Tag: naringenin

News

07/01/25

Mexican oregano extract induces death in triple negative breast cancer cells

07/21/11

Organically grown tomatoes have more chemopreventive compounds

07/19/11

Citrus flavonoid naringenin inhibits metastasis in mice

Foods

• • grapefruit
  • Mexican oregano
  • oranges

Studies

• Mechanistic Insights into Flavonoid Subclasses as Cardioprotective Agents Against Doxorubicin-Induced Cardiotoxicity: A Comprehensive Review Cite
  Shang W, Li X, Zeng L, Li Z, Hu Y, Wen H, et al. Mechanistic Insights into Flavonoid Subclasses as Cardioprotective Agents Against Doxorubicin-Induced Cardiotoxicity: A Comprehensive Review. Drug Design, Development and Therapy. Informa UK Limited; 2025; Volume 19:5553-5596 10.2147/dddt.s535517
• Apoptotic Potential of Polyphenol Extract of Mexican Oregano Lippia graveolens Kunth on Breast Cancer Cells MDA-MB-231 Cite
  Criollo-Mendoza MS, Heredia JB, Contreras-Angulo LA, García-Aguiar I, Gutiérrez-Grijalva EP. Apoptotic Potential of Polyphenol Extract of Mexican Oregano Lippia graveolens Kunth on Breast Cancer Cells MDA-MB-231. Applied Sciences. MDPI AG; 2025; 15:6393 10.3390/app15126393
• Naringin mitigated doxorubicin-induced kidney injury by the reduction of oxidative stress and inflammation with a synergistic anticancer effect Cite
  Gad NS, Shabana SM, Amer ME, Othman AI, El-Missiry MA. Naringin mitigated doxorubicin-induced kidney injury by the reduction of oxidative stress and inflammation with a synergistic anticancer effect. BMC Pharmacology and Toxicology. Springer Science and Business Media LLC; 2025; 26 10.1186/s40360-025-00947-7
• Naringenin impairs mitochondrial function via ROS to induce apoptosis in tamoxifen resistant MCF-7 breast cancer cells Cite
  Eanes LA, Eldeeb M, Storholt D, Patel YM. Naringenin impairs mitochondrial function via ROS to induce apoptosis in tamoxifen resistant MCF-7 breast cancer cells. PLOS ONE. Public Library of Science (PLoS); 2025; 20:e0320020 10.1371/journal.pone.0320020
• Dataset of transcriptomic changes induced by naringenin treatment in MCF-7 breast cancer cells Cite
  Hoang VT, Hawes ML, Elliott JR, Elliott S, Zou B, Boué SM, et al. Dataset of transcriptomic changes induced by naringenin treatment in MCF-7 breast cancer cells. Data in Brief. Elsevier BV; 2025; 59:111299 10.1016/j.dib.2025.111299
• Epigenetic Properties of Compounds Contained in Functional Foods Against Cancer Cite
  Casari G, Romaldi B, Scirè A, Minnelli C, Marzioni D, Ferretti G, et al. Epigenetic Properties of Compounds Contained in Functional Foods Against Cancer. Biomolecules. MDPI AG; 2024; 15:15 10.3390/biom15010015
• Phytochemical‐mediated modulation of autophagy and endoplasmic reticulum stress as a cancer therapeutic approach Cite
  Al Azzani M, Nizami ZN, Magramane R, Sekkal MN, Eid AH, Al Dhaheri Y, et al. Phytochemical‐mediated modulation of autophagy and endoplasmic reticulum stress as a cancer therapeutic approach. Phytotherapy Research. Wiley; 2024; 10.1002/ptr.8283
• Assessing the antioxidant properties of Naringin and Rutin and investigating their oxidative DNA damage effects in breast cancer Cite
  Pravin B, Nanaware V, Ashwini B, Wondmie GF, Jardan YAB, Bourhia M. Assessing the antioxidant properties of Naringin and Rutin and investigating their oxidative DNA damage effects in breast cancer. Scientific Reports. Springer Science and Business Media LLC; 2024; 14 10.1038/s41598-024-63498-7
• In-Vitro Cytotoxicity, Apoptotic Property, and Gene Expression Changes Induced by Naringenin-7-O-Glucoside in Triple-Negative Breast Cancer Cite
