Tag: thymoquinone

News

09/26/17

Black cumin enhances Adriamycin toxicity and reduces cardiomyopathy

Foods

• • black cumin

Studies

• An updated review on the phytochemistry and pharmacological activity of black cumin (Nigella sativa L.) Cite
  Pandey R, Pandey B, Bhargava A. An updated review on the phytochemistry and pharmacological activity of black cumin (Nigella sativa L.). Advanced Chinese Medicine. Wiley; 2025; 10.1002/acm4.33
• Thymoquinone and cancer: Mechanisms and potential therapeutic applications Cite
  Ilhan S, Oguz F, Atmaca H. Thymoquinone and cancer: Mechanisms and potential therapeutic applications. Studies in Natural Products Chemistry. Elsevier; 2025;:67-99 10.1016/b978-0-443-23752-2.00009-8
• Thymoquinone-PLGA-PF68 Nanoparticles Induce S Phase Cell Cycle Arrest and Apoptosis, Leading to the Inhibition of Migration and Colony Formation in Tamoxifen-Resistant Breast Cancer Cells Cite
  Noor NS, Hamid SBS. Thymoquinone-PLGA-PF68 Nanoparticles Induce S Phase Cell Cycle Arrest and Apoptosis, Leading to the Inhibition of Migration and Colony Formation in Tamoxifen-Resistant Breast Cancer Cells. Current Molecular Medicine. Bentham Science Publishers Ltd.; 2025; 25 10.2174/0115665240347014241203065055
• Arginase Activity Inhibition With Thymoquinone Induces a Hybrid Type of Cell‐Death in MDA‐MB‐231 Cell Line Cite
  Bday J, Souid M, Pires V, Gabbouj S, Véjux A, Lizard G, et al. Arginase Activity Inhibition With Thymoquinone Induces a Hybrid Type of Cell‐Death in MDA‐MB‐231 Cell Line. Journal of Biochemical and Molecular Toxicology. Wiley; 2025; 39 10.1002/jbt.70130
• Nigella sativa (Black Seed) and Breast Cancer: A Systematic Review Cite
  Esmaeli M, Ghanbari A, Barazesh M, Dehabadi MD. Nigella sativa (Black Seed) and Breast Cancer: A Systematic Review. Indian Journal of Gynecologic Oncology. Springer Science and Business Media LLC; 2024; 22 10.1007/s40944-024-00920-y
• Tyrosine kinase inhibitors versus thymoquinone in management of cancer: A mechanistic approach Cite
  Nath SK, Garg M, Babbar R. Tyrosine kinase inhibitors versus thymoquinone in management of cancer: A mechanistic approach. AIP Conference Proceedings. AIP Publishing; 2024; 3232:060014 10.1063/5.0227771
• Systemic Codelivery of Thymoquinone and Doxorubicin by Targeted Mesoporous Silica Nanoparticle Sensitizes Doxorubicin-Resistant Breast Cancer by Interfering between the MDR1/P-gp and miR 298 Crosstalk Cite
  Bhattacharjee M, Ghosh A, Das S, Sarker S, Bhattacharya S, Das A, et al. Systemic Codelivery of Thymoquinone and Doxorubicin by Targeted Mesoporous Silica Nanoparticle Sensitizes Doxorubicin-Resistant Breast Cancer by Interfering between the MDR1/P-gp and miR 298 Crosstalk. ACS Biomaterials Science & Engineering. American Chemical Society (ACS); 2024; 10.1021/acsbiomaterials.4c01081
• Assessment of the Synergistic Effect of Thymoquinone and Cisplatin on MCF-7 Breast Cancer Cells Cite
  Mousavinasab F, Hashemipour N, Soghala S, Talebi M, aghazadeh m, Baghalzadeh Salmasi E, et al. Assessment of the Synergistic Effect of Thymoquinone and Cisplatin on MCF-7 Breast Cancer Cells. Zenodo; 2024; 10.5281/ZENODO.13194610
• Innovative approach against cancer: Thymoquinone-loaded PHEMA-based magnetic nanoparticles and their effects on MCF-7 breast cancer Cite
  Yıldırım M, Acet Ö, Önal Acet B, Karakoç V, Odabaşı M. Innovative approach against cancer: Thymoquinone-loaded PHEMA-based magnetic nanoparticles and their effects on MCF-7 breast cancer. Biochemical and Biophysical Research Communications. Elsevier BV; 2024; 734:150464 10.1016/j.bbrc.2024.150464
• Chemopreventive Agents from Nature: A Review of Apigenin, Rosmarinic Acid, and Thymoquinone Cite
  Abutayeh RF, Altah M, Mehdawi A, Al-Ataby I, Ardakani A. Chemopreventive Agents from Nature: A Review of Apigenin, Rosmarinic Acid, and Thymoquinone. Current Issues in Molecular Biology. MDPI AG; 2024; 46:6600-6619 10.3390/cimb46070393
• Recent advances on Nigella sativa – A Promising herb: Antihypertensive properties, thimoquinone nanoformulations, and health applications Cite
  Raghavendra VB, Sagar N, Kusha LM, Krishna KL, Sharma M, Sridhar K, et al. Recent advances on Nigella sativa – A Promising herb: Antihypertensive properties, thimoquinone nanoformulations, and health applications. Pharmacological Research - Natural Products. Elsevier BV; 2024;:100052 10.1016/j.prenap.2024.100052
