Tag: rosmarinicAcid

News

07/23/25

Rosmarinic acid can cause ER+/PR+ cell death by inhibiting integrin-linked kinase

Foods

• • holy basil
  • Mexican oregano
  • mint
  • oregano
  • rosemary
  • sage
  • thyme

Studies

• Rosmarinus officinalis suppresses cancer cell viability and inflammatory mediators in RAW 264.7 cells: in vitro and in silico analysis Cite
  Assaggaf H, Hachlafi NE, Mrabti NN, Taibi M, Elbouzidi A, Qasem A, et al. Rosmarinus officinalis suppresses cancer cell viability and inflammatory mediators in RAW 264.7 cells: in vitro and in silico analysis. Discover Oncology. Springer Science and Business Media LLC; 2025; 16 10.1007/s12672-025-02957-7
• The role of the miR-30a-5p/BCL2L11 pathway in rosmarinic acid-induced apoptosis in MDA-MB-231-derived breast cancer stem-like cells Cite
  Wang W, Zhang Y, Huang X, Li D, Lin Q, Zhuang H, et al. The role of the miR-30a-5p/BCL2L11 pathway in rosmarinic acid-induced apoptosis in MDA-MB-231-derived breast cancer stem-like cells. Frontiers in Pharmacology. Frontiers Media SA; 2024; 15 10.3389/fphar.2024.1445034
• Identification of rosmarinic acid as a potent inhibitor of integrin-linked kinase (ILK) with anticancer activity in breast cancer cells Cite
  Wahab S, Alshehri SA, Usmani S, Almoyad MAA, Ahmad W. Identification of rosmarinic acid as a potent inhibitor of integrin-linked kinase (ILK) with anticancer activity in breast cancer cells. South African Journal of Botany. Elsevier BV; 2025; 184:362-375 10.1016/j.sajb.2025.06.013
• In Vitro Therapeutic Potential and Morphological Effects of Rosmarinic Acid Derivatives on Triple‐Negative Breast Cancer Cell Line Cite
  Yesilay G, Bolat ZB, Hocaoglu G, Aydin ZB, Mermer A. In Vitro Therapeutic Potential and Morphological Effects of Rosmarinic Acid Derivatives on Triple‐Negative Breast Cancer Cell Line. ChemistrySelect. Wiley; 2025; 10 10.1002/slct.202404422
• Rosmarinus officinalis L. as Fascinating Source of Potential Anticancer Agents Targeting Aromatase and COX-2: An Overview Cite
  Gargano A, Greco I, Lupia C, Alcaro S, Ambrosio FA. Rosmarinus officinalis L. as Fascinating Source of Potential Anticancer Agents Targeting Aromatase and COX-2: An Overview. Molecules. MDPI AG; 2025; 30:1733 10.3390/molecules30081733
• Rosmarinic acid promotes mitochondrial fission and induces ferroptosis in triple-negative breast cancer cells Cite
  Xie C, Chan L, Pang Y, Shang Y, Wang W, Zhao L. Rosmarinic acid promotes mitochondrial fission and induces ferroptosis in triple-negative breast cancer cells. Naunyn-Schmiedeberg's Archives of Pharmacology. Springer Science and Business Media LLC; 2025; 10.1007/s00210-025-03927-0
• Anti-proliferative effects of Rosmarinus officinalis L. (Rosemary) against human breast and liver carcinoma cells Cite
  Darra R, Majdalawieh AF, Mahasneh A, Rah B, Hamad M, Kanan SM. Anti-proliferative effects of Rosmarinus officinalis L. (Rosemary) against human breast and liver carcinoma cells. Food Bioscience. Elsevier BV; 2025; 65:106164 10.1016/j.fbio.2025.106164
• The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity Cite
  Kowalczyk A, Tuberoso CIG, Jerković I. The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity. Antioxidants. MDPI AG; 2024; 13:1313 10.3390/antiox13111313
• Review on effects and mechanisms of plant-derived natural products against breast cancer bone metastasis Cite
  Zhang X, Miao J, Song Y, Zhang J, Miao M. Review on effects and mechanisms of plant-derived natural products against breast cancer bone metastasis. Heliyon. Elsevier BV; 2024;:e37894 10.1016/j.heliyon.2024.e37894
• Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity Cite
  Villegas C, Cortez N, Ogundele AV, Burgos V, Pardi PC, Cabrera-Pardo JR, et al. Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity. Biomolecules. MDPI AG; 2024; 14:867 10.3390/biom14070867
• Chemopreventive Agents from Nature: A Review of Apigenin, Rosmarinic Acid, and Thymoquinone Cite
  Abutayeh RF, Altah M, Mehdawi A, Al-Ataby I, Ardakani A. Chemopreventive Agents from Nature: A Review of Apigenin, Rosmarinic Acid, and Thymoquinone. Current Issues in Molecular Biology. MDPI AG; 2024; 46:6600-6619 10.3390/cimb46070393
• The ameliorative effect of rosmarinic acid and epigallocatechin gallate against doxorubicin-induced genotoxicity Cite
