Tag: fucoidan

Fucoidan: A sulfated polysaccharide found primarily in brown seaweeds such as kelp, limu moui, mozuku, and hijiki. A form of fucoidan is also found in sea cucumber.

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News

06/03/17: Enterolactone reduces TN proliferation, migration and metastasis
11/17/11: Brown seaweed compound fucoidan induces breast cancer cell death

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- seaweed

Studies

Recent Advances in Marine-Derived Bioactives Towards Cancer Therapy Cite
Tamzi NN, Rahman MM, Das S. Recent Advances in Marine-Derived Bioactives Towards Cancer Therapy. International Journal of Translational Medicine. MDPI AG; 2024; 4:740-781 10.3390/ijtm4040051
Metabolite Profiling of Macroalgae: Biosynthesis and Beneficial Biological Properties of Active Compounds Cite
Carpena M, Pereira CSGP, Silva A, Barciela P, Jorge AOS, Perez-Vazquez A, et al. Metabolite Profiling of Macroalgae: Biosynthesis and Beneficial Biological Properties of Active Compounds. Marine Drugs. MDPI AG; 2024; 22:478 10.3390/md22100478
Zn2+ enhanced the anti-breast cancer activity of fucoidan based nanoparticles by activating the cGAS-STING pathway Cite
Xue P, Wang Y, Wang X, Zhou S, Wu X, Long L, et al. Zn2+ enhanced the anti-breast cancer activity of fucoidan based nanoparticles by activating the cGAS-STING pathway. Chemical Engineering Journal. Elsevier BV; 2024;:156729 10.1016/j.cej.2024.156729
Fucoidan‐Based Hydrogels in Pharmaceutical and Biomedical Applications Cite
Unnikrishnan Meenakshi D, Ganesan P, Joseph PS, Thekkila‐Veedu S, Pathayappurakkal Mohanan D, George AM, et al. Fucoidan‐Based Hydrogels in Pharmaceutical and Biomedical Applications. Biopolymers in Pharmaceutical and Food Applications. Wiley; 2024;:383-415 10.1002/9783527848133.ch19
Recent biotechnological applications of value-added bioactive compounds from microalgae and seaweeds Cite
Eladl SN, Elnabawy AM, Eltanahy EG. Recent biotechnological applications of value-added bioactive compounds from microalgae and seaweeds. Botanical Studies. Springer Science and Business Media LLC; 2024; 65 10.1186/s40529-024-00434-y
The Antitumour Mechanisms of Carotenoids: A Comprehensive Review Cite
Baeza-Morales A, Medina-García M, Martínez-Peinado P, Pascual-García S, Pujalte-Satorre C, López-Jaén AB, et al. The Antitumour Mechanisms of Carotenoids: A Comprehensive Review. Antioxidants. MDPI AG; 2024; 13:1060 10.3390/antiox13091060
Marine anticancer drugs in modulating miRNAs and antioxidant signaling Cite
Chuang Y, Yen C, Tang J, Wu K, Chang F, Tsai Y, et al. Marine anticancer drugs in modulating miRNAs and antioxidant signaling. Chemico-Biological Interactions. Elsevier BV; 2024;:111142 10.1016/j.cbi.2024.111142
Fucoidan extract from brown seaweed (Sargassum echinocarpum): molecular weight, elemental composition, selectivity and anticancer activity against breast cancer cells Cite
Yunianta Y, Laeliocattleya RA, Wulan SN, Risjani Y. Fucoidan extract from brown seaweed (Sargassum echinocarpum): molecular weight, elemental composition, selectivity and anticancer activity against breast cancer cells. Natural Product Research. Informa UK Limited; 2024;:1-9 10.1080/14786419.2024.2326978
Fucoidan’s Molecular Targets: A Comprehensive Review of Its Unique and Multiple Targets Accounting for Promising Bioactivities Supported by In Silico Studies Cite
