Tag: enterolactone

News

03/11/18

Flaxseed lignans increase treatment effects of Adriamycin & Taxotere

06/03/17

Enterolactone reduces TN proliferation, migration and metastasis

11/02/16

Enterolactone increases radiation-induced breast cancer cell death

11/27/11

Women with high circulating enterolactone have better outcomes

09/15/11

High lignan intake may improve survival among women with ER- BC

02/27/11

Prediagnostic enterolactone levels linked to lower BC mortality

Foods

• • blackberries
  • buckwheat
  • dry beans
  • flaxseed
  • garlic
  • onions
  • pumpkins
  • rye
  • seaweed
  • sesame seeds and sesame oil

Studies

• From dietary lignans to cancer therapy: Integrative systems analysis of enterolactone's molecular targets and signaling pathways in combatting cancer stem cells in triple-negative breast cancer Cite
  Mahajan A, Sharma N, Ulhe A, Patil R, Hegde M, Mali A. From dietary lignans to cancer therapy: Integrative systems analysis of enterolactone's molecular targets and signaling pathways in combatting cancer stem cells in triple-negative breast cancer. Food Bioscience. Elsevier BV; 2024; 58:103732 10.1016/j.fbio.2024.103732
• Phytonutrients and outcomes following breast cancer: a systematic review and meta-analysis of observational studies Cite
  van Die MD, Bone KM, Visvanathan K, Kyrø C, Aune D, Ee C, et al. Phytonutrients and outcomes following breast cancer: a systematic review and meta-analysis of observational studies. JNCI Cancer Spectrum. Oxford University Press (OUP); 2023; 10.1093/jncics/pkad104
• Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer Cite
  da Silva FC, Brandão DC, Ferreira EA, Siqueira RP, Ferreira HSV, Da Silva Filho AA, et al. Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer. Pharmaceuticals. MDPI AG; 2023; 16:1466 10.3390/ph16101466
• Proliferative response of ERα-positive breast cancer cells to 10 μM enterolactone, and the associated alteration in the transcriptomic landscape Cite
  Hatwik J, Patil HN, Limaye AM. Proliferative response of ERα-positive breast cancer cells to 10 μM enterolactone, and the associated alteration in the transcriptomic landscape. Gene. Elsevier BV; 2023;:147640 10.1016/j.gene.2023.147640
• Transcriptomic data of MCF-7 breast cancer cells treated with 10 µM enterolactone Cite
  Hatwik J, Pal U, Limaye AM. Transcriptomic data of MCF-7 breast cancer cells treated with 10 µM enterolactone. Data in Brief. Elsevier BV; 2023; 48:109098 10.1016/j.dib.2023.109098
• Association of urinary phytoestrogens with hormone-related cancers and cancer biomarkers: NHANES 1999-2010 Cite
  Liu F, Peng Y, Qiao Y, Wang P, Si C, Wang X, et al. Association of urinary phytoestrogens with hormone-related cancers and cancer biomarkers: NHANES 1999-2010. British Journal of Nutrition. Cambridge University Press (CUP); 2022;:1-37 10.1017/s0007114522003877
• The secoisolariciresinol diglycoside (SDG) lignan content of oil flax: Genotypic and environmental variations and association with other traits Cite
  Zhang J, Xie Y, Miao C, Wang L, Zhao W, Li W, et al. The secoisolariciresinol diglycoside (SDG) lignan content of oil flax: Genotypic and environmental variations and association with other traits. Oil Crop Science. Elsevier BV; 2022; 10.1016/j.ocsci.2022.02.004
• Screening of Phytochemicals as Potential Inhibitors of Breast Cancer using Structure Based Multitargeted Molecular Docking Analysis Cite