  James AR, Jayaprakash S, Sundeep LM. In-Vitro Cytotoxicity, Apoptotic Property, and Gene Expression Changes Induced by Naringenin-7-O-Glucoside in Triple-Negative Breast Cancer. Cureus. Springer Science and Business Media LLC; 2024; 10.7759/cureus.58634
• Developing liver-targeted naringenin nanoparticles for breast cancer endocrine therapy by promoting estrogen metabolism Cite
  Zhao Y, Tan H, Zhang J, Zhan D, Yang B, Hong S, et al. Developing liver-targeted naringenin nanoparticles for breast cancer endocrine therapy by promoting estrogen metabolism. Journal of Nanobiotechnology. Springer Science and Business Media LLC; 2024; 22 10.1186/s12951-024-02356-0
• Phytochemicals and Their Usefulness in the Maintenance of Health Cite
  Rodríguez-Negrete EV, Morales-González Á, Madrigal-Santillán EO, Sánchez-Reyes K, Álvarez-González I, Madrigal-Bujaidar E, et al. Phytochemicals and Their Usefulness in the Maintenance of Health. Plants. MDPI AG; 2024; 13:523 10.3390/plants13040523
• Combined effects of naringin and doxorubicin on the JAK/STAT signaling pathway reduce the development and spread of breast cancer cells Cite
  Effat H, Abosharaf HA, Radwan AM. Combined effects of naringin and doxorubicin on the JAK/STAT signaling pathway reduce the development and spread of breast cancer cells. Scientific Reports. Springer Science and Business Media LLC; 2024; 14 10.1038/s41598-024-53320-9
• Chitosan-encapsulated naringenin promotes ROS mediated through the activation of executioner caspase-3 Cite
  Ramya Devi KT, Jaganathan MK, Ganesh MR, Dharshene K. Chitosan-encapsulated naringenin promotes ROS mediated through the activation of executioner caspase-3. Medical Oncology. Springer Science and Business Media LLC; 2023; 41 10.1007/s12032-023-02227-y
• Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling Cite
  Kubatka P, Koklesova L, Mazurakova A, Brockmueller A, Büsselberg D, Kello M, et al. Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling. Cancer and Metastasis Reviews. Springer Science and Business Media LLC; 2023; 10.1007/s10555-023-10134-x
• Naringenin induces different proliferative effects in estrogen receptor-alpha-66 negative breast cancer cells Cite
  Xu Z, Hu S, Luo N, Liu J, Ren X, Pan X. Naringenin induces different proliferative effects in estrogen receptor-alpha-66 negative breast cancer cells. Research Square Platform LLC; 2023; 10.21203/rs.3.rs-3266516/v1
• Phytochemicals Modify the Action of Cancer Cells Mitochondrial Drug-Resistance Mechanism Cite
  Das S. Phytochemicals Modify the Action of Cancer Cells Mitochondrial Drug-Resistance Mechanism. Sciences of Pharmacy. Etflin; 2023; 2:79-105 10.58920/sciphar02030079
• Naringenin in combination with quercetin/fisetin shows synergistic anti-proliferative and migration reduction effects in breast cancer cell lines Cite
  Jalalpour Choupanan M, Shahbazi S, Reiisi S. Naringenin in combination with quercetin/fisetin shows synergistic anti-proliferative and migration reduction effects in breast cancer cell lines. Molecular Biology Reports. Springer Science and Business Media LLC; 2023; 10.1007/s11033-023-08664-2
• Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer Cite
  Madureira MB, Concato VM, Cruz EMS, Bitencourt de Morais JM, Inoue FSR, Concimo Santos N, et al. Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer. Antioxidants. MDPI AG; 2023; 12:586 10.3390/antiox12030586
• The Combined Therapeutic Effect of Capecitabine and Naringin on HER2+ (SK-BR-3) and HER2- (MCF-7) Human Breast Cancer Cells Lines Cite
