Tag: alphaLinolenicAcid

News

05/22/16

Plant-based omega-3 fatty acid ALA reduces ER+/PR+ BC growth

01/04/16

Walnut compounds have chemopreventive actions

04/23/12

High omega-6 in cooking oils interferes with vegetable omega-3

Foods

• • canola oil
  • flaxseed
  • walnuts

Studies

• The Antitumor Effects of α-Linolenic Acid Cite
  Yan H, Zhang S, Yang L, Jiang M, Xin Y, Liao X, et al. The Antitumor Effects of α-Linolenic Acid. Journal of Personalized Medicine. MDPI AG; 2024; 14:260 10.3390/jpm14030260
• Cecal microbiota and mammary gland microRNA signatures are related and modifiable by dietary flaxseed with implications for breast cancer risk Cite
  Wu D, Thompson LU, Comelli EM. Cecal microbiota and mammary gland microRNA signatures are related and modifiable by dietary flaxseed with implications for breast cancer risk. Microbiology Spectrum. American Society for Microbiology; 2023; 10.1128/spectrum.02290-23
• Erythrocyte membrane n-3 polyunsaturated fatty acid are inversely associated with breast cancer risk among Chinese women Cite
  Zhang Z, Ho SC, Shi D, Zhan X, Wu Q, Xu L, et al. Erythrocyte membrane n-3 polyunsaturated fatty acid are inversely associated with breast cancer risk among Chinese women. British Journal of Nutrition. Cambridge University Press (CUP); 2023;:1-28 10.1017/s0007114523001447
• Antioxidant and Anti-Inflammatory Properties of Walnut Constituents: Focus on Personalized Cancer Prevention and the Microbiome Cite
  Fan N, Fusco JL, Rosenberg DW. Antioxidant and Anti-Inflammatory Properties of Walnut Constituents: Focus on Personalized Cancer Prevention and the Microbiome. Antioxidants. MDPI AG; 2023; 12:982 10.3390/antiox12050982
• α‐linolenic acid interconversion is sufficient as a source of longer chain ω‐3 polyunsaturated fatty acids in humans: An opinion Cite
  Burdge GC. α‐linolenic acid interconversion is sufficient as a source of longer chain ω‐3 polyunsaturated fatty acids in humans: An opinion. Lipids. Wiley; 2022; 10.1002/lipd.12355
• Association of dietary intake of n-3 polyunsaturated fatty acids with breast cancer risk in pre- and postmenopausal Chinese women Cite
  Zhang Z, Ho SC, Liu K, Mo X, Feng X, Li L, et al. Association of dietary intake of n-3 polyunsaturated fatty acids with breast cancer risk in pre- and postmenopausal Chinese women. Menopause. Ovid Technologies (Wolters Kluwer Health); 2022; 29:932-943 10.1097/gme.0000000000001990
• In Vivo Antitumoral Effects of Linseed Oil and Its Combination With Doxorubicin Cite
  Shadyro O, Sosnovskaya A, Edimecheva I, Ihnatovich L, Dubovik B, Krasny S, et al. In Vivo Antitumoral Effects of Linseed Oil and Its Combination With Doxorubicin. Frontiers in Pharmacology. Frontiers Media SA; 2022; 13 10.3389/fphar.2022.882197
• α-Linolenic acid induces apoptosis, inhibits the invasion and metastasis, and arrests cell cycle in human breast cancer cells by inhibiting fatty acid synthase Cite
  Huang W, Guo X, Wang C, Alzhan A, Liu Z, Ma X, et al. α-Linolenic acid induces apoptosis, inhibits the invasion and metastasis, and arrests cell cycle in human breast cancer cells by inhibiting fatty acid synthase. Journal of Functional Foods. Elsevier BV; 2022; 92:105041 10.1016/j.jff.2022.105041
• Fatty acids and their lipid mediators in the induction of cellular apoptosis in cancer cells Cite
  Biswas P, Datta C, Rathi P, Bhattacharjee A. Fatty acids and their lipid mediators in the induction of cellular apoptosis in cancer cells. Prostaglandins & Other Lipid Mediators. Elsevier BV; 2022;:106637 10.1016/j.prostaglandins.2022.106637
