Tag: apigenin

Articles

• Supplements with warnings for breast cancer

News

11/07/20

Apigenin sensitizes triple negative breast cancer to Adriamycin

02/29/16

Apigenin reduces TN proliferation & growth through epigenetic changes

01/17/12

Apigenin increases effectiveness of Taxol chemotherapy

05/10/11

Apigenin may prevent BC that develops in response to progestin

Foods

• • artichokes
  • bell peppers
  • celery
  • chamomile
  • garlic
  • parsley
  • thyme

Studies

• Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment Cite
  Nguyen MH, Nguyen TYN, Le THN, Le TNT, Chau NTN, Le TMH, et al. Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment. Heliyon. Elsevier BV; 2024; 10:e39229 10.1016/j.heliyon.2024.e39229
• Chemopreventive Agents from Nature: A Review of Apigenin, Rosmarinic Acid, and Thymoquinone Cite
  Abutayeh RF, Altah M, Mehdawi A, Al-Ataby I, Ardakani A. Chemopreventive Agents from Nature: A Review of Apigenin, Rosmarinic Acid, and Thymoquinone. Current Issues in Molecular Biology. MDPI AG; 2024; 46:6600-6619 10.3390/cimb46070393
• Natural compounds targeting YAP/TAZ axis in cancer: Current state of art and challenges Cite
  Kumar A, BharathwajChetty B, Manickasamy MK, Unnikrishnan J, Alqahtani MS, Abbas M, et al. Natural compounds targeting YAP/TAZ axis in cancer: Current state of art and challenges. Pharmacological Research. Elsevier BV; 2024;:107167 10.1016/j.phrs.2024.107167
• Dietary factors and their influence on immunotherapy strategies in oncology: a comprehensive review Cite
  Golonko A, Pienkowski T, Swislocka R, Orzechowska S, Marszalek K, Szczerbinski L, et al. Dietary factors and their influence on immunotherapy strategies in oncology: a comprehensive review. Cell Death & Disease. Springer Science and Business Media LLC; 2024; 15 10.1038/s41419-024-06641-6
• Triple Negative Breast Cancer (TNBC): Signalling pathways-Role of plant-based inhibitors Cite
  Ravindra B. Malabadi , Sadiya MR , Kiran P. Kolkar , Simuzar S. Mammadova , Raju K. Chalannavar , Himansu Baijnath , et al. Triple Negative Breast Cancer (TNBC): Signalling pathways-Role of plant-based inhibitors. Open Access Research Journal of Biology and Pharmacy. Open Access Research Journals Publication; 2024; 10:028-071 10.53022/oarjbp.2024.10.2.0013
• Apigenin promotes apoptosis of 4T1 cells through PI3K/AKT/Nrf2 pathway and improves tumor immune microenvironment in vivo Cite
  Zhang C, Liao Y, Li T, Zhong H, Shan L, Yu P, et al. Apigenin promotes apoptosis of 4T1 cells through PI3K/AKT/Nrf2 pathway and improves tumor immune microenvironment in vivo. Toxicology Research. Oxford University Press (OUP); 2024; 13 10.1093/toxres/tfae011
• Transcriptome reprogramming through alternative splicing triggered by apigenin drives cell death in triple-negative breast cancer Cite
  Sudhakaran M, Navarrete TG, Mejía-Guerra K, Mukundi E, Eubank TD, Grotewold E, et al. Transcriptome reprogramming through alternative splicing triggered by apigenin drives cell death in triple-negative breast cancer. Cell Death & Disease. Springer Science and Business Media LLC; 2023; 14 10.1038/s41419-023-06342-6
• Dually Active Apigenin-Loaded Nanostructured Lipid Carriers for Cancer Treatment Cite
  Bonilla-Vidal L, Świtalska M, Espina M, Wietrzyk J, García ML, Souto EB, et al. Dually Active Apigenin-Loaded Nanostructured Lipid Carriers for Cancer Treatment. International Journal of Nanomedicine. Informa UK Limited; 2023; Volume 18:6979-6997 10.2147/ijn.s429565
• Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer Cite
  da Silva FC, Brandão DC, Ferreira EA, Siqueira RP, Ferreira HSV, Da Silva Filho AA, et al. Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer. Pharmaceuticals. MDPI AG; 2023; 16:1466 10.3390/ph16101466
• Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling Cite
  Kubatka P, Koklesova L, Mazurakova A, Brockmueller A, Büsselberg D, Kello M, et al. Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling. Cancer and Metastasis Reviews. Springer Science and Business Media LLC; 2023; 10.1007/s10555-023-10134-x
• Apigenin is an anoikis sensitizer with strong anti-metastatic properties in experimental breast cancer Cite
  Xu R, Yao Z, Zhang H, Li H, Chen W. Apigenin is an anoikis sensitizer with strong anti-metastatic properties in experimental breast cancer. Food Science and Human Wellness. Tsinghua University Press; 2023; 10.26599/fshw.2022.9250185
• A Systematic Review on Chemical Actives from Plant Sources, Targets and Chemotherapy for Triple-Negative Breast Cancer Cite
  Varne AA, Bhatia MS, Ashtek SS. A Systematic Review on Chemical Actives from Plant Sources, Targets and Chemotherapy for Triple-Negative Breast Cancer. Pharmaceutical Chemistry Journal. Springer Science and Business Media LLC; 2023; 57:694-702 10.1007/s11094-023-02940-y
• Phytochemicals Modify the Action of Cancer Cells Mitochondrial Drug-Resistance Mechanism Cite
  Das S. Phytochemicals Modify the Action of Cancer Cells Mitochondrial Drug-Resistance Mechanism. Sciences of Pharmacy. Etflin; 2023; 2:79-105 10.58920/sciphar02030079
• Insights on the Role of Polyphenols in Combating Cancer Drug Resistance Cite
  Farhan M. Insights on the Role of Polyphenols in Combating Cancer Drug Resistance. Biomedicines. MDPI AG; 2023; 11:1709 10.3390/biomedicines11061709
• Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells Cite
  Ghanbari-Movahed M, Shafiee S, Burcher JT, Lagoa R, Farzaei MH, Bishayee A. Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells. Metabolites. MDPI AG; 2023; 13:404 10.3390/metabo13030404
• 42P Apigenin: An immunomodulatory nutraceutical overriding PD-L1 inhibitors by halting AKT/mTOR pathway in triple-negative breast cancer (TNBC) Cite
  Samir A, Abdeltawab R, Stein U, Thabit S, El Tayebi H. 42P Apigenin: An immunomodulatory nutraceutical overriding PD-L1 inhibitors by halting AKT/mTOR pathway in triple-negative breast cancer (TNBC). ESMO Open. Elsevier BV; 2023; 8:101008 10.1016/j.esmoop.2023.101008
• Apigenin alleviates resistance to doxorubicin in breast cancer cells by acting on the JAK/STAT signaling pathway Cite
  Maashi MS, Al-Mualm M, Al-Awsi GRL, Opulencia MJC, Al-Gazally ME, Abdullaev B, et al. Apigenin alleviates resistance to doxorubicin in breast cancer cells by acting on the JAK/STAT signaling pathway. Molecular Biology Reports. Springer Science and Business Media LLC; 2022; 10.1007/s11033-022-07727-0
• Role of Induced Programmed Cell Death in the Chemopreventive Potential of Apigenin Cite
  Jang JY, Sung B, Kim ND. Role of Induced Programmed Cell Death in the Chemopreventive Potential of Apigenin. International Journal of Molecular Sciences. MDPI AG; 2022; 23:3757 10.3390/ijms23073757
• Natural Products Targeting Cancer Stem Cells for Augmenting Cancer Therapeutics Cite
  Meerson A, Khatib S, Mahajna J. Natural Products Targeting Cancer Stem Cells for Augmenting Cancer Therapeutics. International Journal of Molecular Sciences. MDPI AG; 2021; 22:13044 10.3390/ijms222313044
• Role of Dietary Ingredients on Expression of Oncogenic and Tumour Suppressor miRNA Cite
  Gacche RN. Role of Dietary Ingredients on Expression of Oncogenic and Tumour Suppressor miRNA. Dietary Research and Cancer. Springer Singapore; 2021;:69-76 10.1007/978-981-16-6050-4_7
• Manipulation of Dietary Intake on Changes in Circulating Testosterone Concentrations Cite
  Zamir A, Ben-Zeev T, Hoffman JR. Manipulation of Dietary Intake on Changes in Circulating Testosterone Concentrations. Nutrients. MDPI AG; 2021; 13:3375 10.3390/nu13103375
