Tag: silibinin

News

05/17/15

Artichoke compound silibinin promotes ER+/PR+ BC cell death

Foods

• • artichokes

Studies

• Inhibition of YAP/TAZ pathway contributes to the cytotoxicity of silibinin in MCF-7 and MDA-MB-231 human breast cancer cells Cite
  Fu J, Liu W, Liu S, Zhao R, Hayashi T, Zhao H, et al. Inhibition of YAP/TAZ pathway contributes to the cytotoxicity of silibinin in MCF-7 and MDA-MB-231 human breast cancer cells. Cellular Signalling. Elsevier BV; 2024;:111186 10.1016/j.cellsig.2024.111186
• Triple Negative Breast Cancer (TNBC): Signalling pathways-Role of plant-based inhibitors Cite
  Ravindra B. Malabadi , Sadiya MR , Kiran P. Kolkar , Simuzar S. Mammadova , Raju K. Chalannavar , Himansu Baijnath , et al. Triple Negative Breast Cancer (TNBC): Signalling pathways-Role of plant-based inhibitors. Open Access Research Journal of Biology and Pharmacy. Open Access Research Journals Publication; 2024; 10:028-071 10.53022/oarjbp.2024.10.2.0013
• The role of miR-133a in silibinin-mediated inhibition of the PI3K/AKT/mTOR pathway in MCF-7 breast carcinoma cells Cite
  HosseinTehrani M, Abbasalipourkabir R, Ziamajidi N. The role of miR-133a in silibinin-mediated inhibition of the PI3K/AKT/mTOR pathway in MCF-7 breast carcinoma cells. Molecular Biology Research Communications. Shiraz University Press; 2024; 10.22099/mbrc.2024.48818.1903
• Phytochemicals and Their Usefulness in the Maintenance of Health Cite
  Rodríguez-Negrete EV, Morales-González Á, Madrigal-Santillán EO, Sánchez-Reyes K, Álvarez-González I, Madrigal-Bujaidar E, et al. Phytochemicals and Their Usefulness in the Maintenance of Health. Plants. MDPI AG; 2024; 13:523 10.3390/plants13040523
• Insights on the Role of Polyphenols in Combating Cancer Drug Resistance Cite
  Farhan M. Insights on the Role of Polyphenols in Combating Cancer Drug Resistance. Biomedicines. MDPI AG; 2023; 11:1709 10.3390/biomedicines11061709
• Effect of Silibinin on the Expression of Mir-20b, Bcl2L11, and Erbb2 in Breast Cancer Cell Lines Cite
  Ranapour S, Motamed N. Effect of Silibinin on the Expression of Mir-20b, Bcl2L11, and Erbb2 in Breast Cancer Cell Lines. Molecular Biotechnology. Springer Science and Business Media LLC; 2023; 10.1007/s12033-023-00702-5
• Silibinin induces immunogenic cell death in cancer cells and enhances the induced immunogenicity by chemotherapy Cite
  Jafari S, Heydarian S, Lai R, Mehdizadeh Aghdam E, Molavi O. Silibinin induces immunogenic cell death in cancer cells and enhances the induced immunogenicity by chemotherapy. BioImpacts. Maad Rayan Publishing Company; 2022; 10.34172/bi.2022.23698
• Silibinin, Synergistically Enhances Vinblastine-Mediated Apoptosis in Triple Negative Breast Cancer Cell Line: Involvement of Bcl2/Bax and Caspase-3 Pathway Cite
  Dariushnejad H, Roshanravan N, Wasman HM, Pirzeh L, Ghorbanzadeh v. Silibinin, Synergistically Enhances Vinblastine-Mediated Apoptosis in Triple Negative Breast Cancer Cell Line: Involvement of Bcl2/Bax and Caspase-3 Pathway. Research Square Platform LLC; 2022; 10.21203/rs.3.rs-1341486/v1
• Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy Cite
  Fatima N, Baqri SSR, Bhattacharya A, Koney NK, Husain K, Abbas A, et al. Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy. Frontiers in Genetics. Frontiers Media SA; 2021; 12 10.3389/fgene.2021.758733
• Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis Cite
  Maroni P, Bendinelli P, Fulgenzi A, Ferraretto A. Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis. Biomolecules. MDPI AG; 2021; 11:1336 10.3390/biom11091336
• Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy Cite
  Sabo AA, Dudau M, Constantin GL, Pop TC, Geilfus C, Naccarati A, et al. Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy. Frontiers in Pharmacology. Frontiers Media SA; 2021; 12 10.3389/fphar.2021.652074
