Tag: insulin

Articles

• High glycemic load should be avoided in breast cancer diet
• Type 2 diabetes increases breast cancer risk

News

06/09/22

Breast cancer cells increase access to glucose by interfering with insulin production

02/15/21

Time-restricted eating inhibits mammary tumor growth in obese mice

10/08/17

Use of metformin linked to lower recurrence among older BC survivors

04/28/13

High circulating insulin increases HER2+ tumor size and metastases

Studies

• Insulin and Insulin-like Growth Factor and Risk of Postmenopausal Estrogen Receptor–Positive Breast Cancer: A Case–Cohort Analysis Cite
  Albers FE, Swain CT, Lou MW, Dashti SG, Rinaldi S, Viallon V, et al. Insulin and Insulin-like Growth Factor and Risk of Postmenopausal Estrogen Receptor–Positive Breast Cancer: A Case–Cohort Analysis. Cancer Epidemiology, Biomarkers & Prevention. American Association for Cancer Research (AACR); 2025;:OF1-OF9 10.1158/1055-9965.epi-24-1304
• Investigating the relationship between insulin use and all-cause mortality, breast cancer mortality, and recurrence risk in diabetic patients with breast cancer: A comprehensive systematic review and meta-analysis Cite
  Loktionova MV, Mohammadian M, Choopani R, Kheiri S, Mohammadian-Hafshejani A. Investigating the relationship between insulin use and all-cause mortality, breast cancer mortality, and recurrence risk in diabetic patients with breast cancer: A comprehensive systematic review and meta-analysis. PLOS ONE. Public Library of Science (PLoS); 2024; 19:e0314565 10.1371/journal.pone.0314565
• Abstract A020: Elevated extracellular glucose level in tumor microenvironment by hyperglycemia increases glycolysis rate, stiffness, contractility, and motility of breast cancer cells through the cAMP-RhoA-Rock and AMPK-YAP-RhoA axes to promote metastasis Cite
  Kim T, Bhat AQ, Choe J, Yoon D. Abstract A020: Elevated extracellular glucose level in tumor microenvironment by hyperglycemia increases glycolysis rate, stiffness, contractility, and motility of breast cancer cells through the cAMP-RhoA-Rock and AMPK-YAP-RhoA axes to promote metastasis. Cancer Research. American Association for Cancer Research (AACR); 2024; 84:A020-A020 10.1158/1538-7445.tumbody-a020
• Breast Cancer Risk After Bariatric Surgery and Influence of Insulin Levels Cite
  Kristensson FM, Andersson-Assarsson JC, Peltonen M, Jacobson P, Ahlin S, Svensson P, et al. Breast Cancer Risk After Bariatric Surgery and Influence of Insulin Levels. JAMA Surgery. American Medical Association (AMA); 2024; 10.1001/jamasurg.2024.1169
• Abstract 2218: Dietary insulinemic potential and survival after breast cancer diagnosis Cite
  Romanos-Nanclares A, Wang T, Rosner BA, Holmes MD, Chen WY, Willett WC, et al. Abstract 2218: Dietary insulinemic potential and survival after breast cancer diagnosis. Cancer Research. American Association for Cancer Research (AACR); 2024; 84:2218-2218 10.1158/1538-7445.am2024-2218
• Antidiabetic Drugs in Breast Cancer Patients Cite
  Garczorz W, Kosowska A, Francuz T. Antidiabetic Drugs in Breast Cancer Patients. Cancers. MDPI AG; 2024; 16:299 10.3390/cancers16020299
• Association between prediabetes and breast cancer: a comprehensive meta-analysis Cite
  Keesari PR, Jain A, Ganampet NR, Subhasri GSD, Edusa S, Muslehuddin Z, et al. Association between prediabetes and breast cancer: a comprehensive meta-analysis. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2023; 10.1007/s10549-023-07181-x
• Insulin promotes growth in breast cancer cells through the type I IGF receptor in insulin receptor deficient cells Cite
  Monteiro M, Zhang X, Yee D. Insulin promotes growth in breast cancer cells through the type I IGF receptor in insulin receptor deficient cells. Experimental Cell Research. Elsevier BV; 2023;:113862 10.1016/j.yexcr.2023.113862
• 2275P Circulating leptin and adiponectin levels in premenopausal women with and without breast cancer (BC) and a body mass index (BMI) ≥25 kg/m2 Cite