• Therapeutic role of flavonoids and flavones in cancer prevention: Current trends and future perspectives Cite
  Khan AU, Dagur HS, Khan M, Malik N, Alam M, Mushtaque M. Therapeutic role of flavonoids and flavones in cancer prevention: Current trends and future perspectives. European Journal of Medicinal Chemistry Reports. Elsevier BV; 2021;:100010 10.1016/j.ejmcr.2021.100010
• Role of Phytochemicals in Cancer Chemoprevention: Insights Cite
  George BP, Chandran R, Abrahamse H. Role of Phytochemicals in Cancer Chemoprevention: Insights. Antioxidants. MDPI AG; 2021; 10:1455 10.3390/antiox10091455
• Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer Cite
  Al-Bari MAA, Ito Y, Ahmed S, Radwan N, Ahmed HS, Eid N. Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer. International Journal of Molecular Sciences. MDPI AG; 2021; 22:9807 10.3390/ijms22189807
• Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis Cite
  Maroni P, Bendinelli P, Fulgenzi A, Ferraretto A. Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis. Biomolecules. MDPI AG; 2021; 11:1336 10.3390/biom11091336
• Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy Cite
  Sabo AA, Dudau M, Constantin GL, Pop TC, Geilfus C, Naccarati A, et al. Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy. Frontiers in Pharmacology. Frontiers Media SA; 2021; 12 10.3389/fphar.2021.652074
• Apigenin acts as a partial agonist action at estrogen receptors in vivo Cite
  Yao L, Fan Z, Han S, Sun N, Che H. Apigenin acts as a partial agonist action at estrogen receptors in vivo. European Journal of Pharmacology. Elsevier BV; 2021;:174175 10.1016/j.ejphar.2021.174175
• Distinct Classes of Flavonoids and Epigallocatechin Gallate, Polyphenol Affects an Oncogenic Mutant p53 Protein, Cell Growth and Invasion in a TNBC Breast Cancer Cell Line Cite
  Kollareddy M, Martinez LA. Distinct Classes of Flavonoids and Epigallocatechin Gallate, Polyphenol Affects an Oncogenic Mutant p53 Protein, Cell Growth and Invasion in a TNBC Breast Cancer Cell Line. Cells. MDPI AG; 2021; 10:797 10.3390/cells10040797
• Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation Cite
  Wu Q, Li W, Zhao J, Sun W, Yang Q, Chen C, et al. Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation. Biomedicine & Pharmacotherapy. Elsevier BV; 2021; 137:111308 10.1016/j.biopha.2021.111308
• Modulation of Autophagy in Cancer Cells by Dietary Polyphenols Cite
  Musial C, Siedlecka-Kroplewska K, Kmiec Z, Gorska-Ponikowska M. Modulation of Autophagy in Cancer Cells by Dietary Polyphenols. Antioxidants. MDPI AG; 2021; 10:123 10.3390/antiox10010123
• Apigenin, a Partial Antagonist of the Estrogen Receptor (ER), Inhibits ER-Positive Breast Cancer Cell Proliferation through Akt/FOXM1 Signaling Cite
  Pham TH, Page YL, Percevault F, Ferrière F, Flouriot G, Pakdel F. Apigenin, a Partial Antagonist of the Estrogen Receptor (ER), Inhibits ER-Positive Breast Cancer Cell Proliferation through Akt/FOXM1 Signaling. International Journal of Molecular Sciences. MDPI AG; 2021; 22:470 10.3390/ijms22010470
• Bioactive Compounds, Antioxidant Activities, and Health Beneficial Effects of Selected Commercial Berry Fruits: A Review Cite
  Nemzer BV, Kalita D, Yashin AY, Yashin YI. Bioactive Compounds, Antioxidant Activities, and Health Beneficial Effects of Selected Commercial Berry Fruits: A Review. Journal of Food Research. Canadian Center of Science and Education; 2020; 9:78 10.5539/jfr.v9n5p78
• Apigenin by targeting hnRNPA2 sensitizes triple-negative breast cancer spheroids to doxorubicin-induced apoptosis and regulates expression of ABCC4 and ABCG2 drug efflux transporters Cite