• Network pharmacology-based evaluation of natural compounds with paclitaxel for the treatment of metastatic breast cancer Cite
  Rathaur P, Soni MN, Gelat B, Rawal R, Pandya HA, Johar K. Network pharmacology-based evaluation of natural compounds with paclitaxel for the treatment of metastatic breast cancer. Toxicology and Applied Pharmacology. Elsevier BV; 2021;:115576 10.1016/j.taap.2021.115576
• Distinct Classes of Flavonoids and Epigallocatechin Gallate, Polyphenol Affects an Oncogenic Mutant p53 Protein, Cell Growth and Invasion in a TNBC Breast Cancer Cell Line Cite
  Kollareddy M, Martinez LA. Distinct Classes of Flavonoids and Epigallocatechin Gallate, Polyphenol Affects an Oncogenic Mutant p53 Protein, Cell Growth and Invasion in a TNBC Breast Cancer Cell Line. Cells. MDPI AG; 2021; 10:797 10.3390/cells10040797
• Chemopreventive potential of plant-derived epigenetic inhibitors silibinin and quercetin: an involvement of apoptotic signaling cascade modulation Cite
  Baksi R, Rana R, Nivsarkar M. Chemopreventive potential of plant-derived epigenetic inhibitors silibinin and quercetin: an involvement of apoptotic signaling cascade modulation. Future Journal of Pharmaceutical Sciences. Springer Science and Business Media LLC; 2021; 7 10.1186/s43094-021-00214-6
• Functional oral nanoparticles for delivering silibinin and cryptotanshinone against breast cancer lung metastasis Cite
  Liu Y, Xie X, Hou X, Shen J, Shi J, Chen H, et al. Functional oral nanoparticles for delivering silibinin and cryptotanshinone against breast cancer lung metastasis. Journal of Nanobiotechnology. Springer Science and Business Media LLC; 2020; 18 10.1186/s12951-020-00638-x
• The Anticancer Properties of Silibinin: Its Molecular Mechanism and Therapeutic Effect in Breast Cancer Cite
  Binienda A, Ziolkowska S, Pluciennik E. The Anticancer Properties of Silibinin: Its Molecular Mechanism and Therapeutic Effect in Breast Cancer. Anti-Cancer Agents in Medicinal Chemistry. Bentham Science Publishers Ltd.; 2020; 20:1787-1796 10.2174/1871520620666191220142741
• Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion Cite
  Si L, Fu J, Liu W, Hayashi T, Nie Y, Mizuno K, et al. Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion. Molecular and Cellular Biochemistry. Springer Science and Business Media LLC; 2019; 463:189-201 10.1007/s11010-019-03640-6
• Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review Cite
  Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Phytotherapy Research. Wiley; 2019; 33:1627-1638 10.1002/ptr.6361
• Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment Cite
  Si L, Liu W, Hayashi T, Ji Y, Fu J, Nie Y, et al. Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment. Archives of Biochemistry and Biophysics. Elsevier BV; 2019; 671:42-51 10.1016/j.abb.2019.05.009
• Silibinin: An Inhibitor of Mir-181a Gene Expression in Sk-Br-3 Breast Cancer Cell Line Cite
  Shahinfar P, Motamed N, Birjandian E, Shabanpour O. Silibinin: An Inhibitor of Mir-181a Gene Expression in Sk-Br-3 Breast Cancer Cell Line. Indian Journal of Pharmaceutical Education and Research. EManuscript Services; 2017; 51:597-602 10.5530/ijper.51.4.89
• Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies Cite
  Yuan Z, Li Y, Liu Z, Feng S, Zhou H, Liu C, et al. Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies. Pharmacological Research. Elsevier BV; 2018; 128:153-166 10.1016/j.phrs.2017.09.019
• Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer Cite
  Dong X, Lang T, Yin Q, Zhang P, Li Y. Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer. Acta Pharmacologica Sinica. Springer Science and Business Media LLC; 2017; 38:1655-1662 10.1038/aps.2017.74
• Synergistic Anticancer Effects of Silibinin and Chrysin in T47D Breast Cancer Cells Cite
