Tag: naringenin
Naringenin: A flavanone found in primarily in grapefruit and Mexican oregano. Oranges and limes are also sources of naringenin.
News
- 07/01/25
- Mexican oregano extract induces death in triple negative breast cancer cells
- 07/21/11
- Organically grown tomatoes have more chemopreventive compounds
- 07/19/11
- Citrus flavonoid naringenin inhibits metastasis in mice
Foods
Studies
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Mechanistic Insights into Flavonoid Subclasses as Cardioprotective Agents Against Doxorubicin-Induced Cardiotoxicity: A Comprehensive Review
Cite
Shang W, Li X, Zeng L, Li Z, Hu Y, Wen H, et al. Mechanistic Insights into Flavonoid Subclasses as Cardioprotective Agents Against Doxorubicin-Induced Cardiotoxicity: A Comprehensive Review. Drug Design, Development and Therapy. Informa UK Limited; 2025; Volume 19:5553-5596 10.2147/dddt.s535517
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Apoptotic Potential of Polyphenol Extract of Mexican Oregano Lippia graveolens Kunth on Breast Cancer Cells MDA-MB-231
Cite
Criollo-Mendoza MS, Heredia JB, Contreras-Angulo LA, García-Aguiar I, Gutiérrez-Grijalva EP. Apoptotic Potential of Polyphenol Extract of Mexican Oregano Lippia graveolens Kunth on Breast Cancer Cells MDA-MB-231. Applied Sciences. MDPI AG; 2025; 15:6393 10.3390/app15126393
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Naringin mitigated doxorubicin-induced kidney injury by the reduction of oxidative stress and inflammation with a synergistic anticancer effect
Cite
Gad NS, Shabana SM, Amer ME, Othman AI, El-Missiry MA. Naringin mitigated doxorubicin-induced kidney injury by the reduction of oxidative stress and inflammation with a synergistic anticancer effect. BMC Pharmacology and Toxicology. Springer Science and Business Media LLC; 2025; 26 10.1186/s40360-025-00947-7
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Naringenin impairs mitochondrial function via ROS to induce apoptosis in tamoxifen resistant MCF-7 breast cancer cells
Cite
Eanes LA, Eldeeb M, Storholt D, Patel YM. Naringenin impairs mitochondrial function via ROS to induce apoptosis in tamoxifen resistant MCF-7 breast cancer cells. PLOS ONE. Public Library of Science (PLoS); 2025; 20:e0320020 10.1371/journal.pone.0320020
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Dataset of transcriptomic changes induced by naringenin treatment in MCF-7 breast cancer cells
Cite
Hoang VT, Hawes ML, Elliott JR, Elliott S, Zou B, Boué SM, et al. Dataset of transcriptomic changes induced by naringenin treatment in MCF-7 breast cancer cells. Data in Brief. Elsevier BV; 2025; 59:111299 10.1016/j.dib.2025.111299
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Epigenetic Properties of Compounds Contained in Functional Foods Against Cancer
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Casari G, Romaldi B, Scirè A, Minnelli C, Marzioni D, Ferretti G, et al. Epigenetic Properties of Compounds Contained in Functional Foods Against Cancer. Biomolecules. MDPI AG; 2024; 15:15 10.3390/biom15010015
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Phytochemical‐mediated modulation of autophagy and endoplasmic reticulum stress as a cancer therapeutic approach
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Al Azzani M, Nizami ZN, Magramane R, Sekkal MN, Eid AH, Al Dhaheri Y, et al. Phytochemical‐mediated modulation of autophagy and endoplasmic reticulum stress as a cancer therapeutic approach. Phytotherapy Research. Wiley; 2024; 10.1002/ptr.8283
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Assessing the antioxidant properties of Naringin and Rutin and investigating their oxidative DNA damage effects in breast cancer
Cite
Pravin B, Nanaware V, Ashwini B, Wondmie GF, Jardan YAB, Bourhia M. Assessing the antioxidant properties of Naringin and Rutin and investigating their oxidative DNA damage effects in breast cancer. Scientific Reports. Springer Science and Business Media LLC; 2024; 14 10.1038/s41598-024-63498-7
