Tag: capsaicin

Articles

• Supplements with warnings for breast cancer

News

07/20/25

Capsaicin increases doxorubicin toxicity in mouse model of triple negative BC

01/12/18

Hot pepper compound capsaicin reduces tumor development

Foods

• • hot peppers

Studies

• Combination therapy with capsaicin and doxorubicin inhibits TNBC metastasis by targeting TGF-beta thereby increasing survival in a 4T1 transplanted murine model Cite
  Ghosal J, Gupta PS, Mukherjee G, Bhattacharjee S, Mandal DP. Combination therapy with capsaicin and doxorubicin inhibits TNBC metastasis by targeting TGF-beta thereby increasing survival in a 4T1 transplanted murine model. European Journal of Pharmacology. Elsevier BV; 2025;:177948 10.1016/j.ejphar.2025.177948
• Capsanthin inhibits migration and reduces N-linked glycosylation of PD-L1 via the EZH2-PD-L1 axis in triple-negative breast cancer brain metastasis Cite
  Chien Y, Wu J, Liu L, Yu Y. Capsanthin inhibits migration and reduces N-linked glycosylation of PD-L1 via the EZH2-PD-L1 axis in triple-negative breast cancer brain metastasis. Cell Death Discovery. Springer Science and Business Media LLC; 2025; 11 10.1038/s41420-025-02368-1
• Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment Cite
  Nguyen MH, Nguyen TYN, Le THN, Le TNT, Chau NTN, Le TMH, et al. Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment. Heliyon. Elsevier BV; 2024; 10:e39229 10.1016/j.heliyon.2024.e39229
• Capsaicin orchestrates metastasis in gastric cancer via modulating expression of TRPV1 channels and driving gut microbiota disorder Cite
  Deng R, Yu S, Ruan X, Liu H, Zong G, Cheng P, et al. Capsaicin orchestrates metastasis in gastric cancer via modulating expression of TRPV1 channels and driving gut microbiota disorder. Cell Communication and Signaling. Springer Science and Business Media LLC; 2023; 21 10.1186/s12964-023-01265-3
• Topical treatment of chemotherapy-induced peripheral neuropathy (CIPN) with high-concentration (179 mg) capsaicin patch in breast cancer patients – results of the QUCIP study Cite
  Lux MP, Flöther L, Frömter C, Rack B, Veselinovic K, Heine M, et al. Topical treatment of chemotherapy-induced peripheral neuropathy (CIPN) with high-concentration (179 mg) capsaicin patch in breast cancer patients – results of the QUCIP study. Frontiers in Oncology. Frontiers Media SA; 2024; 14 10.3389/fonc.2024.1452099
• The Antitumour Mechanisms of Carotenoids: A Comprehensive Review Cite
  Baeza-Morales A, Medina-García M, Martínez-Peinado P, Pascual-García S, Pujalte-Satorre C, López-Jaén AB, et al. The Antitumour Mechanisms of Carotenoids: A Comprehensive Review. Antioxidants. MDPI AG; 2024; 13:1060 10.3390/antiox13091060
• Capsaicin exerts synergistic pro-apoptotic effects with cisplatin in TSCC through the calpain pathway via TRPV1 Cite
  Zhou X, Zhao Q, Li Z, Liu X, Wang Y, Wu F, et al. Capsaicin exerts synergistic pro-apoptotic effects with cisplatin in TSCC through the calpain pathway via TRPV1. Journal of Cancer. Ivyspring International Publisher; 2024; 15:4801-4817 10.7150/jca.98075
• Phytochemical‐mediated modulation of autophagy and endoplasmic reticulum stress as a cancer therapeutic approach Cite
  Al Azzani M, Nizami ZN, Magramane R, Sekkal MN, Eid AH, Al Dhaheri Y, et al. Phytochemical‐mediated modulation of autophagy and endoplasmic reticulum stress as a cancer therapeutic approach. Phytotherapy Research. Wiley; 2024; 10.1002/ptr.8283
• Capsaicin ameliorates chemotherapy response via cancer hallmarks modulation: an overview of its synergic potential Cite