  Javan-Maasomi Z, Pilehvar-Soltanahmadi Y, Dadashpour M, Alipour S, Abolhasani S, Zarghami N. Synergistic Anticancer Effects of Silibinin and Chrysin in T47D Breast Cancer Cells. Asian Pacific Journal of Cancer Prevention. Asian Pacific Organization for Cancer Prevention; 2017; 18 10.22034/APJCP.2017.18.5.1283
• Silibinin downregulates MMP2 expression via Jak2/STAT3 pathway and inhibits the migration and invasive potential in MDA-MB-231 cells Cite
  Byun HJ, Darvin P, Kang DY, Sp N, Joung YH, Park JH, et al. Silibinin downregulates MMP2 expression via Jak2/STAT3 pathway and inhibits the migration and invasive potential in MDA-MB-231 cells. Oncology Reports. Spandidos Publications; 2017; 37:3270-3278 10.3892/or.2017.5588
• Clinical Evidence of Herbal Drugs As Perpetrators of Pharmacokinetic Drug Interactions Cite
  Hermann R, von Richter O. Clinical Evidence of Herbal Drugs As Perpetrators of Pharmacokinetic Drug Interactions. Planta Medica. Georg Thieme Verlag KG; 2012; 78:1458-1477 10.1055/s-0032-1315117
• The apoptotic effects of silibinin on MDA-MB-231 and MCF-7 human breast carcinoma cells Cite
  Bayram D, Çetin E, Kara M, Özgöçmen M, Candan I. The apoptotic effects of silibinin on MDA-MB-231 and MCF-7 human breast carcinoma cells. Human & Experimental Toxicology. SAGE Publications; 2016; 36:573-586 10.1177/0960327116658105
• Silibinin and indocyanine green-loaded nanoparticles inhibit the growth and metastasis of mammalian breast cancer cells in vitro Cite
  Sun H, Su J, Meng Q, Yin Q, Zhang Z, Yu H, et al. Silibinin and indocyanine green-loaded nanoparticles inhibit the growth and metastasis of mammalian breast cancer cells in vitro. Acta Pharmacologica Sinica. Springer Science and Business Media LLC; 2016; 37:941-949 10.1038/aps.2016.20
• Silibinin-Induced Apoptosis and Downregulation of MicroRNA-21 and MicroRNA-155 in MCF-7 Human Breast Cancer Cells Cite
  Zadeh MM, Motamed N, Ranji N, Majidi M, Falahi F. Silibinin-Induced Apoptosis and Downregulation of MicroRNA-21 and MicroRNA-155 in MCF-7 Human Breast Cancer Cells. Journal of Breast Cancer. Korean Breast Cancer Society; 2016; 19:45 10.4048/jbc.2016.19.1.45
• Silibinin inhibits triple negative breast cancer cell motility by suppressing TGF-β2 expression Cite
  Kim S, Han J, Jeon M, You D, Lee J, Kim HJ, et al. Silibinin inhibits triple negative breast cancer cell motility by suppressing TGF-β2 expression. Tumor Biology. Springer Science and Business Media LLC; 2016; 37:11397-11407 10.1007/s13277-016-5000-7
• Effects of Aqueous Extracts of Chicory and Milk Thistle on Serum Concentrations of Copper, Zinc, and Manganese in Tamoxifen-Treated Rats Cite
  Abbasalipourkabir R, Ziamajidi N, Nasiri A, Behrouj H. Effects of Aqueous Extracts of Chicory and Milk Thistle on Serum Concentrations of Copper, Zinc, and Manganese in Tamoxifen-Treated Rats. Biological Trace Element Research. Springer Science and Business Media LLC; 2016; 173:140-143 10.1007/s12011-016-0629-z
• ERβ up-regulation was involved in silibinin-induced growth inhibition of human breast cancer MCF-7 cells Cite
  Zheng N, Liu L, Liu W, Zhang P, Huang H, Zang L, et al. ERβ up-regulation was involved in silibinin-induced growth inhibition of human breast cancer MCF-7 cells. Archives of Biochemistry and Biophysics. Elsevier BV; 2016; 591:141-149 10.1016/j.abb.2016.01.002
• Renoprotective effect of Mangifera indica polysaccharides and silymarin against cyclophosphamide toxicity in rats Cite
  Amien AI, Fahmy SR, Abd-Elgleel FM, Elaskalany SM. Renoprotective effect of Mangifera indica polysaccharides and silymarin against cyclophosphamide toxicity in rats. The Journal of Basic & Applied Zoology. Elsevier BV; 2015; 72:154-162 10.1016/j.jobaz.2015.09.006
