Tag: broccoli

News

03/12/17

Sulforaphane in broccoli heightens taxane effects against TN disease

05/23/15

Sulforaphane inhibits HER2+ and triple negative breast cancer

05/31/13

Black pepper compound increases effectiveness of Taxol in HER2+ BC

11/05/12

Frozen broccoli has less bioavailable sulforaphane than fresh broccoli

02/20/12

Cruciferous vegetable consumption linked to reduced risk of cancer

10/15/10

Vegetables can reduce risk of ER-/PR- BC in African Americans

04/18/10

Broccoli compound sulforaphane reduces BC stem cell survival

12/08/09

DIM from broccoli prevents metastasis in mice

Foods

• • broccoli

Studies

• Cruciferous Plant Extracts, Their Isothyocianate or Indol Derivatives, and Their Effect on Cellular Viability of Breast Cancer Cell Lines Cite
  Sanchez-Guzman X, Alvarez-Domínguez L, Ramírez-Torres MF, Montes-Alvarado JB, Garcia-Ibañez P, Moreno DA, et al. Cruciferous Plant Extracts, Their Isothyocianate or Indol Derivatives, and Their Effect on Cellular Viability of Breast Cancer Cell Lines. Journal of Medicinal Food. Mary Ann Liebert Inc; 2024; 10.1089/jmf.2023.0199
• Effects of Different Combinations of Phytochemical-Rich Fruits and Vegetables on Chronic Disease Risk Markers and Gene Expression Changes: Insights from the MiBLEND Study, a Randomized Trial Cite
  DeBenedictis JN, Murrell C, Hauser D, van Herwijnen M, Elen B, de Kok TM, et al. Effects of Different Combinations of Phytochemical-Rich Fruits and Vegetables on Chronic Disease Risk Markers and Gene Expression Changes: Insights from the MiBLEND Study, a Randomized Trial. Antioxidants. MDPI AG; 2024; 13:915 10.3390/antiox13080915
• The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment Cite
  Yan S, Lu J, Chen B, Yuan L, Chen L, Ju L, et al. The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment. Antioxidants. MDPI AG; 2024; 13:897 10.3390/antiox13080897
• Improvement of sulforaphane production in hairy root cultures of broccoli (Brassica oleracea L. var. italica) by eliciting Myrosinase gene expression and its effect on breast cancer cells Cite
  Amer MA, Mohamed TR, Rahman RAA, Shalaby MA, Badr A. Improvement of sulforaphane production in hairy root cultures of broccoli (Brassica oleracea L. var. italica) by eliciting Myrosinase gene expression and its effect on breast cancer cells. Plant Cell, Tissue and Organ Culture (PCTOC). Springer Science and Business Media LLC; 2024; 158 10.1007/s11240-024-02802-9
• Anti-Inflammatory Therapeutic Mechanisms of Isothiocyanates: Insights from Sulforaphane Cite
  Habtemariam S. Anti-Inflammatory Therapeutic Mechanisms of Isothiocyanates: Insights from Sulforaphane. Biomedicines. MDPI AG; 2024; 12:1169 10.3390/biomedicines12061169
• Glucosinolates in cancer prevention and treatment: experimental and clinical evidence Cite
  Orouji N, Asl SK, Taghipour Z, Habtemariam S, Nabavi SM, Rahimi R. Glucosinolates in cancer prevention and treatment: experimental and clinical evidence. Medical Oncology. Springer Science and Business Media LLC; 2023; 40 10.1007/s12032-023-02211-6
• Broccoli and Cress Sprouts Cite
  Kang P, Kaur S, Singh J, Rasane P. Broccoli and Cress Sprouts. Advances in Plant Sprouts. Springer International Publishing; 2023;:331-362 10.1007/978-3-031-40916-5_14
• Can edible sprouts be the element of effective chemopreventive strategy? - A systematic review of in vitro and in vivo study Cite
  Grudzińska M, Galanty A, Paśko P. Can edible sprouts be the element of effective chemopreventive strategy? - A systematic review of in vitro and in vivo study. Trends in Food Science & Technology. Elsevier BV; 2023; 139:104130 10.1016/j.tifs.2023.104130