  Soltannezhad S, Jouni FJ, Osgoei LT. The Combined Therapeutic Effect of Capecitabine and Naringin on HER2+ (SK-BR-3) and HER2- (MCF-7) Human Breast Cancer Cells Lines. Research Square Platform LLC; 2023; 10.21203/rs.3.rs-2887641/v1
• Insights on the Role of Polyphenols in Combating Cancer Drug Resistance Cite
  Farhan M. Insights on the Role of Polyphenols in Combating Cancer Drug Resistance. Biomedicines. MDPI AG; 2023; 11:1709 10.3390/biomedicines11061709
• A comparative evaluation of the phenol and lycopene content of tomato by-products subjected to different drying methods Cite
  Souza da Costa B, García MO, Muro GS, Motilva M. A comparative evaluation of the phenol and lycopene content of tomato by-products subjected to different drying methods. LWT. Elsevier BV; 2023; 179:114644 10.1016/j.lwt.2023.114644
• Naringin prevents cyclophosphamide-induced erythrocytotoxicity in rats by abrogating oxidative stress Cite
  Akamo AJ, Akinloye DI, Ugbaja RN, Adeleye OO, Dosumu OA, Eteng OE, et al. Naringin prevents cyclophosphamide-induced erythrocytotoxicity in rats by abrogating oxidative stress. Toxicology Reports. Elsevier BV; 2021; 10.1016/j.toxrep.2021.10.011
• The Orange Peel: An Outstanding Source of Chemical Resources Cite
  Fontana G. The Orange Peel: An Outstanding Source of Chemical Resources. Citrus - Research, Development and Biotechnology [Working Title]. IntechOpen; 2021; 10.5772/intechopen.96298
• Hesperidin and naringenin Cite
  Rehman MFu, Batool AI, Qadir R, Aslam M. Hesperidin and naringenin. A Centum of Valuable Plant Bioactives. Elsevier; 2021;:403-444 10.1016/b978-0-12-822923-1.00027-3
• Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy Cite
  Sabo AA, Dudau M, Constantin GL, Pop TC, Geilfus C, Naccarati A, et al. Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy. Frontiers in Pharmacology. Frontiers Media SA; 2021; 12 10.3389/fphar.2021.652074
• Enhanced antitumor activity of doxorubicin by naringenin and metformin in breast carcinoma: an experimental study Cite
  Pateliya B, Burade V, Goswami S. Enhanced antitumor activity of doxorubicin by naringenin and metformin in breast carcinoma: an experimental study. Naunyn-Schmiedeberg's Archives of Pharmacology. Springer Science and Business Media LLC; 2021; 10.1007/s00210-021-02104-3
• Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer Cite
  El-Kersh DM, Ezzat SM, Salama MM, Mahrous EA, Attia YM, Ahmed MS, et al. Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer. Scientific Reports. Springer Science and Business Media LLC; 2021; 11 10.1038/s41598-021-86599-z
• Naringenin and Metformin Enhance the Antitumor Effect of Doxorubicin Against Experimental Models of Breast Carcinoma Cite
  Pateliya B, Burade V, Goswami S. Naringenin and Metformin Enhance the Antitumor Effect of Doxorubicin Against Experimental Models of Breast Carcinoma. Research Square; 2021; 10.21203/rs.3.rs-182895/v1
• Identification of Potential Therapeutic Target of Naringenin in Breast Cancer Stem Cells Inhibition by Bioinformatics and In Vitro Studies Cite
  Hermawan A, Ikawati M, Istighfari Jenie R, Khumaira A, Putri H, Putri Nurhayati I, et al. Identification of Potential Therapeutic Target of Naringenin in Breast Cancer Stem Cells Inhibition by Bioinformatics and In Vitro Studies. Saudi Pharmaceutical Journal. Elsevier BV; 2020; 10.1016/j.jsps.2020.12.002
• Combining naringenin and metformin with doxorubicin enhances anticancer activity against triple-negative breast cancer in vitro and in vivo Cite