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In-Vitro Cytotoxicity, Apoptotic Property, and Gene Expression Changes Induced by Naringenin-7-O-Glucoside in Triple-Negative Breast Cancer
Cite
James AR, Jayaprakash S, Sundeep LM. In-Vitro Cytotoxicity, Apoptotic Property, and Gene Expression Changes Induced by Naringenin-7-O-Glucoside in Triple-Negative Breast Cancer. Cureus. Springer Science and Business Media LLC; 2024; 10.7759/cureus.58634
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Developing liver-targeted naringenin nanoparticles for breast cancer endocrine therapy by promoting estrogen metabolism
Cite
Zhao Y, Tan H, Zhang J, Zhan D, Yang B, Hong S, et al. Developing liver-targeted naringenin nanoparticles for breast cancer endocrine therapy by promoting estrogen metabolism. Journal of Nanobiotechnology. Springer Science and Business Media LLC; 2024; 22 10.1186/s12951-024-02356-0
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Phytochemicals and Their Usefulness in the Maintenance of Health
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Rodríguez-Negrete EV, Morales-González Á, Madrigal-Santillán EO, Sánchez-Reyes K, Álvarez-González I, Madrigal-Bujaidar E, et al. Phytochemicals and Their Usefulness in the Maintenance of Health. Plants. MDPI AG; 2024; 13:523 10.3390/plants13040523
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Combined effects of naringin and doxorubicin on the JAK/STAT signaling pathway reduce the development and spread of breast cancer cells
Cite
Effat H, Abosharaf HA, Radwan AM. Combined effects of naringin and doxorubicin on the JAK/STAT signaling pathway reduce the development and spread of breast cancer cells. Scientific Reports. Springer Science and Business Media LLC; 2024; 14 10.1038/s41598-024-53320-9
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Chitosan-encapsulated naringenin promotes ROS mediated through the activation of executioner caspase-3
Cite
Ramya Devi KT, Jaganathan MK, Ganesh MR, Dharshene K. Chitosan-encapsulated naringenin promotes ROS mediated through the activation of executioner caspase-3. Medical Oncology. Springer Science and Business Media LLC; 2023; 41 10.1007/s12032-023-02227-y
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Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling
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Kubatka P, Koklesova L, Mazurakova A, Brockmueller A, Büsselberg D, Kello M, et al. Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling. Cancer and Metastasis Reviews. Springer Science and Business Media LLC; 2023; 10.1007/s10555-023-10134-x
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Naringenin induces different proliferative effects in estrogen receptor-alpha-66 negative breast cancer cells
Cite
Xu Z, Hu S, Luo N, Liu J, Ren X, Pan X. Naringenin induces different proliferative effects in estrogen receptor-alpha-66 negative breast cancer cells. Research Square Platform LLC; 2023; 10.21203/rs.3.rs-3266516/v1
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Phytochemicals Modify the Action of Cancer Cells Mitochondrial Drug-Resistance Mechanism
Cite
Das S. Phytochemicals Modify the Action of Cancer Cells Mitochondrial Drug-Resistance Mechanism. Sciences of Pharmacy. Etflin; 2023; 2:79-105 10.58920/sciphar02030079
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Naringenin in combination with quercetin/fisetin shows synergistic anti-proliferative and migration reduction effects in breast cancer cell lines
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Jalalpour Choupanan M, Shahbazi S, Reiisi S. Naringenin in combination with quercetin/fisetin shows synergistic anti-proliferative and migration reduction effects in breast cancer cell lines. Molecular Biology Reports. Springer Science and Business Media LLC; 2023; 10.1007/s11033-023-08664-2
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Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer
Cite
Madureira MB, Concato VM, Cruz EMS, Bitencourt de Morais JM, Inoue FSR, Concimo Santos N, et al. Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer. Antioxidants. MDPI AG; 2023; 12:586 10.3390/antiox12030586