• Futuristic food fortification with a balanced ratio of dietary ω-3/ω-6 omega fatty acids for the prevention of lifestyle diseases Cite
  Patel A, Desai SS, Mane VK, Enman J, Rova U, Christakopoulos P, et al. Futuristic food fortification with a balanced ratio of dietary ω-3/ω-6 omega fatty acids for the prevention of lifestyle diseases. Trends in Food Science & Technology. Elsevier BV; 2022; 120:140-153 10.1016/j.tifs.2022.01.006
• Effects of plant-based versus marine-based omega-3 fatty acids and sucrose on brain and liver fatty acids in a mouse model of chemotherapy Cite
  Ormiston K, Gaudier-Diaz MM, TinKai T, Fitzgerald J, Cole RM, Andridge R, et al. Effects of plant-based versus marine-based omega-3 fatty acids and sucrose on brain and liver fatty acids in a mouse model of chemotherapy. Nutritional Neuroscience. Informa UK Limited; 2021;:1-9 10.1080/1028415x.2021.1998296
• Dietary intake and biomarkers of alpha linolenic acid and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of cohort studies Cite
  Naghshi S, Aune D, Beyene J, Mobarak S, Asadi M, Sadeghi O. Dietary intake and biomarkers of alpha linolenic acid and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of cohort studies. BMJ. BMJ; 2021;:n2213 10.1136/bmj.n2213
• Altered Levels of Desaturation and ω-6 Fatty Acids in Breast Cancer Patients’ Red Blood Cell Membranes Cite
  Amézaga J, Ugartemendia G, Larraioz A, Bretaña N, Iruretagoyena A, Camba J, et al. Altered Levels of Desaturation and ω-6 Fatty Acids in Breast Cancer Patients’ Red Blood Cell Membranes. Metabolites. MDPI AG; 2020; 10:469 10.3390/metabo10110469
• α-Linolenic acid inhibits the migration of human triple-negative breast cancer cells by attenuating Twist1 expression and suppressing Twist1-mediated epithelial-mesenchymal transition Cite
  Wang S, Sun H, Hsu Y, Liu S, Lii C, Tsai C, et al. α-Linolenic acid inhibits the migration of human triple-negative breast cancer cells by attenuating Twist1 expression and suppressing Twist1-mediated epithelial-mesenchymal transition. Biochemical Pharmacology. Elsevier BV; 2020; 180:114152 10.1016/j.bcp.2020.114152
• Flaxseed extracts induce apoptosis and regulate the growth of MCF-7 human breast cancer cells Cite
  Hu T, Xiao J. Flaxseed extracts induce apoptosis and regulate the growth of MCF-7 human breast cancer cells. Free Radical Biology and Medicine. Elsevier BV; 2018; 128:S117 10.1016/j.freeradbiomed.2018.10.286
• Omega-3 Polyunsaturated Fatty Acids Time-Dependently Reduce Cell Viability and Oncogenic MicroRNA-21 Expression in Estrogen Receptor-Positive Breast Cancer Cells (MCF-7) Cite
  LeMay-Nedjelski L, Mason-Ennis J, Taibi A, Comelli E, Thompson L. Omega-3 Polyunsaturated Fatty Acids Time-Dependently Reduce Cell Viability and Oncogenic MicroRNA-21 Expression in Estrogen Receptor-Positive Breast Cancer Cells (MCF-7). International Journal of Molecular Sciences. MDPI AG; 2018; 19:244 10.3390/ijms19010244
• Marine fish oil is more potent than plant-based n-3 polyunsaturated fatty acids in the prevention of mammary tumors Cite
  Liu J, Abdelmagid SA, Pinelli CJ, Monk JM, Liddle DM, Hillyer LM, et al. Marine fish oil is more potent than plant-based n-3 polyunsaturated fatty acids in the prevention of mammary tumors. The Journal of Nutritional Biochemistry. Elsevier BV; 2017; 55:41-52 10.1016/j.jnutbio.2017.12.011
• Erythrocyte membrane fatty acids and breast cancer risk: a prospective analysis in the nurses' health study II Cite