  Jha V, Devkar S, Gharat K, Kasbe S, Matharoo DK, Pendse S, et al. Screening of Phytochemicals as Potential Inhibitors of Breast Cancer using Structure Based Multitargeted Molecular Docking Analysis. Phytomedicine Plus. Elsevier BV; 2022; 2:100227 10.1016/j.phyplu.2022.100227
• Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review Cite
  Andargie M, Vinas M, Rathgeb A, Möller E, Karlovsky P. Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review. Molecules. MDPI AG; 2021; 26:883 10.3390/molecules26040883
• Antiestrogenic and antiproliferative potency of secoisolariciresinol diglucoside derivatives on MCF-7 breast cancer cells Cite
  Scherbakov AM, Stasevich OV, Salnikova DI, Andreeva OE, Mikhaevich EI. Antiestrogenic and antiproliferative potency of secoisolariciresinol diglucoside derivatives on MCF-7 breast cancer cells. Natural Product Research. Informa UK Limited; 2020;:1-7 10.1080/14786419.2020.1826479
• Prognostic associations of circulating phytoestrogens and biomarker changes in long-term survivors of postmenopausal breast cancer Cite
  Jaskulski S, Jung AY, Huebner M, Poschet G, Hell R, Hüsing A, et al. Prognostic associations of circulating phytoestrogens and biomarker changes in long-term survivors of postmenopausal breast cancer. Nutrition and Cancer. Informa UK Limited; 2019; 72:1155-1169 10.1080/01635581.2019.1672762
• Dietary flaxseed and tamoxifen affect the inflammatory microenvironment in vivo in normal human breast tissue of postmenopausal women Cite
  Lindahl G, Abrahamsson A, Dabrosin C. Dietary flaxseed and tamoxifen affect the inflammatory microenvironment in vivo in normal human breast tissue of postmenopausal women. European Journal of Clinical Nutrition. Springer Science and Business Media LLC; 2019; 73:1250-1259 10.1038/s41430-019-0396-y
• The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth Cite
  Bowers LW, Lineberger CG, Ford NA, Rossi EL, Punjala A, Camp KK, et al. The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2018; 173:545-557 10.1007/s10549-018-5021-6
• Circulating enterolactone concentrations and prognosis of postmenopausal breast cancer: assessment of mediation by inflammatory markers Cite
  Jaskulski S, Jung AY, Behrens S, Johnson T, Kaaks R, Thöne K, et al. Circulating enterolactone concentrations and prognosis of postmenopausal breast cancer: assessment of mediation by inflammatory markers. International Journal of Cancer. Wiley; 2018; 143:2698-2708 10.1002/ijc.31647
• Pre-diagnostic plasma enterolactone concentrations and breast cancer prognosis among postmenopausal women – The Danish Diet, Cancer and Health cohort Cite
  Kyrø C, Hansen L, Frederiksen K, Nørskov NP, Bach Knudsen KE, Eriksen AK, et al. Pre-diagnostic plasma enterolactone concentrations and breast cancer prognosis among postmenopausal women – The Danish Diet, Cancer and Health cohort. Clinical Nutrition. Elsevier BV; 2018; 37:2217-2225 10.1016/j.clnu.2017.10.023
• Enterolactone concentrations and prognosis after postmenopausal breast cancer: Assessment of effect modification and meta-analysis Cite
  Seibold P, Vrieling A, Johnson TS, Buck K, Behrens S, Kaaks R, et al. Enterolactone concentrations and prognosis after postmenopausal breast cancer: Assessment of effect modification and meta-analysis. International Journal of Cancer. Wiley; 2014; 135:923-933 10.1002/ijc.28729
• Flaxseed Lignans Enhance the Cytotoxicity of Chemotherapeutic Agents against Breast Cancer Cell Lines MDA-MB-231 and SKBR3 Cite
  Di Y, De Silva F, Krol ES, Alcorn J. Flaxseed Lignans Enhance the Cytotoxicity of Chemotherapeutic Agents against Breast Cancer Cell Lines MDA-MB-231 and SKBR3. Nutrition and Cancer. Informa UK Limited; 2018; 70:306-315 10.1080/01635581.2018.1421677