• Broccoli: A Multi-Faceted Vegetable for Health: An In-Depth Review of Its Nutritional Attributes, Antimicrobial Abilities, and Anti-inflammatory Properties Cite
  Syed RU, Moni SS, Break MKB, Khojali WMA, Jafar M, Alshammari MD, et al. Broccoli: A Multi-Faceted Vegetable for Health: An In-Depth Review of Its Nutritional Attributes, Antimicrobial Abilities, and Anti-inflammatory Properties. Antibiotics. MDPI AG; 2023; 12:1157 10.3390/antibiotics12071157
• Anticancer activity of broccoli, its organosulfur and polyphenolic compounds Cite
  Gasmi A, Gasmi Benahmed A, Shanaida M, Chirumbolo S, Menzel A, Anzar W, et al. Anticancer activity of broccoli, its organosulfur and polyphenolic compounds. Critical Reviews in Food Science and Nutrition. Informa UK Limited; 2023;:1-19 10.1080/10408398.2023.2195493
• Interplay between Cruciferous Vegetables and the Gut Microbiome: A Multi-Omic Approach Cite
  Bouranis JA, Beaver LM, Jiang D, Choi J, Wong CP, Davis EW, et al. Interplay between Cruciferous Vegetables and the Gut Microbiome: A Multi-Omic Approach. Nutrients. MDPI AG; 2022; 15:42 10.3390/nu15010042
• Optimization and validation of analytical RP-HPLC methods for the quantification of glucosinolates and isothiocyanates in Nasturtium officinale R. Br and Brassica oleracea Cite
  Theunis M, Naessens T, Peeters L, Brits M, Foubert K, Pieters L. Optimization and validation of analytical RP-HPLC methods for the quantification of glucosinolates and isothiocyanates in Nasturtium officinale R. Br and Brassica oleracea. LWT. Elsevier BV; 2022; 165:113668 10.1016/j.lwt.2022.113668
• Antioxidant and antiproliferative activities of solvent fractions of broccoli (Brassica oleracea L.) sprout Cite
  Kim JS, Cuong DM, Bae YB, Cho SK. Antioxidant and antiproliferative activities of solvent fractions of broccoli (Brassica oleracea L.) sprout. Applied Biological Chemistry. Springer Science and Business Media LLC; 2022; 65 10.1186/s13765-022-00700-2
• A Presurgical‐Window Intervention Trial of Isothiocyanate‐Rich Broccoli Sprout Extract in Patients with Breast Cancer Cite
  Wang Z, Tu C, Pratt R, Khoury T, Qu J, Fahey JW, et al. A Presurgical‐Window Intervention Trial of Isothiocyanate‐Rich Broccoli Sprout Extract in Patients with Breast Cancer. Molecular Nutrition & Food Research. Wiley; 2022;:2101094 10.1002/mnfr.202101094
• Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway Cite
  Zhang Y, Lu Q, Li N, Xu M, Miyamoto T, Liu J. Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway. npj Breast Cancer. Springer Science and Business Media LLC; 2022; 8 10.1038/s41523-022-00402-4
• Sulforaphane: The Principal Broccoli Phytochemical as a Cancer Challenger Cite
  Djaldetti M. Sulforaphane: The Principal Broccoli Phytochemical as a Cancer Challenger. Recent Progress in Nutrition. LIDSEN Publishing Inc; 2022; 2:1-1 10.21926/rpn.2201008
• Antinutrients: Lectins, goitrogens, phytates and oxalates, friends or foe? Cite
  López-Moreno M, Garcés-Rimón M, Miguel M. Antinutrients: Lectins, goitrogens, phytates and oxalates, friends or foe?. Journal of Functional Foods. Elsevier BV; 2022; 89:104938 10.1016/j.jff.2022.104938
• Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms Cite
  Slika H, Mansour H, Wehbe N, Nasser SA, Iratni R, Nasrallah G, et al. Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms. Biomedicine & Pharmacotherapy. Elsevier BV; 2022; 146:112442 10.1016/j.biopha.2021.112442
• Cytokine Secretions in Partial Breast Tumor Microenvironment With and Without Sulforaphane Cite
  Merrick C, Housley L. Cytokine Secretions in Partial Breast Tumor Microenvironment With and Without Sulforaphane. Current Developments in Nutrition. Oxford University Press (OUP); 2021; 5:274-274 10.1093/cdn/nzab036_016