• Thymoquinone: A novel treatment option for triple negative breast cancer Cite
  Mamillapalli V, Rallapalli V, Mohammed Z, Motukuru D, Sowgandhika Kosuri S, Kantamaneni P. Thymoquinone: A novel treatment option for triple negative breast cancer. Biomedicine. Indian Association of Biomedical Scientists; 2024; 44:13-20 10.51248/.v44i1.4155
• Targeting cisplatin resistance in breast cancer using a combination of Thymoquinone and Silymarin: an in vitro and in vivo study Cite
  Hamed RA, Talib WH. Targeting cisplatin resistance in breast cancer using a combination of Thymoquinone and Silymarin: an in vitro and in vivo study. Pharmacia. Pensoft Publishers; 2024; 71:1-19 10.3897/pharmacia.71.e117997
• Thymoquinone Nanoparticle Induces Apoptosis and Cell Migration Retardation through Modulating of SUMOylation Process Genes in Breast Cancer Cell Line Cite
  Sabouni F, Hamta A, Sohrabi B, Qadbeigi M. Thymoquinone Nanoparticle Induces Apoptosis and Cell Migration Retardation through Modulating of SUMOylation Process Genes in Breast Cancer Cell Line. Iranian Journal of Biotechnology. National Institute of Genetic Engineering and Biotechnology of Iran; 2024; 22 10.30498/ijb.2024.390400.3676
• In Vitro and In Vivo Preventive Effects of Thymoquinone against Breast Cancer: Role of DNMT1 Cite
  Kaleem M, Kayali A, Sheikh RA, Kuerban A, Hassan MA, Almalki NAR, et al. In Vitro and In Vivo Preventive Effects of Thymoquinone against Breast Cancer: Role of DNMT1. Molecules. MDPI AG; 2024; 29:434 10.3390/molecules29020434
• Combination of Thymoquinone and Intermittent Fasting as a Treatment for Breast Cancer Implanted in Mice Cite
  Haif SK, Al Kury LT, Talib WH. Combination of Thymoquinone and Intermittent Fasting as a Treatment for Breast Cancer Implanted in Mice. Plants. MDPI AG; 2023; 13:35 10.3390/plants13010035
• Effectiveness of Nigella sativa Addition against TNF-Alpha in Stage III and IV Breast Cancer Undergoing Doxorubicin and Cyclophosphamide Chemotherapy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Cite
  Friyoga Syahril , Wirdah A, Nur Qodir , Irfanuddin , Irsan Saleh , Yenny Dian Andayani , et al. Effectiveness of Nigella sativa Addition against TNF-Alpha in Stage III and IV Breast Cancer Undergoing Doxorubicin and Cyclophosphamide Chemotherapy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Bioscientia Medicina : Journal of Biomedicine and Translational Research. Hanif Medisiana Publisher; 2023; 8:4009-4014 10.37275/bsm.v8i2.924
• Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer Cite
  da Silva FC, Brandão DC, Ferreira EA, Siqueira RP, Ferreira HSV, Da Silva Filho AA, et al. Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer. Pharmaceuticals. MDPI AG; 2023; 16:1466 10.3390/ph16101466
• A study on concurring effect of paclitaxel and thymoquinone on MCF-7 cell line – In vitro Cite
  Anandan I, Gokul T, K N, Elango A, Vivekkumar P. A study on concurring effect of paclitaxel and thymoquinone on MCF-7 cell line – In vitro. National Journal of Physiology, Pharmacy and Pharmacology. ScopeMed; 2023;:1 10.5455/njppp.2023.13.09428202319092023
• Anticancer activity of thymoquinone against breast cancer cells: Mechanisms of action and delivery approaches Cite
  Shabani H, Karami MH, Kolour J, Sayyahi Z, Parvin MA, Soghala S, et al. Anticancer activity of thymoquinone against breast cancer cells: Mechanisms of action and delivery approaches. Biomedicine & Pharmacotherapy. Elsevier BV; 2023; 165:114972 10.1016/j.biopha.2023.114972
• A mechanistic insight into the potential anti-cancerous property of Nigella sativa on breast cancer through micro-RNA regulation: An in vitro & in vivo study Cite
  Das S, Ghosh A, Upadhyay P, Sarker S, Bhattacharjee M, Gupta P, et al. A mechanistic insight into the potential anti-cancerous property of Nigella sativa on breast cancer through micro-RNA regulation: An in vitro & in vivo study. Fitoterapia. Elsevier BV; 2023;:105601 10.1016/j.fitote.2023.105601
• Targeting Breast Cancer in Diabetic Mice Using a Combination of Thymoquinone and Metformin Cite
  Talib WH, Aboulqassim NSS. Targeting Breast Cancer in Diabetic Mice Using a Combination of Thymoquinone and Metformin. The Natural Products Journal. Bentham Science Publishers Ltd.; 2023; 13 10.2174/2210315512666220615114025
• Thymoquinone, piperine, and sorafenib combinations attenuate liver and breast cancers progression: epigenetic and molecular docking approaches Cite
