Tag: fluorouracil5FU

News

08/18/13

Cadmium reduces effectiveness of 5-FU chemotherapy in ER+/PR+ breast cancer cells

05/31/13

Black pepper compound increases effectiveness of Taxol against HER2+ breast cancer

02/15/12

Grapes and other foods might help protect against Adriamycin-induced heart damage

01/17/12

Apigenin increases effectiveness of Taxol chemotherapy

12/07/11

Modern chemotherapy reduces breast cancer death by about a third compared to no chemotherapy

10/27/11

The beta blocker propranolol increases the effectiveness of Taxol

10/09/11

Low white blood cell count as a result of chemotherapy indicates the treatment is working

07/11/11

Taking Celebrex might reduce the effectiveness of chemotherapy for breast cancer

12/10/10

Adding the bisphosphonate zoledronic acid to chemotherapy does not improve outcome markers

Studies

• Resveratrol as Chemosensitizer Agent: State of Art and Future Perspectives Cite
  Cocetta V, Quagliariello V, Fiorica F, Berretta M, Montopoli M. Resveratrol as Chemosensitizer Agent: State of Art and Future Perspectives. International Journal of Molecular Sciences. MDPI AG; 2021; 22:2049 10.3390/ijms22042049
• Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion Cite
  Ke W, Saba JA, Yao C, Hilzendeger MA, Drangowska-Way A, Joshi C, et al. Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion. Nature Communications. Springer Science and Business Media LLC; 2020; 11 10.1038/s41467-020-16220-w
• Impact of Cumulative Chemotherapy Dose on Survival With Adjuvant FEC-D Chemotherapy for Breast Cancer Cite
  Veitch Z, Khan OF, Tilley D, Tang PA, Ribnikar D, Stewart DA, et al. Impact of Cumulative Chemotherapy Dose on Survival With Adjuvant FEC-D Chemotherapy for Breast Cancer. Journal of the National Comprehensive Cancer Network. Harborside Press, LLC; 2019; 17:957-967 10.6004/jnccn.2019.7286
• Effect of resveratrol on the radiosensitivity of 5‐FU in human breast cancer MCF‐7 cells Cite
  Aghamiri S, Jafarpour A, Zandsalimi F, Aghemiri M, Shoja M. Effect of resveratrol on the radiosensitivity of 5‐FU in human breast cancer MCF‐7 cells. Journal of Cellular Biochemistry. Wiley; 2019; 120:15671-15677 10.1002/jcb.28836
• Inflammation markers and cognitive performance in breast cancer survivors 20 years after completion of chemotherapy: a cohort study Cite
  van der Willik KD, Koppelmans V, Hauptmann M, Compter A, Ikram MA, Schagen SB. Inflammation markers and cognitive performance in breast cancer survivors 20 years after completion of chemotherapy: a cohort study. Breast Cancer Research. Springer Science and Business Media LLC; 2018; 20 10.1186/s13058-018-1062-3
• Neurobiological Mechanisms of Chemotherapy-induced Cognitive Impairment in a Transgenic Model of Breast Cancer Cite
  Winocur G, Berman H, Nguyen M, Binns MA, Henkelman M, van Eede M, et al. Neurobiological Mechanisms of Chemotherapy-induced Cognitive Impairment in a Transgenic Model of Breast Cancer. Neuroscience. Elsevier BV; 2018; 369:51-65 10.1016/j.neuroscience.2017.10.048
• Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line Cite
  Milczarek M, Wiktorska K, Mielczarek L, Koronkiewicz M, Dąbrowska A, Lubelska K, et al. Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line. Food and Chemical Toxicology. Elsevier BV; 2018; 111:1-8 10.1016/j.fct.2017.10.056
• Role of taxanes in chemotherapy-related cognitive impairment: A prospective longitudinal study Cite
  Cerulla N, Arcusa À, Navarro J, Garolera M, Enero C, Chico G, et al. Role of taxanes in chemotherapy-related cognitive impairment: A prospective longitudinal study. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2017; 164:179-187 10.1007/s10549-017-4240-6
• Weight change during chemotherapy in breast cancer patients: a meta-analysis Cite
  van den Berg M, Winkels R, de Kruif J, van Laarhoven H, Visser M, de Vries J, et al. Weight change during chemotherapy in breast cancer patients: a meta-analysis. BMC Cancer. Springer Science and Business Media LLC; 2017; 17 10.1186/s12885-017-3242-4