• Studies on exogenous elicitors promotion of sulforaphane content in broccoli sprouts and its effect on the MDA-MB-231 breast cancer cell line Cite
  Amer MA, Mohamed TR, Abdel Rahman RA, Ali M, Badr A. Studies on exogenous elicitors promotion of sulforaphane content in broccoli sprouts and its effect on the MDA-MB-231 breast cancer cell line. Annals of Agricultural Sciences. Elsevier BV; 2021; 66:46-52 10.1016/j.aoas.2021.02.001
• Combined Broccoli Sprouts and Green Tea Polyphenols Contribute to the Prevention of Estrogen Receptor–Negative Mammary Cancer via Cell Cycle Arrest and Inducing Apoptosis in HER2/neu Mice Cite
  Li S, Wu H, Tollefsbol TO. Combined Broccoli Sprouts and Green Tea Polyphenols Contribute to the Prevention of Estrogen Receptor–Negative Mammary Cancer via Cell Cycle Arrest and Inducing Apoptosis in HER2/neu Mice. The Journal of Nutrition. Oxford University Press (OUP); 2020; 10.1093/jn/nxaa315
• Temporal Efficacy of a Sulforaphane-Based Broccoli Sprout Diet in Prevention of Breast Cancer through Modulation of Epigenetic Mechanisms Cite
  Li Y, Buckhaults P, Li S, Tollefsbol T. Temporal Efficacy of a Sulforaphane-Based Broccoli Sprout Diet in Prevention of Breast Cancer through Modulation of Epigenetic Mechanisms. Cancer Prevention Research. American Association for Cancer Research (AACR); 2018; 11:451-464 10.1158/1940-6207.capr-17-0423
• Home food preparation techniques impacted the availability of natural antioxidants and bioactivities in kale and broccoli Cite
  Yu L, Gao B, Li Y, Wang TTY, Luo Y, Wang J, et al. Home food preparation techniques impacted the availability of natural antioxidants and bioactivities in kale and broccoli. Food & Function. Royal Society of Chemistry (RSC); 2018; 9:585-593 10.1039/c7fo00948h
• High-Pressure Processing of Broccoli Sprouts: Influence on Bioactivation of Glucosinolates to Isothiocyanates Cite
  Westphal A, Riedl KM, Cooperstone JL, Kamat S, Balasubramaniam VM, Schwartz SJ, et al. High-Pressure Processing of Broccoli Sprouts: Influence on Bioactivation of Glucosinolates to Isothiocyanates. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2017; 65:8578-8585 10.1021/acs.jafc.7b01380
• Isothiocyanates, Nitriles, and Epithionitriles from Glucosinolates Are Affected by Genotype and Developmental Stage in Brassica oleracea Varieties Cite
  Hanschen FS, Schreiner M. Isothiocyanates, Nitriles, and Epithionitriles from Glucosinolates Are Affected by Genotype and Developmental Stage in Brassica oleracea Varieties. Frontiers in Plant Science. Frontiers Media SA; 2017; 8 10.3389/fpls.2017.01095
• Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism Cite
  Felker P, Bunch R, Leung AM. Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism. Nutrition Reviews. Oxford University Press (OUP); 2016; 74:248-258 10.1093/nutrit/nuv110
• Analysis and Antioxidant Activity of Extracts from Broccoli (Brassica oleracea L.) Sprouts Cite
  Jang HW, Moon J, Shibamoto T. Analysis and Antioxidant Activity of Extracts from Broccoli (Brassica oleracea L.) Sprouts. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2015; 63:1169-1174 10.1021/jf504929m
• Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition Cite
  Tortorella SM, Royce SG, Licciardi PV, Karagiannis TC. Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition. Antioxidants & Redox Signaling. Mary Ann Liebert Inc; 2015; 22:1382-1424 10.1089/ars.2014.6097
• Low levels of 3,3′-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol Cite