• Pre-diagnostic plasma enterolactone concentrations and breast cancer prognosis among postmenopausal women – The Danish Diet, Cancer and Health cohort Cite
  Kyrø C, Hansen L, Frederiksen K, Nørskov NP, Bach Knudsen KE, Eriksen AK, et al. Pre-diagnostic plasma enterolactone concentrations and breast cancer prognosis among postmenopausal women – The Danish Diet, Cancer and Health cohort. Clinical Nutrition. Elsevier BV; 2018; 37:2217-2225 10.1016/j.clnu.2017.10.023
• The Breast Cancer Resistance Protein (BCRP/ABCG2) influences the levels of enterolignans and their metabolites in plasma, milk and mammary gland Cite
  García-Mateos D, García-Villalba R, Marañón JA, Espín JC, Merino G, Álvarez AI. The Breast Cancer Resistance Protein (BCRP/ABCG2) influences the levels of enterolignans and their metabolites in plasma, milk and mammary gland. Journal of Functional Foods. Elsevier BV; 2017; 35:648-654 10.1016/j.jff.2017.06.038
• Association between Urinary Phytoestrogens and C-reactive Protein in the Continuous National Health and Nutrition Examination Survey Cite
  Reger MK, Zollinger TW, Liu Z, Jones J, Zhang J. Association between Urinary Phytoestrogens and C-reactive Protein in the Continuous National Health and Nutrition Examination Survey. Journal of the American College of Nutrition. Informa UK Limited; 2017; 36:434-441 10.1080/07315724.2017.1318722
• Enterolactone Suppresses Proliferation, Migration and Metastasis of MDA-MB-231 Breast Cancer Cells Through Inhibition of uPA Induced Plasmin Activation and MMPs-Mediated ECM Remodeling Cite
  Mali A, Joshi A, Hegde M, Kadam S. Enterolactone Suppresses Proliferation, Migration and Metastasis of MDA-MB-231 Breast Cancer Cells Through Inhibition of uPA Induced Plasmin Activation and MMPs-Mediated ECM Remodeling. Asian Pacific Journal of Cancer Prevention. Asian Pacific Organization for Cancer Prevention; 2017; 18 10.22034/APJCP.2017.18.4.905
• Antioxidant and antimicrobial activity of linseed lignans and phenolic acids Cite
  Kyselka J, Rabiej D, Dragoun M, Kreps F, Burčová Z, Němečková I, et al. Antioxidant and antimicrobial activity of linseed lignans and phenolic acids. European Food Research and Technology. Springer Science and Business Media LLC; 2017; 243:1633-1644 10.1007/s00217-017-2871-9
• Association between Dietary Share of Ultra-Processed Foods and Urinary Concentrations of Phytoestrogens in the US Cite
  Martínez Steele E, Monteiro C. Association between Dietary Share of Ultra-Processed Foods and Urinary Concentrations of Phytoestrogens in the US. Nutrients. MDPI AG; 2017; 9:209 10.3390/nu9030209
• Associations of urinary phthalate and phenol biomarkers with menarche in a multiethnic cohort of young girls Cite
  Wolff MS, Pajak A, Pinney SM, Windham GC, Galvez M, Rybak M, et al. Associations of urinary phthalate and phenol biomarkers with menarche in a multiethnic cohort of young girls. Reproductive Toxicology. Elsevier BV; 2017; 67:56-64 10.1016/j.reprotox.2016.11.009
• Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis Cite
  Bigdeli B, Goliaei B, Masoudi-Khoram N, Jooyan N, Nikoofar A, Rouhani M, et al. Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis. Toxicology and Applied Pharmacology. Elsevier BV; 2016; 313:180-194 10.1016/j.taap.2016.10.021
• Abstract P2-05-28: The impact of the plant lignin secoisolariciresinol diglycoside on preclinical models of estrogen receptor positive breast cancer Cite