Zayed A, Al-Saedi DA, Mensah EO, Kanwugu ON, Adadi P, Ulber R. Fucoidan’s Molecular Targets: A Comprehensive Review of Its Unique and Multiple Targets Accounting for Promising Bioactivities Supported by In Silico Studies. Marine Drugs. MDPI AG; 2023; 22:29 10.3390/md22010029
The Anticancer Effects of Marine Carotenoid Fucoxanthin through Phosphatidylinositol 3-Kinase (PI3K)-AKT Signaling on Triple-Negative Breast Cancer Cells Cite
Ahmed SA, Mendonca P, Messeha SS, Oriaku ET, Soliman KFA. The Anticancer Effects of Marine Carotenoid Fucoxanthin through Phosphatidylinositol 3-Kinase (PI3K)-AKT Signaling on Triple-Negative Breast Cancer Cells. Molecules. MDPI AG; 2023; 29:61 10.3390/molecules29010061
Synergistic Effects of Carotenoids: Therapeutic Benefits on Human Health Cite
Islam F, Khan J, Zehravi M, Das R, Akiful Haque M, Banu A, et al. Synergistic Effects of Carotenoids: Therapeutic Benefits on Human Health. Process Biochemistry. Elsevier BV; 2023; 10.1016/j.procbio.2023.11.033
Opportunities and challenges of fucoidan for tumors therapy Cite
Yu H, Zhang Q, Farooqi AA, Wang J, Yue Y, Geng L, et al. Opportunities and challenges of fucoidan for tumors therapy. Carbohydrate Polymers. Elsevier BV; 2023;:121555 10.1016/j.carbpol.2023.121555
In silico molecular docking, molecular dynamics, ADMET analysis of fucoidan against receptor frizzled-8 and coreceptor LRP6 in Wnt/β-Catenin pathway and in vitro analysis of fucoidan extract from Sargassum echinocarpum as β-catenin inhibitor in breast cancer cell line (MCF-7) Cite
Laeliocattleya RA, Yunianta Y, Risjani Y, Wulan SN. In silico molecular docking, molecular dynamics, ADMET analysis of fucoidan against receptor frizzled-8 and coreceptor LRP6 in Wnt/β-Catenin pathway and in vitro analysis of fucoidan extract from Sargassum echinocarpum as β-catenin inhibitor in breast cancer cell line (MCF-7). Journal of Biomolecular Structure and Dynamics. Informa UK Limited; 2023;:1-16 10.1080/07391102.2023.2265488
Advances in oligosaccharides production from brown seaweeds: extraction, characterization, antimetabolic syndrome, and other potential applications Cite
Krishna Perumal P, Huang C, Chen C, Anisha GS, Singhania RR, Dong C, et al. Advances in oligosaccharides production from brown seaweeds: extraction, characterization, antimetabolic syndrome, and other potential applications. Bioengineered. Informa UK Limited; 2023; 14 10.1080/21655979.2023.2252659
Structure and Metabolically Oriented Efficacy of Fucoidan from Brown Alga Sargassum muticum in the Model of Colony Formation of Melanoma and Breast Cancer Cells Cite
Usoltseva RV, Zueva AO, Malyarenko OS, Anastyuk SD, Moiseenko OP, Isakov VV, et al. Structure and Metabolically Oriented Efficacy of Fucoidan from Brown Alga Sargassum muticum in the Model of Colony Formation of Melanoma and Breast Cancer Cells. Marine Drugs. MDPI AG; 2023; 21:486 10.3390/md21090486
Fucoidan/chitosan layered PLGA nanoparticles with melatonin loading for inducing intestinal absorption and addressing triple-negative breast cancer progression Cite
Yen Y, Lee Y, Yu L, Li C, Shueng P, Chiu H, et al. Fucoidan/chitosan layered PLGA nanoparticles with melatonin loading for inducing intestinal absorption and addressing triple-negative breast cancer progression. International Journal of Biological Macromolecules. Elsevier BV; 2023; 250:126211 10.1016/j.ijbiomac.2023.126211