  Marques M, Laflamme L, Benassou I, Cissokho C, Guillemette B, Gaudreau L. Low levels of 3,3′-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol. BMC Cancer. Springer Science and Business Media LLC; 2014; 14 10.1186/1471-2407-14-524
• Phenolic profile and antioxidant activity in selected seeds and sprouts Cite
  Pająk P, Socha R, Gałkowska D, Rożnowski J, Fortuna T. Phenolic profile and antioxidant activity in selected seeds and sprouts. Food Chemistry. Elsevier BV; 2014; 143:300-306 10.1016/j.foodchem.2013.07.064
• Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli Cite
  Saha S, Hollands W, Teucher B, Needs PW, Narbad A, Ortori CA, et al. Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli. Molecular Nutrition & Food Research. Wiley; 2012; 56:1906-1916 10.1002/mnfr.201200225
• Analysis of total glucosinolates and chromatographically purified benzylglucosinolate in organic and conventional vegetables Cite
  Miranda Rossetto MR, Shiga TM, Vianello F, Pereira Lima GP. Analysis of total glucosinolates and chromatographically purified benzylglucosinolate in organic and conventional vegetables. LWT - Food Science and Technology. Elsevier BV; 2013; 50:247-252 10.1016/j.lwt.2012.05.022
• Low concentrations of isothiocyanates protect mesenchymal stem cells from oxidative injuries, while high concentrations exacerbate DNA damage Cite
  Zanichelli F, Capasso S, Di Bernardo G, Cipollaro M, Pagnotta E, Cartenì M, et al. Low concentrations of isothiocyanates protect mesenchymal stem cells from oxidative injuries, while high concentrations exacerbate DNA damage. Apoptosis. Springer Science and Business Media LLC; 2012; 17:964-974 10.1007/s10495-012-0740-3
• Mechanisms of action of isothiocyanates in cancer chemoprevention: an update Cite
  Navarro SL, Li F, Lampe JW. Mechanisms of action of isothiocyanates in cancer chemoprevention: an update. Food & Function. Royal Society of Chemistry (RSC); 2011; 2:579 10.1039/c1fo10114e
• Cruciferous vegetables and cancer risk in a network of case–control studies Cite
  Bosetti C, Filomeno M, Riso P, Polesel J, Levi F, Talamini R, et al. Cruciferous vegetables and cancer risk in a network of case–control studies. Annals of Oncology. Elsevier BV; 2012; 23:2198-2203 10.1093/annonc/mdr604
• Comparison of Isothiocyanate Metabolite Levels and Histone Deacetylase Activity in Human Subjects Consuming Broccoli Sprouts or Broccoli Supplement Cite
  Clarke JD, Riedl K, Bella D, Schwartz SJ, Stevens JF, Ho E. Comparison of Isothiocyanate Metabolite Levels and Histone Deacetylase Activity in Human Subjects Consuming Broccoli Sprouts or Broccoli Supplement. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2011; 59:10955-10963 10.1021/jf202887c
• Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design Cite
  Clarke JD, Hsu A, Riedl K, Bella D, Schwartz SJ, Stevens JF, et al. Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design. Pharmacological Research. Elsevier BV; 2011; 64:456-463 10.1016/j.phrs.2011.07.005
• Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice Cite
  Tsubura A. Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice. Oncology Reports. Spandidos Publications; 2011; 10.3892/or.2011.1311
• Glucoraphanin hydrolysis by microbiota in the rat cecum results in sulforaphane absorption Cite
  Lai R, Miller MJ, Jeffery E. Glucoraphanin hydrolysis by microbiota in the rat cecum results in sulforaphane absorption. Food & Function. Royal Society of Chemistry (RSC); 2010; 1:161 10.1039/c0fo00110d
• Fruit and Vegetable Intake in Relation to Risk of Breast Cancer in the Black Women's Health Study Cite
  Boggs DA, Palmer JR, Wise LA, Spiegelman D, Stampfer MJ, Adams-Campbell LL, et al. Fruit and Vegetable Intake in Relation to Risk of Breast Cancer in the Black Women's Health Study. American Journal of Epidemiology. Oxford University Press (OUP); 2010; 172:1268-1279 10.1093/aje/kwq293