  Bowers L, Ford N, Rossi E, Shamsunder M, Kimler B, Fabian C, et al. Abstract P2-05-28: The impact of the plant lignin secoisolariciresinol diglycoside on preclinical models of estrogen receptor positive breast cancer. Poster Session Abstracts. American Association for Cancer Research; 2016; 10.1158/1538-7445.sabcs15-p2-05-28
• Inhibitory Effects of Enterolactone on Growth and Metastasis in Human Breast Cancer Cite
  Xiong X, Hu X, Li Y, Liu C. Inhibitory Effects of Enterolactone on Growth and Metastasis in Human Breast Cancer. Nutrition and Cancer. Informa UK Limited; 2015; 67:1326-1334 10.1080/01635581.2015.1082113
• Age-dependency in the metabolism of flaxseed lignans by healthy adults Cite
  Edel AL, Pierce GN, Aliani M. Age-dependency in the metabolism of flaxseed lignans by healthy adults. Journal of Functional Foods. Elsevier BV; 2015; 17:948-957 10.1016/j.jff.2015.06.042
• Enterolactone concentrations and prognosis after postmenopausal breast cancer: Assessment of effect modification and meta-analysis Cite
  Seibold P, Vrieling A, Johnson TS, Buck K, Behrens S, Kaaks R, et al. Enterolactone concentrations and prognosis after postmenopausal breast cancer: Assessment of effect modification and meta-analysis. International Journal of Cancer. Wiley; 2014; 135:923-933 10.1002/ijc.28729
• Plasma enterolactone and breast cancer risk in the Nurses’ Health Study II Cite
  Xie J, Tworoger SS, Franke AA, Terry KL, Rice MS, Rosner BA, et al. Plasma enterolactone and breast cancer risk in the Nurses’ Health Study II. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2013; 139:801-809 10.1007/s10549-013-2586-y
• Influence of Berry Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention Cite
  Aiyer HS, Warri AM, Woode DR, Hilakivi-Clarke L, Clarke R. Influence of Berry Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2012; 60:5693-5708 10.1021/jf204084f
• Comparative Effects of Sesame Seed Lignan and Flaxseed Lignan in Reducing the Growth of Human Breast Tumors (MCF-7) at High Levels of Circulating Estrogen in Athymic Mice Cite
  Truan JS, Chen J, Thompson LU. Comparative Effects of Sesame Seed Lignan and Flaxseed Lignan in Reducing the Growth of Human Breast Tumors (MCF-7) at High Levels of Circulating Estrogen in Athymic Mice. Nutrition and Cancer. Informa UK Limited; 2012; 64:65-71 10.1080/01635581.2012.630165
• Estimated enterolignans, lignan-rich foods, and fibre in relation to survival after postmenopausal breast cancer Cite
  Buck K, Zaineddin AK, Vrieling A, Heinz J, Linseisen J, Flesch-Janys D, et al. Estimated enterolignans, lignan-rich foods, and fibre in relation to survival after postmenopausal breast cancer. British Journal of Cancer. Springer Science and Business Media LLC; 2011; 105:1151-1157 10.1038/bjc.2011.374
• Serum Enterolactone and Prognosis of Postmenopausal Breast Cancer Cite
  Buck K, Vrieling A, Zaineddin AK, Becker S, Hüsing A, Kaaks R, et al. Serum Enterolactone and Prognosis of Postmenopausal Breast Cancer. Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2011; 29:3730-3738 10.1200/jco.2011.34.6478
• Serum enterolactone and postmenopausal breast cancer risk by estrogen, progesterone and herceptin 2 receptor status Cite
  Zaineddin AK, Vrieling A, Buck K, Becker S, Linseisen J, Flesch-Janys D, et al. Serum enterolactone and postmenopausal breast cancer risk by estrogen, progesterone and herceptin 2 receptor status. International Journal of Cancer. Wiley; 2011; 130:1401-1410 10.1002/ijc.26157
• Breast, colorectal, and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition-Norfolk in relation to phytoestrogen intake derived from an improved database Cite
