Tag: DIM

Articles

• Supplements with warnings for breast cancer

News

07/31/12

I3C in cruciferous vegetables inhibits proliferation of ER+ BC cells

02/20/12

Cruciferous vegetable consumption linked to reduced risk of cancer

12/08/09

DIM from broccoli prevents metastasis in mice

Foods

• • broccoli
  • brussels sprouts
  • cauliflower
  • greens
  • horseradish
  • kale
  • turnips and turnip greens
  • watercress

Studies

• Indole-3-carbinol as a radiosensitizer and modulator of IR-dependent stemness in triple-negative breast cancer Cite
  Eissa ZS, Rady MI, Khalifa MA, Alwasify HM, Elsherbini YM, Abdraboh ME. Indole-3-carbinol as a radiosensitizer and modulator of IR-dependent stemness in triple-negative breast cancer. Egyptian Journal of Basic and Applied Sciences. Informa UK Limited; 2024; 11:479-495 10.1080/2314808x.2024.2355735
• Exosome-sheathed porous silica nanoparticle-mediated co-delivery of 3,3′-diindolylmethane and doxorubicin attenuates cancer stem cell-driven EMT in triple negative breast cancer Cite
  Sarkar R, Biswas S, Ghosh R, Samanta P, Pakhira S, Mondal M, et al. Exosome-sheathed porous silica nanoparticle-mediated co-delivery of 3,3′-diindolylmethane and doxorubicin attenuates cancer stem cell-driven EMT in triple negative breast cancer. Journal of Nanobiotechnology. Springer Science and Business Media LLC; 2024; 22 10.1186/s12951-024-02518-0
• Exploring the Impact of 3,3’-Diindolylmethane on the Urinary Estrogen Profile of Premenopausal Women Cite
  Newman M, Smeaton J. Exploring the Impact of 3,3’-Diindolylmethane on the Urinary Estrogen Profile of Premenopausal Women. Research Square Platform LLC; 2024; 10.21203/rs.3.rs-3944853/v1
• Resveratrol and 3,3’-diindolylmethane differentially regulate aryl hydrocarbon receptor and estrogen receptor alpha to modulate diverse signalling pathways in MCF-7 human breast cancer cells Cite
  Das S, Ulven SM, Matthews J. Resveratrol and 3,3’-diindolylmethane differentially regulate aryl hydrocarbon receptor and estrogen receptor alpha to modulate diverse signalling pathways in MCF-7 human breast cancer cells. Research Square Platform LLC; 2023; 10.21203/rs.3.rs-3255817/v1
• The Interplay between Microbiota and Chemotherapy-Derived Metabolites in Breast Cancer Cite
  Plaza-Diaz J, Álvarez-Mercado AI. The Interplay between Microbiota and Chemotherapy-Derived Metabolites in Breast Cancer. Metabolites. MDPI AG; 2023; 13:703 10.3390/metabo13060703
• Indole-3-Carbinol: Occurrence, Health-Beneficial Properties, and Cellular/Molecular Mechanisms Cite
  Amarakoon D, Lee W, Tamia G, Lee S. Indole-3-Carbinol: Occurrence, Health-Beneficial Properties, and Cellular/Molecular Mechanisms. Annual Review of Food Science and Technology. Annual Reviews; 2023; 14:347-366 10.1146/annurev-food-060721-025531
• The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female Cite
  Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Military Medicine. Oxford University Press (OUP); 2022; 10.1093/milmed/usac367
• Role of Dietary Ingredients on Expression of Oncogenic and Tumour Suppressor miRNA Cite
  Gacche RN. Role of Dietary Ingredients on Expression of Oncogenic and Tumour Suppressor miRNA. Dietary Research and Cancer. Springer Singapore; 2021;:69-76 10.1007/978-981-16-6050-4_7
• Distinct Classes of Flavonoids and Epigallocatechin Gallate, Polyphenol Affects an Oncogenic Mutant p53 Protein, Cell Growth and Invasion in a TNBC Breast Cancer Cell Line Cite