  Calvo I, Argente M, Conde A, Sampayo M, Rodríguez MG, Yelo C, et al. 2275P Circulating leptin and adiponectin levels in premenopausal women with and without breast cancer (BC) and a body mass index (BMI) ≥25 kg/m2. Annals of Oncology. Elsevier BV; 2023; 34:S1167-S1168 10.1016/j.annonc.2023.09.1303
• Nutritional Metabolomics in Diet–Breast Cancer Relations: Current Research, Challenges, and Future Directions—A Review Cite
  Vahid F, Hajizadeghan K, Khodabakhshi A. Nutritional Metabolomics in Diet–Breast Cancer Relations: Current Research, Challenges, and Future Directions—A Review. Biomedicines. MDPI AG; 2023; 11:1845 10.3390/biomedicines11071845
• Does insulin make breast cancer cells resistant to doxorubicin toxicity? Cite
  Lykhova O, Zavelevich M, Philchenkov A, Vidasov N, Kozak T, Lozovska Y, et al. Does insulin make breast cancer cells resistant to doxorubicin toxicity?. Naunyn-Schmiedeberg's Archives of Pharmacology. Springer Science and Business Media LLC; 2023; 10.1007/s00210-023-02516-3
• The Insulin-like Growth Factor Signaling Pathway in Breast Cancer: An Elusive Therapeutic Target Cite
  Lee J, Tocheny CE, Shaw LM. The Insulin-like Growth Factor Signaling Pathway in Breast Cancer: An Elusive Therapeutic Target. Life. MDPI AG; 2022; 12:1992 10.3390/life12121992
• The metastatic spread of breast cancer accelerates during sleep Cite
  Diamantopoulou Z, Castro-Giner F, Schwab FD, Foerster C, Saini M, Budinjas S, et al. The metastatic spread of breast cancer accelerates during sleep. Nature. Springer Science and Business Media LLC; 2022; 10.1038/s41586-022-04875-y
• Metformin counteracts stimulatory effects induced by insulin in primary breast cancer cells Cite
  Scordamaglia D, Cirillo F, Talia M, Santolla MF, Rigiracciolo DC, Muglia L, et al. Metformin counteracts stimulatory effects induced by insulin in primary breast cancer cells. Journal of Translational Medicine. Springer Science and Business Media LLC; 2022; 20 10.1186/s12967-022-03463-y
• Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth Cite
  Cao M, Isaac R, Yan W, Ruan X, Jiang L, Wan Y, et al. Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth. Nature Cell Biology. Springer Science and Business Media LLC; 2022; 10.1038/s41556-022-00919-7
• Novel Mechanisms of Tumor Promotion by the Insulin Receptor Isoform A in Triple-Negative Breast Cancer Cells Cite
  Vella V, Giuliano M, La Ferlita A, Pellegrino M, Gaudenzi G, Alaimo S, et al. Novel Mechanisms of Tumor Promotion by the Insulin Receptor Isoform A in Triple-Negative Breast Cancer Cells. Cells. MDPI AG; 2021; 10:3145 10.3390/cells10113145
• Estrogen receptor variant ERα46 and insulin receptor drive in primary breast cancer cells growth effects and interleukin 11 induction prompting the motility of cancer‐associated fibroblasts Cite
  Cirillo F, Pellegrino M, Talia M, Perrotta ID, Rigiracciolo DC, Spinelli A, et al. Estrogen receptor variant ERα46 and insulin receptor drive in primary breast cancer cells growth effects and interleukin 11 induction prompting the motility of cancer‐associated fibroblasts. Clinical and Translational Medicine. Wiley; 2021; 11 10.1002/ctm2.516
• Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs Cite
  Olatunde A, Nigam M, Singh RK, Panwar AS, Lasisi A, Alhumaydhi FA, et al. Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs. Cancer Cell International. Springer Science and Business Media LLC; 2021; 21 10.1186/s12935-021-02202-5
• Impact of insulin use on outcomes of diabetic breast cancer patients: a systematic review and meta-analysis Cite
  Wang L, Zhang H, Liu Y, Chen G. Impact of insulin use on outcomes of diabetic breast cancer patients: a systematic review and meta-analysis. European Review for Medical and Pharmacological Sciences. Verduci Editore s.r.l.; 2021; 25:3507-3518. 10.26355/eurrev_202105_25833