• Epigenetic activities of flavonoids in the prevention and treatment of cancer Cite
  Busch C, Burkard M, Leischner C, Lauer UM, Frank J, Venturelli S. Epigenetic activities of flavonoids in the prevention and treatment of cancer. Clinical Epigenetics. Springer Science and Business Media LLC; 2015; 7 10.1186/s13148-015-0095-z
• ERα down-regulation plays a key role in silibinin-induced autophagy and apoptosis in human breast cancer MCF-7 cells Cite
  Zheng N, Zhang P, Huang H, Liu W, Hayashi T, Zang L, et al. ERα down-regulation plays a key role in silibinin-induced autophagy and apoptosis in human breast cancer MCF-7 cells. Journal of Pharmacological Sciences. Elsevier BV; 2015; 128:97-107 10.1016/j.jphs.2015.05.001
• Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells Cite
  JIANG K, WANG W, JIN X, WANG Z, JI Z, MENG G. Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells. Oncology Reports. Spandidos Publications; 2015; 33:2711-2718 10.3892/or.2015.3915
• Silibinin affects tumor cell growth because of reduction of stemness properties and induction of apoptosis in 2D and 3D models of MDA-MB-468 Cite
  Abdollahi P, Ebrahimi M, Motamed N, Samani FS. Silibinin affects tumor cell growth because of reduction of stemness properties and induction of apoptosis in 2D and 3D models of MDA-MB-468. Anti-Cancer Drugs. Ovid Technologies (Wolters Kluwer Health); 2015; 26:487-497 10.1097/cad.0000000000000205
• Anticancer effect of silibinin on the xenograft model using MDA-MB-468 breast cancer cells Cite
  Kil WH, Kim SM, Lee JE, Park KS, Nam SJ. Anticancer effect of silibinin on the xenograft model using MDA-MB-468 breast cancer cells. Annals of Surgical Treatment and Research. The Korean Surgical Society; 2014; 87:167 10.4174/astr.2014.87.4.167
• Silibinin Induces Cell Death through Reactive Oxygen Species–Dependent Downregulation of Notch-1/ERK/Akt Signaling in Human Breast Cancer Cells Cite
  Kim TH, Woo JS, Kim YK, Kim KH. Silibinin Induces Cell Death through Reactive Oxygen Species–Dependent Downregulation of Notch-1/ERK/Akt Signaling in Human Breast Cancer Cells. Journal of Pharmacology and Experimental Therapeutics. American Society for Pharmacology & Experimental Therapeutics (ASPET); 2014; 349:268-278 10.1124/jpet.113.207563
• Silibinin inhibits TPA-induced cell migration and MMP-9 expression in thyroid and breast cancer cells Cite
  OH S, JUNG SP, HAN J, KIM S, KIM JS, NAM SJ, et al. Silibinin inhibits TPA-induced cell migration and MMP-9 expression in thyroid and breast cancer cells. Oncology Reports. Spandidos Publications; 2013; 29:1343-1348 10.3892/or.2013.2252
• Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells Cite
  Lu W, Lin C, King TD, Chen H, Reynolds RC, Li Y. Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells. Cellular Signalling. Elsevier BV; 2012; 24:2291-2296 10.1016/j.cellsig.2012.07.009
• Tumor Angiogenesis as a Target for Dietary Cancer Prevention Cite
  Li WW, Li VW, Hutnik M, Chiou AS. Tumor Angiogenesis as a Target for Dietary Cancer Prevention. Journal of Oncology. Hindawi Limited; 2012; 2012:1-23 10.1155/2012/879623
• Effects of the Flavonoids Biochanin A, Morin, Phloretin, and Silymarin on P-Glycoprotein-Mediated Transport Cite
  Zhang S, Morris ME. Effects of the Flavonoids Biochanin A, Morin, Phloretin, and Silymarin on P-Glycoprotein-Mediated Transport. Journal of Pharmacology and Experimental Therapeutics. American Society for Pharmacology & Experimental Therapeutics (ASPET); 2002; 304:1258-1267 10.1124/jpet.102.044412
• Enhancement of mammary carcinogenesis in two rodent models by silymarin dietary supplements Cite
  Malewicz B. Enhancement of mammary carcinogenesis in two rodent models by silymarin dietary supplements. Carcinogenesis. Oxford University Press (OUP); 2006; 27:1739-1747 10.1093/carcin/bgl032