  Kollareddy M, Martinez LA. Distinct Classes of Flavonoids and Epigallocatechin Gallate, Polyphenol Affects an Oncogenic Mutant p53 Protein, Cell Growth and Invasion in a TNBC Breast Cancer Cell Line. Cells. MDPI AG; 2021; 10:797 10.3390/cells10040797
• 3,3-Diindolylmethane (DIM): a nutritional intervention and its impact on breast density in healthy BRCA carriers. A prospective clinical trial Cite
  Yerushalmi R, Bargil S, Ber Y, Ozlavo R, Sivan T, Rapson Y, et al. 3,3-Diindolylmethane (DIM): a nutritional intervention and its impact on breast density in healthy BRCA carriers. A prospective clinical trial. Carcinogenesis. Oxford University Press (OUP); 2020; 41:1395-1401 10.1093/carcin/bgaa050
• 3, 3′-Diindolylmethane-encapsulated chitosan nanoparticles accelerate molecular events during chemical carcinogen-induced mammary cancer in Sprague Dawley rats Cite
  Isabella S, Mirunalini S. 3, 3′-Diindolylmethane-encapsulated chitosan nanoparticles accelerate molecular events during chemical carcinogen-induced mammary cancer in Sprague Dawley rats. Breast Cancer. Springer Science and Business Media LLC; 2019; 26:499-509 10.1007/s12282-019-00950-x
• Abstract 5800: Vorinostat and indole-3-carbinol modulate microRNAs and histone deacetylase activity in subtypes of triple-negative breast cancer Cite
  Lyn-Cook B, NouriEmamzaden F, Hawkins A, Hammons G, Word B. Abstract 5800: Vorinostat and indole-3-carbinol modulate microRNAs and histone deacetylase activity in subtypes of triple-negative breast cancer. Experimental and Molecular Therapeutics. American Association for Cancer Research; 2018; 10.1158/1538-7445.am2018-5800
• Indole-3-Carbinol (I3C) enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin (DOX) through inhibition of NF-κβ, blocking angiogenesis and regulation of mitochondrial apoptotic pathway Cite
  Hajra S, Patra AR, Basu A, Saha P, Bhattacharya S. Indole-3-Carbinol (I3C) enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin (DOX) through inhibition of NF-κβ, blocking angiogenesis and regulation of mitochondrial apoptotic pathway. Chemico-Biological Interactions. Elsevier BV; 2018; 290:19-36 10.1016/j.cbi.2018.05.005
• Glucosinolate and isothiocyanate intakes are inversely associated with breast cancer risk: a case–control study in China Cite
  Zhang N, Ho SC, Mo X, Lin F, Huang W, Luo H, et al. Glucosinolate and isothiocyanate intakes are inversely associated with breast cancer risk: a case–control study in China. British Journal of Nutrition. Cambridge University Press (CUP); 2018; 119:957-964 10.1017/s0007114518000600
• 3,3′-Diindolylmethane Suppressed Cyprodinil-Induced Epithelial-Mesenchymal Transition and Metastatic-Related Behaviors of Human Endometrial Ishikawa Cells via an Estrogen Receptor-Dependent Pathway Cite
  Kim B, Kim J, Kim S, Go R, Hwang K, Choi K. 3,3′-Diindolylmethane Suppressed Cyprodinil-Induced Epithelial-Mesenchymal Transition and Metastatic-Related Behaviors of Human Endometrial Ishikawa Cells via an Estrogen Receptor-Dependent Pathway. International Journal of Molecular Sciences. MDPI AG; 2018; 19:189 10.3390/ijms19010189
• Inhibitory effects of 3,3′-diindolylmethane on epithelial-mesenchymal transition induced by endocrine disrupting chemicals in cellular and xenograft mouse models of breast cancer Cite
  Lee G, Hwang K, Choi K. Inhibitory effects of 3,3′-diindolylmethane on epithelial-mesenchymal transition induced by endocrine disrupting chemicals in cellular and xenograft mouse models of breast cancer. Food and Chemical Toxicology. Elsevier BV; 2017; 109:284-295 10.1016/j.fct.2017.08.037