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The Combined Therapeutic Effect of Capecitabine and Naringin on HER2+ (SK-BR-3) and HER2- (MCF-7) Human Breast Cancer Cells Lines
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Soltannezhad S, Jouni FJ, Osgoei LT. The Combined Therapeutic Effect of Capecitabine and Naringin on HER2+ (SK-BR-3) and HER2- (MCF-7) Human Breast Cancer Cells Lines. Research Square Platform LLC; 2023; 10.21203/rs.3.rs-2887641/v1
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Insights on the Role of Polyphenols in Combating Cancer Drug Resistance
Cite
Farhan M. Insights on the Role of Polyphenols in Combating Cancer Drug Resistance. Biomedicines. MDPI AG; 2023; 11:1709 10.3390/biomedicines11061709
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A comparative evaluation of the phenol and lycopene content of tomato by-products subjected to different drying methods
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Souza da Costa B, García MO, Muro GS, Motilva M. A comparative evaluation of the phenol and lycopene content of tomato by-products subjected to different drying methods. LWT. Elsevier BV; 2023; 179:114644 10.1016/j.lwt.2023.114644
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Naringin prevents cyclophosphamide-induced erythrocytotoxicity in rats by abrogating oxidative stress
Cite
Akamo AJ, Akinloye DI, Ugbaja RN, Adeleye OO, Dosumu OA, Eteng OE, et al. Naringin prevents cyclophosphamide-induced erythrocytotoxicity in rats by abrogating oxidative stress. Toxicology Reports. Elsevier BV; 2021; 10.1016/j.toxrep.2021.10.011
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The Orange Peel: An Outstanding Source of Chemical Resources
Cite
Fontana G. The Orange Peel: An Outstanding Source of Chemical Resources. Citrus - Research, Development and Biotechnology [Working Title]. IntechOpen; 2021; 10.5772/intechopen.96298
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Hesperidin and naringenin
Cite
Rehman MFu, Batool AI, Qadir R, Aslam M. Hesperidin and naringenin. A Centum of Valuable Plant Bioactives. Elsevier; 2021;:403-444 10.1016/b978-0-12-822923-1.00027-3
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Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy
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Sabo AA, Dudau M, Constantin GL, Pop TC, Geilfus C, Naccarati A, et al. Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy. Frontiers in Pharmacology. Frontiers Media SA; 2021; 12 10.3389/fphar.2021.652074
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Enhanced antitumor activity of doxorubicin by naringenin and metformin in breast carcinoma: an experimental study
Cite
Pateliya B, Burade V, Goswami S. Enhanced antitumor activity of doxorubicin by naringenin and metformin in breast carcinoma: an experimental study. Naunyn-Schmiedeberg's Archives of Pharmacology. Springer Science and Business Media LLC; 2021; 10.1007/s00210-021-02104-3
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Naringenin and Metformin Enhance the Antitumor Effect of Doxorubicin Against Experimental Models of Breast Carcinoma
Cite
Pateliya B, Burade V, Goswami S. Naringenin and Metformin Enhance the Antitumor Effect of Doxorubicin Against Experimental Models of Breast Carcinoma. Research Square; 2021; 10.21203/rs.3.rs-182895/v1
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Identification of Potential Therapeutic Target of Naringenin in Breast Cancer Stem Cells Inhibition by Bioinformatics and In Vitro Studies
Cite
Hermawan A, Ikawati M, Istighfari Jenie R, Khumaira A, Putri H, Putri Nurhayati I, et al. Identification of Potential Therapeutic Target of Naringenin in Breast Cancer Stem Cells Inhibition by Bioinformatics and In Vitro Studies. Saudi Pharmaceutical Journal. Elsevier BV; 2020; 10.1016/j.jsps.2020.12.002
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Combining naringenin and metformin with doxorubicin enhances anticancer activity against triple-negative breast cancer in vitro and in vivo