  Helvacioglu S, Charehsaz M, Bankoglu EE, Stopper H, Aydin A. The ameliorative effect of rosmarinic acid and epigallocatechin gallate against doxorubicin-induced genotoxicity. Drug and Chemical Toxicology. Informa UK Limited; 2024;:1-13 10.1080/01480545.2024.2332790
• Green Tea Leaves and Rosemary Extracts Selectively Induce Cell Death in Triple-Negative Breast Cancer Cells and Cancer Stem Cells and Enhance the Efficacy of Common Chemotherapeutics Cite
  Raad C, Raad A, Pandey S. Green Tea Leaves and Rosemary Extracts Selectively Induce Cell Death in Triple-Negative Breast Cancer Cells and Cancer Stem Cells and Enhance the Efficacy of Common Chemotherapeutics. Evidence-Based Complementary and Alternative Medicine. Hindawi Limited; 2024; 2024:1-21 10.1155/2024/9458716
• Exploring the Potential of Rosemary Derived Compounds (Rosmarinic and Carnosic Acids) as Cancer Therapeutics: Current Knowledge and Future Perspectives Cite
  Sirajudeen F, Bou Malhab LJ, Bustanji Y, Shahwan M, Alzoubi KH, Semreen MH, et al. Exploring the Potential of Rosemary Derived Compounds (Rosmarinic and Carnosic Acids) as Cancer Therapeutics: Current Knowledge and Future Perspectives. Biomolecules & Therapeutics. The Korean Society of Applied Pharmacology; 2024; 32:38-55 10.4062/biomolther.2023.054
• Use of [18F]FLT/PET for assessing the tumor evolution and monitoring the antitumor activity of rosmarinic acid in a mouse 4T1 breast tumor model Cite
  Pereira JM, Schirmer BGdA, Araujo MR, Nascimento LTC, Ferreira AV, Gonçalves AdBB, et al. Use of [18F]FLT/PET for assessing the tumor evolution and monitoring the antitumor activity of rosmarinic acid in a mouse 4T1 breast tumor model. Brazilian Journal of Radiation Sciences. Sociedade Brasilieira de Protecao Radiologica - SBPR; 2023; 11:01-23 10.15392/2319-0612.2023.2300
• Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications Cite
  Ijaz S, Iqbal J, Abbasi BA, Ullah Z, Yaseen T, Kanwal S, et al. Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications. Biomedicine & Pharmacotherapy. Elsevier BV; 2023; 162:114687 10.1016/j.biopha.2023.114687
• Metabolomic profile and computational analysis for the identification of the potential anti-inflammatory mechanisms of action of the traditional medicinal plants Ocimum basilicum and Ocimum tenuiflorum Cite
  Beltrán-Noboa A, Proaño-Ojeda J, Guevara M, Gallo B, Berrueta LA, Giampieri F, et al. Metabolomic profile and computational analysis for the identification of the potential anti-inflammatory mechanisms of action of the traditional medicinal plants Ocimum basilicum and Ocimum tenuiflorum. Food and Chemical Toxicology. Elsevier BV; 2022; 164:113039 10.1016/j.fct.2022.113039
• Rosmarinic acid suppresses inflammation, angiogenesis, and improves paclitaxel induced apoptosis in a breast cancer model via NF3 κB-p53-caspase-3 pathways modulation Cite
  Mahmoud MA, Okda TM, Omran GA, Abd-Alhaseeb MM. Rosmarinic acid suppresses inflammation, angiogenesis, and improves paclitaxel induced apoptosis in a breast cancer model via NF3 κB-p53-caspase-3 pathways modulation. Journal of Applied Biomedicine. University of South Bohemia in Ceske Budejovice; 2021; 10.32725/jab.2021.024
• Role of Dietary Ingredients on Expression of Oncogenic and Tumour Suppressor miRNA Cite
  Gacche RN. Role of Dietary Ingredients on Expression of Oncogenic and Tumour Suppressor miRNA. Dietary Research and Cancer. Springer Singapore; 2021;:69-76 10.1007/978-981-16-6050-4_7
• Herb-drug interactions and toxicity: Underscoring potential mechanisms and forecasting clinically relevant interactions induced by common phytoconstituents via data mining and computational approaches Cite
  Suroowan S, Abdallah HH, Mahomoodally MF. Herb-drug interactions and toxicity: Underscoring potential mechanisms and forecasting clinically relevant interactions induced by common phytoconstituents via data mining and computational approaches. Food and Chemical Toxicology. Elsevier BV; 2021;:112432 10.1016/j.fct.2021.112432
• In Vivo and In Vitro Protective Effects of Rosmarinic Acid against Doxorubicin-Induced Cardiotoxicity Cite
  Rahbardar MG, Eisvand F, Rameshrad M, Razavi BM, Hosseinzadeh H. In Vivo and In Vitro Protective Effects of Rosmarinic Acid against Doxorubicin-Induced Cardiotoxicity. Nutrition and Cancer. Informa UK Limited; 2021;:1-15 10.1080/01635581.2021.1931362
• Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells Cite
