Tag: flaxseed

Articles

• Cadmium increases the risk of breast cancer

News

03/11/18

Flaxseed lignans increase treatment effects of Adriamycin & Taxotere

05/22/16

Plant-based omega-3 fatty acid ALA reduces ER+/PR+ BC growth

02/27/11

Prediagnostic enterolactone levels linked to lower BC mortality

Foods

• • flaxseed

Studies

• Effect of thermal treatment on selected bioactive compounds and physicochemical properties of a blackberry-soy-flaxseed beverage Cite
  Bonilla AI, Usaga J, Cortés C, Pérez AM. Effect of thermal treatment on selected bioactive compounds and physicochemical properties of a blackberry-soy-flaxseed beverage. NFS Journal. Elsevier BV; 2024;:100177 10.1016/j.nfs.2024.100177
• Effect of Lifelong Exposure to Dietary Plant and Marine Sources of n-3 Polyunsaturated Fatty Acids on Morphologic and Gene Expression Biomarkers of Intestinal Health in Early Life Cite
  Acosta JE, Burns JL, Hillyer LM, Van K, Brendel EBK, Law C, et al. Effect of Lifelong Exposure to Dietary Plant and Marine Sources of n-3 Polyunsaturated Fatty Acids on Morphologic and Gene Expression Biomarkers of Intestinal Health in Early Life. Nutrients. MDPI AG; 2024; 16:719 10.3390/nu16050719
• Flaxseed (Linum usitatissimum); phytochemistry, pharmacological characteristics and functional food applications Cite
  Kauser S, Hussain A, Ashraf S, Fatima G, Ambreen , Javaria S, et al. Flaxseed (Linum usitatissimum); phytochemistry, pharmacological characteristics and functional food applications. Food Chemistry Advances. Elsevier BV; 2024; 4:100573 10.1016/j.focha.2023.100573
• Cecal microbiota and mammary gland microRNA signatures are related and modifiable by dietary flaxseed with implications for breast cancer risk Cite
  Wu D, Thompson LU, Comelli EM. Cecal microbiota and mammary gland microRNA signatures are related and modifiable by dietary flaxseed with implications for breast cancer risk. Microbiology Spectrum. American Society for Microbiology; 2023; 10.1128/spectrum.02290-23
• Can edible sprouts be the element of effective chemopreventive strategy? - A systematic review of in vitro and in vivo study Cite
  Grudzińska M, Galanty A, Paśko P. Can edible sprouts be the element of effective chemopreventive strategy? - A systematic review of in vitro and in vivo study. Trends in Food Science & Technology. Elsevier BV; 2023; 139:104130 10.1016/j.tifs.2023.104130
• A comprehensive review of the health benefits of flaxseed oil in relation to its chemical composition and comparison with other omega-3-rich oils Cite
  Al-Madhagy S, Ashmawy NS, Mamdouh A, Eldahshan OA, Farag MA. A comprehensive review of the health benefits of flaxseed oil in relation to its chemical composition and comparison with other omega-3-rich oils. European Journal of Medical Research. Springer Science and Business Media LLC; 2023; 28 10.1186/s40001-023-01203-6
• Physiological and Pathological Considerations for the Use of Flaxseed as a Therapeutic Dietary Strategy Cite
  Hirst BC, Dibrov E, Hirst SD, Pierce GN. Physiological and Pathological Considerations for the Use of Flaxseed as a Therapeutic Dietary Strategy. Reviews in Cardiovascular Medicine. IMR Press; 2023; 24:149 10.31083/j.rcm2405149
• In utero and postnatal exposure to Foeniculum vulgare and Linum usitatissimum seed extracts: modifications of key enzymes involved in epigenetic regulation and estrogen receptors expression in the offspring’s ovaries of NMRI mice Cite