  El-Shehawy AA, Elmetwalli A, El-Far AH, Mosallam SAE, Salama AF, Babalghith AO, et al. Thymoquinone, piperine, and sorafenib combinations attenuate liver and breast cancers progression: epigenetic and molecular docking approaches. BMC Complementary Medicine and Therapies. Springer Science and Business Media LLC; 2023; 23 10.1186/s12906-023-03872-6
• Thymoquinone may alleviate cisplatin-induced muscle atrophy in rats by regulating mitofusin 2 and meteorin-like levels Cite
  Yalçın T, Kaya S. Thymoquinone may alleviate cisplatin-induced muscle atrophy in rats by regulating mitofusin 2 and meteorin-like levels. Comparative Clinical Pathology. Springer Science and Business Media LLC; 2023; 10.1007/s00580-023-03442-9
• Thymoquinone-treated mouse mesenchymal stem cells-derived conditioned medium inhibits human breast cancer cells in vitro Cite
  Hajmomeni P, Sisakhtnezhad S, Bidmeshkipour A. Thymoquinone-treated mouse mesenchymal stem cells-derived conditioned medium inhibits human breast cancer cells in vitro. Chemico-Biological Interactions. Elsevier BV; 2023; 369:110283 10.1016/j.cbi.2022.110283
• Protective effect of short-term thymoquinone administration on the central nervous system in cisplatin-induced neurotoxicity Cite
  Durak M, Ozhan O, Yildiz A, Durhan M, Vardi N, Cigremis Y, et al. Protective effect of short-term thymoquinone administration on the central nervous system in cisplatin-induced neurotoxicity. European Review for Medical and Pharmacological Sciences. Verduci Editore s.r.l.; 2022; 26:6935-6943. 10.26355/eurrev_202210_29874
• Thymoquinone upregulates IL17RD in controlling the growth and metastasis of triple negative breast cancer cells in vitro Cite
  Khan MA, Zheng M, Fu J, Tania M, Li J, Fu J. Thymoquinone upregulates IL17RD in controlling the growth and metastasis of triple negative breast cancer cells in vitro. BMC Cancer. Springer Science and Business Media LLC; 2022; 22 10.1186/s12885-022-09782-z
• A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update Cite
  Machado TQ, da Fonseca ACC, Duarte ABS, Robbs BK, de Sousa DP. A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update. BioMed Research International. Hindawi Limited; 2022; 2022:1-20 10.1155/2022/6317201
• Protective Effect of Curcumin, Chrysin and Thymoquinone Injection on Trastuzumab-Induced Cardiotoxicity via Mitochondrial Protection Cite
  Shirmard LR, Shabani M, Moghadam AA, Zamani N, Ghanbari H, Salimi A. Protective Effect of Curcumin, Chrysin and Thymoquinone Injection on Trastuzumab-Induced Cardiotoxicity via Mitochondrial Protection. Cardiovascular Toxicology. Springer Science and Business Media LLC; 2022; 10.1007/s12012-022-09750-w
• Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis Cite
  Homayoonfal M, Asemi Z, Yousefi B. Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis. Cellular & Molecular Biology Letters. Springer Science and Business Media LLC; 2022; 27 10.1186/s11658-022-00320-0
• Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review Cite
  Kamran S, Sinniah A, Abdulghani MAM, Alshawsh MA. Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review. Cancers. MDPI AG; 2022; 14:1100 10.3390/cancers14051100
• Insights into the Protective Effects of Thymoquinone against Toxicities Induced by Chemotherapeutic Agents Cite
  Farooq J, Sultana R, Taj T, Asdaq SMB, Alsalman AJ, Mohaini MA, et al. Insights into the Protective Effects of Thymoquinone against Toxicities Induced by Chemotherapeutic Agents. Molecules. MDPI AG; 2021; 27:226 10.3390/molecules27010226
• Therapeutic Potential of Thymoquinone in Triple-Negative Breast Cancer Prevention and Progression through the Modulation of the Tumor Microenvironment Cite
  Adinew GM, Taka E, Mochona B, Badisa RB, Mazzio EA, Elhag R, et al. Therapeutic Potential of Thymoquinone in Triple-Negative Breast Cancer Prevention and Progression through the Modulation of the Tumor Microenvironment. Nutrients. MDPI AG; 2021; 14:79 10.3390/nu14010079
• Thymoquinone and its pharmacological perspective: a review Cite
  Tabassum S, Rosli N, Ichwan SJA, Mishra P. Thymoquinone and its pharmacological perspective: a review. Pharmacological Research - Modern Chinese Medicine. Elsevier BV; 2021;:100020 10.1016/j.prmcm.2021.100020
• PIK3CA hotspot mutations p. H1047R and p. H1047L sensitize breast cancer cells to thymoquinone treatment by regulating the PI3K/Akt1 pathway Cite