  Sudhakaran M, Parra MR, Stoub H, Gallo KA, Doseff AI. Apigenin by targeting hnRNPA2 sensitizes triple-negative breast cancer spheroids to doxorubicin-induced apoptosis and regulates expression of ABCC4 and ABCG2 drug efflux transporters. Biochemical Pharmacology. Elsevier BV; 2020; 182:114259 10.1016/j.bcp.2020.114259
• Flavonoid-induced apoptotic cell death in human cancer cells and its mechanisms Cite
  Bhosale PB, Ha SE, Vetrivel P, Kim HH, Kim J, Park K, et al. Flavonoid-induced apoptotic cell death in human cancer cells and its mechanisms. Journal of Biomedical Translational Research. Research Institute of Veterinary Medicine; 2020; 21:50-58 10.12729/jbtr.2020.21.2.050
• Flavonoids in Cancer Metastasis Cite
  Liskova A, Koklesova L, Samec M, Smejkal K, Samuel SM, Varghese E, et al. Flavonoids in Cancer Metastasis. Cancers. MDPI AG; 2020; 12:1498 10.3390/cancers12061498
• Association between flavonoids, flavonoid subclasses intake and breast cancer risk: a case-control study in China Cite
  Feng X, Ho SC, Mo X, Lin F, Zhang N, Luo H, et al. Association between flavonoids, flavonoid subclasses intake and breast cancer risk: a case-control study in China. European Journal of Cancer Prevention. Ovid Technologies (Wolters Kluwer Health); 2019; 29:493-500 10.1097/cej.0000000000000561
• Whole Transcriptomic Analysis of Apigenin on TNFα Immuno-activated MDA-MB-231 Breast Cancer Cells Cite
  BAUER D, MAZZIO E, SOLIMAN KF. Whole Transcriptomic Analysis of Apigenin on TNFα Immuno-activated MDA-MB-231 Breast Cancer Cells. Cancer Genomics - Proteomics. Anticancer Research USA Inc.; 2019; 16:421-431 10.21873/cgp.20146
• The Flavonoid Apigenin Is a Progesterone Receptor Modulator with In Vivo Activity in the Uterus Cite
  Dean M, Austin J, Jinhong R, Johnson ME, Lantvit DD, Burdette JE. The Flavonoid Apigenin Is a Progesterone Receptor Modulator with In Vivo Activity in the Uterus. Hormones and Cancer. Springer Science and Business Media LLC; 2018; 9:265-277 10.1007/s12672-018-0333-x
• Apigenin, a dietary flavonoid, induces apoptosis, DNA damage, and oxidative stress in human breast cancer MCF-7 and MDA MB-231 cells Cite
  Vrhovac Madunić I, Madunić J, Antunović M, Paradžik M, Garaj-Vrhovac V, Breljak D, et al. Apigenin, a dietary flavonoid, induces apoptosis, DNA damage, and oxidative stress in human breast cancer MCF-7 and MDA MB-231 cells. Naunyn-Schmiedeberg's Archives of Pharmacology. Springer Science and Business Media LLC; 2018; 391:537-550 10.1007/s00210-018-1486-4
• Apigenin and Luteolin Attenuate the Breaching of MDA-MB231 Breast Cancer Spheroids Through the Lymph Endothelial Barrier in Vitro Cite
  Hong J, Fristiohady A, Nguyen CH, Milovanovic D, Huttary N, Krieger S, et al. Apigenin and Luteolin Attenuate the Breaching of MDA-MB231 Breast Cancer Spheroids Through the Lymph Endothelial Barrier in Vitro. Frontiers in Pharmacology. Frontiers Media SA; 2018; 9 10.3389/fphar.2018.00220
• Cytochrome P450 CYP1 metabolism of hydroxylated flavones and flavonols: Selective bioactivation of luteolin in breast cancer cells Cite
  Wilsher NE, Arroo RR, Matsoukas M, Tsatsakis AM, Spandidos DA, Androutsopoulos VP. Cytochrome P450 CYP1 metabolism of hydroxylated flavones and flavonols: Selective bioactivation of luteolin in breast cancer cells. Food and Chemical Toxicology. Elsevier BV; 2017; 110:383-394 10.1016/j.fct.2017.10.051
• Apigenin overcomes drug resistance by blocking the signal transducer and activator of transcription 3 signaling in breast cancer cells Cite
  Seo H, Ku JM, Choi HS, Woo J, Lee BH, Kim DS, et al. Apigenin overcomes drug resistance by blocking the signal transducer and activator of transcription 3 signaling in breast cancer cells. Oncology Reports. Spandidos Publications; 2017; 38:715-724 10.3892/or.2017.5752
• Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells Cite
  Perrott KM, Wiley CD, Desprez P, Campisi J. Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. GeroScience. Springer Science and Business Media LLC; 2017; 39:161-173 10.1007/s11357-017-9970-1
• Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms Cite
  Gaballah HH, Gaber RA, Mohamed DA. Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms. Toxicology and Applied Pharmacology. Elsevier BV; 2017; 316:27-35 10.1016/j.taap.2016.12.012
• Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells Cite
  Coombs MRP, Harrison ME, Hoskin DW. Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells. Cancer Letters. Elsevier BV; 2016; 380:424-433 10.1016/j.canlet.2016.06.023
• Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1expression Cite
  Tseng T, Chien M, Lin W, Wen Y, Chow J, Chen C, et al. Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1expression. Environmental Toxicology. Wiley; 2016; 32:434-444 10.1002/tox.22247
• Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells Cite
  Seo H, Jo J, Ku J, Choi H, Choi Y, Woo J, et al. Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells. Bioscience Reports. Portland Press Ltd.; 2015; 35 10.1042/bsr20150165
• Epigenetic activities of flavonoids in the prevention and treatment of cancer Cite
  Busch C, Burkard M, Leischner C, Lauer UM, Frank J, Venturelli S. Epigenetic activities of flavonoids in the prevention and treatment of cancer. Clinical Epigenetics. Springer Science and Business Media LLC; 2015; 7 10.1186/s13148-015-0095-z
• Exposure of breast cancer cells to a subcytotoxic dose of apigenin causes growth inhibition, oxidative stress, and hypophosphorylation of Akt Cite
  Harrison ME, Power Coombs MR, Delaney LM, Hoskin DW. Exposure of breast cancer cells to a subcytotoxic dose of apigenin causes growth inhibition, oxidative stress, and hypophosphorylation of Akt. Experimental and Molecular Pathology. Elsevier BV; 2014; 97:211-217 10.1016/j.yexmp.2014.07.006
• Determination of Phenolic Compounds in Artichoke, Garlic and Spinach by Ultra-High-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry Cite
  Alarcón-Flores MI, Romero-González R, Martínez Vidal JL, Garrido Frenich A. Determination of Phenolic Compounds in Artichoke, Garlic and Spinach by Ultra-High-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry. Food Analytical Methods. Springer Science and Business Media LLC; 2014; 7:2095-2106 10.1007/s12161-014-9852-4
• Effects of Dietary Apigenin on Tumor Latency, Incidence and Multiplicity in a Medroxyprogesterone Acetate- Accelerated 7,12-Dimethylbenz(a)anthracene- Induced Breast Cancer Model Cite
  Mafuvadze B, Cook M, Xu Z, Besch-Williford CL, Hyder SM. Effects of Dietary Apigenin on Tumor Latency, Incidence and Multiplicity in a Medroxyprogesterone Acetate- Accelerated 7,12-Dimethylbenz(a)anthracene- Induced Breast Cancer Model. Nutrition and Cancer. Informa UK Limited; 2013; 65:1184-1191 10.1080/01635581.2013.833637
• Ocimum SanctumL (Holy Basil or Tulsi) and Its Phytochemicals in the Prevention and Treatment of Cancer Cite
  Baliga MS, Jimmy R, Thilakchand KR, Sunitha V, Bhat NR, Saldanha E, et al. Ocimum SanctumL (Holy Basil or Tulsi) and Its Phytochemicals in the Prevention and Treatment of Cancer. Nutrition and Cancer. Informa UK Limited; 2013; 65:26-35 10.1080/01635581.2013.785010
• Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin Cite
  Choudhury D, Ganguli A, Dastidar DG, Acharya BR, Das A, Chakrabarti G. Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin. Biochimie. Elsevier BV; 2013; 95:1297-1309 10.1016/j.biochi.2013.02.010