Novel Fucoidan Pharmaceutical Formulations and Their Potential Application in Oncology—A Review Cite
Zahariev N, Katsarov P, Lukova P, Pilicheva B. Novel Fucoidan Pharmaceutical Formulations and Their Potential Application in Oncology—A Review. Polymers. MDPI AG; 2023; 15:3242 10.3390/polym15153242
Production of high- and low-molecular weight fucoidan fragments with defined sulfation patterns and heightened in vitro anticancer activity against TNBC cells using novel endo-fucanases of the GH107 family Cite
Zueva AO, Silchenko AS, Rasin AB, Malyarenko OS, Kusaykin MI, Kalinovsky AI, et al. Production of high- and low-molecular weight fucoidan fragments with defined sulfation patterns and heightened in vitro anticancer activity against TNBC cells using novel endo-fucanases of the GH107 family. Carbohydrate Polymers. Elsevier BV; 2023;:121128 10.1016/j.carbpol.2023.121128
Therapeutic Potential of Polyphenols and Other Micronutrients of Marine Origin Cite
Pereira L, Cotas J. Therapeutic Potential of Polyphenols and Other Micronutrients of Marine Origin. Marine Drugs. MDPI AG; 2023; 21:323 10.3390/md21060323
Marine Carotenoid Fucoxanthin as a Promising Anticancer Therapeutic Against Triple-Negative Breast Cancer (TNBC) Cite
Ahmed S, Mendonca P, Messeha SS, Soliman KF. Marine Carotenoid Fucoxanthin as a Promising Anticancer Therapeutic Against Triple-Negative Breast Cancer (TNBC). ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development. American Society for Pharmacology and Experimental Therapeutics; 2023; 10.1124/jpet.122.176370
Marine fucoidans: Structural, extraction, biological activities and their applications in the food industry Cite
Mensah EO, Kanwugu ON, Panda PK, Adadi P. Marine fucoidans: Structural, extraction, biological activities and their applications in the food industry. Food Hydrocolloids. Elsevier BV; 2023;:108784 10.1016/j.foodhyd.2023.108784
An extensive review of marine pigments: sources, biotechnological applications, and sustainability Cite
Muñoz-Miranda LA, Iñiguez-Moreno M. An extensive review of marine pigments: sources, biotechnological applications, and sustainability. Aquatic Sciences. Springer Science and Business Media LLC; 2023; 85 10.1007/s00027-023-00966-8
The Biochemistry and Effectiveness of Antioxidants in Food, Fruits, and Marine Algae Cite
Pruteanu LL, Bailey DS, Grădinaru AC, Jäntschi L. The Biochemistry and Effectiveness of Antioxidants in Food, Fruits, and Marine Algae. Antioxidants. MDPI AG; 2023; 12:860 10.3390/antiox12040860
In vitro Anticancer potential of Laminarin and Fucoidan from Brown seaweeds Cite
Sanniyasi E, G RK, Damotharan R, A A, S M, S N, et al. In vitro Anticancer potential of Laminarin and Fucoidan from Brown seaweeds. Research Square Platform LLC; 2023; 10.21203/rs.3.rs-2444953/v1
Abstract C021: Fucoxanthin anti-tumor effects on the proliferation, angiogenesis, apoptosis, and migration of triple-negative breast cancer cells Cite
Ahmed S, Mendonca P, Messeha S, Badisa R, Soliman KF. Abstract C021: Fucoxanthin anti-tumor effects on the proliferation, angiogenesis, apoptosis, and migration of triple-negative breast cancer cells. Cancer Epidemiology, Biomarkers & Prevention. American Association for Cancer Research (AACR); 2023; 32:C021-C021 10.1158/1538-7755.disp22-c021