  Costa RF, Cadoná FC. Capsaicin ameliorates chemotherapy response via cancer hallmarks modulation: an overview of its synergic potential. Journal of Herbal Medicine. Elsevier BV; 2024;:100882 10.1016/j.hermed.2024.100882
• Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy Cite
  Khan F, Pandey P, Verma M, Ramniwas S, Lee D, Moon S, et al. Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy. Biomedicine & Pharmacotherapy. Elsevier BV; 2024; 173:116363 10.1016/j.biopha.2024.116363
• Chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases Cite
  Hudáková T, Šemeláková M, Očenáš P, Kožurková M, Krochtová K, Sovová S, et al. Chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases. BMC Complementary Medicine and Therapies. Springer Science and Business Media LLC; 2024; 24 10.1186/s12906-024-04394-5
• Phytochemicals and Their Usefulness in the Maintenance of Health Cite
  Rodríguez-Negrete EV, Morales-González Á, Madrigal-Santillán EO, Sánchez-Reyes K, Álvarez-González I, Madrigal-Bujaidar E, et al. Phytochemicals and Their Usefulness in the Maintenance of Health. Plants. MDPI AG; 2024; 13:523 10.3390/plants13040523
• Capsaicin alleviates doxorubicin-induced acute myocardial injury by regulating iron homeostasis and PI3K-Akt signaling pathway Cite
  Wang L, Liu Y, Li S, Zha Z, Chen Y, Wang Q, et al. Capsaicin alleviates doxorubicin-induced acute myocardial injury by regulating iron homeostasis and PI3K-Akt signaling pathway. Aging. Impact Journals, LLC; 2023; 15:11845-11859 10.18632/aging.205138
• Capsaicin Ameliorates Chemotherapy Response via Cancer Hallmarks Modulation: An Overview of its Synergic Potential Cite
  Costa R, Cadoná F. Capsaicin Ameliorates Chemotherapy Response via Cancer Hallmarks Modulation: An Overview of its Synergic Potential. Journal of Herbal Medicine. Elsevier BV; 2024; 45:100882 10.1016/j.hermed.2024.100882
• Anticancer Activity of Region B Capsaicin Analogs Cite
  Brown KC, Modi KJ, Light RS, Cox AJ, Long TE, Gadepalli RS, et al. Anticancer Activity of Region B Capsaicin Analogs. Journal of Medicinal Chemistry. American Chemical Society (ACS); 2023; 10.1021/acs.jmedchem.2c01594
• Capsaicin alleviates cisplatin‐induced muscle loss and atrophy in vitro and in vivo Cite
  Huang K, Chiang Y, Huang T, Chen H, Lin P, Ali M, et al. Capsaicin alleviates cisplatin‐induced muscle loss and atrophy in vitro and in vivo. Journal of Cachexia, Sarcopenia and Muscle. Wiley; 2022; 14:182-197 10.1002/jcsm.13120
• Capsanthin-Loaded Micelles: Preparation, Characterization and in vitro Evaluation of Cytotoxicity Using MDA-MB-231 Breast Cancer Cell Line Cite
  Shanmugham V, Subban R. Capsanthin-Loaded Micelles: Preparation, Characterization and in vitro Evaluation of Cytotoxicity Using MDA-MB-231 Breast Cancer Cell Line. Food Technology and Biotechnology. Faculty of Food Technology and Biotechnology - University of Zagreb; 2022; 60:350-360 10.17113/ftb.60.03.22.7405
• Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer Cite
  Adetunji TL, Olawale F, Olisah C, Adetunji AE, Aremu AO. Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer. Frontiers in Oncology. Frontiers Media SA; 2022; 12 10.3389/fonc.2022.908487
• Effect of capsaicin on breast cancer resistance protein (Bcrp/Abcg2) and pharmacokinetics of probe substrates in rats Cite
  Chen F, Wang L, Zhai X, Wang N, Qin Y, Zhu C, et al. Effect of capsaicin on breast cancer resistance protein (Bcrp/Abcg2) and pharmacokinetics of probe substrates in rats. Xenobiotica. Informa UK Limited; 2022;:1-15 10.1080/00498254.2021.2025281
• The reversal effect of capsaicin on doxorubicin-resistant breast cancer cells Cite
  . The reversal effect of capsaicin on doxorubicin-resistant breast cancer cells. Journal of Chinese Pharmaceutical Sciences. Journal of Chinese Pharmaceutical Sciences; 2021; 30:666-674 10.5246/jcps.2021.08.054
• Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy Cite
  Sabo AA, Dudau M, Constantin GL, Pop TC, Geilfus C, Naccarati A, et al. Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy. Frontiers in Pharmacology. Frontiers Media SA; 2021; 12 10.3389/fphar.2021.652074
• Capsaicin suppresses breast cancer cell viability by regulating the CDK8/PI3K/Akt/Wnt/β‑catenin signaling pathway Cite
  Wu D, Jia H, Zhang Z, Li S. Capsaicin suppresses breast cancer cell viability by regulating the CDK8/PI3K/Akt/Wnt/β‑catenin signaling pathway. Molecular Medicine Reports. Spandidos Publications; 2020; 22:4868-4876 10.3892/mmr.2020.11585
• Co-Delivery of Paclitaxel by a Capsaicin Prodrug Micelle Facilitating for Combination Therapy on Breast Cancer Cite
  Lan Y, Sun Y, Yang T, Ma X, Cao M, Liu L, et al. Co-Delivery of Paclitaxel by a Capsaicin Prodrug Micelle Facilitating for Combination Therapy on Breast Cancer. Molecular Pharmaceutics. American Chemical Society (ACS); 2019; 16:3430-3440 10.1021/acs.molpharmaceut.9b00209
• Carotenoids of Capsicum Fruits: Pigment Profile and Health-Promoting Functional Attributes Cite
  Mohd Hassan N, Yusof NA, Yahaya AF, Mohd Rozali NN, Othman R. Carotenoids of Capsicum Fruits: Pigment Profile and Health-Promoting Functional Attributes. Antioxidants. MDPI AG; 2019; 8:469 10.3390/antiox8100469
• Application of capsaicin as a potential new therapeutic drug in human cancers Cite
  Zhang S, Wang D, Huang J, Hu Y, Xu Y. Application of capsaicin as a potential new therapeutic drug in human cancers. Journal of Clinical Pharmacy and Therapeutics. Wiley; 2019; 45:16-28 10.1111/jcpt.13039
• Pharmacotherapeutics and Molecular Mechanism of Phytochemicals in Alleviating Hormone-Responsive Breast Cancer Cite
  Rampogu S, Park C, Ravinder D, Son M, Baek A, Zeb A, et al. Pharmacotherapeutics and Molecular Mechanism of Phytochemicals in Alleviating Hormone-Responsive Breast Cancer. Oxidative Medicine and Cellular Longevity. Wiley; 2019; 2019:1-14 10.1155/2019/5189490
• Study the Effects of Capsaicin on Triple Negative Breast Cancer Cells Cite
  Alasmari MM, Alshaeri HK, Alashari RA, Böhlke M, Maher T, Pino‐Figueroa A. Study the Effects of Capsaicin on Triple Negative Breast Cancer Cells. The FASEB Journal. Wiley; 2019; 33 10.1096/fasebj.2019.33.1_supplement.816.12
• Capsaicin and Piperine Can Overcome Multidrug Resistance in Cancer Cells to Doxorubicin Cite
  Li H, Krstin S, Wang S, Wink M. Capsaicin and Piperine Can Overcome Multidrug Resistance in Cancer Cells to Doxorubicin. Molecules. MDPI AG; 2018; 23:557 10.3390/molecules23030557
• The Impact of Capsaicin Intake on Risk of Developing Gastric Cancers: A Meta-Analysis Cite
  Pabalan N, Jarjanazi H, Ozcelik H. The Impact of Capsaicin Intake on Risk of Developing Gastric Cancers: A Meta-Analysis. Journal of Gastrointestinal Cancer. Springer Science and Business Media LLC; 2014; 45:334-341 10.1007/s12029-014-9610-2
• Suppressive effects of capsaicin against N-nitrosomethylurea-induced mammary tumorigenesis in rats Cite
  El-kott AF, Bin-Meferij MM. Suppressive effects of capsaicin against N-nitrosomethylurea-induced mammary tumorigenesis in rats. Biomedicine & Pharmacotherapy. Elsevier BV; 2018; 98:673-679 10.1016/j.biopha.2017.12.036
• Capsaicinoids are silent estrogens, a class of estrogenic chemicals without cell-proliferation activity Cite
  Zhu Y, Kiyama R. Capsaicinoids are silent estrogens, a class of estrogenic chemicals without cell-proliferation activity. Environmental Technology & Innovation. Elsevier BV; 2017; 7:182-193 10.1016/j.eti.2017.02.006