• Evaluation of antioxidant activity, total phenols and phenolic compounds in thyme (Thymus vulgaris L.), sage (Salvia officinalis L.), and marjoram (Origanum majorana L.) extracts Cite
  Roby MHH, Sarhan MA, Selim KA, Khalel KI. Evaluation of antioxidant activity, total phenols and phenolic compounds in thyme (Thymus vulgaris L.), sage (Salvia officinalis L.), and marjoram (Origanum majorana L.) extracts. Industrial Crops and Products. Elsevier BV; 2013; 43:827-831 10.1016/j.indcrop.2012.08.029
• Apigenin Induces Apoptosis and Blocks Growth of Medroxyprogesterone Acetate-Dependent BT-474 Xenograft Tumors Cite
  Mafuvadze B, Liang Y, Besch-Williford C, Zhang X, Hyder SM. Apigenin Induces Apoptosis and Blocks Growth of Medroxyprogesterone Acetate-Dependent BT-474 Xenograft Tumors. Hormones and Cancer. Springer Science and Business Media LLC; 2012; 3:160-171 10.1007/s12672-012-0114-x
• Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway Cite
  Lamy S, Akla N, Ouanouki A, Lord-Dufour S, Béliveau R. Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway. Experimental Cell Research. Elsevier BV; 2012; 318:1586-1596 10.1016/j.yexcr.2012.04.004
• Acute Exposure of Apigenin Induces Hepatotoxicity in Swiss Mice Cite
  Singh P, Mishra SK, Noel S, Sharma S, Rath SK. Acute Exposure of Apigenin Induces Hepatotoxicity in Swiss Mice. PLoS ONE. Public Library of Science (PLoS); 2012; 7:e31964 10.1371/journal.pone.0031964
• Comparative analysis of phenolic profile, antioxidant, anti-inflammatory and cytotoxic activity of two closely-related Plantain species: Plantago altissima L. and Plantago lanceolata L. Cite
  Beara IN, Lesjak MM, Orčić DZ, Simin NĐ, Četojević-Simin DD, Božin BN, et al. Comparative analysis of phenolic profile, antioxidant, anti-inflammatory and cytotoxic activity of two closely-related Plantain species: Plantago altissima L. and Plantago lanceolata L.. LWT - Food Science and Technology. Elsevier BV; 2012; 47:64-70 10.1016/j.lwt.2012.01.001
• Synergistic Effects of Apigenin and Paclitaxel on Apoptosis of Cancer Cells Cite
  Xu Y, Xin Y, Diao Y, Lu C, Fu J, Luo L, et al. Synergistic Effects of Apigenin and Paclitaxel on Apoptosis of Cancer Cells. PLoS ONE. Public Library of Science (PLoS); 2011; 6:e29169 10.1371/journal.pone.0029169
• Polyphenols, isothiocyanates, and carotenoid derivatives enhance estrogenic activity in bone cells but inhibit it in breast cancer cells Cite
  Veprik A, Khanin M, Linnewiel-Hermoni K, Danilenko M, Levy J, Sharoni Y. Polyphenols, isothiocyanates, and carotenoid derivatives enhance estrogenic activity in bone cells but inhibit it in breast cancer cells. American Journal of Physiology-Endocrinology and Metabolism. American Physiological Society; 2012; 303:E815-E824 10.1152/ajpendo.00142.2011
• Potential interaction of natural dietary bioactive compounds with COX-2 Cite
  Maldonado-Rojas W, Olivero-Verbel J. Potential interaction of natural dietary bioactive compounds with COX-2. Journal of Molecular Graphics and Modelling. Elsevier BV; 2011; 30:157-166 10.1016/j.jmgm.2011.07.002
• Apigenin Prevents Development of Medroxyprogesterone Acetate-Accelerated 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Sprague–Dawley Rats Cite
  Mafuvadze B, Benakanakere I, López Pérez FR, Besch-Williford C, Ellersieck MR, Hyder SM. Apigenin Prevents Development of Medroxyprogesterone Acetate-Accelerated 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Sprague–Dawley Rats. Cancer Prevention Research. American Association for Cancer Research (AACR); 2011; 4:1316-1324 10.1158/1940-6207.capr-10-0382
• Flavonoids, Proanthocyanidins, and Cancer Risk: A Network of Case-Control Studies From Italy Cite