  Hirko KA, Chai B, Spiegelman D, Campos H, Farvid MS, Hankinson SE, et al. Erythrocyte membrane fatty acids and breast cancer risk: a prospective analysis in the nurses' health study II. International Journal of Cancer. Wiley; 2017; 142:1116-1129 10.1002/ijc.31133
• The ratio of 1/3 linoleic acid to alpha linolenic acid is optimal for oligodendrogenesis of embryonic neural stem cells Cite
  Hejr H, Ghareghani M, Zibara K, Ghafari M, Sadri F, Salehpour Z, et al. The ratio of 1/3 linoleic acid to alpha linolenic acid is optimal for oligodendrogenesis of embryonic neural stem cells. Neuroscience Letters. Elsevier BV; 2017; 651:216-225 10.1016/j.neulet.2017.05.020
• Exploration of mechanisms of α-linolenic acid in reducing the growth of oestrogen receptor positive breast cancer cells (MCF-7) Cite
  Mason-Ennis JK, LeMay-Nedjelski LP, Wiggins AK, Thompson LU. Exploration of mechanisms of α-linolenic acid in reducing the growth of oestrogen receptor positive breast cancer cells (MCF-7). Journal of Functional Foods. Elsevier BV; 2016; 24:513-519 10.1016/j.jff.2016.04.037
• Increased dietary levels of α-linoleic acid inhibit mammary tumor growth and metastasis Cite
  Vara-Messler M, Pasqualini ME, Comba A, Silva R, Buccellati C, Trenti A, et al. Increased dietary levels of α-linoleic acid inhibit mammary tumor growth and metastasis. European Journal of Nutrition. Springer Science and Business Media LLC; 2015; 56:509-519 10.1007/s00394-015-1096-6
• α-Linolenic Acid Reduces Growth of Both Triple Negative and Luminal Breast Cancer Cells in High and Low Estrogen Environments Cite
  Wiggins AKA, Kharotia S, Mason JK, Thompson LU. α-Linolenic Acid Reduces Growth of Both Triple Negative and Luminal Breast Cancer Cells in High and Low Estrogen Environments. Nutrition and Cancer. Informa UK Limited; 2015; 67:1001-1009 10.1080/01635581.2015.1053496
• Growth and gene expression differ over time in alpha-linolenic acid treated breast cancer cells Cite
  Wiggins AK, Mason JK, Thompson LU. Growth and gene expression differ over time in alpha-linolenic acid treated breast cancer cells. Experimental Cell Research. Elsevier BV; 2015; 333:147-154 10.1016/j.yexcr.2015.02.020
• Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies Cite
  Zheng J, Hu X, Zhao Y, Yang J, Li D. Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies. BMJ. BMJ; 2013; 346:f3706-f3706 10.1136/bmj.f3706
• Plasma Fatty Acid Ratios Affect Blood Gene Expression Profiles - A Cross-Sectional Study of the Norwegian Women and Cancer Post-Genome Cohort Cite
  Olsen KS, Fenton C, Frøyland L, Waaseth M, Paulssen RH, Lund E. Plasma Fatty Acid Ratios Affect Blood Gene Expression Profiles - A Cross-Sectional Study of the Norwegian Women and Cancer Post-Genome Cohort. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e67270 10.1371/journal.pone.0067270
• Uptake of α-Linolenic Acid and Its Conversion to Long Chain Omega-3 Fatty Acids in Rats Fed Microemulsions of Linseed Oil Cite
  Sugasini D, Lokesh BR. Uptake of α-Linolenic Acid and Its Conversion to Long Chain Omega-3 Fatty Acids in Rats Fed Microemulsions of Linseed Oil. Lipids. Wiley; 2012; 47:1155-1167 10.1007/s11745-012-3731-9
• Mechanistic Examination of Walnuts in Prevention of Breast Cancer Cite
  Heuvel JPV, Belda BJ, Hannon DB, Kris-Etherton PM, Grieger JA, Zhang J, et al. Mechanistic Examination of Walnuts in Prevention of Breast Cancer. Nutrition and Cancer. Informa UK Limited; 2012; 64:1078-1086 10.1080/01635581.2012.717679
• Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats Cite
  Poudyal H, Panchal SK, Ward LC, Brown L. Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. The Journal of Nutritional Biochemistry. Elsevier BV; 2013; 24:1041-1052 10.1016/j.jnutbio.2012.07.014
