Tag: equol

Equol: A metabolite of soy isoflavones. Equol has been hypothesized to be largely responsible for the estrogen-like activities of soy and its isoflavones. However, only 25% to 35% of the U.S. Caucasian population is capable of converting daidzein to equol.

Articles

Supplements with warnings for breast cancer

Foods

- genistein and daidzein

Studies

Phytosterols activating nuclear receptors are involving in steroid hormone-dependent cancers: Myth or fact? Cite
Bakrim S, El Omari N, Khan EJ, Khalid A, Abdalla AN, Chook JB, et al. Phytosterols activating nuclear receptors are involving in steroid hormone-dependent cancers: Myth or fact?. Biomedicine & Pharmacotherapy. Elsevier BV; 2023; 169:115783 10.1016/j.biopha.2023.115783
Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer Cite
da Silva FC, Brandão DC, Ferreira EA, Siqueira RP, Ferreira HSV, Da Silva Filho AA, et al. Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer. Pharmaceuticals. MDPI AG; 2023; 16:1466 10.3390/ph16101466
Association of urinary phytoestrogens with hormone-related cancers and cancer biomarkers: NHANES 1999-2010 Cite
Liu F, Peng Y, Qiao Y, Wang P, Si C, Wang X, et al. Association of urinary phytoestrogens with hormone-related cancers and cancer biomarkers: NHANES 1999-2010. British Journal of Nutrition. Cambridge University Press (CUP); 2022;:1-37 10.1017/s0007114522003877
Estrogenic in vitro evaluation of zearalenone and its phase I and II metabolites in combination with soy isoflavones Cite
Grgic D, Betschler A, Früholz R, Novak B, Varga E, Marko D. Estrogenic in vitro evaluation of zearalenone and its phase I and II metabolites in combination with soy isoflavones. Archives of Toxicology. Springer Science and Business Media LLC; 2022; 10.1007/s00204-022-03358-3
Isoflavones in Soybean as a Daily Nutrient: The Mechanisms of Action and How They Alter the Pharmacokinetics of Drugs Cite
SOYATA A, HASANAH AN, RUSDIANA T. Isoflavones in Soybean as a Daily Nutrient: The Mechanisms of Action and How They Alter the Pharmacokinetics of Drugs. Turkish Journal of Pharmaceutical Sciences. Galenos Yayinevi; 2021; 18:799-810 10.4274/tjps.galenos.2020.79106
Soy isoflavone metabolite equol inhibits cancer cell proliferation in a PAP associated domain containing 5-dependent and an estrogen receptor-independent manner Cite
Yamashita S, Lin I, Oka C, Kumazoe M, Komatsu S, Murata M, et al. Soy isoflavone metabolite equol inhibits cancer cell proliferation in a PAP associated domain containing 5-dependent and an estrogen receptor-independent manner. The Journal of Nutritional Biochemistry. Elsevier BV; 2021;:108910 10.1016/j.jnutbio.2021.108910
Urinary equol levels are positively associated with urinary estradiol excretion in women Cite
Fujitani T, Fujii Y, Lyu Z, Harada Sassa M, Harada KH. Urinary equol levels are positively associated with urinary estradiol excretion in women. Scientific Reports. Springer Science and Business Media LLC; 2021; 11 10.1038/s41598-021-98872-2
Abstract PS5-31: Molecular markers of response to s-equol, a novel oral estrogen receptor (ER) beta agonist for triple negative breast cancer Cite
Lathrop K, Kaklamani V, Brenner A, Li R, Nazarullah A, Hackman S, et al. Abstract PS5-31: Molecular markers of response to s-equol, a novel oral estrogen receptor (ER) beta agonist for triple negative breast cancer. Poster Session Abstracts. American Association for Cancer Research; 2021; 10.1158/1538-7445.sabcs20-ps5-31
A Systematic Review of the Effects of Equol (Soy Metabolite) on Breast Cancer Cite
Hod R, Maniam S, Mohd Nor NH. A Systematic Review of the Effects of Equol (Soy Metabolite) on Breast Cancer. Molecules. MDPI AG; 2021; 26:1105 10.3390/molecules26041105