• KU32 prevents 5-fluorouracil induced cognitive impairment Cite
  Sofis MJ, Jarmolowicz DP, Kaplan SV, Gehringer RC, Lemley SM, Garg G, et al. KU32 prevents 5-fluorouracil induced cognitive impairment. Behavioural Brain Research. Elsevier BV; 2017; 329:186-190 10.1016/j.bbr.2017.03.042
• Crocetin shifts autophagic cell survival to death of breast cancer cells in chemotherapy Cite
  Zhang A, Li J. Crocetin shifts autophagic cell survival to death of breast cancer cells in chemotherapy. Tumor Biology. SAGE Publications; 2017; 39:101042831769453 10.1177/1010428317694536
• Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms Cite
  Gaballah HH, Gaber RA, Mohamed DA. Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms. Toxicology and Applied Pharmacology. Elsevier BV; 2017; 316:27-35 10.1016/j.taap.2016.12.012
• Serum IL-6 level as a predictor of response to neo-Adjuvant chemotherapy in patients of breast carcinoma Cite
  Mittal P, Gupta N, Goswami B. Serum IL-6 level as a predictor of response to neo-Adjuvant chemotherapy in patients of breast carcinoma. Hellenic Journal of Surgery. Springer Science and Business Media LLC; 2016; 88:306-310 10.1007/s13126-016-0338-2
• The synergystic effects of omega-3 fatty acids against 5-fluorouracil-induced mucosal impairment in mice Cite
  Sebe M, Tsutsumi R, Yamaguchi S, Horikawa YT, Harada N, Oyama T, et al. The synergystic effects of omega-3 fatty acids against 5-fluorouracil-induced mucosal impairment in mice. BMC Nutrition. Springer Science and Business Media LLC; 2016; 2 10.1186/s40795-016-0057-7
• Chemotherapy Agents Alter Plasma Lipids in Breast Cancer Patients and Show Differential Effects on Lipid Metabolism Genes in Liver Cells Cite
  Sharma M, Tuaine J, McLaren B, Waters DL, Black K, Jones LM, et al. Chemotherapy Agents Alter Plasma Lipids in Breast Cancer Patients and Show Differential Effects on Lipid Metabolism Genes in Liver Cells. PLOS ONE. Public Library of Science (PLoS); 2016; 11:e0148049 10.1371/journal.pone.0148049
• The Dietary Flavonoid Fisetin Causes Cell Cycle Arrest, Caspase-Dependent Apoptosis, and Enhanced Cytotoxicity of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells Cite
  Smith ML, Murphy K, Doucette CD, Greenshields AL, Hoskin DW. The Dietary Flavonoid Fisetin Causes Cell Cycle Arrest, Caspase-Dependent Apoptosis, and Enhanced Cytotoxicity of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells. Journal of Cellular Biochemistry. Wiley; 2016; 117:1913-1925 10.1002/jcb.25490
• Wheat bran arabinoxylan supplementation alleviates 5-fluorouracil induced mucositis and myelosuppression in BALB/c mice Cite
  Song M, Baik HW, Hong S, Sung M. Wheat bran arabinoxylan supplementation alleviates 5-fluorouracil induced mucositis and myelosuppression in BALB/c mice. Journal of Functional Foods. Elsevier BV; 2016; 21:312-320 10.1016/j.jff.2015.12.001
• Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-γ pathway Cite
  Woo CC, Loo SY, Gee V, Yap CW, Sethi G, Kumar AP, et al. Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-γ pathway. Biochemical Pharmacology. Elsevier BV; 2011; 82:464-475 10.1016/j.bcp.2011.05.030
• Curcuminoids from Curcuma longa L. reduced intestinal mucositis induced by 5-fluorouracil in mice: Bioadhesive, proliferative, anti-inflammatory and antioxidant effects Cite
  dos Santos Filho EX, Ávila PHM, Bastos CCC, Batista AC, Naves LN, Marreto RN, et al. Curcuminoids from Curcuma longa L. reduced intestinal mucositis induced by 5-fluorouracil in mice: Bioadhesive, proliferative, anti-inflammatory and antioxidant effects. Toxicology Reports. Elsevier BV; 2016; 3:55-62 10.1016/j.toxrep.2015.10.010
• Cardiac assessment of early breast cancer patients 18years after treatment with cyclophosphamide-, methotrexate-, fluorouracil- or epirubicin-based chemotherapy Cite
  de Azambuja E, Ameye L, Diaz M, Vandenbossche S, Aftimos P, Hernández SB, et al. Cardiac assessment of early breast cancer patients 18years after treatment with cyclophosphamide-, methotrexate-, fluorouracil- or epirubicin-based chemotherapy. European Journal of Cancer. Elsevier BV; 2015; 51:2517-2524 10.1016/j.ejca.2015.08.011