  Pourjafari F, Ezzatabadipour M, Nematollahi-Mahani SN, Afgar A, Haghpanah T. In utero and postnatal exposure to Foeniculum vulgare and Linum usitatissimum seed extracts: modifications of key enzymes involved in epigenetic regulation and estrogen receptors expression in the offspring’s ovaries of NMRI mice. BMC Complementary Medicine and Therapies. Springer Science and Business Media LLC; 2023; 23 10.1186/s12906-023-03875-3
• Anticancer potential of lignans from flaxseed: metabolites, molecular target, synthetic lignan, current challenges and perspectives Cite
  Mueed A, Deng Z, Korma SA, Shibli S, Jahangir M. Anticancer potential of lignans from flaxseed: metabolites, molecular target, synthetic lignan, current challenges and perspectives. Food & Function. Royal Society of Chemistry (RSC); 2023; 10.1039/d2fo02208g
• Early life dietary exposures mediate persistent shifts in the gut microbiome and visceral fat metabolism Cite
  Newman TM, Clear KY, Wilson AS, Soto-Pantoja DR, Ochs-Balcom HM, Cook KL. Early life dietary exposures mediate persistent shifts in the gut microbiome and visceral fat metabolism. American Journal of Physiology-Cell Physiology. American Physiological Society; 2022; 10.1152/ajpcell.00380.2021
• In Vivo Antitumoral Effects of Linseed Oil and Its Combination With Doxorubicin Cite
  Shadyro O, Sosnovskaya A, Edimecheva I, Ihnatovich L, Dubovik B, Krasny S, et al. In Vivo Antitumoral Effects of Linseed Oil and Its Combination With Doxorubicin. Frontiers in Pharmacology. Frontiers Media SA; 2022; 13 10.3389/fphar.2022.882197
• Flaxseed Alters Gut Microbiota-Mammary Gland MicroRNA Relationships Differently Than its Oil and Lignan Components Cite
  Wu D, Taibi A, Thompson L, Comelli E. Flaxseed Alters Gut Microbiota-Mammary Gland MicroRNA Relationships Differently Than its Oil and Lignan Components. Current Developments in Nutrition. Oxford University Press (OUP); 2022; 6:342-342 10.1093/cdn/nzac053.083
• Lignans: a versatile source of anticancer drugs Cite
  Mukhija M, Joshi BC, Bairy PS, Bhargava A, Sah AN. Lignans: a versatile source of anticancer drugs. Beni-Suef University Journal of Basic and Applied Sciences. Springer Science and Business Media LLC; 2022; 11 10.1186/s43088-022-00256-6
• Availability of bioactive flax lignan from foods and supplements Cite
  Tse TJ, Guo Y, Shim YY, Purdy SK, Kim JH, Cho JY, et al. Availability of bioactive flax lignan from foods and supplements. Critical Reviews in Food Science and Nutrition. Informa UK Limited; 2022;:1-16 10.1080/10408398.2022.2072807
• Comparing Flaxseed and Perindopril in the Prevention of Doxorubicin and Trastuzumab-Induced Cardiotoxicity in C57Bl/6 Mice Cite
  Eekhoudt CR, Bortoluzzi T, Varghese SS, Cheung DYC, Christie S, Eastman S, et al. Comparing Flaxseed and Perindopril in the Prevention of Doxorubicin and Trastuzumab-Induced Cardiotoxicity in C57Bl/6 Mice. Current Oncology. MDPI AG; 2022; 29:2941-2953 10.3390/curroncol29050241
• Abstract P1-09-04: Flaxseed & breast cancer: A systematic review Cite
  Wang R, Yang M, Zhi I, Bao T. Abstract P1-09-04: Flaxseed & breast cancer: A systematic review. Cancer Research. American Association for Cancer Research (AACR); 2022; 82:P1-09-04-P1-09-04 10.1158/1538-7445.sabcs21-p1-09-04
• Omega-9 fatty acids: potential roles in inflammation and cancer management Cite
  Farag MA, Gad MZ. Omega-9 fatty acids: potential roles in inflammation and cancer management. Journal of Genetic Engineering and Biotechnology. Springer Science and Business Media LLC; 2022; 20 10.1186/s43141-022-00329-0
• Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements Cite
  Annemarie A, Renner B. Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements. Journal of Clinical Medicine. MDPI AG; 2022; 11:1567 10.3390/jcm11061567
• The secoisolariciresinol diglycoside (SDG) lignan content of oil flax: Genotypic and environmental variations and association with other traits Cite
  Zhang J, Xie Y, Miao C, Wang L, Zhao W, Li W, et al. The secoisolariciresinol diglycoside (SDG) lignan content of oil flax: Genotypic and environmental variations and association with other traits. Oil Crop Science. Elsevier BV; 2022; 10.1016/j.ocsci.2022.02.004
• Futuristic food fortification with a balanced ratio of dietary ω-3/ω-6 omega fatty acids for the prevention of lifestyle diseases Cite
  Patel A, Desai SS, Mane VK, Enman J, Rova U, Christakopoulos P, et al. Futuristic food fortification with a balanced ratio of dietary ω-3/ω-6 omega fatty acids for the prevention of lifestyle diseases. Trends in Food Science & Technology. Elsevier BV; 2022; 120:140-153 10.1016/j.tifs.2022.01.006
• Disposition of Dietary Polyphenols in Breast Cancer Patients’ Tumors, and their Associated Anticancer Activity: the Particular Case of Curcumin Cite
  Ávila‐Gálvez MÁ, González‐Sarrías A, Martínez‐Díaz F, Abellán B, Martínez‐Torrano AJ, Fernández‐López AJ, et al. Disposition of Dietary Polyphenols in Breast Cancer Patients’ Tumors, and their Associated Anticancer Activity: the Particular Case of Curcumin. Molecular Nutrition & Food Research. Wiley; 2021;:2100163 10.1002/mnfr.202100163
• Her-2 Breast Cancer Outcomes Are Mitigated by Consuming n-3 Polyunsaturated, Saturated, and Monounsaturated Fatty Acids Compared to n-6 Polyunsaturated Fatty Acids Cite
  Hillyer LM, Hucik B, Baracuhy EM, Lin Z, Muller WJ, Robinson LE, et al. Her-2 Breast Cancer Outcomes Are Mitigated by Consuming n-3 Polyunsaturated, Saturated, and Monounsaturated Fatty Acids Compared to n-6 Polyunsaturated Fatty Acids. Nutrients. MDPI AG; 2020; 12:3901 10.3390/nu12123901
• Antiestrogenic and antiproliferative potency of secoisolariciresinol diglucoside derivatives on MCF-7 breast cancer cells Cite
  Scherbakov AM, Stasevich OV, Salnikova DI, Andreeva OE, Mikhaevich EI. Antiestrogenic and antiproliferative potency of secoisolariciresinol diglucoside derivatives on MCF-7 breast cancer cells. Natural Product Research. Informa UK Limited; 2020;:1-7 10.1080/14786419.2020.1826479
• Comparative analysis of cadmium uptake and distribution in contrasting canadian flax cultivars Cite
  House MA, Young LW, Liu X, Liber K, Diederichsen A, Booker HM. Comparative analysis of cadmium uptake and distribution in contrasting canadian flax cultivars. BMC Research Notes. Springer Science and Business Media LLC; 2020; 13 10.1186/s13104-020-05265-1
• The Cardioprotective Role of Flaxseed in the Prevention of Doxorubicin- and Trastuzumab-Mediated Cardiotoxicity in C57BL/6 Mice Cite
  Asselin CY, Lam A, Cheung DYC, Eekhoudt CR, Zhu A, Mittal I, et al. The Cardioprotective Role of Flaxseed in the Prevention of Doxorubicin- and Trastuzumab-Mediated Cardiotoxicity in C57BL/6 Mice. The Journal of Nutrition. Oxford University Press (OUP); 2020; 150:2353-2363 10.1093/jn/nxaa144
• Effects of Flaxseed and Its Components on Mammary Gland MiRNome: Identification of Potential Biomarkers to Prevent Breast Cancer Development Cite