A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent Cite
Jayawardena TU, Nagahawatta DP, Fernando IPS, Kim Y, Kim J, Kim W, et al. A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent. Marine Drugs. MDPI AG; 2022; 20:755 10.3390/md20120755
Fucoxanthin: A Promising Phytochemical on Diverse Pharmacological Targets Cite
Mumu M, Das A, Emran TB, Mitra S, Islam F, Roy A, et al. Fucoxanthin: A Promising Phytochemical on Diverse Pharmacological Targets. Frontiers in Pharmacology. Frontiers Media SA; 2022; 13 10.3389/fphar.2022.929442
Fucoxanthinol Promotes Apoptosis in MCF-7 and MDA-MB-231 Cells by Attenuating Laminins–Integrins Axis Cite
Yasuda A, Wagatsuma M, Murase W, Kubota A, Kojima H, Ohta T, et al. Fucoxanthinol Promotes Apoptosis in MCF-7 and MDA-MB-231 Cells by Attenuating Laminins–Integrins Axis. Onco. MDPI AG; 2022; 2:145-163 10.3390/onco2030010
Fucoxanthin Is a Potential Therapeutic Agent for the Treatment of Breast Cancer Cite
Lau T, Kwan H. Fucoxanthin Is a Potential Therapeutic Agent for the Treatment of Breast Cancer. Marine Drugs. MDPI AG; 2022; 20:370 10.3390/md20060370
Tumor preventive properties of selected marine pigments against colon and breast cancer Cite
Manochkumar J, Doss CGP, Efferth T, Ramamoorthy S. Tumor preventive properties of selected marine pigments against colon and breast cancer. Algal Research. Elsevier BV; 2022; 61:102594 10.1016/j.algal.2021.102594
Inhibition of fucoidan on breast cancer cells and potential enhancement of their sensitivity to chemotherapy by regulating autophagy Cite
Zhang N, Xue M, Wang Q, Liang H, Yang J, Pei Z, et al. Inhibition of fucoidan on breast cancer cells and potential enhancement of their sensitivity to chemotherapy by regulating autophagy. Phytotherapy Research. Wiley; 2021; 10.1002/ptr.7303
The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles Cite
Jin J, Chauhan PS, Arukha AP, Chavda V, Dubey A, Yadav D. The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles. Marine Drugs. MDPI AG; 2021; 19:265 10.3390/md19050265
Carotenoids in Cancer Metastasis—Status Quo and Outlook Cite
Koklesova L, Liskova A, Samec M, Zhai K, Abotaleb M, Ashrafizadeh M, et al. Carotenoids in Cancer Metastasis—Status Quo and Outlook. Biomolecules. MDPI AG; 2020; 10:1653 10.3390/biom10121653
On a Beam of Light: Photoprotective Activities of the Marine Carotenoids Astaxanthin and Fucoxanthin in Suppression of Inflammation and Cancer Cite
Catanzaro E, Bishayee A, Fimognari C. On a Beam of Light: Photoprotective Activities of the Marine Carotenoids Astaxanthin and Fucoxanthin in Suppression of Inflammation and Cancer. Marine Drugs. MDPI AG; 2020; 18:544 10.3390/md18110544
Fucoidan-Doxorubicin Nanoparticles Targeting P-Selectin for Effective Breast Cancer Therapy Cite
Jafari M, Sriram V, Xu Z, Harris GM, Lee J. Fucoidan-Doxorubicin Nanoparticles Targeting P-Selectin for Effective Breast Cancer Therapy. Carbohydrate Polymers. Elsevier BV; 2020; 249:116837 10.1016/j.carbpol.2020.116837
The carotenoid fucoxanthin can sensitize multidrug resistant cancer cells to doxorubicin via induction of apoptosis, inhibition of multidrug resistance proteins and metabolic enzymes Cite