• 3,3′-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice Cite
  Lu L, Dong J, Li D, Zhang J, Fan S. 3,3′-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice. Free Radical Biology and Medicine. Elsevier BV; 2016; 99:463-471 10.1016/j.freeradbiomed.2016.09.007
• The estrogenic effect of trigonelline and 3,3-diindolymethane on cell growth in non-malignant colonocytes Cite
  Yoo G, Allred CD. The estrogenic effect of trigonelline and 3,3-diindolymethane on cell growth in non-malignant colonocytes. Food and Chemical Toxicology. Elsevier BV; 2016; 87:23-30 10.1016/j.fct.2015.11.015
• Low levels of 3,3′-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol Cite
  Marques M, Laflamme L, Benassou I, Cissokho C, Guillemette B, Gaudreau L. Low levels of 3,3′-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol. BMC Cancer. Springer Science and Business Media LLC; 2014; 14 10.1186/1471-2407-14-524
• Cruciferous vegetables intake is inversely associated with risk of breast cancer: A meta-analysis Cite
  Liu X, Lv K. Cruciferous vegetables intake is inversely associated with risk of breast cancer: A meta-analysis. The Breast. Elsevier BV; 2013; 22:309-313 10.1016/j.breast.2012.07.013
• 3,3′-Diindolymethane ameliorates adriamycin-induced cardiac fibrosis via activation of a BRCA1-dependent anti-oxidant pathway Cite
  Yao Z, Hu W, Yin S, Huang Z, Zhu Q, Chen J, et al. 3,3′-Diindolymethane ameliorates adriamycin-induced cardiac fibrosis via activation of a BRCA1-dependent anti-oxidant pathway. Pharmacological Research. Elsevier BV; 2013; 70:139-146 10.1016/j.phrs.2013.01.006
• 3, 3′-diindolylmethane Enhances the Effectiveness of Herceptin against HER-2/Neu-Expressing Breast Cancer Cells Cite
  Ahmad A, Ali S, Ahmed A, Ali AS, Raz A, Sakr WA, et al. 3, 3′-diindolylmethane Enhances the Effectiveness of Herceptin against HER-2/Neu-Expressing Breast Cancer Cells. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e54657 10.1371/journal.pone.0054657
• Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3′-diindolylmethene in human breast epithelial cell lines Cite
  Licznerska BE, Szaefer H, Murias M, Bartoszek A, Baer-Dubowska W. Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3′-diindolylmethene in human breast epithelial cell lines. European Journal of Nutrition. Springer Science and Business Media LLC; 2012; 52:1483-1492 10.1007/s00394-012-0455-9
• Modulation of CYP1A1, CYP1A2 and CYP1B1 Expression by Cabbage Juices and Indoles in Human Breast Cell Lines Cite
  Szaefer H, Licznerska B, Krajka-Kuźniak V, Bartoszek A, Baer-Dubowska W. Modulation of CYP1A1, CYP1A2 and CYP1B1 Expression by Cabbage Juices and Indoles in Human Breast Cell Lines. Nutrition and Cancer. Informa UK Limited; 2012; 64:879-888 10.1080/01635581.2012.690928
• Diindolilmethane (DIM) selectively inhibits cancer stem cells Cite
  Semov A, Iourtchenco L, Lin Fang L, Shengmin L, Xu Y, Su X, et al. Diindolilmethane (DIM) selectively inhibits cancer stem cells. Biochemical and Biophysical Research Communications. Elsevier BV; 2012; 424:45-51 10.1016/j.bbrc.2012.06.062
• 3,3′-Diindolylmethane induces immunotoxicity via splenocyte apoptosis in neonatal mice Cite
  Roh YS, Cho A, Islam MR, Cho S, Kim J, Kim JH, et al. 3,3′-Diindolylmethane induces immunotoxicity via splenocyte apoptosis in neonatal mice. Toxicology Letters. Elsevier BV; 2011; 206:218-228 10.1016/j.toxlet.2011.07.021