• Postdiagnostic Dietary Glycemic Index, Glycemic Load, Dietary Insulin Index, and Insulin Load and Breast Cancer Survival Cite
  Farvid MS, Tamimi RM, Poole EM, Chen WY, Rosner BA, Willett WC, et al. Postdiagnostic Dietary Glycemic Index, Glycemic Load, Dietary Insulin Index, and Insulin Load and Breast Cancer Survival. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2020; 30:335-343 10.1158/1055-9965.epi-20-0764
• Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models Cite
  Das M, Ellies LG, Kumar D, Sauceda C, Oberg A, Gross E, et al. Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models. Nature Communications. Springer Science and Business Media LLC; 2021; 12 10.1038/s41467-020-20743-7
• Post-diagnostic dietary glycemic index, glycemic load, dietary insulin index, and insulin load and breast cancer survival Cite
  Farvid MS, Tamimi RM, Poole EM, Chen WY, Rosner BA, Willett WC, et al. Post-diagnostic dietary glycemic index, glycemic load, dietary insulin index, and insulin load and breast cancer survival. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2020;:cebp.0764.2020 10.1158/1055-9965.epi-20-0764
• Effects of Weight Loss and Weight Regain on Circulating Biomarkers in Overweight/Obese Breast Cancer Survivors Enrolled in a Weight Loss Trial in the Rural Midwest Cite
  Befort CA, Kimler BF, Bantis LE, Phillips TA, Fabian CJ. Effects of Weight Loss and Weight Regain on Circulating Biomarkers in Overweight/Obese Breast Cancer Survivors Enrolled in a Weight Loss Trial in the Rural Midwest. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2020; 29:1321-1328 10.1158/1055-9965.epi-19-1572
• Differential Effects of Insulin and IGF1 Receptors on ERK and AKT Subcellular Distribution in Breast Cancer Cells Cite
  Sarfstein R, Nagaraj K, LeRoith D, Werner H. Differential Effects of Insulin and IGF1 Receptors on ERK and AKT Subcellular Distribution in Breast Cancer Cells. Cells. MDPI AG; 2019; 8:1499 10.3390/cells8121499
• Association of antidiabetic medication and statins with breast cancer incidence in women with type 2 diabetes Cite
  Hosio M, Urpilainen E, Marttila M, Hautakoski A, Arffman M, Sund R, et al. Association of antidiabetic medication and statins with breast cancer incidence in women with type 2 diabetes. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2019; 175:741-748 10.1007/s10549-019-05185-0
• Association of Body Fat and Risk of Breast Cancer in Postmenopausal Women With Normal Body Mass Index Cite
  Iyengar NM, Arthur R, Manson JE, Chlebowski RT, Kroenke CH, Peterson L, et al. Association of Body Fat and Risk of Breast Cancer in Postmenopausal Women With Normal Body Mass Index. JAMA Oncology. American Medical Association (AMA); 2019; 5:155 10.1001/jamaoncol.2018.5327
• Long-term exposure to insulin and volumetric mammographic density: observational and genetic associations in the Karma study Cite
  Borgquist S, Rosendahl AH, Czene K, Bhoo-Pathy N, Dorkhan M, Hall P, et al. Long-term exposure to insulin and volumetric mammographic density: observational and genetic associations in the Karma study. Breast Cancer Research. Springer Science and Business Media LLC; 2018; 20 10.1186/s13058-018-1026-7
• Linoleic acid induces an increased response to insulin in MDA‐MB‐231 breast cancer cells Cite
  Rodriguez‐Monterrosas C, Diaz‐Aragon R, Cortes‐Reynosa P, Salazar EP. Linoleic acid induces an increased response to insulin in MDA‐MB‐231 breast cancer cells. Journal of Cellular Biochemistry. Wiley; 2018; 119:5413-5425 10.1002/jcb.26694
• Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells Cite
  Agrawal S, Wozniak M, Luc M, Walaszek K, Pielka E, Szeja W, et al. Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells. Oncotarget. Impact Journals, LLC; 2017; 8:114173-114182 10.18632/oncotarget.23170
• Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production Cite
  ter Braak B, Siezen CL, Lee JS, Rao P, Voorhoeve C, Ruppin E, et al. Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production. Breast Cancer Research. Springer Science and Business Media LLC; 2017; 19 10.1186/s13058-017-0802-0