Serum isoflavones and lignans and odds of breast cancer in pre- and postmenopausal Chinese women Cite
Feng X, Ho SC, Zhan X, Zuo L, Mo X, Zhang X, et al. Serum isoflavones and lignans and odds of breast cancer in pre- and postmenopausal Chinese women. Menopause. Ovid Technologies (Wolters Kluwer Health); 2021; Publish Ahead of Print 10.1097/gme.0000000000001715
Effect of isoflavones on breast cancer cell development and their impact on breast cancer treatments Cite
Hatono M, Ikeda H, Suzuki Y, Kajiwara Y, Kawada K, Tsukioki T, et al. Effect of isoflavones on breast cancer cell development and their impact on breast cancer treatments. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2020; 10.1007/s10549-020-05957-z
Abstract 4642: Effects of soy protein diet on plasma isoflavones levels in obese DMBA-induced mammary tumor rat model Cite
Hakkak R, Korourian S. Abstract 4642: Effects of soy protein diet on plasma isoflavones levels in obese DMBA-induced mammary tumor rat model. Epidemiology. American Association for Cancer Research; 2020; 10.1158/1538-7445.am2020-4642
(±)-Equol does not interact with genistein on estrogen-dependent breast tumor growth Cite
Song H, Hughes JR, Turner RT, Iwaniec UT, Doerge DR, Helferich WG. (±)-Equol does not interact with genistein on estrogen-dependent breast tumor growth. Food and Chemical Toxicology. Elsevier BV; 2020; 136:110979 10.1016/j.fct.2019.110979
Abstract 4390: Dietary soy isoflavone equol promotes breast cancer progression via regulation of protein synthesis initiation Cite
Cruz-Collazo AM, Parra CDl, Schneider R, Dharmawardhane S. Abstract 4390: Dietary soy isoflavone equol promotes breast cancer progression via regulation of protein synthesis initiation. Molecular and Cellular Biology / Genetics. American Association for Cancer Research; 2019; 10.1158/1538-7445.am2019-4390
Abstract P2-05-06: Effects of a soy isoflavone in breast cancer treatment Cite
Hatono M, Ikeda H, Taira N, Suzuki Y, Kajiwara Y, Kawata K, et al. Abstract P2-05-06: Effects of a soy isoflavone in breast cancer treatment. Poster Session Abstracts. American Association for Cancer Research; 2019; 10.1158/1538-7445.sabcs18-p2-05-06
Effect of daidzein and equol on DNA replication in MCF-7 cells Cite
Tsuji M, Tanaka T, Nagashima R, Sagisaka Y, Tousen Y, Nishide Y, et al. Effect of daidzein and equol on DNA replication in MCF-7 cells. The Journal of Biochemistry. Oxford University Press (OUP); 2018; 163:371-380 10.1093/jb/mvy006
Equol Enhances Apoptosis-inducing Activity of Genistein by Increasing Bax/Bcl-xL Expression Ratio in MCF-7 Human Breast Cancer Cells Cite
Ono M, Ejima K, Higuchi T, Takeshima M, Wakimoto R, Nakano S. Equol Enhances Apoptosis-inducing Activity of Genistein by Increasing Bax/Bcl-xL Expression Ratio in MCF-7 Human Breast Cancer Cells. Nutrition and Cancer. Informa UK Limited; 2017; 69:1300-1307 10.1080/01635581.2017.1367945
Estrogen receptor-α and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells Cite
Gong P, Madak-Erdogan Z, Flaws JA, Shapiro DJ, Katzenellenbogen JA, Katzenellenbogen BS. Estrogen receptor-α and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells. Molecular and Cellular Endocrinology. Elsevier BV; 2016; 437:190-200 10.1016/j.mce.2016.08.025
Plasma equol concentration is not associated with breast cancer and fibrocystic breast conditions among women in Shanghai, China Cite
Atkinson C, Ray RM, Li W, Lin M, Gao DL, Shannon J, et al. Plasma equol concentration is not associated with breast cancer and fibrocystic breast conditions among women in Shanghai, China. Nutrition Research. Elsevier BV; 2016; 36:863-871 10.1016/j.nutres.2016.03.008
Breast Cancer Cell Apoptosis with Phytoestrogens Is Dependent on an Estrogen-Deprived State Cite