• 3,3′-diindolylmethane enhances taxotere-induced growth inhibition of breast cancer cells through downregulation of FoxM1 Cite
  Ahmad A, Ali S, Wang Z, Ali AS, Sethi S, Sakr WA, et al. 3,3′-diindolylmethane enhances taxotere-induced growth inhibition of breast cancer cells through downregulation of FoxM1. International Journal of Cancer. Wiley; 2011; 129:1781-1791 10.1002/ijc.25839
• Oral Administration of 3,3′-Diindolylmethane Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells in BALB/c Mice Cite
  Kim EJ, Shin M, Park H, Hong JE, Shin H, Kim J, et al. Oral Administration of 3,3′-Diindolylmethane Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells in BALB/c Mice. The Journal of Nutrition. Oxford University Press (OUP); 2009; 139:2373-2379 10.3945/jn.109.111864
• Differences in the hepatic P450-dependent metabolism of estrogen and tamoxifen in response to treatment of rats with 3,3′-diindolylmethane and its parent compound indole-3-carbinol Cite
  Parkin DR, Malejka-Giganti D. Differences in the hepatic P450-dependent metabolism of estrogen and tamoxifen in response to treatment of rats with 3,3′-diindolylmethane and its parent compound indole-3-carbinol. Cancer Detection and Prevention. Elsevier BV; 2004; 28:72-79 10.1016/j.cdp.2003.11.006
• Low Concentrations of Diindolylmethane, a Metabolite of Indole-3-Carbinol, Protect against Oxidative Stress in a BRCA1-Dependent Manner Cite
  Fan S, Meng Q, Saha T, Sarkar FH, Rosen EM. Low Concentrations of Diindolylmethane, a Metabolite of Indole-3-Carbinol, Protect against Oxidative Stress in a BRCA1-Dependent Manner. Cancer Research. American Association for Cancer Research (AACR); 2009; 69:6083-6091 10.1158/0008-5472.can-08-3309
• 3,3′-Diindolylmethane and Paclitaxel Act Synergistically to Promote Apoptosis in HER2/Neu Human Breast Cancer Cells Cite
  McGuire K, Ngoubilly N, Neavyn M, Lanza-Jacoby S. 3,3′-Diindolylmethane and Paclitaxel Act Synergistically to Promote Apoptosis in HER2/Neu Human Breast Cancer Cells. Journal of Surgical Research. Elsevier BV; 2006; 132:208-213 10.1016/j.jss.2006.02.008
• Ligand-independent activation of estrogen receptor function by 3,3′-diindolylmethane in human breast cancer cells Cite
  Riby JE, Chang GH, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3′-diindolylmethane in human breast cancer cells. Biochemical Pharmacology. Elsevier BV; 2000; 60:167-177 10.1016/s0006-2952(00)00307-5
• 3,3′-Diindolylmethane Is a Novel Mitochondrial H+-ATP Synthase Inhibitor that Can Induce p21Cip1/Waf1 Expression by Induction of Oxidative Stress in Human Breast Cancer Cells Cite
  Gong Y, Sohn H, Xue L, Firestone GL, Bjeldanes LF. 3,3′-Diindolylmethane Is a Novel Mitochondrial H+-ATP Synthase Inhibitor that Can Induce p21Cip1/Waf1 Expression by Induction of Oxidative Stress in Human Breast Cancer Cells. Cancer Research. American Association for Cancer Research (AACR); 2006; 66:4880-4887 10.1158/0008-5472.can-05-4162
• Expression profile ofCYP19in human breast cancer cell lines treated with indole-3-carbinol, 3,3'-diindolylmethane, and sulforaphane. Cite
  Licznerska B, Matuszak I, Baer-Dubowska W. Expression profile ofCYP19in human breast cancer cell lines treated with indole-3-carbinol, 3,3'-diindolylmethane, and sulforaphane.. Poster Session Abstracts. American Association for Cancer Research; 2009; 10.1158/0008-5472.sabcs-1113