• Long-Term Use of Long-Acting Insulin Analogs and Breast Cancer Incidence in Women With Type 2 Diabetes Cite
  Wu JW, Azoulay L, Majdan A, Boivin J, Pollak M, Suissa S. Long-Term Use of Long-Acting Insulin Analogs and Breast Cancer Incidence in Women With Type 2 Diabetes. Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2017; 35:3647-3653 10.1200/jco.2017.73.4491
• Diabetes Treatments and Risks of Adverse Breast Cancer Outcomes among Early-Stage Breast Cancer Patients: A SEER-Medicare Analysis Cite
  Chen L, Chubak J, Boudreau DM, Barlow WE, Weiss NS, Li CI. Diabetes Treatments and Risks of Adverse Breast Cancer Outcomes among Early-Stage Breast Cancer Patients: A SEER-Medicare Analysis. Cancer Research. American Association for Cancer Research (AACR); 2017; 77:6033-6041 10.1158/0008-5472.can-17-0687
• Pleiotropic effects of nutritional ketosis: Conceptual framework for keto-adaptation as a breast cancer therapy Cite
  Hyde PN, Lustberg MB, Miller VJ, LaFountain RA, Volek JS. Pleiotropic effects of nutritional ketosis: Conceptual framework for keto-adaptation as a breast cancer therapy. Cancer Treatment and Research Communications. Elsevier BV; 2017; 12:32-39 10.1016/j.ctarc.2017.06.001
• Impact of Diabetes, Insulin, and Metformin Use on the Outcome of Patients With Human Epidermal Growth Factor Receptor 2–Positive Primary Breast Cancer: Analysis From the ALTTO Phase III Randomized Trial Cite
  Sonnenblick A, Agbor-Tarh D, Bradbury I, Di Cosimo S, Azim HA, Fumagalli D, et al. Impact of Diabetes, Insulin, and Metformin Use on the Outcome of Patients With Human Epidermal Growth Factor Receptor 2–Positive Primary Breast Cancer: Analysis From the ALTTO Phase III Randomized Trial. Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2017; 35:1421-1429 10.1200/jco.2016.69.7722
• Long-term incidence of female-specific cancer after bariatric surgery or usual care in the Swedish Obese Subjects Study Cite
  Anveden Å, Taube M, Peltonen M, Jacobson P, Andersson-Assarsson JC, Sjöholm K, et al. Long-term incidence of female-specific cancer after bariatric surgery or usual care in the Swedish Obese Subjects Study. Gynecologic Oncology. Elsevier BV; 2017; 145:224-229 10.1016/j.ygyno.2017.02.036
• Insulin use, adipokine profiles and breast cancer prognosis Cite
  Wintrob ZA, Hammel JP, Khoury T, Nimako GK, Fu H, Fayazi ZS, et al. Insulin use, adipokine profiles and breast cancer prognosis. Cytokine. Elsevier BV; 2017; 89:45-61 10.1016/j.cyto.2016.10.017
• Effects of Exercise on Insulin, IGF Axis, Adipocytokines, and Inflammatory Markers in Breast Cancer Survivors: A Systematic Review and Meta-analysis Cite
  Kang D, Lee J, Suh S, Ligibel J, Courneya KS, Jeon JY. Effects of Exercise on Insulin, IGF Axis, Adipocytokines, and Inflammatory Markers in Breast Cancer Survivors: A Systematic Review and Meta-analysis. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2016; 26:355-365 10.1158/1055-9965.epi-16-0602
• Pretreatment Insulin Levels as a Prognostic Factor for Breast Cancer Progression Cite
  Ferroni P, Riondino S, Laudisi A, Portarena I, Formica V, Alessandroni J, et al. Pretreatment Insulin Levels as a Prognostic Factor for Breast Cancer Progression. The Oncologist. Wiley; 2016; 21:1041-1049 10.1634/theoncologist.2015-0462
• Non-metabolisable insulin glargine does not promote breast cancer growth in a mouse model of type 2 diabetes Cite
  Gallagher EJ, Zelenko Z, Tobin-Hess A, Werner U, Tennagels N, LeRoith D. Non-metabolisable insulin glargine does not promote breast cancer growth in a mouse model of type 2 diabetes. Diabetologia. Springer Science and Business Media LLC; 2016; 59:2018-2025 10.1007/s00125-016-4000-x
• Insulin glargine use and breast cancer risk: Associations with cumulative exposure Cite