  Messeha SS, Zarmouh NO, Asiri A, Soliman KF. Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells. European Journal of Pharmacology. Elsevier BV; 2020; 885:173419 10.1016/j.ejphar.2020.173419
• Rosmarinic Acid Exhibits Anticancer Effects via MARK4 Inhibition Cite
  Anwar S, Shamsi A, Shahbaaz M, Queen A, Khan P, Hasan GM, et al. Rosmarinic Acid Exhibits Anticancer Effects via MARK4 Inhibition. Scientific Reports. Springer Science and Business Media LLC; 2020; 10 10.1038/s41598-020-65648-z
• Pharmacotherapeutics and Molecular Mechanism of Phytochemicals in Alleviating Hormone-Responsive Breast Cancer Cite
  Rampogu S, Park C, Ravinder D, Son M, Baek A, Zeb A, et al. Pharmacotherapeutics and Molecular Mechanism of Phytochemicals in Alleviating Hormone-Responsive Breast Cancer. Oxidative Medicine and Cellular Longevity. Wiley; 2019; 2019:1-14 10.1155/2019/5189490
• Expression profiling of genes modulated by rosmarinic acid (RA) in MCF-7 breast cancer cells Cite
  Juskowiak B, Bogacz A, Wolek M, Kamiński A, Uzar I, Seremak-Mrozikiewicz A, et al. Expression profiling of genes modulated by rosmarinic acid (RA) in MCF-7 breast cancer cells. Ginekologia Polska. VM Media SP. zo.o VM Group SK; 2018; 89:541-545 10.5603/gp.a2018.0092
• Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin-induced neurotoxicity in rats Cite
  Rizk HA, Masoud MA, Maher OW. Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin-induced neurotoxicity in rats. Journal of Biochemical and Molecular Toxicology. Wiley; 2017; 31:e21977 10.1002/jbt.21977
• Deodorization of Garlic Breath by Foods, and the Role of Polyphenol Oxidase and Phenolic Compounds Cite
  Mirondo R, Barringer S. Deodorization of Garlic Breath by Foods, and the Role of Polyphenol Oxidase and Phenolic Compounds. Journal of Food Science. Wiley; 2016; 81:C2425-C2430 10.1111/1750-3841.13439
• Inhibition of Bone Metastasis from Breast Carcinoma by Rosmarinic Acid Cite
  Xu Y, Jiang Z, Ji G, Liu J. Inhibition of Bone Metastasis from Breast Carcinoma by Rosmarinic Acid. Planta Medica. Georg Thieme Verlag KG; 2010; 76:956-962 10.1055/s-0029-1240893
• Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy Cite
  González-Vallinas M, Reglero G, Ramírez de Molina A. Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy. Nutrition and Cancer. Informa UK Limited; 2015; 67:1223-1231 10.1080/01635581.2015.1082110
• Ocimum SanctumL (Holy Basil or Tulsi) and Its Phytochemicals in the Prevention and Treatment of Cancer Cite
  Baliga MS, Jimmy R, Thilakchand KR, Sunitha V, Bhat NR, Saldanha E, et al. Ocimum SanctumL (Holy Basil or Tulsi) and Its Phytochemicals in the Prevention and Treatment of Cancer. Nutrition and Cancer. Informa UK Limited; 2013; 65:26-35 10.1080/01635581.2013.785010
• Comparative study of rosmarinic acid content in some plants of Labiatae family Cite
  Hajimehdipoor H, Saeidnia S, Gohari A, Hamedani M, Shekarchi M. Comparative study of rosmarinic acid content in some plants of Labiatae family. Pharmacognosy Magazine. Medknow; 2012; 8:37 10.4103/0973-1296.93316
• Identification and quantification of a major anti-oxidant and anti-inflammatory phenolic compound found in basil, lemon thyme, mint, oregano, rosemary, sage, and thyme Cite
  Park JB. Identification and quantification of a major anti-oxidant and anti-inflammatory phenolic compound found in basil, lemon thyme, mint, oregano, rosemary, sage, and thyme. International Journal of Food Sciences and Nutrition. Informa UK Limited; 2011; 62:577-584 10.3109/09637486.2011.562882
• Antioxidant Activities and Phenolic Composition of Extracts from Greek Oregano, Greek Sage, and Summer Savory Cite
  Exarchou V, Nenadis N, Tsimidou M, Gerothanassis IP, Troganis A, Boskou D. Antioxidant Activities and Phenolic Composition of Extracts from Greek Oregano, Greek Sage, and Summer Savory. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2002; 50:5294-5299 10.1021/jf020408a
• Inhibitory effects of rosmarinic acid on adriamycin-induced apoptosis in H9c2 cardiac muscle cells by inhibiting reactive oxygen species and the activations of c-Jun N-terminal kinase and extracellular signal-regulated kinase Cite
  Kim D, Kim H, Woo E, Hong S, Chae H, Chae S. Inhibitory effects of rosmarinic acid on adriamycin-induced apoptosis in H9c2 cardiac muscle cells by inhibiting reactive oxygen species and the activations of c-Jun N-terminal kinase and extracellular signal-regulated kinase. Biochemical Pharmacology. Elsevier BV; 2005; 70:1066-1078 10.1016/j.bcp.2005.06.026