  Zhou J, Imani S, Shasaltaneh MD, Liu S, Lu T, Fu J. PIK3CA hotspot mutations p. H1047R and p. H1047L sensitize breast cancer cells to thymoquinone treatment by regulating the PI3K/Akt1 pathway. Molecular Biology Reports. Springer Science and Business Media LLC; 2021; 10.1007/s11033-021-06990-x
• Targeting microRNAs with thymoquinone: a new approach for cancer therapy Cite
  Homayoonfal M, Asemi Z, Yousefi B. Targeting microRNAs with thymoquinone: a new approach for cancer therapy. Cellular & Molecular Biology Letters. Springer Science and Business Media LLC; 2021; 26 10.1186/s11658-021-00286-5
• Thymoquinone upregulates miR‐125a‐5p, attenuates STAT3 activation, and potentiates doxorubicin antitumor activity in murine solid Ehrlich carcinoma Cite
  Atteia HH, Arafa MH, Mohammad NS, Amin DM, Sakr AT. Thymoquinone upregulates miR‐125a‐5p, attenuates STAT3 activation, and potentiates doxorubicin antitumor activity in murine solid Ehrlich carcinoma. Journal of Biochemical and Molecular Toxicology. Wiley; 2021; 10.1002/jbt.22924
• 1764P A dose and time-dependent inhibitory effect of thymoquinone on inflammasome pathway in hormone receptor positive breast cancer: A novel personalized adjuvant therapy Cite
  Elgohary S, Abdeltawab R, El Tayebi H. 1764P A dose and time-dependent inhibitory effect of thymoquinone on inflammasome pathway in hormone receptor positive breast cancer: A novel personalized adjuvant therapy. Annals of Oncology. Elsevier BV; 2021; 32:S1212 10.1016/j.annonc.2021.08.1708
• Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer Cite
  Al-Bari MAA, Ito Y, Ahmed S, Radwan N, Ahmed HS, Eid N. Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer. International Journal of Molecular Sciences. MDPI AG; 2021; 22:9807 10.3390/ijms22189807
• Thymoquinone and its derivatives against breast cancer with HER2 positive: in silico studies of ADMET, docking and QSPR Cite
  Wulandari AA, Choiri AA, Fitria , Widiandani T. Thymoquinone and its derivatives against breast cancer with HER2 positive: in silico studies of ADMET, docking and QSPR. Journal of Basic and Clinical Physiology and Pharmacology. Walter de Gruyter GmbH; 2021; 32:393-401 10.1515/jbcpp-2020-0431
• Synergistic Role of Thymoquinone on Anticancer Activity of 5-fluorouracil in Triple-Negative Breast Cancer Cells Cite
  Zheng M, Mei Z, Junaid M, Tania M, Fu J, Chen H, et al. Synergistic Role of Thymoquinone on Anticancer Activity of 5-fluorouracil in Triple-Negative Breast Cancer Cells. Anti-Cancer Agents in Medicinal Chemistry. Bentham Science Publishers Ltd.; 2021; 21 10.2174/1871520621666210624111613
• A review on pharmacological activities and anti-microbial properties of Nigella sativa and isolated Thymoquinone Cite
  Perera W, Liyanage J, Dissanayake K, Chandrasiri W, Gunathilaka H. A review on pharmacological activities and anti-microbial properties of Nigella sativa and isolated Thymoquinone. Journal of Medicinal Plants Studies. AkiNik Publications; 2021; 9:118-122 10.22271/plants.2021.v9.i3b.1277
• Low Doses of Thymoquinone and Ferulic Acid in Combination Effectively Inhibit Proliferation of Cultured MDA-MB 231 Breast Adenocarcinoma Cells Cite
  Al-Mutairi A, Rahman A, Rao MS. Low Doses of Thymoquinone and Ferulic Acid in Combination Effectively Inhibit Proliferation of Cultured MDA-MB 231 Breast Adenocarcinoma Cells. Nutrition and Cancer. Informa UK Limited; 2020; 73:282-289 10.1080/01635581.2020.1743869
• Thymoquinone inhibited vasculogenic capacity and promoted mesenchymal-epithelial transition of human breast cancer stem cells Cite
  Haiaty S, Rashidi M, Akbarzadeh M, Bazmany A, Mostafazadeh M, Nikanfar S, et al. Thymoquinone inhibited vasculogenic capacity and promoted mesenchymal-epithelial transition of human breast cancer stem cells. BMC Complementary Medicine and Therapies. Springer Science and Business Media LLC; 2021; 21 10.1186/s12906-021-03246-w
• Abstract PS19-28: Thymoquinone and tamoxifen co-treatment synergistically inhibit proliferation, invasion and induce apoptosis in human breast cancer cell lines in vitro and in vivo Cite
  Yahiya I, Helmy H, Sultan A. Abstract PS19-28: Thymoquinone and tamoxifen co-treatment synergistically inhibit proliferation, invasion and induce apoptosis in human breast cancer cell lines in vitro and in vivo. Poster Session Abstracts. American Association for Cancer Research; 2021; 10.1158/1538-7445.sabcs20-ps19-28
