Tag: testosterone

Testosterone: The most important androgen.Testosterone is secreted by the ovaries and to some extent by the adrenal glands in women, in whom it acts to maintain libido, bone strength, and muscle mass. Testosterone can be converted to estradiol by aromatase activity.

News

05/22/12: Losing weight through diet and exercise can improve hormonal profile
01/05/10: Pomegranate compounds inhibit aromatase and reduces proliferation

Studies

Abstract P4-10-01: Testosterone & Tamoxifen (T&T) trial: adding Testosterone to Tamoxifen in male breast cancer patients Cite
Moustaquim J, van Geel J, van Kruchten M, de Vries E, Stokkel M, Glaudemans A, et al. Abstract P4-10-01: Testosterone & Tamoxifen (T&T) trial: adding Testosterone to Tamoxifen in male breast cancer patients. Clinical Cancer Research. American Association for Cancer Research (AACR); 2025; 31:P4-10-01-P4-10-01 10.1158/1557-3265.sabcs24-p4-10-01
The Effect of Low‐Fat Diets Versus High‐Fat Diet on Sex Hormones: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials Cite
Soltani S, Hejazi M, Meshkini F, Torabinasab K, Zeraattalab‐Motlagh S, Sangsefidi Zs, et al. The Effect of Low‐Fat Diets Versus High‐Fat Diet on Sex Hormones: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials. Journal of Food Science. Wiley; 2025; 90 10.1111/1750-3841.70266
Causal relationships between four types of lipids and breast cancer risk with potential mediators: evidence from Mendelian randomization study and bioinformatics analysis Cite
Li X, Wang B, Tang Y. Causal relationships between four types of lipids and breast cancer risk with potential mediators: evidence from Mendelian randomization study and bioinformatics analysis. Discover Oncology. Springer Science and Business Media LLC; 2025; 16 10.1007/s12672-025-02597-x
Association between triglyceride-glucose related indicators, genetic risk, and incident breast cancer among postmenopausal women in UK Biobank Cite
Li Z, Zhao Z, Zhang T, Yang X, Chen H, Yin X, et al. Association between triglyceride-glucose related indicators, genetic risk, and incident breast cancer among postmenopausal women in UK Biobank. BMC Cancer. Springer Science and Business Media LLC; 2025; 25 10.1186/s12885-025-13970-y
Gynecomastia and its potential progression to male breast cancer: Mechanisms, genetic factors, and hormonal interactions Cite
Fu D, Miao H, Wang Z, Yang C. Gynecomastia and its potential progression to male breast cancer: Mechanisms, genetic factors, and hormonal interactions. Critical Reviews in Oncology/Hematology. Elsevier BV; 2025; 208:104651 10.1016/j.critrevonc.2025.104651
Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study Cite
Mostofsky E, Buring JE, Come SE, Tung NM, Zhang C, Mukamal KJ. Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study. Breast Cancer Research. Springer Science and Business Media LLC; 2025; 27 10.1186/s13058-024-01940-4
Disentangling the relationships of body mass index and circulating sex hormone concentrations in mammographic density using Mendelian randomization Cite
Haas CB, Chen H, Harrison T, Fan S, Gago-Dominguez M, Castelao JE, et al. Disentangling the relationships of body mass index and circulating sex hormone concentrations in mammographic density using Mendelian randomization. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2024; 206:295-305 10.1007/s10549-024-07306-w
Effect of baseline oestradiol serum concentration on the efficacy of anastrozole for preventing breast cancer in postmenopausal women at high risk: a case-control study of the IBIS-II prevention trial Cite
Cuzick J, Chu K, Keevil B, Brentnall AR, Howell A, Zdenkowski N, et al. Effect of baseline oestradiol serum concentration on the efficacy of anastrozole for preventing breast cancer in postmenopausal women at high risk: a case-control study of the IBIS-II prevention trial. The Lancet Oncology. Elsevier BV; 2023; 10.1016/s1470-2045(23)00578-8