  Peeters PJHL, Bazelier MT, Leufkens HGM, Auvinen A, van Staa TP, de Vries F, et al. Insulin glargine use and breast cancer risk: Associations with cumulative exposure. Acta Oncologica. Informa UK Limited; 2016; 55:851-858 10.3109/0284186x.2016.1155736
• Type 2 diabetes, insulin treatment and prognosis of breast cancer Cite
  Mu L, Zhu N, Zhang J, Xing F, Li D, Wang X. Type 2 diabetes, insulin treatment and prognosis of breast cancer. Diabetes/Metabolism Research and Reviews. Wiley; 2016; 33:e2823 10.1002/dmrr.2823
• High glucose and insulin enhance uPA expression, ROS formation and invasiveness in breast cancer-derived cells Cite
  Flores-López LA, Martínez-Hernández MG, Viedma-Rodríguez R, Díaz-Flores M, Baiza-Gutman LA. High glucose and insulin enhance uPA expression, ROS formation and invasiveness in breast cancer-derived cells. Cellular Oncology. Springer Science and Business Media LLC; 2016; 39:365-378 10.1007/s13402-016-0282-8
• Comparative safety of diabetes medications and risk of incident invasive breast cancer: a population-based cohort study Cite
  Calip GS, Yu O, Elmore JG, Boudreau DM. Comparative safety of diabetes medications and risk of incident invasive breast cancer: a population-based cohort study. Cancer Causes & Control. Springer Science and Business Media LLC; 2016; 27:709-720 10.1007/s10552-016-0744-3
• From obesity to diabetes and cancer: epidemiological links and role of therapies Cite
  García-Jiménez C, Gutiérrez-Salmerón M, Chocarro-Calvo A, García-Martinez JM, Castaño A, De la Vieja A. From obesity to diabetes and cancer: epidemiological links and role of therapies. British Journal of Cancer. Springer Science and Business Media LLC; 2016; 114:716-722 10.1038/bjc.2016.37
• Serum glucose and hemoglobin A1C levels at cancer diagnosis and disease outcome Cite
  Boursi B, Giantonio BJ, Lewis JD, Haynes K, Mamtani R, Yang Y. Serum glucose and hemoglobin A1C levels at cancer diagnosis and disease outcome. European Journal of Cancer. Elsevier BV; 2016; 59:90-98 10.1016/j.ejca.2016.02.018
• Diabetes, diabetes treatment, and mammographic density in Danish Diet, Cancer, and Health cohort Cite
  Buschard K, Thomassen K, Lynge E, Vejborg I, Tjønneland A, von Euler-Chelpin M, et al. Diabetes, diabetes treatment, and mammographic density in Danish Diet, Cancer, and Health cohort. Cancer Causes & Control. Springer Science and Business Media LLC; 2016; 28:13-21 10.1007/s10552-016-0829-z
• Systemic Correlates of White Adipose Tissue Inflammation in Early-Stage Breast Cancer Cite
  Iyengar NM, Zhou XK, Gucalp A, Morris PG, Howe LR, Giri DD, et al. Systemic Correlates of White Adipose Tissue Inflammation in Early-Stage Breast Cancer. Clinical Cancer Research. American Association for Cancer Research (AACR); 2015; 22:2283-2289 10.1158/1078-0432.ccr-15-2239
• Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence Cite
  Bronsveld HK, ter Braak B, Karlstad Ø, Vestergaard P, Starup-Linde J, Bazelier MT, et al. Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence. Breast Cancer Research. Springer Science and Business Media LLC; 2015; 17 10.1186/s13058-015-0611-2
• Inhibition of Type I Insulin-Like Growth Factor Receptor Signaling Attenuates the Development of Breast Cancer Brain Metastasis Cite
  Saldana SM, Lee H, Lowery FJ, Khotskaya YB, Xia W, Zhang C, et al. Inhibition of Type I Insulin-Like Growth Factor Receptor Signaling Attenuates the Development of Breast Cancer Brain Metastasis. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e73406 10.1371/journal.pone.0073406
• Prognostic value of insulin-like growth factor 1 and insulin-like growth factor binding protein 3 blood levels in breast cancer Cite
  Hartog H, Boezen H, de Jong M, Schaapveld M, Wesseling J, van der Graaf W. Prognostic value of insulin-like growth factor 1 and insulin-like growth factor binding protein 3 blood levels in breast cancer. The Breast. Elsevier BV; 2013; 22:1155-1160 10.1016/j.breast.2013.07.038