  Rossi M, Bosetti C, Negri E, Lagiou P, Vecchia CL. Flavonoids, Proanthocyanidins, and Cancer Risk: A Network of Case-Control Studies From Italy. Nutrition and Cancer. Informa UK Limited; 2010; 62:871-877 10.1080/01635581.2010.509534
• 5-Fluorouracil combined with apigenin enhances anticancer activity through induction of apoptosis in human breast cancer MDA-MB-453 cells Cite
  Choi . 5-Fluorouracil combined with apigenin enhances anticancer activity through induction of apoptosis in human breast cancer MDA-MB-453 cells. Oncology Reports. Spandidos Publications; 2009; 22 10.3892/or_00000598
• The Chemopreventive Flavonoid Apigenin Confers Radiosensitizing Effect in Human Tumor Cells Grown as Monolayers and Spheroids Cite
  WATANABE N, HIRAYAMA R, KUBOTA N. The Chemopreventive Flavonoid Apigenin Confers Radiosensitizing Effect in Human Tumor Cells Grown as Monolayers and Spheroids. Journal of Radiation Research. Oxford University Press (OUP); 2007; 48:45-50 10.1269/jrr.0635
• Differential modulation of cisplatin and doxorubicin efficacies in leukemia cells by flavonoids Cite
  Čipák L, Novotný L, Čipáková I, Rauko P. Differential modulation of cisplatin and doxorubicin efficacies in leukemia cells by flavonoids. Nutrition Research. Elsevier BV; 2003; 23:1045-1057 10.1016/s0271-5317(03)00078-2
• Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha Cite
  Seo H, DeNardo DG, Jacquot Y, Laïos I, Vidal DS, Zambrana CR, et al. Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2006; 99:121-134 10.1007/s10549-006-9191-2
• Degradation of HER2/neuby apigenin induces apoptosis through cytochromecrelease and caspase-3 activation in HER2/neu-overexpressing breast cancer cells Cite
  Way T, Kao M, Lin J. Degradation of HER2/neuby apigenin induces apoptosis through cytochromecrelease and caspase-3 activation in HER2/neu-overexpressing breast cancer cells. FEBS Letters. Wiley; 2004; 579:145-152 10.1016/j.febslet.2004.11.061
• Respiratory activity and phenolic compounds in pre-cut celery Cite
  Viña SZ, Chaves AR. Respiratory activity and phenolic compounds in pre-cut celery. Food Chemistry. Elsevier BV; 2007; 100:1654-1660 10.1016/j.foodchem.2005.12.060
• Antigenotoxic effect of apigenin against anti-cancerous drugs Cite
  Siddique YH, Beg T, Afzal M. Antigenotoxic effect of apigenin against anti-cancerous drugs. Toxicology in Vitro. Elsevier BV; 2008; 22:625-631 10.1016/j.tiv.2007.12.002
• Flavonoids and Breast Cancer Risk in Italy Cite
  Bosetti C. Flavonoids and Breast Cancer Risk in Italy. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2005; 14:805-808 10.1158/1055-9965.epi-04-0838
• Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells Cite
  Lee W, Chen W, Wang C, Lin W, Tseng T. Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells. Toxicology and Applied Pharmacology. Elsevier BV; 2008; 226:178-191 10.1016/j.taap.2007.09.013
• Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-α-dependent and estrogen receptor-α-independent mechanisms Cite
  Long X, Fan M, Bigsby RM, Nephew KP. Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-α-dependent and estrogen receptor-α-independent mechanisms. Molecular Cancer Therapeutics. American Association for Cancer Research (AACR); 2008; 7:2096-2108 10.1158/1535-7163.mct-07-2350
• Apigenin Induces Apoptosis through Proteasomal Degradation of HER2/neuin HER2/neu-overexpressing Breast Cancer Cells via the Phosphatidylinositol 3-Kinase/Akt-dependent Pathway Cite
  Way T, Kao M, Lin J. Apigenin Induces Apoptosis through Proteasomal Degradation of HER2/neuin HER2/neu-overexpressing Breast Cancer Cells via the Phosphatidylinositol 3-Kinase/Akt-dependent Pathway. Journal of Biological Chemistry. American Society for Biochemistry & Molecular Biology (ASBMB); 2003; 279:4479-4489 10.1074/jbc.m305529200