Alcohol intake and endogenous sex hormones in women: meta-analysis of cohort studies and Mendelian randomization Cite
Tin ST, Smith-Byrne K, Ferrari P, Rinaldi S, McCullough ML, Teras LR, et al. Alcohol intake and endogenous sex hormones in women: meta-analysis of cohort studies and Mendelian randomization. Research Square Platform LLC; 2023; 10.21203/rs.3.rs-3249588/v1
Resveratrol exhibits diverse anti-cancer activities through epigenetic regulation of E-cadherin and p21 in triple-negative breast cancer cells Cite
Sakamoto T, Tanimoto K, Eguchi H, Sasaki S, Tsuboi K, Hayashi S, et al. Resveratrol exhibits diverse anti-cancer activities through epigenetic regulation of E-cadherin and p21 in triple-negative breast cancer cells. Breast Cancer. Springer Science and Business Media LLC; 2023; 10.1007/s12282-023-01465-2
Metformin and testosterone replacement therapy inversely associated with hormone‐associated cancers (prostate, colorectal and male breast cancers) among older White and Black men Cite
Lopez DS, Malagaris I, Polychronopoulou E, Tsilidis KK, Milani SA, Kristen Peek M, et al. Metformin and testosterone replacement therapy inversely associated with hormone‐associated cancers (prostate, colorectal and male breast cancers) among older White and Black men. Clinical Endocrinology. Wiley; 2022; 10.1111/cen.14803
Manipulation of Dietary Intake on Changes in Circulating Testosterone Concentrations Cite
Zamir A, Ben-Zeev T, Hoffman JR. Manipulation of Dietary Intake on Changes in Circulating Testosterone Concentrations. Nutrients. MDPI AG; 2021; 13:3375 10.3390/nu13103375
Endogenous hormones and risk of invasive breast cancer in pre- and post-menopausal women: findings from the UK Biobank Cite
Tin Tin S, Reeves GK, Key TJ. Endogenous hormones and risk of invasive breast cancer in pre- and post-menopausal women: findings from the UK Biobank. British Journal of Cancer. Springer Science and Business Media LLC; 2021; 10.1038/s41416-021-01392-z
Exercise type and fat mass loss regulate breast cancer-related sex hormones in obese and overweight postmenopausal women Cite
Gonzalo-Encabo P, Valadés D, García-Honduvilla N, de Cos Blanco A, Friedenreich CM, Pérez-López A. Exercise type and fat mass loss regulate breast cancer-related sex hormones in obese and overweight postmenopausal women. European Journal of Applied Physiology. Springer Science and Business Media LLC; 2020; 120:1277-1287 10.1007/s00421-020-04361-1
Incidence of invasive breast cancer in women treated with testosterone implants: a prospective 10-year cohort study Cite
Glaser RL, York AE, Dimitrakakis C. Incidence of invasive breast cancer in women treated with testosterone implants: a prospective 10-year cohort study. BMC Cancer. Springer Science and Business Media LLC; 2019; 19 10.1186/s12885-019-6457-8
Synergistic action of folate intake and testosterone associated with breast cancer risk Cite
Sánchez-Zamorano LM, Angeles-Llerenas A, Salinas-Rodríguez A, Lazcano-Ponce EC, Romieu I, Pérez-Rodríguez E, et al. Synergistic action of folate intake and testosterone associated with breast cancer risk. Nutrition Research. Elsevier BV; 2019; 71:100-110 10.1016/j.nutres.2019.10.002
The Androgen Receptor Supports Tumor Progression After the Loss of Ovarian Function in a Preclinical Model of Obesity and Breast Cancer Cite
Wellberg EA, Checkley LA, Giles ED, Johnson SJ, Oljira R, Wahdan-Alaswad R, et al. The Androgen Receptor Supports Tumor Progression After the Loss of Ovarian Function in a Preclinical Model of Obesity and Breast Cancer. Hormones and Cancer. Springer Science and Business Media LLC; 2017; 8:269-285 10.1007/s12672-017-0302-9
Associations of obesity and physical activity with serum and intratumoral sex steroid hormone levels among postmenopausal women with breast cancer: analysis of paired serum and tumor tissue samples Cite