• High glucose and insulin differentially modulates proliferation in MCF-7 and MDA-MB-231 cells Cite
  Gupta C, Tikoo K. High glucose and insulin differentially modulates proliferation in MCF-7 and MDA-MB-231 cells. Journal of Molecular Endocrinology. Bioscientifica; 2013; 51:119-129 10.1530/jme-13-0062
• Hyperinsulinemia promotes metastasis to the lung in a mouse model of Her2-mediated breast cancer Cite
  Ferguson RD, Gallagher EJ, Cohen D, Tobin-Hess A, Alikhani N, Novosyadlyy R, et al. Hyperinsulinemia promotes metastasis to the lung in a mouse model of Her2-mediated breast cancer. Endocrine-Related Cancer. Bioscientifica; 2013; 20:391-401 10.1530/erc-12-0333
• Investigating New Therapeutic Strategies Targeting Hyperinsulinemia's Mitogenic Effects in a Female Mouse Breast Cancer Model Cite
  Rostoker R, Bitton-Worms K, Caspi A, Shen-Orr Z, LeRoith D. Investigating New Therapeutic Strategies Targeting Hyperinsulinemia's Mitogenic Effects in a Female Mouse Breast Cancer Model. Endocrinology. The Endocrine Society; 2013; 154:1701-1710 10.1210/en.2012-2263
• Favorable Changes in Serum Estrogens and Other Biologic Factors After Weight Loss in Breast Cancer Survivors Who are Overweight or Obese Cite
  Rock CL, Pande C, Flatt SW, Ying C, Pakiz B, Parker BA, et al. Favorable Changes in Serum Estrogens and Other Biologic Factors After Weight Loss in Breast Cancer Survivors Who are Overweight or Obese. Clinical Breast Cancer. Elsevier BV; 2013; 13:188-195 10.1016/j.clbc.2012.12.002
• Targeting insulin inhibition as a metabolic therapy in advanced cancer: A pilot safety and feasibility dietary trial in 10 patients Cite
  Fine EJ, Segal-Isaacson C, Feinman RD, Herszkopf S, Romano MC, Tomuta N, et al. Targeting insulin inhibition as a metabolic therapy in advanced cancer: A pilot safety and feasibility dietary trial in 10 patients. Nutrition. Elsevier BV; 2012; 28:1028-1035 10.1016/j.nut.2012.05.001
• Dietary glycemic index and glycemic load and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cite
  Romieu I, Ferrari P, Rinaldi S, Slimani N, Jenab M, Olsen A, et al. Dietary glycemic index and glycemic load and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). The American Journal of Clinical Nutrition. Oxford University Press (OUP); 2012; 96:345-355 10.3945/ajcn.111.026724
• Diabetes, Metformin, and Breast Cancer in Postmenopausal Women Cite
  Chlebowski RT, McTiernan A, Wactawski-Wende J, Manson JE, Aragaki AK, Rohan T, et al. Diabetes, Metformin, and Breast Cancer in Postmenopausal Women. Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2012; 30:2844-2852 10.1200/jco.2011.39.7505
• Effect of Different Doses of Metformin on Serum Testosterone and Insulin in Non-Diabetic Women With Breast Cancer: A Randomized Study Cite
  Campagnoli C, Pasanisi P, Abbà C, Ambroggio S, Biglia N, Brucato T, et al. Effect of Different Doses of Metformin on Serum Testosterone and Insulin in Non-Diabetic Women With Breast Cancer: A Randomized Study. Clinical Breast Cancer. Elsevier BV; 2012; 12:175-182 10.1016/j.clbc.2012.03.004
• Quantifying Mediating Effects of Endogenous Estrogen and Insulin in the Relation between Obesity, Alcohol Consumption, and Breast Cancer Cite
  Hvidtfeldt UA, Gunter MJ, Lange T, Chlebowski RT, Lane D, Farhat GN, et al. Quantifying Mediating Effects of Endogenous Estrogen and Insulin in the Relation between Obesity, Alcohol Consumption, and Breast Cancer. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2012; 21:1203-1212 10.1158/1055-9965.epi-12-0310
• Effect of oral phytoestrogen on androgenicity and insulin sensitivity in postmenopausal women Cite
  Lee CC, Bloem CJ, Kasa-Vubu JZ, Liang L. Effect of oral phytoestrogen on androgenicity and insulin sensitivity in postmenopausal women. Diabetes, Obesity and Metabolism. Wiley; 2011; 14:315-319 10.1111/j.1463-1326.2011.01532.x
• Effects of Energy Restriction and Wheel Running on Mammary Carcinogenesis and Host Systemic Factors in a Rat Model Cite