• Reactivation of mutant p53 by capsaicin, the major constituent of peppers Cite
  Garufi A, Pistritto G, Cirone M, D’Orazi G. Reactivation of mutant p53 by capsaicin, the major constituent of peppers. Journal of Experimental & Clinical Cancer Research. Springer Science and Business Media LLC; 2016; 35 10.1186/s13046-016-0417-9
• An exploration of the estrogen receptor transcription activity of capsaicin analogues via an integrated approach based on in silico prediction and in vitro assays Cite
  Li J, Ma D, Lin Y, Fu J, Zhang A. An exploration of the estrogen receptor transcription activity of capsaicin analogues via an integrated approach based on in silico prediction and in vitro assays. Toxicology Letters. Elsevier BV; 2014; 227:179-188 10.1016/j.toxlet.2014.04.007
• Impact of zinc, selenium and lycopene on capsaicin induced mutagenicity and oxidative damage in mice Cite
  Banji D, Banji OJ, Reddy M, Annamalai A. Impact of zinc, selenium and lycopene on capsaicin induced mutagenicity and oxidative damage in mice. Journal of Trace Elements in Medicine and Biology. Elsevier BV; 2013; 27:230-235 10.1016/j.jtemb.2013.01.001
• Screening of biochemical modulator by tumor cell permeability of doxorubicin Cite
  Sadzuka Y, Hatakeyama H, Daimon T, Sonobe T. Screening of biochemical modulator by tumor cell permeability of doxorubicin. International Journal of Pharmaceutics. Elsevier BV; 2008; 354:63-69 10.1016/j.ijpharm.2007.10.015
• Suppression of Tumor Necrosis Factor-α-Induced Nuclear Factor κB Activation and Aromatase Activity by Capsaicin and Its Analog Capsazepine Cite
  Luqman S, Meena A, Marler LE, Kondratyuk TP, Pezzuto JM. Suppression of Tumor Necrosis Factor-α-Induced Nuclear Factor κB Activation and Aromatase Activity by Capsaicin and Its Analog Capsazepine. Journal of Medicinal Food. Mary Ann Liebert Inc; 2011; 14:1344-1351 10.1089/jmf.2010.0236
• Capsaicin-Mediated tNOX (ENOX2) Up-regulation Enhances Cell Proliferation and Migration in Vitro and in Vivo Cite
  Liu N, Hsieh P, Hsieh M, Zeng Z, Cheng H, Liao J, et al. Capsaicin-Mediated tNOX (ENOX2) Up-regulation Enhances Cell Proliferation and Migration in Vitro and in Vivo. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2012; 60:2758-2765 10.1021/jf204869w
• Tumor Cell Growth Inhibition Is Correlated With Levels of Capsaicin Present in Hot Peppers Cite
  Dou D, Ahmad A, Yang H, Sarkar F. Tumor Cell Growth Inhibition Is Correlated With Levels of Capsaicin Present in Hot Peppers. Nutrition and Cancer. Informa UK Limited; 2011; 63:272-281 10.1080/01635581.2011.523497
• Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway Cite
  Thoennissen NH, O'Kelly J, Lu D, Iwanski GB, La DT, Abbassi S, et al. Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway. Oncogene. Springer Science and Business Media LLC; 2009; 29:285-296 10.1038/onc.2009.335
• Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway Cite
  Chen . Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway. Oncology Reports. Spandidos Publications; 2009; 10.3892/or_00000269
• Comparative analysis of the in vitro antioxidant activity of white and black pepper Cite
  Agbor GA, Vinson JA, Oben JE, Ngogang JY. Comparative analysis of the in vitro antioxidant activity of white and black pepper. Nutrition Research. Elsevier BV; 2006; 26:659-663 10.1016/j.nutres.2006.09.019
• Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity Cite
  Pyun B, Choi S, Lee Y, Kim T, Min J, Kim Y, et al. Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity. Cancer Research. American Association for Cancer Research (AACR); 2008; 68:227-235 10.1158/0008-5472.can-07-2799