• Molecular Mechanisms of Thymoquinone as Anticancer agent Cite
  Alhmied FI, Alammar AH, Alsultan BM, Alshehri M, Pottoo FH. Molecular Mechanisms of Thymoquinone as Anticancer agent. Combinatorial Chemistry & High Throughput Screening. Bentham Science Publishers Ltd.; 2020; 23 10.2174/1386207323999201027225305
• Incorporation of docetaxel and thymoquinone in borage nanoemulsion potentiates their antineoplastic activity in breast cancer cells Cite
  Alkhatib MH, Bawadud RS, Gashlan HM. Incorporation of docetaxel and thymoquinone in borage nanoemulsion potentiates their antineoplastic activity in breast cancer cells. Scientific Reports. Springer Science and Business Media LLC; 2020; 10 10.1038/s41598-020-75017-5
• Abstract 6558: Thymoquinone and epicatechin ameliorate the anticancer properties of tafuramycin-A against naïve and resistant breast cancer cells Cite
  Alshehri OY, Henidi HA, Alabbasi FA, El-Deeb IM, Halwani MA, Al-Abd AM. Abstract 6558: Thymoquinone and epicatechin ameliorate the anticancer properties of tafuramycin-A against naïve and resistant breast cancer cells. Clinical Research (Excluding Clinical Trials). American Association for Cancer Research; 2020; 10.1158/1538-7445.am2020-6558
• Combinatorial therapy of Thymoquinone and Emodin synergistically enhances apoptosis, attenuates cell migration and reduces stemness efficiently in breast cancer Cite
  Bhattacharjee M, Upadhyay P, Sarker S, Basu A, Das S, Ghosh A, et al. Combinatorial therapy of Thymoquinone and Emodin synergistically enhances apoptosis, attenuates cell migration and reduces stemness efficiently in breast cancer. Biochimica et Biophysica Acta (BBA) - General Subjects. Elsevier BV; 2020; 1864:129695 10.1016/j.bbagen.2020.129695
• Combination of Docetaxel with Thymoquinone in Nanoemulsion Impedes the Migration of Breast Cancer Stem Cells Cite
  Bawadud RS B, Alkhatib MH, Gashlan HM G. Combination of Docetaxel with Thymoquinone in Nanoemulsion Impedes the Migration of Breast Cancer Stem Cells. International Journal of Pharmaceutical Investigation. EManuscript Services; 2020; 10:211-216 10.5530/ijpi.2020.2.39
• Evidence-Based Review on Clinical Potential of Thymoquinone in Breast Cancer Cite
  Barkat MA, Harshita , Pottoo FH, Beg S, Rahman M, Ahmad FJ. Evidence-Based Review on Clinical Potential of Thymoquinone in Breast Cancer. Nanomedicine for Bioactives. Springer Singapore; 2020;:471-486 10.1007/978-981-15-1664-1_19
• Antiproliferative Effects of Thymoquinone in MCF-7 Breast and HepG2 Liver Cancer Cells: Possible Role of Ceramide and ER Stress Cite
  Aslan M, Afşar E, Kırımlıoglu E, Çeker T, Yılmaz Ç. Antiproliferative Effects of Thymoquinone in MCF-7 Breast and HepG2 Liver Cancer Cells: Possible Role of Ceramide and ER Stress. Nutrition and Cancer. Informa UK Limited; 2020;:1-13 10.1080/01635581.2020.1751216
• Senescent Colon and Breast Cancer Cells Induced by Doxorubicin Exhibit Enhanced Sensitivity to Curcumin, Caffeine, and Thymoquinone Cite
  El-Far AH, Darwish NHE, Mousa SA. Senescent Colon and Breast Cancer Cells Induced by Doxorubicin Exhibit Enhanced Sensitivity to Curcumin, Caffeine, and Thymoquinone. Integrative Cancer Therapies. SAGE Publications; 2020; 19:153473541990116 10.1177/1534735419901160
• Thymoquinone Enhances Paclitaxel Anti-Breast Cancer Activity via Inhibiting Tumor-Associated Stem Cells Despite Apparent Mathematical Antagonism Cite
  Bashmail HA, Alamoudi AA, Noorwali A, Hegazy GA, Ajabnoor GM, Al-Abd AM. Thymoquinone Enhances Paclitaxel Anti-Breast Cancer Activity via Inhibiting Tumor-Associated Stem Cells Despite Apparent Mathematical Antagonism. Molecules. MDPI AG; 2020; 25:426 10.3390/molecules25020426
• Antiproliferative and apoptotic effects of proteins from black seeds (Nigella sativa) on human breast MCF-7 cancer cell line Cite
  Khurshid Y, Syed B, Simjee SU, Beg O, Ahmed A. Antiproliferative and apoptotic effects of proteins from black seeds (Nigella sativa) on human breast MCF-7 cancer cell line. BMC Complementary Medicine and Therapies. Springer Science and Business Media LLC; 2020; 20 10.1186/s12906-019-2804-1
• Thymoquinone and pentoxifylline enhance the chemotherapeutic effect of cisplatin by targeting Notch signaling pathway in mice Cite
  Mosalam EM, Zidan AA, Mehanna ET, Mesbah NM, Abo-Elmatty DM. Thymoquinone and pentoxifylline enhance the chemotherapeutic effect of cisplatin by targeting Notch signaling pathway in mice. Life Sciences. Elsevier BV; 2020; 244:117299 10.1016/j.lfs.2020.117299