• Low Concentration of Quercetin Antagonizes the Cytotoxic Effects of Anti-Neoplastic Drugs in Ovarian Cancer Cite
  Li N, Sun C, Zhou B, Xing H, Ma D, Chen G, et al. Low Concentration of Quercetin Antagonizes the Cytotoxic Effects of Anti-Neoplastic Drugs in Ovarian Cancer. PLoS ONE. Public Library of Science (PLoS); 2014; 9:e100314 10.1371/journal.pone.0100314
• Metformin reverses multidrug resistance and epithelial–mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells Cite
  Qu C, Zhang W, Zheng G, Zhang Z, Yin J, He Z. Metformin reverses multidrug resistance and epithelial–mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells. Molecular and Cellular Biochemistry. Springer Science and Business Media LLC; 2013; 386:63-71 10.1007/s11010-013-1845-x
• Cadmium Modifies the Cell Cycle and Apoptotic Profiles of Human Breast Cancer Cells Treated with 5-Fluorouracil Cite
  Asara Y, Marchal J, Carrasco E, Boulaiz H, Solinas G, Bandiera P, et al. Cadmium Modifies the Cell Cycle and Apoptotic Profiles of Human Breast Cancer Cells Treated with 5-Fluorouracil. International Journal of Molecular Sciences. MDPI AG; 2013; 14:16600-16616 10.3390/ijms140816600
• Antitumor effect of 5-fluorouracil is enhanced by rosemary extract in both drug sensitive and resistant colon cancer cells Cite
  González-Vallinas M, Molina S, Vicente G, de la Cueva A, Vargas T, Santoyo S, et al. Antitumor effect of 5-fluorouracil is enhanced by rosemary extract in both drug sensitive and resistant colon cancer cells. Pharmacological Research. Elsevier BV; 2013; 72:61-68 10.1016/j.phrs.2013.03.010
• Breast Cancer and Obesity: In Vitro Interferences between Adipokines and Proangiogenic Features and/or Antitumor Therapies? Cite
  Dubois V, Delort L, Billard H, Vasson M, Caldefie-Chezet F. Breast Cancer and Obesity: In Vitro Interferences between Adipokines and Proangiogenic Features and/or Antitumor Therapies?. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e58541 10.1371/journal.pone.0058541
• Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil Cite
  Vinod BS, Antony J, Nair HH, Puliyappadamba VT, Saikia M, Shyam Narayanan S, et al. Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil. Cell Death & Disease. Springer Science and Business Media LLC; 2013; 4:e505-e505 10.1038/cddis.2013.26
• Effects of 5-fluorouracil chemotherapy on fatigue: Role of MCP-1 Cite
  Mahoney S, Davis J, Murphy E, McClellan J, Gordon B, Pena M. Effects of 5-fluorouracil chemotherapy on fatigue: Role of MCP-1. Brain, Behavior, and Immunity. Elsevier BV; 2013; 27:155-161 10.1016/j.bbi.2012.10.012
• Cadmium influences the 5-Fluorouracil cytotoxic effects on breast cancer cells Cite
  Asara Y, Marchal JA, Bandiera P, Mazzarello V, Delogu LG, Sotgiu MA, et al. Cadmium influences the 5-Fluorouracil cytotoxic effects on breast cancer cells. European Journal of Histochemistry. PAGEPress Publications; 2012; 56:1 10.4081/ejh.2012.e1
• Surgery for widely disseminated breast cancer: prolonged control by excision of metastases Cite
  Rees GJ, Britton DC, Malcolm GP, Rees M. Surgery for widely disseminated breast cancer: prolonged control by excision of metastases. JRSM Short Reports. SAGE Publications; 2012; 3:1-4 10.1258/shorts.2012.011162
• Incidence and Prognostic Impact of Amenorrhea During Adjuvant Therapy in High-Risk Premenopausal Breast Cancer: Analysis of a National Cancer Institute of Canada Clinical Trials Group Study—NCIC CTG MA.5 Cite
  Parulekar WR, Day AG, Ottaway JA, Shepherd LE, Trudeau ME, Bramwell V, et al. Incidence and Prognostic Impact of Amenorrhea During Adjuvant Therapy in High-Risk Premenopausal Breast Cancer: Analysis of a National Cancer Institute of Canada Clinical Trials Group Study—NCIC CTG MA.5. Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2005; 23:6002-6008 10.1200/jco.2005.07.096
• Neuropsychological Performance in Survivors of Breast Cancer More Than 20 Years After Adjuvant Chemotherapy Cite