  Pateliya B, Burade V, Goswami S. Combining naringenin and metformin with doxorubicin enhances anticancer activity against triple-negative breast cancer in vitro and in vivo. European Journal of Pharmacology. Elsevier BV; 2020; 891:173725 10.1016/j.ejphar.2020.173725
• Flavonoid-induced apoptotic cell death in human cancer cells and its mechanisms Cite
  Bhosale PB, Ha SE, Vetrivel P, Kim HH, Kim J, Park K, et al. Flavonoid-induced apoptotic cell death in human cancer cells and its mechanisms. Journal of Biomedical Translational Research. Research Institute of Veterinary Medicine; 2020; 21:50-58 10.12729/jbtr.2020.21.2.050
• Naringenin inhibits migration of breast cancer cells via inflammatory and apoptosis cell signaling pathways Cite
  Zhao Z, Jin G, Ge Y, Guo Z. Naringenin inhibits migration of breast cancer cells via inflammatory and apoptosis cell signaling pathways. Inflammopharmacology. Springer Science and Business Media LLC; 2019; 27:1021-1036 10.1007/s10787-018-00556-3
• Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats Cite
  Khan TH, Ganaie MA, Alharthy KM, Madkhali H, Jan BL, Sheikh IA. Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats. Archives of Physiology and Biochemistry. Informa UK Limited; 2018; 126:300-307 10.1080/13813455.2018.1529799
• Naringenin has a chemoprotective effect in MDA‑MB‑231 breast cancer cells via inhibition of caspase‑3 and ‑9 activities Cite
  Wang R, Wang J, Dong T, Shen J, Gao X, Zhou J. Naringenin has a chemoprotective effect in MDA‑MB‑231 breast cancer cells via inhibition of caspase‑3 and ‑9 activities. Oncology Letters. Spandidos Publications; 2018; 10.3892/ol.2018.9704
• Combinatorial anti-proliferative effects of tamoxifen and naringenin: The role of four estrogen receptor subtypes Cite
  Xu Z, Huang B, Liu J, Wu X, Luo N, Wang X, et al. Combinatorial anti-proliferative effects of tamoxifen and naringenin: The role of four estrogen receptor subtypes. Toxicology. Elsevier BV; 2018; 410:231-246 10.1016/j.tox.2018.08.013
• Naringenin Inhibits Proliferation and Survival of Tamoxifen‐ Resistant Breast Cancer Cells Cite
  Ramos J, Hatkevich T, Eanes L, Santos-Sanchez I, Patel YM. Naringenin Inhibits Proliferation and Survival of Tamoxifen‐ Resistant Breast Cancer Cells. Breast Cancer - From Biology to Medicine. InTech; 2017; 10.5772/66698
• Citrus flavonoid naringenin reduces mammary tumor cell viability, adipose mass, and adipose inflammation in obese ovariectomized mice Cite
  Ke J, Banh T, Hsiao Y, Cole RM, Straka SR, Yee LD, et al. Citrus flavonoid naringenin reduces mammary tumor cell viability, adipose mass, and adipose inflammation in obese ovariectomized mice. Molecular Nutrition & Food Research. Wiley; 2017; 61:1600934 10.1002/mnfr.201600934
• Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights Cite
  Nyane NA, Tlaila TB, Malefane TG, Ndwandwe DE, Owira PMO. Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights. European Journal of Pharmacology. Elsevier BV; 2017; 803:103-111 10.1016/j.ejphar.2017.03.042
• Hesperetin and Naringenin sensitize HER2 positive cancer cells to death by serving as HER2 Tyrosine Kinase inhibitors Cite
  Chandrika BB, Steephan M, Kumar TS, Sabu A, Haridas M. Hesperetin and Naringenin sensitize HER2 positive cancer cells to death by serving as HER2 Tyrosine Kinase inhibitors. Life Sciences. Elsevier BV; 2016; 160:47-56 10.1016/j.lfs.2016.07.007
• Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation Cite