Obiorah IE, Fan P, Jordan VC. Breast Cancer Cell Apoptosis with Phytoestrogens Is Dependent on an Estrogen-Deprived State. Cancer Prevention Research. American Association for Cancer Research (AACR); 2014; 7:939-949 10.1158/1940-6207.capr-14-0061
S-(−)equol producing status not associated with breast cancer risk among low isoflavone-consuming US postmenopausal women undergoing a physician-recommended breast biopsy Cite
Virk-Baker MK, Barnes S, Krontiras H, Nagy TR. S-(−)equol producing status not associated with breast cancer risk among low isoflavone-consuming US postmenopausal women undergoing a physician-recommended breast biopsy. Nutrition Research. Elsevier BV; 2014; 34:116-125 10.1016/j.nutres.2013.12.002
Association between precocious puberty and some endocrine disruptors in human plasma Cite
Yum T, Lee S, Kim Y. Association between precocious puberty and some endocrine disruptors in human plasma. Journal of Environmental Science and Health, Part A. Informa UK Limited; 2013; 48:912-917 10.1080/10934529.2013.762734
Breast, colorectal, and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition-Norfolk in relation to phytoestrogen intake derived from an improved database Cite
Ward HA, Kuhnle GG, Mulligan AA, Lentjes MA, Luben RN, Khaw K. Breast, colorectal, and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition-Norfolk in relation to phytoestrogen intake derived from an improved database. American Journal of Clinical Nutrition. Oxford University Press (OUP); 2009; 91:440-448 10.3945/ajcn.2009.28282
Dietary Seaweed Modifies Estrogen and Phytoestrogen Metabolism in Healthy Postmenopausal Women Cite
Teas J, Hurley TG, Hebert JR, Franke AA, Sepkovic DW, Kurzer MS. Dietary Seaweed Modifies Estrogen and Phytoestrogen Metabolism in Healthy Postmenopausal Women. The Journal of Nutrition. Oxford University Press (OUP); 2009; 139:939-944 10.3945/jn.108.100834
Plasma Phytoestrogens Are Not Altered by Probiotic Consumption in Postmenopausal Women with and without a History of Breast Cancer Cite
Nettleton JA, Greany KA, Thomas W, Wangen KE, Adlercreutz H, Kurzer MS. Plasma Phytoestrogens Are Not Altered by Probiotic Consumption in Postmenopausal Women with and without a History of Breast Cancer. The Journal of Nutrition. Oxford University Press (OUP); 2004; 134:1998-2003 10.1093/jn/134.8.1998
The Effect of the Phytoestrogens Genistein, Daidzein, and Equol on the Growth of Tamoxifen-Resistant T47D/PKCα Cite
Tonetti DA, Zhang Y, Zhao H, Lim S, Constantinou AI. The Effect of the Phytoestrogens Genistein, Daidzein, and Equol on the Growth of Tamoxifen-Resistant T47D/PKCα. Nutrition and Cancer. Informa UK Limited; 2007; 58:222-229 10.1080/01635580701328545
Isoflavones in urine, saliva, and blood of infants: data from a pilot study on the estrogenic activity of soy formula Cite
Cao Y, Calafat AM, Doerge DR, Umbach DM, Bernbaum JC, Twaddle NC, et al. Isoflavones in urine, saliva, and blood of infants: data from a pilot study on the estrogenic activity of soy formula. Journal of Exposure Science & Environmental Epidemiology. Springer Science and Business Media LLC; 2008; 19:223-234 10.1038/jes.2008.44
Soy processing influences growth of estrogen-dependent breast cancer tumors Cite
Allred CD. Soy processing influences growth of estrogen-dependent breast cancer tumors. Carcinogenesis. Oxford University Press (OUP); 2004; 25:1649-1657 10.1093/carcin/bgh178
Prevalence of Daidzein-Metabolizing Phenotypes Differs between Caucasian and Korean American Women and Girls Cite
Song KB, Atkinson C, Frankenfeld CL, Jokela T, Wähälä K, Thomas WK, et al. Prevalence of Daidzein-Metabolizing Phenotypes Differs between Caucasian and Korean American Women and Girls. The Journal of Nutrition. Oxford University Press (OUP); 2006; 136:1347-1351 10.1093/jn/136.5.1347