  Koppelmans V, Breteler MM, Boogerd W, Seynaeve C, Gundy C, Schagen SB. Neuropsychological Performance in Survivors of Breast Cancer More Than 20 Years After Adjuvant Chemotherapy. Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2012; 30:1080-1086 10.1200/jco.2011.37.0189
• Cytoprotective effects of fucoidan, an algae-derived polysaccharide on 5-fluorouracil-treated dendritic cells Cite
  Jeong B, Ko E, Joo H. Cytoprotective effects of fucoidan, an algae-derived polysaccharide on 5-fluorouracil-treated dendritic cells. Food and Chemical Toxicology. Elsevier BV; 2012; 50:1480-1484 10.1016/j.fct.2012.01.034
• Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100 000 women in 123 randomised trials Cite
  Early Breast Cancer Trialists' Collaborative Group (EBCTCG) . Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100 000 women in 123 randomised trials. The Lancet. Elsevier BV; 2012; 379:432-444 10.1016/s0140-6736(11)61625-5
• Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment Cite
  Pasquier E, Ciccolini J, Carre M, Giacometti S, Fanciullino R, Pouchy C, et al. Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment. Oncotarget. Impact Journals, LLC; 2011; 2:797-809 10.18632/oncotarget.343
• Prognostic value of chemotherapy-induced neutropenia in early-stage breast cancer Cite
  Han Y, Yu Z, Wen S, Zhang B, Cao X, Wang X. Prognostic value of chemotherapy-induced neutropenia in early-stage breast cancer. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2011; 131:483-490 10.1007/s10549-011-1799-1
• Synchronous Chemo-radiation Can Reduce Local Recurrence in Early Stage Breast Cancer: Results of the SECRAB Trial (ISRCTN: 84214355) Presented on Behalf of the SECRAB Steering Committee Cite
  Fernando I, Bowden S, Brookes C, Grieve R, Spooner D, Agrawal R, et al. Synchronous Chemo-radiation Can Reduce Local Recurrence in Early Stage Breast Cancer: Results of the SECRAB Trial (ISRCTN: 84214355) Presented on Behalf of the SECRAB Steering Committee. European Journal of Cancer. Elsevier BV; 2011; 47:2 10.1016/s0959-8049(11)70097-1
• Interaction of celecoxib with different anti-cancer drugs is antagonistic in breast but not in other cancer cells Cite
  El-Awady RA, Saleh EM, Ezz M, Elsayed AM. Interaction of celecoxib with different anti-cancer drugs is antagonistic in breast but not in other cancer cells. Toxicology and Applied Pharmacology. Elsevier BV; 2011; 255:271-286 10.1016/j.taap.2011.06.019
• Abstract P1-11-01: ANZAC: A Randomised Neoadjuvant Biomarker Study Investigating the Anti-Tumour Activity of the Addition of Zoledronic Acid to Chemotherapy in Breast Cancer Cite
  Winter M, Syddall S, Cross S, Evans A, Ingram C, Jolley I, et al. Abstract P1-11-01: ANZAC: A Randomised Neoadjuvant Biomarker Study Investigating the Anti-Tumour Activity of the Addition of Zoledronic Acid to Chemotherapy in Breast Cancer. Poster Session Abstracts. American Association for Cancer Research; 2010; 10.1158/0008-5472.sabcs10-p1-11-01
• Moderate neutropenia with adjuvant CMF confers improved survival in early breast cancer Cite
  Cameron DA, Massie C, Kerr G, Leonard RCF. Moderate neutropenia with adjuvant CMF confers improved survival in early breast cancer. British Journal of Cancer. Springer Science and Business Media LLC; 2003; 89:1837-1842 10.1038/sj.bjc.6601366
• 5-Fluorouracil combined with apigenin enhances anticancer activity through induction of apoptosis in human breast cancer MDA-MB-453 cells Cite
  Choi . 5-Fluorouracil combined with apigenin enhances anticancer activity through induction of apoptosis in human breast cancer MDA-MB-453 cells. Oncology Reports. Spandidos Publications; 2009; 22 10.3892/or_00000598
• Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer Cite
  Jiralerspong S, Palla SL, Giordano SH, Meric-Bernstam F, Liedtke C, Barnett CM, et al. Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer. Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2009; 27:3297-3302 10.1200/jco.2009.19.6410