Kakugawa Y, Tada H, Kawai M, Suzuki T, Nishino Y, Kanemura S, et al. Associations of obesity and physical activity with serum and intratumoral sex steroid hormone levels among postmenopausal women with breast cancer: analysis of paired serum and tumor tissue samples. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2017; 162:115-125 10.1007/s10549-016-4094-3
Associations of sex steroid hormones with mortality in women with breast cancer Cite
Duggan C, Stanczyk F, Campbell K, Neuhouser ML, Baumgartner RN, Baumgartner KB, et al. Associations of sex steroid hormones with mortality in women with breast cancer. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2016; 155:559-567 10.1007/s10549-016-3704-4
Effects of Pomegranate Juice on Hormonal Biomarkers of Breast Cancer Risk Cite
Kapoor R, Ronnenberg A, Puleo E, Chatterton Jr. RT, Dorgan JF, Seeram NP, et al. Effects of Pomegranate Juice on Hormonal Biomarkers of Breast Cancer Risk. Nutrition and Cancer. Informa UK Limited; 2015; 67:1113-1119 10.1080/01635581.2015.1073756
New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane Cite
HOLE S, PEDERSEN AM, HANSEN SK, LUNDQVIST J, YDE CW, LYKKESFELDT AE. New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane. International Journal of Oncology. Spandidos Publications; 2015; 46:1481-1490 10.3892/ijo.2015.2850
In utero and peripubertal exposure to phthalates and BPA in relation to female sexual maturation Cite
Watkins DJ, Téllez-Rojo MM, Ferguson KK, Lee JM, Solano-Gonzalez M, Blank-Goldenberg C, et al. In utero and peripubertal exposure to phthalates and BPA in relation to female sexual maturation. Environmental Research. Elsevier BV; 2014; 134:233-241 10.1016/j.envres.2014.08.010
Associations between cadmium exposure and circulating levels of sex hormones in postmenopausal women Cite
Ali I, Engström A, Vahter M, Skerfving S, Lundh T, Lidfeldt J, et al. Associations between cadmium exposure and circulating levels of sex hormones in postmenopausal women. Environmental Research. Elsevier BV; 2014; 134:265-269 10.1016/j.envres.2014.08.009
Changes in Estradiol and Testosterone Levels in Postmenopausal Women After Changes in Body Mass Index Cite
Jones ME, Schoemaker M, Rae M, Folkerd EJ, Dowsett M, Ashworth A, et al. Changes in Estradiol and Testosterone Levels in Postmenopausal Women After Changes in Body Mass Index. The Journal of Clinical Endocrinology & Metabolism. The Endocrine Society; 2013; 98:2967-2974 10.1210/jc.2013-1588
Postmenopausal plasma sex hormone levels and breast cancer risk over 20 years of follow-up Cite
Zhang X, Tworoger SS, Eliassen AH, Hankinson SE. Postmenopausal plasma sex hormone levels and breast cancer risk over 20 years of follow-up. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2013; 137:883-892 10.1007/s10549-012-2391-z
Effect of Different Doses of Metformin on Serum Testosterone and Insulin in Non-Diabetic Women With Breast Cancer: A Randomized Study Cite
Campagnoli C, Pasanisi P, Abbà C, Ambroggio S, Biglia N, Brucato T, et al. Effect of Different Doses of Metformin on Serum Testosterone and Insulin in Non-Diabetic Women With Breast Cancer: A Randomized Study. Clinical Breast Cancer. Elsevier BV; 2012; 12:175-182 10.1016/j.clbc.2012.03.004
Reduced-Calorie Dietary Weight Loss, Exercise, and Sex Hormones in Postmenopausal Women: Randomized Controlled Trial Cite
Campbell KL, Foster-Schubert KE, Alfano CM, Wang C, Wang C, Duggan CR, et al. Reduced-Calorie Dietary Weight Loss, Exercise, and Sex Hormones in Postmenopausal Women: Randomized Controlled Trial. Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2012; 30:2314-2326 10.1200/jco.2011.37.9792
Effect of oral phytoestrogen on androgenicity and insulin sensitivity in postmenopausal women Cite
Lee CC, Bloem CJ, Kasa-Vubu JZ, Liang L. Effect of oral phytoestrogen on androgenicity and insulin sensitivity in postmenopausal women. Diabetes, Obesity and Metabolism. Wiley; 2011; 14:315-319 10.1111/j.1463-1326.2011.01532.x