Cite
Pateliya B, Burade V, Goswami S. Combining naringenin and metformin with doxorubicin enhances anticancer activity against triple-negative breast cancer in vitro and in vivo. European Journal of Pharmacology. Elsevier BV; 2020; 891:173725 10.1016/j.ejphar.2020.173725
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Flavonoid-induced apoptotic cell death in human cancer cells and its mechanisms
Cite
Bhosale PB, Ha SE, Vetrivel P, Kim HH, Kim J, Park K, et al. Flavonoid-induced apoptotic cell death in human cancer cells and its mechanisms. Journal of Biomedical Translational Research. Research Institute of Veterinary Medicine; 2020; 21:50-58 10.12729/jbtr.2020.21.2.050
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Naringenin inhibits migration of breast cancer cells via inflammatory and apoptosis cell signaling pathways
Cite
Zhao Z, Jin G, Ge Y, Guo Z. Naringenin inhibits migration of breast cancer cells via inflammatory and apoptosis cell signaling pathways. Inflammopharmacology. Springer Science and Business Media LLC; 2019; 27:1021-1036 10.1007/s10787-018-00556-3
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Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats
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Khan TH, Ganaie MA, Alharthy KM, Madkhali H, Jan BL, Sheikh IA. Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats. Archives of Physiology and Biochemistry. Informa UK Limited; 2018; 126:300-307 10.1080/13813455.2018.1529799
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Naringenin has a chemoprotective effect in MDA‑MB‑231 breast cancer cells via inhibition of caspase‑3 and ‑9 activities
Cite
Wang R, Wang J, Dong T, Shen J, Gao X, Zhou J. Naringenin has a chemoprotective effect in MDA‑MB‑231 breast cancer cells via inhibition of caspase‑3 and ‑9 activities. Oncology Letters. Spandidos Publications; 2018; 10.3892/ol.2018.9704
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Combinatorial anti-proliferative effects of tamoxifen and naringenin: The role of four estrogen receptor subtypes
Cite
Xu Z, Huang B, Liu J, Wu X, Luo N, Wang X, et al. Combinatorial anti-proliferative effects of tamoxifen and naringenin: The role of four estrogen receptor subtypes. Toxicology. Elsevier BV; 2018; 410:231-246 10.1016/j.tox.2018.08.013
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Naringenin Inhibits Proliferation and Survival of Tamoxifen‐ Resistant Breast Cancer Cells
Cite
Ramos J, Hatkevich T, Eanes L, Santos-Sanchez I, Patel YM. Naringenin Inhibits Proliferation and Survival of Tamoxifen‐ Resistant Breast Cancer Cells. Breast Cancer - From Biology to Medicine. InTech; 2017; 10.5772/66698
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Citrus flavonoid naringenin reduces mammary tumor cell viability, adipose mass, and adipose inflammation in obese ovariectomized mice
Cite
Ke J, Banh T, Hsiao Y, Cole RM, Straka SR, Yee LD, et al. Citrus flavonoid naringenin reduces mammary tumor cell viability, adipose mass, and adipose inflammation in obese ovariectomized mice. Molecular Nutrition & Food Research. Wiley; 2017; 61:1600934 10.1002/mnfr.201600934
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Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights
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Nyane NA, Tlaila TB, Malefane TG, Ndwandwe DE, Owira PMO. Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights. European Journal of Pharmacology. Elsevier BV; 2017; 803:103-111 10.1016/j.ejphar.2017.03.042
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Hesperetin and Naringenin sensitize HER2 positive cancer cells to death by serving as HER2 Tyrosine Kinase inhibitors
Cite
Chandrika BB, Steephan M, Kumar TS, Sabu A, Haridas M. Hesperetin and Naringenin sensitize HER2 positive cancer cells to death by serving as HER2 Tyrosine Kinase inhibitors. Life Sciences. Elsevier BV; 2016; 160:47-56 10.1016/j.lfs.2016.07.007
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Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation
Cite
Zhang F, Dong W, Zeng W, Zhang L, Zhang C, Qiu Y, et al. Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation. Breast Cancer Research. Springer Science and Business Media LLC; 2016; 18 10.1186/s13058-016-0698-0
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Protective role of naringin against cisplatin induced oxidative stress, inflammatory response and apoptosis in rat striatum via suppressing ROS-mediated NF-κB and P53 signaling pathways
Cite
Chtourou Y, Aouey B, Kebieche M, Fetoui H. Protective role of naringin against cisplatin induced oxidative stress, inflammatory response and apoptosis in rat striatum via suppressing ROS-mediated NF-κB and P53 signaling pathways. Chemico-Biological Interactions. Elsevier BV; 2015; 239:76-86 10.1016/j.cbi.2015.06.036
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Epigenetic activities of flavonoids in the prevention and treatment of cancer
Cite
Busch C, Burkard M, Leischner C, Lauer UM, Frank J, Venturelli S. Epigenetic activities of flavonoids in the prevention and treatment of cancer. Clinical Epigenetics. Springer Science and Business Media LLC; 2015; 7 10.1186/s13148-015-0095-z
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Cancer prevention and therapy through the modulation of the tumor microenvironment
Cite
Casey SC, Amedei A, Aquilano K, Azmi AS, Benencia F, Bhakta D, et al. Cancer prevention and therapy through the modulation of the tumor microenvironment. Seminars in Cancer Biology. Elsevier BV; 2015; 35:S199-S223 10.1016/j.semcancer.2015.02.007
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A naringenin–tamoxifen combination impairs cell proliferation and survival of MCF-7 breast cancer cells
Cite
Hatkevich T, Ramos J, Santos-Sanchez I, Patel YM. A naringenin–tamoxifen combination impairs cell proliferation and survival of MCF-7 breast cancer cells. Experimental Cell Research. Elsevier BV; 2014; 327:331-339 10.1016/j.yexcr.2014.05.017
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Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway
Cite
Li H, Yang B, Huang J, Xiang T, Yin X, Wan J, et al. Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway. Toxicology Letters. Elsevier BV; 2013; 220:219-228 10.1016/j.toxlet.2013.05.006
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The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice
Cite
Ye L, Chan FL, Chen S, Leung LK. The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice. The Journal of Nutritional Biochemistry. Elsevier BV; 2012; 23:1230-1237 10.1016/j.jnutbio.2011.07.003
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Is there any difference between the phenolic content of organic and conventional tomato juices?
Cite
Vallverdú-Queralt A, Medina-Remón A, Casals-Ribes I, Lamuela-Raventos RM. Is there any difference between the phenolic content of organic and conventional tomato juices?. Food Chemistry. Elsevier BV; 2012; 130:222-227 10.1016/j.foodchem.2011.07.017
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Naringenin reduces lung metastasis in a breast cancer resection model
Cite
Qin L, Jin L, Lu L, Lu X, Zhang C, Zhang F, et al. Naringenin reduces lung metastasis in a breast cancer resection model. Protein & Cell. Springer Science and Business Media LLC; 2011; 2:507-516 10.1007/s13238-011-1056-8
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Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells
Cite
Lee W, Chen W, Wang C, Lin W, Tseng T. Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells. Toxicology and Applied Pharmacology. Elsevier BV; 2008; 226:178-191 10.1016/j.taap.2007.09.013
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Naringenin Inhibits Glucose Uptake in MCF-7 Breast Cancer Cells: A Mechanism for Impaired Cellular Proliferation
Cite
Harmon AW, Patel YM. Naringenin Inhibits Glucose Uptake in MCF-7 Breast Cancer Cells: A Mechanism for Impaired Cellular Proliferation. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2004; 85:103-110 10.1023/b:brea.0000025397.56192.e2