• Co-encapsulation of docetaxel and thymoquinone in mPEG-DSPE-vitamin E TPGS-lipid nanocapsules for breast cancer therapy: Formulation optimization and implications on cellular and in vivo toxicity Cite
  Zafar S, Akhter S, Garg N, Selvapandiyan A, Kumar Jain G, Ahmad FJ. Co-encapsulation of docetaxel and thymoquinone in mPEG-DSPE-vitamin E TPGS-lipid nanocapsules for breast cancer therapy: Formulation optimization and implications on cellular and in vivo toxicity. European Journal of Pharmaceutics and Biopharmaceutics. Elsevier BV; 2020; 148:10-26 10.1016/j.ejpb.2019.12.016
• Co-encapsulation of thymoquinone with docetaxel enhances the encapsulation efficiency into PEGylated liposomes and the chemosensitivity of MCF7 breast cancer cells to docetaxel Cite
  Odeh F, Naffa R, Azzam H, Mahmoud IS, Alshaer W, Al Bawab A, et al. Co-encapsulation of thymoquinone with docetaxel enhances the encapsulation efficiency into PEGylated liposomes and the chemosensitivity of MCF7 breast cancer cells to docetaxel. Heliyon. Elsevier BV; 2019; 5:e02919 10.1016/j.heliyon.2019.e02919
• Improved chemotherapeutic efficacy against resistant human breast cancer cells with co-delivery of Docetaxel and Thymoquinone by Chitosan grafted lipid nanocapsules: Formulation optimization, in vitro and in vivo studies Cite
  Zafar S, Akhter S, Ahmad I, Hafeez Z, Alam Rizvi MM, Jain GK, et al. Improved chemotherapeutic efficacy against resistant human breast cancer cells with co-delivery of Docetaxel and Thymoquinone by Chitosan grafted lipid nanocapsules: Formulation optimization, in vitro and in vivo studies. Colloids and Surfaces B: Biointerfaces. Elsevier BV; 2020; 186:110603 10.1016/j.colsurfb.2019.110603
• Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects Cite
  Ahmad A, Mishra RK, Vyawahare A, Kumar A, Rehman MU, Qamar W, et al. Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects. Saudi Pharmaceutical Journal. Elsevier BV; 2019; 27:1113-1126 10.1016/j.jsps.2019.09.008
• Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics Cite
  Khan MA, Tania M, Fu J. Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics. Drug Discovery Today. Elsevier BV; 2019; 24:2315-2322 10.1016/j.drudis.2019.09.007
• Abstract 2995: Thymoquinone attenuates breast cancer cell resistance to paclitaxel via targeting tumor associated stem cell population Cite
  Bashmail HA, Alamoudi AA, Hegazy GA, Agabnoor GM, Noorwali A, Al-Abd AM. Abstract 2995: Thymoquinone attenuates breast cancer cell resistance to paclitaxel via targeting tumor associated stem cell population. Experimental and Molecular Therapeutics. American Association for Cancer Research; 2019; 10.1158/1538-7445.am2019-2995
• Abstract 3876: Thymoquinone induces the expression of clock genes in breast cancer cells Cite
  Alamoudi AA, Bashmail HA, Ajabnoor GM, Choudhry H, Hassan MA, Aldahlawi AM, et al. Abstract 3876: Thymoquinone induces the expression of clock genes in breast cancer cells. Experimental and Molecular Therapeutics. American Association for Cancer Research; 2019; 10.1158/1538-7445.am2019-3876
• Abstract 3834: Epigenetic modification of oncogenes or tumor suppressor genes by thymoquinone in triple negative breast cancer Cite
  Khan MA, Zheng M, Fu J. Abstract 3834: Epigenetic modification of oncogenes or tumor suppressor genes by thymoquinone in triple negative breast cancer. Experimental and Molecular Therapeutics. American Association for Cancer Research; 2019; 10.1158/1538-7445.am2019-3834
• Thymoquinone Augments Cyclophosphamide-Mediated Inhibition of Cell Proliferation in Breast Cancer Cells Cite
  Khan A, Aldebasy YH, Alsuhaibani SA, Khan MA. Thymoquinone Augments Cyclophosphamide-Mediated Inhibition of Cell Proliferation in Breast Cancer Cells. Asian Pacific Journal of Cancer Prevention. EpiSmart Science Vector Ltd; 2019; 20:1153-1160 10.31557/apjcp.2019.20.4.1153
• Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms Cite
  Qadi SA, Hassan MA, Sheikh RA, Baothman OA, Zamzami MA, Choudhry H, et al. Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms. Epigenetics Insights. SAGE Publications; 2019; 12:251686571983901 10.1177/2516865719839011
• Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone Cite
  Aumeeruddy MZ, Mahomoodally MF. Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone. Cancer. Wiley; 2019; 125:1600-1611 10.1002/cncr.32022
• Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis Cite
  Shanmugam MK, Ahn KS, Hsu A, Woo CC, Yuan Y, Tan KHB, et al. Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis. Frontiers in Pharmacology. Frontiers Media SA; 2018; 9 10.3389/fphar.2018.01294
• Abstract 5813: Thymoquinone influences the anticancer properties of paclitaxel and gemcitabine against breast cancer cells Cite
  Bashmil HA, Alamoudi AA, Noorwali A, Hegazy GA, Ajabnoor G, Al-Abd AM. Abstract 5813: Thymoquinone influences the anticancer properties of paclitaxel and gemcitabine against breast cancer cells. Experimental and Molecular Therapeutics. American Association for Cancer Research; 2018; 10.1158/1538-7445.am2018-5813
• Thymoquinone inhibits cell proliferation, migration, and invasion by regulating the elongation factor 2 kinase (eEF-2K) signaling axis in triple-negative breast cancer Cite
  Kabil N, Bayraktar R, Kahraman N, Mokhlis HA, Calin GA, Lopez-Berestein G, et al. Thymoquinone inhibits cell proliferation, migration, and invasion by regulating the elongation factor 2 kinase (eEF-2K) signaling axis in triple-negative breast cancer. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2018; 171:593-605 10.1007/s10549-018-4847-2
• Loading of doxorubicin and thymoquinone with F2 gel nanofibers improves the antitumor activity and ameliorates doxorubicin-associated nephrotoxicity Cite
  Zidan AA, El-Ashmawy NE, Khedr EG, Ebeid EM, Salem ML, Mosalam EM. Loading of doxorubicin and thymoquinone with F2 gel nanofibers improves the antitumor activity and ameliorates doxorubicin-associated nephrotoxicity. Life Sciences. Elsevier BV; 2018; 207:461-470 10.1016/j.lfs.2018.06.008
• ID:2024 Synthesis and Characterization of PLGA-PEG Thymoquinone Nanoparticle and its Cytotoxicity Effects in Tamoxifen-resistant Breast Cancer Cells Cite
  Ahmad R, Kaus NHM, Hamid S. ID:2024 Synthesis and Characterization of PLGA-PEG Thymoquinone Nanoparticle and its Cytotoxicity Effects in Tamoxifen-resistant Breast Cancer Cells. Biomedical Research and Therapy. Biomedical Research and Therapy; 2017; 4:55 10.15419/bmrat.v4is.248
• Enhanced anticancer effect and reduced toxicity of doxorubicin in combination with thymoquinone released from poly- N -acetyl glucosamine nanomatrix in mice bearing solid Ehrlish carcinoma Cite
  El-Ashmawy NE, Khedr EG, Ebeid EM, Salem ML, Zidan AA, Mosalam EM. Enhanced anticancer effect and reduced toxicity of doxorubicin in combination with thymoquinone released from poly- N -acetyl glucosamine nanomatrix in mice bearing solid Ehrlish carcinoma. European Journal of Pharmaceutical Sciences. Elsevier BV; 2017; 109:525-532 10.1016/j.ejps.2017.09.012
• Abstract 3249: Thymoquinone inhibits elongation factor 2 kinase signaling axis by inducing tumor suppressor miR-603 in triple negative breast cancer cells Cite
  Kabil NN, Bayraktar R, Kahraman N, Ozpolat B. Abstract 3249: Thymoquinone inhibits elongation factor 2 kinase signaling axis by inducing tumor suppressor miR-603 in triple negative breast cancer cells. Cancer Chemistry. American Association for Cancer Research; 2017; 10.1158/1538-7445.am2017-3249
• Regressions of Breast Carcinoma Syngraft Following Treatment with Piperine in Combination with Thymoquinone Cite
  Talib W. Regressions of Breast Carcinoma Syngraft Following Treatment with Piperine in Combination with Thymoquinone. Scientia Pharmaceutica. MDPI AG; 2017; 85:27 10.3390/scipharm85030027
• Abstract 4123: Thymoquinone inhibits bone metastasis in a breast cancer mouse model by modulating CXCR4/CXCL12 signaling axis Cite
  Shanmugam MK, Hsu A, Hui KM, Tan BK, Sethi G. Abstract 4123: Thymoquinone inhibits bone metastasis in a breast cancer mouse model by modulating CXCR4/CXCL12 signaling axis. Tumor Biology. American Association for Cancer Research; 2016; 10.1158/1538-7445.am2016-4123
• Abstract 2176: Targeting eEF-2Kinase by thymoquinone in triple negative breast cancer Cite
  Kabil NN, Bayraktar R, Kahraman N, Ozpolat B. Abstract 2176: Targeting eEF-2Kinase by thymoquinone in triple negative breast cancer. Cancer Chemistry. American Association for Cancer Research; 2016; 10.1158/1538-7445.am2016-2176
• Uptake, delivery, and anticancer activity of thymoquinone nanoparticles in breast cancer cells Cite