  Zhu Z, Jiang W, Zacher JH, Neil ES, McGinley JN, Thompson HJ. Effects of Energy Restriction and Wheel Running on Mammary Carcinogenesis and Host Systemic Factors in a Rat Model. Cancer Prevention Research. American Association for Cancer Research (AACR); 2012; 5:414-422 10.1158/1940-6207.capr-11-0454
• Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer Cite
  He X, Esteva F, Ensor J, Hortobagyi G, Lee M, Yeung SJ. Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer. Annals of Oncology. Elsevier BV; 2012; 23:1771-1780 10.1093/annonc/mdr534
• Cell signaling pathways associated with a reduction in mammary cancer burden by dietary common bean ( Phaseolus vulgaris L.) Cite
  Thompson MD, Mensack MM, Jiang W, Zhu Z, Lewis MR, McGinley JN, et al. Cell signaling pathways associated with a reduction in mammary cancer burden by dietary common bean ( Phaseolus vulgaris L.). Carcinogenesis. Oxford University Press (OUP); 2011; 33:226-232 10.1093/carcin/bgr247
• The relationship between the exposure time of insulin glargine and risk of breast and prostate cancer: An observational study of the time-dependent effects of antidiabetic treatments in patients with diabetes Cite
  Lind M, Fahlén M, Eliasson B, Odén A. The relationship between the exposure time of insulin glargine and risk of breast and prostate cancer: An observational study of the time-dependent effects of antidiabetic treatments in patients with diabetes. Primary Care Diabetes. Elsevier BV; 2012; 6:53-59 10.1016/j.pcd.2011.10.004
• Long-term effects of insulin glargine on the risk of breast cancer Cite
  Suissa S, Azoulay L, Dell’Aniello S, Evans M, Vora J, Pollak M. Long-term effects of insulin glargine on the risk of breast cancer. Diabetologia. Springer Science and Business Media LLC; 2011; 54:2254-2262 10.1007/s00125-011-2190-9
• Abstract 1812: Effects of vitamin D on obesity-induced increase in ER-positive and ER-negative mammary cancer in mice Cite
  Yu W, Kim D, Sumis A, Hilakivi-clarke L. Abstract 1812: Effects of vitamin D on obesity-induced increase in ER-positive and ER-negative mammary cancer in mice. Epidemiology. American Association for Cancer Research; 2011; 10.1158/1538-7445.am2011-1812
• Effects of Tomato- and Soy-Rich Diets on the IGF-I Hormonal Network: A Crossover Study of Postmenopausal Women at High Risk for Breast Cancer Cite
  McLaughlin JM, Olivo-Marston S, Vitolins MZ, Bittoni M, Reeves KW, Degraffinreid CR, et al. Effects of Tomato- and Soy-Rich Diets on the IGF-I Hormonal Network: A Crossover Study of Postmenopausal Women at High Risk for Breast Cancer. Cancer Prevention Research. American Association for Cancer Research (AACR); 2011; 4:702-710 10.1158/1940-6207.capr-10-0329
• Fasting C-Peptide Levels and Death Resulting From All Causes and Breast Cancer: The Health, Eating, Activity, and Lifestyle Study Cite
  Irwin ML, Duggan C, Wang C, Smith AW, McTiernan A, Baumgartner RN, et al. Fasting C-Peptide Levels and Death Resulting From All Causes and Breast Cancer: The Health, Eating, Activity, and Lifestyle Study. Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2011; 29:47-53 10.1200/jco.2010.28.4752
• Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy Cite
  Phoenix KN, Vumbaca F, Fox MM, Evans R, Claffey KP. Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2009; 123:333-344 10.1007/s10549-009-0647-z
• Physical Activity and Postmenopausal Breast Cancer: Proposed Biologic Mechanisms and Areas for Future Research Cite
  Neilson HK, Friedenreich CM, Brockton NT, Millikan RC. Physical Activity and Postmenopausal Breast Cancer: Proposed Biologic Mechanisms and Areas for Future Research. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2009; 18:11-27 10.1158/1055-9965.epi-08-0756
• A high protein moderate carbohydrate diet fed at discrete meals reduces early progression of N-methyl-N-nitrosourea-induced breast tumorigenesis in rats Cite
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