Eid SY, Althubiti MA, Abdallah ME, Wink M, El-Readi MZ. The carotenoid fucoxanthin can sensitize multidrug resistant cancer cells to doxorubicin via induction of apoptosis, inhibition of multidrug resistance proteins and metabolic enzymes. Phytomedicine. Elsevier BV; 2020; 77:153280 10.1016/j.phymed.2020.153280
A review on fucoidan antitumor strategies: From a biological active agent to a structural component of fucoidan-based systems Cite
Oliveira C, Neves NM, Reis RL, Martins A, Silva TH. A review on fucoidan antitumor strategies: From a biological active agent to a structural component of fucoidan-based systems. Carbohydrate Polymers. Elsevier BV; 2020; 239:116131 10.1016/j.carbpol.2020.116131
Fucoidan from Laminaria japonica exerts antitumor effects on angiogenesis and micrometastasis in triple-negative breast cancer cells Cite
Hsu W, Lin M, Kuo T, Chou C, Mi F, Cheng C, et al. Fucoidan from Laminaria japonica exerts antitumor effects on angiogenesis and micrometastasis in triple-negative breast cancer cells. International Journal of Biological Macromolecules. Elsevier BV; 2020; 149:600-608 10.1016/j.ijbiomac.2020.01.256
“Fucoidan, a natural biopolymer in cancer combating: From edible algae to nanocarrier tailoring” Cite
Etman SM, Elnaggar YS, Abdallah OY. “Fucoidan, a natural biopolymer in cancer combating: From edible algae to nanocarrier tailoring”. International Journal of Biological Macromolecules. Elsevier BV; 2020; 147:799-808 10.1016/j.ijbiomac.2019.11.191
Fucoidan Promotes Apoptosis and Inhibits EMT of Breast Cancer Cells Cite
He X, Xue M, Jiang S, Li W, Yu J, Xiang S. Fucoidan Promotes Apoptosis and Inhibits EMT of Breast Cancer Cells. Biological and Pharmaceutical Bulletin. Pharmaceutical Society of Japan; 2019; 42:442-447 10.1248/bpb.b18-00777
Improved chemotherapy against breast cancer through immunotherapeutic activity of fucoidan decorated electrostatically assembled nanoparticles bearing doxorubicin Cite
Pawar VK, Singh Y, Sharma K, Shrivastav A, Sharma A, Singh A, et al. Improved chemotherapy against breast cancer through immunotherapeutic activity of fucoidan decorated electrostatically assembled nanoparticles bearing doxorubicin. International Journal of Biological Macromolecules. Elsevier BV; 2019; 122:1100-1114 10.1016/j.ijbiomac.2018.09.059
The effect of fucoidan on intestinal flora and intestinal barrier function in rats with breast cancer Cite
Xue M, Ji X, Liang H, Liu Y, Wang B, Sun L, et al. The effect of fucoidan on intestinal flora and intestinal barrier function in rats with breast cancer. Food & Function. Royal Society of Chemistry (RSC); 2018; 9:1214-1223 10.1039/c7fo01677h
Cytotoxicity of Fucoidan from Three Tropical Brown Algae Against Breast and Colon Cancer Cell Lines Cite
Isnansetyo A, Laili Lutfia FN, Nursid M, T T, Susidarti RA. Cytotoxicity of Fucoidan from Three Tropical Brown Algae Against Breast and Colon Cancer Cell Lines. Pharmacognosy Journal. EManuscript Services; 2016; 9:14-20 10.5530/pj.2017.1.3
Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells Cite
Wu S, Yan M, Wu AT, Yuan KS, Liu SH. Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells. Journal of Cancer. Ivyspring International Publisher; 2016; 7:2408-2419 10.7150/jca.15703
Lipids, Fatty Acids, and Fucoxanthin Content from Temperate and Tropical Brown Seaweeds Cite