  Taibi A, Lin Z, Tsao R, Thompson LU, Comelli EM. Effects of Flaxseed and Its Components on Mammary Gland MiRNome: Identification of Potential Biomarkers to Prevent Breast Cancer Development. Nutrients. MDPI AG; 2019; 11:2656 10.3390/nu11112656
• Treatment with flaxseed oil induces apoptosis in cultured malignant cells Cite
  Buckner AL, Buckner CA, Montaut S, Lafrenie RM. Treatment with flaxseed oil induces apoptosis in cultured malignant cells. Heliyon. Elsevier BV; 2019; 5:e02251 10.1016/j.heliyon.2019.e02251
• Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells Cite
  Hu T, Linghu K, Huang S, Battino M, Georgiev MI, Zengin G, et al. Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells. Food and Chemical Toxicology. Elsevier BV; 2019; 127:188-196 10.1016/j.fct.2019.03.029
• Dietary flaxseed and tamoxifen affect the inflammatory microenvironment in vivo in normal human breast tissue of postmenopausal women Cite
  Lindahl G, Abrahamsson A, Dabrosin C. Dietary flaxseed and tamoxifen affect the inflammatory microenvironment in vivo in normal human breast tissue of postmenopausal women. European Journal of Clinical Nutrition. Springer Science and Business Media LLC; 2019; 73:1250-1259 10.1038/s41430-019-0396-y
• Flaxseed extracts induce apoptosis and regulate the growth of MCF-7 human breast cancer cells Cite
  Hu T, Xiao J. Flaxseed extracts induce apoptosis and regulate the growth of MCF-7 human breast cancer cells. Free Radical Biology and Medicine. Elsevier BV; 2018; 128:S117 10.1016/j.freeradbiomed.2018.10.286
• The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth Cite
  Bowers LW, Lineberger CG, Ford NA, Rossi EL, Punjala A, Camp KK, et al. The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2018; 173:545-557 10.1007/s10549-018-5021-6
• Maternal exposure to an n-3 polyunsaturated fatty acid diet decreases mammary cancer risk of female offspring in adulthood Cite
  Li J, Li K, Gao J, Guo X, Lu M, Li Z, et al. Maternal exposure to an n-3 polyunsaturated fatty acid diet decreases mammary cancer risk of female offspring in adulthood. Food & Function. Royal Society of Chemistry (RSC); 2018; 9:5768-5777 10.1039/c8fo01006d
• Flaxseed Lignans Enhance the Cytotoxicity of Chemotherapeutic Agents against Breast Cancer Cell Lines MDA-MB-231 and SKBR3 Cite
  Di Y, De Silva F, Krol ES, Alcorn J. Flaxseed Lignans Enhance the Cytotoxicity of Chemotherapeutic Agents against Breast Cancer Cell Lines MDA-MB-231 and SKBR3. Nutrition and Cancer. Informa UK Limited; 2018; 70:306-315 10.1080/01635581.2018.1421677
• The Effect of Flaxseed in Breast Cancer: A Literature Review Cite
  Calado A, Neves PM, Santos T, Ravasco P. The Effect of Flaxseed in Breast Cancer: A Literature Review. Frontiers in Nutrition. Frontiers Media SA; 2018; 5 10.3389/fnut.2018.00004
• Omega-3 Polyunsaturated Fatty Acids Time-Dependently Reduce Cell Viability and Oncogenic MicroRNA-21 Expression in Estrogen Receptor-Positive Breast Cancer Cells (MCF-7) Cite
  LeMay-Nedjelski L, Mason-Ennis J, Taibi A, Comelli E, Thompson L. Omega-3 Polyunsaturated Fatty Acids Time-Dependently Reduce Cell Viability and Oncogenic MicroRNA-21 Expression in Estrogen Receptor-Positive Breast Cancer Cells (MCF-7). International Journal of Molecular Sciences. MDPI AG; 2018; 19:244 10.3390/ijms19010244
• Antioxidant and antimicrobial activity of linseed lignans and phenolic acids Cite