  Zhang F, Dong W, Zeng W, Zhang L, Zhang C, Qiu Y, et al. Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation. Breast Cancer Research. Springer Science and Business Media LLC; 2016; 18 10.1186/s13058-016-0698-0
• Protective role of naringin against cisplatin induced oxidative stress, inflammatory response and apoptosis in rat striatum via suppressing ROS-mediated NF-κB and P53 signaling pathways Cite
  Chtourou Y, Aouey B, Kebieche M, Fetoui H. Protective role of naringin against cisplatin induced oxidative stress, inflammatory response and apoptosis in rat striatum via suppressing ROS-mediated NF-κB and P53 signaling pathways. Chemico-Biological Interactions. Elsevier BV; 2015; 239:76-86 10.1016/j.cbi.2015.06.036
• Epigenetic activities of flavonoids in the prevention and treatment of cancer Cite
  Busch C, Burkard M, Leischner C, Lauer UM, Frank J, Venturelli S. Epigenetic activities of flavonoids in the prevention and treatment of cancer. Clinical Epigenetics. Springer Science and Business Media LLC; 2015; 7 10.1186/s13148-015-0095-z
• Cancer prevention and therapy through the modulation of the tumor microenvironment Cite
  Casey SC, Amedei A, Aquilano K, Azmi AS, Benencia F, Bhakta D, et al. Cancer prevention and therapy through the modulation of the tumor microenvironment. Seminars in Cancer Biology. Elsevier BV; 2015; 35:S199-S223 10.1016/j.semcancer.2015.02.007
• A naringenin–tamoxifen combination impairs cell proliferation and survival of MCF-7 breast cancer cells Cite
  Hatkevich T, Ramos J, Santos-Sanchez I, Patel YM. A naringenin–tamoxifen combination impairs cell proliferation and survival of MCF-7 breast cancer cells. Experimental Cell Research. Elsevier BV; 2014; 327:331-339 10.1016/j.yexcr.2014.05.017
• Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway Cite
  Li H, Yang B, Huang J, Xiang T, Yin X, Wan J, et al. Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway. Toxicology Letters. Elsevier BV; 2013; 220:219-228 10.1016/j.toxlet.2013.05.006
• The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice Cite
  Ye L, Chan FL, Chen S, Leung LK. The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice. The Journal of Nutritional Biochemistry. Elsevier BV; 2012; 23:1230-1237 10.1016/j.jnutbio.2011.07.003
• Is there any difference between the phenolic content of organic and conventional tomato juices? Cite
  Vallverdú-Queralt A, Medina-Remón A, Casals-Ribes I, Lamuela-Raventos RM. Is there any difference between the phenolic content of organic and conventional tomato juices?. Food Chemistry. Elsevier BV; 2012; 130:222-227 10.1016/j.foodchem.2011.07.017
• Naringenin reduces lung metastasis in a breast cancer resection model Cite
  Qin L, Jin L, Lu L, Lu X, Zhang C, Zhang F, et al. Naringenin reduces lung metastasis in a breast cancer resection model. Protein & Cell. Springer Science and Business Media LLC; 2011; 2:507-516 10.1007/s13238-011-1056-8
• Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells Cite
  Lee W, Chen W, Wang C, Lin W, Tseng T. Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells. Toxicology and Applied Pharmacology. Elsevier BV; 2008; 226:178-191 10.1016/j.taap.2007.09.013
• Naringenin Inhibits Glucose Uptake in MCF-7 Breast Cancer Cells: A Mechanism for Impaired Cellular Proliferation Cite
  Harmon AW, Patel YM. Naringenin Inhibits Glucose Uptake in MCF-7 Breast Cancer Cells: A Mechanism for Impaired Cellular Proliferation. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2004; 85:103-110 10.1023/b:brea.0000025397.56192.e2