• Vegetable intake is associated with reduced breast cancer recurrence in tamoxifen users: a secondary analysis from the Women’s Healthy Eating and Living Study Cite
  Thomson CA, Rock CL, Thompson PA, Caan BJ, Cussler E, Flatt SW, et al. Vegetable intake is associated with reduced breast cancer recurrence in tamoxifen users: a secondary analysis from the Women’s Healthy Eating and Living Study. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2010; 125:519-527 10.1007/s10549-010-1014-9
• p53-Independent Apoptosis by Benzyl Isothiocyanate in Human Breast Cancer Cells Is Mediated by Suppression of XIAP Expression Cite
  Kim S, Singh SV. p53-Independent Apoptosis by Benzyl Isothiocyanate in Human Breast Cancer Cells Is Mediated by Suppression of XIAP Expression. Cancer Prevention Research. American Association for Cancer Research (AACR); 2010; 3:718-726 10.1158/1940-6207.capr-10-0048
• Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells Cite
  Li Y, Zhang T, Korkaya H, Liu S, Lee H, Newman B, et al. Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells. Clinical Cancer Research. American Association for Cancer Research (AACR); 2010; 16:2580-2590 10.1158/1078-0432.ccr-09-2937
• A vegetable-fruit-soy dietary pattern protects against breast cancer among postmenopausal Singapore Chinese women Cite
  Butler LM, Wu AH, Wang R, Koh W, Yuan J, Yu MC. A vegetable-fruit-soy dietary pattern protects against breast cancer among postmenopausal Singapore Chinese women. The American Journal of Clinical Nutrition. Oxford University Press (OUP); 2010; 91:1013-1019 10.3945/ajcn.2009.28572
• Antioxidant and Antiproliferative Activities of Common Vegetables Cite
  Chu Y, Sun J, Wu X, Liu RH. Antioxidant and Antiproliferative Activities of Common Vegetables. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2002; 50:6910-6916 10.1021/jf020665f
• Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment Cite
  Moiseeva EP, Fox LH, Howells LM, Temple LAF, Manson MM. Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment. Apoptosis. Springer Science and Business Media LLC; 2006; 11:799-812 10.1007/s10495-006-5877-5
• Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells Cite
  Rose P, Huang Q, Ong CN, Whiteman M. Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. Toxicology and Applied Pharmacology. Elsevier BV; 2005; 209:105-113 10.1016/j.taap.2005.04.010
• 3,3′-Diindolylmethane Is a Novel Mitochondrial H+-ATP Synthase Inhibitor that Can Induce p21Cip1/Waf1 Expression by Induction of Oxidative Stress in Human Breast Cancer Cells Cite
  Gong Y, Sohn H, Xue L, Firestone GL, Bjeldanes LF. 3,3′-Diindolylmethane Is a Novel Mitochondrial H+-ATP Synthase Inhibitor that Can Induce p21Cip1/Waf1 Expression by Induction of Oxidative Stress in Human Breast Cancer Cells. Cancer Research. American Association for Cancer Research (AACR); 2006; 66:4880-4887 10.1158/0008-5472.can-05-4162
• Regulation of estrogen receptor α expression in human breast cancer cells by sulforaphane Cite
  Ramirez MC, Singletary K. Regulation of estrogen receptor α expression in human breast cancer cells by sulforaphane. The Journal of Nutritional Biochemistry. Elsevier BV; 2009; 20:195-201 10.1016/j.jnutbio.2008.02.002
• Dietary flavonols and flavonol-rich foods intake and the risk of breast cancer Cite
  Adebamowo CA, Cho E, Sampson L, Katan MB, Spiegelman D, Willett WC, et al. Dietary flavonols and flavonol-rich foods intake and the risk of breast cancer. International Journal of Cancer. Wiley; 2005; 114:628-633 10.1002/ijc.20741