  Kyselka J, Rabiej D, Dragoun M, Kreps F, Burčová Z, Němečková I, et al. Antioxidant and antimicrobial activity of linseed lignans and phenolic acids. European Food Research and Technology. Springer Science and Business Media LLC; 2017; 243:1633-1644 10.1007/s00217-017-2871-9
• Combining doxorubicin with a phenolic extract from flaxseed oil: Evaluation of the effect on two breast cancer cell lines Cite
  Guerriero E, Sorice A, Capone F, Storti G, Colonna G, Ciliberto G, et al. Combining doxorubicin with a phenolic extract from flaxseed oil: Evaluation of the effect on two breast cancer cell lines. International Journal of Oncology. Spandidos Publications; 2017; 50:468-476 10.3892/ijo.2017.3835
• Linseed as a Functional Food for the Management of Obesity Cite
  Shafie SR, Poudyal H, Panchal SK, Brown L. Linseed as a Functional Food for the Management of Obesity. Omega-3 Fatty Acids. Springer International Publishing; 2016;:173-187 10.1007/978-3-319-40458-5_13
• Comparison of phytochemical profiles and health benefits in fiber and oil flaxseeds ( Linum usitatissimum L.) Cite
  Wang H, Wang J, Qiu C, Ye Y, Guo X, Chen G, et al. Comparison of phytochemical profiles and health benefits in fiber and oil flaxseeds ( Linum usitatissimum L.). Food Chemistry. Elsevier BV; 2017; 214:227-233 10.1016/j.foodchem.2016.07.075
• Maternal flaxseed oil intake during lactation changes body fat, inflammatory markers and glucose homeostasis in the adult progeny: role of gender dimorphism Cite
  Guarda DS, de Moura EG, Carvalho JC, Reis AMd, Soares PN, Lisboa PC, et al. Maternal flaxseed oil intake during lactation changes body fat, inflammatory markers and glucose homeostasis in the adult progeny: role of gender dimorphism. The Journal of Nutritional Biochemistry. Elsevier BV; 2016; 35:74-80 10.1016/j.jnutbio.2016.05.011
• Adipokines and Vascular Endothelial Growth Factor in Normal Human Breast Tissue in Vivo – Correlations and Attenuation by Dietary Flaxseed Cite
  Morad V, Abrahamsson A, Kjölhede P, Dabrosin C. Adipokines and Vascular Endothelial Growth Factor in Normal Human Breast Tissue in Vivo – Correlations and Attenuation by Dietary Flaxseed. Journal of Mammary Gland Biology and Neoplasia. Springer Science and Business Media LLC; 2016; 21:69-76 10.1007/s10911-016-9352-9
• Differential Response of Two Human Breast Cancer Cell Lines to the Phenolic Extract from Flaxseed Oil Cite
  Sorice A, Guerriero E, Volpe M, Capone F, La Cara F, Ciliberto G, et al. Differential Response of Two Human Breast Cancer Cell Lines to the Phenolic Extract from Flaxseed Oil. Molecules. MDPI AG; 2016; 21:319 10.3390/molecules21030319
• Abstract P2-05-28: The impact of the plant lignin secoisolariciresinol diglycoside on preclinical models of estrogen receptor positive breast cancer Cite
  Bowers L, Ford N, Rossi E, Shamsunder M, Kimler B, Fabian C, et al. Abstract P2-05-28: The impact of the plant lignin secoisolariciresinol diglycoside on preclinical models of estrogen receptor positive breast cancer. Poster Session Abstracts. American Association for Cancer Research; 2016; 10.1158/1538-7445.sabcs15-p2-05-28
• Flaxseed oil enhances the effectiveness of trastuzumab in reducing the growth of HER2-overexpressing human breast tumors (BT-474) Cite
  Mason JK, Fu M, Chen J, Thompson LU. Flaxseed oil enhances the effectiveness of trastuzumab in reducing the growth of HER2-overexpressing human breast tumors (BT-474). The Journal of Nutritional Biochemistry. Elsevier BV; 2015; 26:16-23 10.1016/j.jnutbio.2014.08.001
• Age-dependency in the metabolism of flaxseed lignans by healthy adults Cite