• Fatty acid profile, trans-octadecenoic, α-linolenic and conjugated linoleic acid contents differing in certified organic and conventional probiotic fermented milks Cite
  Florence ACR, Béal C, Silva RC, Bogsan CS, Pilleggi ALO, Gioielli LA, et al. Fatty acid profile, trans-octadecenoic, α-linolenic and conjugated linoleic acid contents differing in certified organic and conventional probiotic fermented milks. Food Chemistry. Elsevier BV; 2012; 135:2207-2214 10.1016/j.foodchem.2012.07.026
• Organic milk improves Bifidobacterium lactis counts and bioactive fatty acids contents in fermented milk Cite
  Florence ACR, Oliveira RP, Silva RC, Soares FA, Gioielli LA, Oliveira MN. Organic milk improves Bifidobacterium lactis counts and bioactive fatty acids contents in fermented milk. LWT. Elsevier BV; 2012; 49:89-95 10.1016/j.lwt.2012.04.023
• Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids Cite
  Gibson R, Neumann M, Lien E, Boyd K, Tu W. Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. Prostaglandins, Leukotrienes and Essential Fatty Acids. Elsevier BV; 2013; 88:139-146 10.1016/j.plefa.2012.04.003
• Dietary intakes of ω-6 and ω-3 polyunsaturated fatty acids and the risk of breast cancer Cite
  Thiébaut AC, Chajès V, Gerber M, Boutron-Ruault M, Joulin V, Lenoir G, et al. Dietary intakes of ω-6 and ω-3 polyunsaturated fatty acids and the risk of breast cancer. International Journal of Cancer. Wiley; 2009; 124:924-931 10.1002/ijc.23980
• N-3 fatty acids in the Mediterranean diet Cite
  Galli C, Marangoni F. N-3 fatty acids in the Mediterranean diet. Prostaglandins, Leukotrienes and Essential Fatty Acids. Elsevier BV; 2006; 75:129-133 10.1016/j.plefa.2006.05.007
• The effect of dietary walnuts compared to fatty fish on eicosanoids, cytokines, soluble endothelial adhesion molecules and lymphocyte subsets: a randomized, controlled crossover trial Cite
  Chiang Y, Haddad E, Rajaram S, Shavlik D, Sabaté J. The effect of dietary walnuts compared to fatty fish on eicosanoids, cytokines, soluble endothelial adhesion molecules and lymphocyte subsets: a randomized, controlled crossover trial. Prostaglandins, Leukotrienes and Essential Fatty Acids. Elsevier BV; 2012; 87:111-117 10.1016/j.plefa.2012.07.007
• Dietary fatty acids regulate the activation status of Her-2/neu (c-erbB-2) oncogene in breast cancer cells Cite
  Menendez J, Ropero S, Lupu R, Colomer R. Dietary fatty acids regulate the activation status of Her-2/neu (c-erbB-2) oncogene in breast cancer cells. Annals of Oncology. Elsevier BV; 2004; 15:1719-1721 10.1093/annonc/mdh442
• HER2 (erbB-2)-targeted effects of the ϖ-3 polyunsaturated. Fatty acid α-linolenic acid (ALA; 18:3n-3) in breast cancer cells: the «fat features» of the «Mediterranean diet» as an «anti-HER2 cocktail» Cite
  Menéndez JA, Vázquez-Martín A, Ropero S, Colomer R, Lupu R, Trueta J. HER2 (erbB-2)-targeted effects of the ϖ-3 polyunsaturated. Fatty acid α-linolenic acid (ALA; 18:3n-3) in breast cancer cells: the «fat features» of the «Mediterranean diet» as an «anti-HER2 cocktail». Clinical and Translational Oncology. Springer Science and Business Media LLC; 2006; 8:812-820 10.1007/s12094-006-0137-2
• Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells Cite
  Menéndez J, del Mar Barbacid M, Montero S, Sevilla E, Escrich E, Solanas M, et al. Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells. European Journal of Cancer. Elsevier BV; 2001; 37:402-413 10.1016/s0959-8049(00)00408-1