of Brassica oleracea L. var. capitata on the volatile glucosinolate hydrolysis compounds of sauerkrauts Cite
  Peñas E, Pihlava J, Vidal-Valverde C, Frias J. Influence of fermentation conditions of Brassica oleracea L. var. capitata on the volatile glucosinolate hydrolysis compounds of sauerkrauts. LWT - Food Science and Technology. Elsevier BV; 2012; 48:16-23 10.1016/j.lwt.2012.03.005
• Benzyl Isothiocyanate Causes FoxO1-Mediated Autophagic Death in Human Breast Cancer Cells Cite
  Xiao D, Bommareddy A, Kim S, Sehrawat A, Hahm E, Singh SV. Benzyl Isothiocyanate Causes FoxO1-Mediated Autophagic Death in Human Breast Cancer Cells. PLoS ONE. Public Library of Science (PLoS); 2012; 7:e32597 10.1371/journal.pone.0032597
• Natural isothiocyanates: Genotoxic potential versus chemoprevention Cite
  Fimognari C, Turrini E, Ferruzzi L, Lenzi M, Hrelia P. Natural isothiocyanates: Genotoxic potential versus chemoprevention. Mutation Research/Reviews in Mutation Research. Elsevier BV; 2012; 750:107-131 10.1016/j.mrrev.2011.12.001
• Comparison of Isothiocyanate Metabolite Levels and Histone Deacetylase Activity in Human Subjects Consuming Broccoli Sprouts or Broccoli Supplement Cite
  Clarke JD, Riedl K, Bella D, Schwartz SJ, Stevens JF, Ho E. Comparison of Isothiocyanate Metabolite Levels and Histone Deacetylase Activity in Human Subjects Consuming Broccoli Sprouts or Broccoli Supplement. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2011; 59:10955-10963 10.1021/jf202887c
• Polyphenols, isothiocyanates, and carotenoid derivatives enhance estrogenic activity in bone cells but inhibit it in breast cancer cells Cite
  Veprik A, Khanin M, Linnewiel-Hermoni K, Danilenko M, Levy J, Sharoni Y. Polyphenols, isothiocyanates, and carotenoid derivatives enhance estrogenic activity in bone cells but inhibit it in breast cancer cells. American Journal of Physiology-Endocrinology and Metabolism. American Physiological Society; 2012; 303:E815-E824 10.1152/ajpendo.00142.2011
• Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design Cite
  Clarke JD, Hsu A, Riedl K, Bella D, Schwartz SJ, Stevens JF, et al. Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design. Pharmacological Research. Elsevier BV; 2011; 64:456-463 10.1016/j.phrs.2011.07.005
• Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice Cite
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