  Fakhoury I, Saad W, Bouhadir K, Nygren P, Schneider-Stock R, Gali-Muhtasib H. Uptake, delivery, and anticancer activity of thymoquinone nanoparticles in breast cancer cells. Journal of Nanoparticle Research. Springer Science and Business Media LLC; 2016; 18 10.1007/s11051-016-3517-8
• Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin Cite
  Effenberger-Neidnicht K, Schobert R. Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin. Cancer Chemotherapy and Pharmacology. Springer Science and Business Media LLC; 2010; 67:867-874 10.1007/s00280-010-1386-x
• Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-γ pathway Cite
  Woo CC, Loo SY, Gee V, Yap CW, Sethi G, Kumar AP, et al. Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-γ pathway. Biochemical Pharmacology. Elsevier BV; 2011; 82:464-475 10.1016/j.bcp.2011.05.030
• NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis Cite
  Sutton KM, Doucette CD, Hoskin DW. NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis. Biochemical and Biophysical Research Communications. Elsevier BV; 2012; 426:421-426 10.1016/j.bbrc.2012.08.111
• Radiosensitization in human breast carcinoma cells by thymoquinone: role of cell cycle and apoptosis Cite
  Velho‑Pereira R, Kumar A, Pandey BN, Jagtap AG, Mishra KP. Radiosensitization in human breast carcinoma cells by thymoquinone: role of cell cycle and apoptosis. Cell Biology International. Wiley; 2011; 35:1025-1029 10.1042/cbi20100701
• Thymoquinone: Potential cure for inflammatory disorders and cancer Cite
  Woo CC, Kumar AP, Sethi G, Tan KHB. Thymoquinone: Potential cure for inflammatory disorders and cancer. Biochemical Pharmacology. Elsevier BV; 2012; 83:443-451 10.1016/j.bcp.2011.09.029
• Targeted Apoptotic Effects of Thymoquinone and Tamoxifen on XIAP Mediated Akt Regulation in Breast Cancer Cite
  Rajput S, Kumar BNP, Sarkar S, Das S, Azab B, Santhekadur PK, et al. Targeted Apoptotic Effects of Thymoquinone and Tamoxifen on XIAP Mediated Akt Regulation in Breast Cancer. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e61342 10.1371/journal.pone.0061342
• Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS Cite
  Woo CC, Hsu A, Kumar AP, Sethi G, Tan KHB. Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e75356 10.1371/journal.pone.0075356
• Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells Cite
  Rajput S, Kumar BP, Dey KK, Pal I, Parekh A, Mandal M. Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells. Life Sciences. Elsevier BV; 2013; 93:783-790 10.1016/j.lfs.2013.09.009
• Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells Cite
  MOTAGHED M, AL-HASSAN FM, HAMID SS. Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells. International Journal of Molecular Medicine. Spandidos Publications; 2013; 33:8-16 10.3892/ijmm.2013.1563
• The combination of thymoquinone and paclitaxel shows anti-tumor activity through the interplay with apoptosis network in triple-negative breast cancer Cite
  Şakalar Ç, İzgi K, İskender B, Sezen S, Aksu H, Çakır M, et al. The combination of thymoquinone and paclitaxel shows anti-tumor activity through the interplay with apoptosis network in triple-negative breast cancer. Tumor Biology. Springer Science and Business Media LLC; 2015; 37:4467-4477 10.1007/s13277-015-4307-0
• Thymoquinone, A Bioactive Component of Black Caraway Seeds, Causes G1 Phase Cell Cycle Arrest and Apoptosis in Triple-Negative Breast Cancer Cells with Mutant p53 Cite
  Sutton KM, Greenshields AL, Hoskin DW. Thymoquinone, A Bioactive Component of Black Caraway Seeds, Causes G1 Phase Cell Cycle Arrest and Apoptosis in Triple-Negative Breast Cancer Cells with Mutant p53. Nutrition and Cancer. Informa UK Limited; 2014; 66:408-418 10.1080/01635581.2013.878739
• Proapoptotic and Antimetastatic Properties of Supercritical CO2 Extract of Nigella sativa Linn. Against Breast Cancer Cells Cite
  Baharetha HM, Nassar ZD, Aisha AF, Ahamed MBK, Al-Suede FSR, Kadir MOA, et al. Proapoptotic and Antimetastatic Properties of Supercritical CO2 Extract of Nigella sativa Linn. Against Breast Cancer Cells. Journal of Medicinal Food. Mary Ann Liebert Inc; 2013; 16:1121-1130 10.1089/jmf.2012.2624
• Antiradical and antimicrobial properties of cold-pressed black cumin and cumin oils Cite
  Ramadan MF, Asker MMS, Tadros M. Antiradical and antimicrobial properties of cold-pressed black cumin and cumin oils. European Food Research and Technology. Springer Science and Business Media LLC; 2012; 234:833-844 10.1007/s00217-012-1696-9