  Edel AL, Pierce GN, Aliani M. Age-dependency in the metabolism of flaxseed lignans by healthy adults. Journal of Functional Foods. Elsevier BV; 2015; 17:948-957 10.1016/j.jff.2015.06.042
• Linseed, the multipurpose plant Cite
  Zuk M, Richter D, Matuła J, Szopa J. Linseed, the multipurpose plant. Industrial Crops and Products. Elsevier BV; 2015; 75:165-177 10.1016/j.indcrop.2015.05.005
• Effects of Flaxseed Lignan Secoisolariciresinol Diglucosideon Preneoplastic Biomarkers of Cancer Progression in a Model of Simultaneous Breast and Ovarian Cancer Development Cite
  Delman DM, Fabian CJ, Kimler BF, Yeh H, Petroff BK. Effects of Flaxseed Lignan Secoisolariciresinol Diglucosideon Preneoplastic Biomarkers of Cancer Progression in a Model of Simultaneous Breast and Ovarian Cancer Development. Nutrition and Cancer. Informa UK Limited; 2015; 67:857-864 10.1080/01635581.2015.1042549
• Studies on functional and antioxidant property of dietary fibre extracted from defatted sesame husk, rice bran and flaxseed Cite
  Nandi I, Ghosh M. Studies on functional and antioxidant property of dietary fibre extracted from defatted sesame husk, rice bran and flaxseed. Bioactive Carbohydrates and Dietary Fibre. Elsevier BV; 2015; 5:129-136 10.1016/j.bcdf.2015.03.001
• Growth and gene expression differ over time in alpha-linolenic acid treated breast cancer cells Cite
  Wiggins AK, Mason JK, Thompson LU. Growth and gene expression differ over time in alpha-linolenic acid treated breast cancer cells. Experimental Cell Research. Elsevier BV; 2015; 333:147-154 10.1016/j.yexcr.2015.02.020
• Consumption of flaxseed, a rich source of lignans, is associated with reduced breast cancer risk Cite
  Lowcock EC, Cotterchio M, Boucher BA. Consumption of flaxseed, a rich source of lignans, is associated with reduced breast cancer risk. Cancer Causes & Control. Springer Science and Business Media LLC; 2013; 24:813-816 10.1007/s10552-013-0155-7
• Uptake of α-Linolenic Acid and Its Conversion to Long Chain Omega-3 Fatty Acids in Rats Fed Microemulsions of Linseed Oil Cite
  Sugasini D, Lokesh BR. Uptake of α-Linolenic Acid and Its Conversion to Long Chain Omega-3 Fatty Acids in Rats Fed Microemulsions of Linseed Oil. Lipids. Wiley; 2012; 47:1155-1167 10.1007/s11745-012-3731-9
• Estradiol, Tamoxifen, and Flaxseed Alter IL-1β and IL-1Ra Levels in Normal Human Breast Tissue in Vivo Cite
  Abrahamsson A, Morad V, Saarinen NM, Dabrosin C. Estradiol, Tamoxifen, and Flaxseed Alter IL-1β and IL-1Ra Levels in Normal Human Breast Tissue in Vivo. The Journal of Clinical Endocrinology & Metabolism. The Endocrine Society; 2012; 97:E2044-E2054 10.1210/jc.2012-2288
• Dietary flaxseed oil reduces adipocyte size, adipose monocyte chemoattractant protein-1 levels and T-cell infiltration in obese, insulin-resistant rats Cite
  Baranowski M, Enns J, Blewett H, Yakandawala U, Zahradka P, Taylor CG. Dietary flaxseed oil reduces adipocyte size, adipose monocyte chemoattractant protein-1 levels and T-cell infiltration in obese, insulin-resistant rats. Cytokine. Elsevier BV; 2012; 59:382-391 10.1016/j.cyto.2012.04.004
• Flaxseed cotyledon fraction reduces tumour growth and sensitises tamoxifen treatment of human breast cancer xenograft (MCF-7) in athymic mice Cite
  Chen J, Saggar JK, Corey P, Thompson LU. Flaxseed cotyledon fraction reduces tumour growth and sensitises tamoxifen treatment of human breast cancer xenograft (MCF-7) in athymic mice. British Journal of Nutrition. Cambridge University Press (CUP); 2010; 105:339-347 10.1017/s0007114510003557