Susanto E, Fahmi AS, Abe M, Hosokawa M, Miyashita K. Lipids, Fatty Acids, and Fucoxanthin Content from Temperate and Tropical Brown Seaweeds. Aquatic Procedia. Elsevier BV; 2016; 7:66-75 10.1016/j.aqpro.2016.07.009
Fucoidan Induces Cancer Cell Apoptosis by Modulating the Endoplasmic Reticulum Stress Cascades Cite
Chen S, Zhao Y, Zhang Y, Zhang D. Fucoidan Induces Cancer Cell Apoptosis by Modulating the Endoplasmic Reticulum Stress Cascades. PLoS ONE. Public Library of Science (PLoS); 2014; 9:e108157 10.1371/journal.pone.0108157
Fucoidan extract enhances the anti-cancer activity of chemotherapeutic agents in breast cancer cells Cite
Shirahata S, Zhang Z, Yoshida T, Eto H, Teruya K. Fucoidan extract enhances the anti-cancer activity of chemotherapeutic agents in breast cancer cells. BMC Proceedings. Springer Science and Business Media LLC; 2013; 7 10.1186/1753-6561-7-s6-p70
Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer Cite
Senthilkumar K, Manivasagan P, Venkatesan J, Kim S. Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer. International Journal of Biological Macromolecules. Elsevier BV; 2013; 60:366-374 10.1016/j.ijbiomac.2013.06.030
The fucoidans from brown algae of Far-Eastern seas: Anti-tumor activity and structure–function relationship Cite
Vishchuk OS, Ermakova SP, Zvyagintseva TN. The fucoidans from brown algae of Far-Eastern seas: Anti-tumor activity and structure–function relationship. Food Chemistry. Elsevier BV; 2013; 141:1211-1217 10.1016/j.foodchem.2013.03.065
Anticancer Properties and Mechanisms of Fucoidan on Mouse Breast Cancer In Vitro and In Vivo Cite
Xue M, Ge Y, Zhang J, Wang Q, Hou L, Liu Y, et al. Anticancer Properties and Mechanisms of Fucoidan on Mouse Breast Cancer In Vitro and In Vivo. PLoS ONE. Public Library of Science (PLoS); 2012; 7:e43483 10.1371/journal.pone.0043483
Cytoprotective effects of fucoidan, an algae-derived polysaccharide on 5-fluorouracil-treated dendritic cells Cite
Jeong B, Ko E, Joo H. Cytoprotective effects of fucoidan, an algae-derived polysaccharide on 5-fluorouracil-treated dendritic cells. Food and Chemical Toxicology. Elsevier BV; 2012; 50:1480-1484 10.1016/j.fct.2012.01.034
Fucoidan Extract Induces Apoptosis in MCF-7 Cells via a Mechanism Involving the ROS-Dependent JNK Activation and Mitochondria-Mediated Pathways Cite
Zhang Z, Teruya K, Eto H, Shirahata S. Fucoidan Extract Induces Apoptosis in MCF-7 Cells via a Mechanism Involving the ROS-Dependent JNK Activation and Mitochondria-Mediated Pathways. PLoS ONE. Public Library of Science (PLoS); 2011; 6:e27441 10.1371/journal.pone.0027441
Fucoidan Induces Apoptosis through Activation of Caspase-8 on Human Breast Cancer MCF-7 Cells Cite
Yamasaki-Miyamoto Y, Yamasaki M, Tachibana H, Yamada K. Fucoidan Induces Apoptosis through Activation of Caspase-8 on Human Breast Cancer MCF-7 Cells. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2009; 57:8677-8682 10.1021/jf9010406
Fucoidan from Laminaria cichorioides inhibits AP-1 transactivation and cell transformation in the mouse epidermal JB6 cells Cite
Lee NY, Ermakova SP, Choi H, Kusaykin MI, Shevchenko NM, Zvyagintseva TN, et al. Fucoidan from Laminaria cichorioides inhibits AP-1 transactivation and cell transformation in the mouse epidermal JB6 cells. Molecular Carcinogenesis. Wiley; 2008; 47:629-637 10.1002/mc.20428