Triclosan Exposure Modulates Estrogen-Dependent Responses in the Female Wistar Rat Cite
Stoker TE, Gibson EK, Zorrilla LM. Triclosan Exposure Modulates Estrogen-Dependent Responses in the Female Wistar Rat. Toxicological Sciences. Oxford University Press (OUP); 2010; 117:45-53 10.1093/toxsci/kfq180
Oestrogenic and androgenic activity of triclosan in breast cancer cells Cite
Gee RH, Charles A, Taylor N, Darbre PD. Oestrogenic and androgenic activity of triclosan in breast cancer cells. Journal of Applied Toxicology. Wiley; 2007; 28:78-91 10.1002/jat.1316
Red Versus White Wine as a Nutritional Aromatase Inhibitor in Premenopausal Women: A Pilot Study Cite
Shufelt C, Merz CNB, Yang Y, Kirschner J, Polk D, Stanczyk F, et al. Red Versus White Wine as a Nutritional Aromatase Inhibitor in Premenopausal Women: A Pilot Study. Journal of Women's Health. Mary Ann Liebert Inc; 2012; 21:281-284 10.1089/jwh.2011.3001
Analgesic Use and Sex Steroid Hormone Concentrations in Postmenopausal Women Cite
Gates MA, Tworoger SS, Eliassen AH, Missmer SA, Hankinson SE. Analgesic Use and Sex Steroid Hormone Concentrations in Postmenopausal Women. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2010; 19:1033-1041 10.1158/1055-9965.epi-09-0975
Menopausal hormone therapy and breast cancer risk: Impact of different treatments. The European Prospective Investigation into Cancer and Nutrition Cite
Bakken K, Fournier A, Lund E, Waaseth M, Dumeaux V, Clavel-Chapelon F, et al. Menopausal hormone therapy and breast cancer risk: Impact of different treatments. The European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer. Wiley; 2010; 128:144-156 10.1002/ijc.25314
Physical Activity and Postmenopausal Breast Cancer: Proposed Biologic Mechanisms and Areas for Future Research Cite
Neilson HK, Friedenreich CM, Brockton NT, Millikan RC. Physical Activity and Postmenopausal Breast Cancer: Proposed Biologic Mechanisms and Areas for Future Research. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2009; 18:11-27 10.1158/1055-9965.epi-08-0756
Circulating Steroid Hormone Levels and Risk of Breast Cancer for Postmenopausal Women Cite
Baglietto L, Severi G, English DR, Krishnan K, Hopper JL, McLean C, et al. Circulating Steroid Hormone Levels and Risk of Breast Cancer for Postmenopausal Women. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2010; 19:492-502 10.1158/1055-9965.epi-09-0532
Pomegranate Ellagitannin–Derived Compounds Exhibit Antiproliferative and Antiaromatase Activity in Breast Cancer Cells In vitro Cite
Adams LS, Zhang Y, Seeram NP, Heber D, Chen S. Pomegranate Ellagitannin–Derived Compounds Exhibit Antiproliferative and Antiaromatase Activity in Breast Cancer Cells In vitro. Cancer Prevention Research. American Association for Cancer Research (AACR); 2010; 3:108-113 10.1158/1940-6207.capr-08-0225
Anti-Aromatase Activity of Phytochemicals in White Button Mushrooms (Agaricus bisporus) Cite
Chen S, Oh S, Phung S, Hur G, Ye JJ, Kwok SL, et al. Anti-Aromatase Activity of Phytochemicals in White Button Mushrooms (Agaricus bisporus). Cancer Research. American Association for Cancer Research (AACR); 2006; 66:12026-12034 10.1158/0008-5472.can-06-2206
Estrogenic action of commonly used fragrant agent citral induces prostatic hyperplasia Cite
Geldof AA, Engel C, Rao BR. Estrogenic action of commonly used fragrant agent citral induces prostatic hyperplasia. Urological Research. Springer Science and Business Media LLC; 1992; 20:139-144 10.1007/bf00296526
Association between Alcohol Intake and Serum Sex Hormones and Peptides Differs by Tamoxifen Use in Breast Cancer Survivors Cite
Wayne S, Neuhouser ML, Ulrich CM, Koprowski C, Wiggins C, Baumgartner KB, et al. Association between Alcohol Intake and Serum Sex Hormones and Peptides Differs by Tamoxifen Use in Breast Cancer Survivors. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2008; 17:3224-3232 10.1158/1055-9965.epi-08-0171