• Effect of wheat bran and flaxseed on cadmium effects and retention in rats Cite
  Callegaro M, Milbradt B, Alves E, Diettrich T, Kemerich D, Hausen B, et al. Effect of wheat bran and flaxseed on cadmium effects and retention in rats. Human & Experimental Toxicology. SAGE Publications; 2010; 30:981-991 10.1177/0960327110384526
• Comparative Effects of Sesame Seed Lignan and Flaxseed Lignan in Reducing the Growth of Human Breast Tumors (MCF-7) at High Levels of Circulating Estrogen in Athymic Mice Cite
  Truan JS, Chen J, Thompson LU. Comparative Effects of Sesame Seed Lignan and Flaxseed Lignan in Reducing the Growth of Human Breast Tumors (MCF-7) at High Levels of Circulating Estrogen in Athymic Mice. Nutrition and Cancer. Informa UK Limited; 2012; 64:65-71 10.1080/01635581.2012.630165
• Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer Cite
  Mabrok HB, Klopfleisch R, Ghanem KZ, Clavel T, Blaut M, Loh G. Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer. Carcinogenesis. Oxford University Press (OUP); 2011; 33:203-208 10.1093/carcin/bgr256
• Estimated enterolignans, lignan-rich foods, and fibre in relation to survival after postmenopausal breast cancer Cite
  Buck K, Zaineddin AK, Vrieling A, Heinz J, Linseisen J, Flesch-Janys D, et al. Estimated enterolignans, lignan-rich foods, and fibre in relation to survival after postmenopausal breast cancer. British Journal of Cancer. Springer Science and Business Media LLC; 2011; 105:1151-1157 10.1038/bjc.2011.374
• Serum Enterolactone and Prognosis of Postmenopausal Breast Cancer Cite
  Buck K, Vrieling A, Zaineddin AK, Becker S, Hüsing A, Kaaks R, et al. Serum Enterolactone and Prognosis of Postmenopausal Breast Cancer. Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2011; 29:3730-3738 10.1200/jco.2011.34.6478
• Maternal flaxseed diet during pregnancy or lactation increases female rat offspring's susceptibility to carcinogen-induced mammary tumorigenesis Cite
  KHAN G, PENTTINEN P, CABANES A, FOXWORTH A, CHEZEK A, MASTROPOLE K, et al. Maternal flaxseed diet during pregnancy or lactation increases female rat offspring's susceptibility to carcinogen-induced mammary tumorigenesis. Reproductive Toxicology. Elsevier BV; 2007; 23:397-406 10.1016/j.reprotox.2007.02.002
• Changes in biomarkers of estrogen receptor and growth factor signaling pathways in MCF-7 tumors after short- and long-term treatment with soy and flaxseed Cite
  Power KA, Chen JM, Saarinen NM, Thompson LU. Changes in biomarkers of estrogen receptor and growth factor signaling pathways in MCF-7 tumors after short- and long-term treatment with soy and flaxseed. The Journal of Steroid Biochemistry and Molecular Biology. Elsevier BV; 2008; 112:13-19 10.1016/j.jsbmb.2008.07.003
• Flaxseed and its components reduce metastasis after surgical excision of solid human breast tumor in nude mice Cite
  Chen J, Wang L, Thompson LU. Flaxseed and its components reduce metastasis after surgical excision of solid human breast tumor in nude mice. Cancer Letters. Elsevier BV; 2006; 234:168-175 10.1016/j.canlet.2005.03.056
• Mammalian Lignan Formation in Rats Fed a Wheat Bran Diet Cite
  Nicolle C, Manach C, Morand C, Mazur W, Adlercreutz H, Rémésy C, et al. Mammalian Lignan Formation in Rats Fed a Wheat Bran Diet. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2002; 50:6222-6226 10.1021/jf020208z