  Ward HA, Kuhnle GG, Mulligan AA, Lentjes MA, Luben RN, Khaw K. Breast, colorectal, and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition-Norfolk in relation to phytoestrogen intake derived from an improved database. American Journal of Clinical Nutrition. Oxford University Press (OUP); 2009; 91:440-448 10.3945/ajcn.2009.28282
• Dietary Seaweed Modifies Estrogen and Phytoestrogen Metabolism in Healthy Postmenopausal Women Cite
  Teas J, Hurley TG, Hebert JR, Franke AA, Sepkovic DW, Kurzer MS. Dietary Seaweed Modifies Estrogen and Phytoestrogen Metabolism in Healthy Postmenopausal Women. The Journal of Nutrition. Oxford University Press (OUP); 2009; 139:939-944 10.3945/jn.108.100834
• Lignans and breast cancer risk in pre- and post-menopausal women: meta-analyses of observational studies Cite
  Velentzis LS, Cantwell MM, Cardwell C, Keshtgar MR, Leathem AJ, Woodside JV. Lignans and breast cancer risk in pre- and post-menopausal women: meta-analyses of observational studies. British Journal of Cancer. Springer Science and Business Media LLC; 2009; 100:1492-1498 10.1038/sj.bjc.6605003
• Mammalian Lignan Formation in Rats Fed a Wheat Bran Diet Cite
  Nicolle C, Manach C, Morand C, Mazur W, Adlercreutz H, Rémésy C, et al. Mammalian Lignan Formation in Rats Fed a Wheat Bran Diet. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2002; 50:6222-6226 10.1021/jf020208z
• Dietary Lignan Intake and Postmenopausal Breast Cancer Risk by Estrogen and Progesterone Receptor Status Cite
  Touillaud MS, Thiebaut ACM, Fournier A, Niravong M, Boutron-Ruault M, Clavel-Chapelon F. Dietary Lignan Intake and Postmenopausal Breast Cancer Risk by Estrogen and Progesterone Receptor Status. JNCI Journal of the National Cancer Institute. Oxford University Press (OUP); 2007; 99:475-486 10.1093/jnci/djk096
• Enterolactone Is Differently Associated with Estrogen Receptor β–Negative and –Positive Breast Cancer in a Swedish Nested Case-Control Study Cite
  Sonestedt E, Borgquist S, Ericson U, Gullberg B, Olsson H, Adlercreutz H, et al. Enterolactone Is Differently Associated with Estrogen Receptor β–Negative and –Positive Breast Cancer in a Swedish Nested Case-Control Study. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2008; 17:3241-3251 10.1158/1055-9965.epi-08-0393
• Dietary phytoestrogen intake and premenopausal breast cancer risk in a German case-control study Cite
  Linseisen J, Piller R, Hermann S, Chang-Claude J. Dietary phytoestrogen intake and premenopausal breast cancer risk in a German case-control study. International Journal of Cancer. Wiley; 2004; 110:284-290 10.1002/ijc.20119
• Dietary lignans and postmenopausal breast cancer risk by oestrogen receptor status: a prospective cohort study of Swedish women Cite
  Suzuki R, Rylander-Rudqvist T, Saji S, Bergkvist L, Adlercreutz H, Wolk A. Dietary lignans and postmenopausal breast cancer risk by oestrogen receptor status: a prospective cohort study of Swedish women. British Journal of Cancer. Springer Science and Business Media LLC; 2008; 98:636-640 10.1038/sj.bjc.6604175
• Dietary Fiber Intake and Endogenous Serum Hormone Levels in Naturally Postmenopausal Mexican American Women: The Multiethnic Cohort Study Cite
  Monroe KR, Murphy SP, Henderson BE, Kolonel LN, Stanczyk FZ, Adlercreutz H, et al. Dietary Fiber Intake and Endogenous Serum Hormone Levels in Naturally Postmenopausal Mexican American Women: The Multiethnic Cohort Study. Nutrition and Cancer. Informa UK Limited; 2007; 58:127-135 10.1080/01635580701327935