Tag: saffron

News

04/01/17

Saffron carotenoid crocin inhibits breast cancer cell division

Foods

• • saffron

Studies

• Crocin Induces Apoptosis in Primary Cancer Epithelial Cells Isolated from Human Breast Tumors via Different Mechanisms in HER2- Negative or Positive Cells: A Preliminary Study Cite
  Bathaie SZ, Faridi N, Hydrazideh H, Hashemi SA, Abroun S, Tamanoi F, et al. Crocin Induces Apoptosis in Primary Cancer Epithelial Cells Isolated from Human Breast Tumors via Different Mechanisms in HER2- Negative or Positive Cells: A Preliminary Study. Springer Science and Business Media LLC; 2024; 10.21203/rs.3.rs-4711052/v1
• Folic acid-modified nanocrystalline cellulose for enhanced delivery and anti-cancer effects of crocin Cite
  Soltani M, Farhadi A, Rajabi S, Homayouni‐Tabrizi M, Hussein FS, Mohammadian N. Folic acid-modified nanocrystalline cellulose for enhanced delivery and anti-cancer effects of crocin. Scientific Reports. Springer Science and Business Media LLC; 2024; 14 10.1038/s41598-024-64758-2
• Exploring the therapeutic efficacy of crocetin in oncology: an evidence-based review Cite
  Koch W, Wawruszak A, Kukula-Koch W, Zdziebło M, Helon P, Almarhoon ZM, et al. Exploring the therapeutic efficacy of crocetin in oncology: an evidence-based review. Naunyn-Schmiedeberg's Archives of Pharmacology. Springer Science and Business Media LLC; 2023; 10.1007/s00210-023-02714-z
• Advances on the anti-tumor mechanisms of the carotenoid Crocin Cite
  Bao X, Hu J, Zhao Y, Jia R, Zhang H, Xia L. Advances on the anti-tumor mechanisms of the carotenoid Crocin. PeerJ. PeerJ; 2023; 11:e15535 10.7717/peerj.15535
• Crocin-loaded liposomes sensitize MDA-MB 231 breast cancer cells to doxorubicin by inducing apoptosis Cite
  Chavoshi H, Taheri M, Wan MLY, Sabzichi M. Crocin-loaded liposomes sensitize MDA-MB 231 breast cancer cells to doxorubicin by inducing apoptosis. Process Biochemistry. Elsevier BV; 2023; 10.1016/j.procbio.2023.04.012
• Abstract 1319: Saffron (Crocus sativus) extract inhibits migration and invasion of cancer cells through modulation of MMP-3 and MMP-9 expression Cite
  King T, Moscardini S, Martin M, Rehman FK. Abstract 1319: Saffron (Crocus sativus) extract inhibits migration and invasion of cancer cells through modulation of MMP-3 and MMP-9 expression. Cancer Research. American Association for Cancer Research (AACR); 2023; 83:1319-1319 10.1158/1538-7445.am2023-1319
• Crocin suppresses breast cancer cell proliferation by down‐regulating tumor promoter miR-122-5p and up‐regulating tumor suppressors FOXP2 and SPRY2 Cite
  Jia Y, Yang H, Yu J, Li Z, Jia G, Ding B, et al. Crocin suppresses breast cancer cell proliferation by down‐regulating tumor promoter miR-122-5p and up‐regulating tumor suppressors FOXP2 and SPRY2. Environmental Toxicology. Wiley; 2023; 10.1002/tox.23789
• Mechanism of Saffron Extract against Cardiotoxicity Induced by Doxorubicin: 4D Label-Free Quantitative proteomics Analysis and Bioinformatic Study Cite
  Sa R, Lin Z, Huang J, Wang Y, Lv J, Zhang X, et al. Mechanism of Saffron Extract against Cardiotoxicity Induced by Doxorubicin: 4D Label-Free Quantitative proteomics Analysis and Bioinformatic Study. Research Square Platform LLC; 2023; 10.21203/rs.3.rs-2580481/v1
• pH-responsive co-delivery of Doxorubicin and Saffron via Cross-linked Chitosan/Laponite RD Nanoparticles for Enhanced-Chemotherapy Cite
  Heragh BK, Taherinezhad H, Mahdavinia GR, Javanshir S, Labib P, Ghasemsolb S. pH-responsive co-delivery of Doxorubicin and Saffron via Cross-linked Chitosan/Laponite RD Nanoparticles for Enhanced-Chemotherapy. Materials Today Communications. Elsevier BV; 2022;:104956 10.1016/j.mtcomm.2022.104956
• Untargeted Metabolomics Analysis of Crocus cancellatus subsp. damascenus (Herb.) B. Mathew Stigmas and Their Anticarcinogenic Effect on Breast Cancer Cells Cite
  Shakeri R, Savari B, Sheikholeslami MN, Radjabian T, Khorshidi J, Safavi M. Untargeted Metabolomics Analysis of Crocus cancellatus subsp. damascenus (Herb.) B. Mathew Stigmas and Their Anticarcinogenic Effect on Breast Cancer Cells. Evidence-Based Complementary and Alternative Medicine. Hindawi Limited; 2022; 2022:1-15 10.1155/2022/3861783
• Comprehensive review of two groups of flavonoids in Carthamus tinctorius L. Cite
  Xian B, Wang R, Jiang H, Zhou Y, Yan J, Huang X, et al. Comprehensive review of two groups of flavonoids in Carthamus tinctorius L.. Biomedicine & Pharmacotherapy. Elsevier BV; 2022; 153:113462 10.1016/j.biopha.2022.113462
• Crocin Inhibit the Metastasis of MDA-MB-231 cell line by Suppressing Epithelial to Mesenchymal Transition through WNT/β-catenin Signaling Pathway Cite
  Dariushnejad H, ALJAF KAH, Wasman HM, Pirzeh L, Ghorbanzadeh V. Crocin Inhibit the Metastasis of MDA-MB-231 cell line by Suppressing Epithelial to Mesenchymal Transition through WNT/β-catenin Signaling Pathway. Research Square Platform LLC; 2022; 10.21203/rs.3.rs-1539821/v1
• Comprehensive proteomics and sialiomics of the anti-proliferative activity of safranal on triple negative MDA-MB-231 breast cancer cell lines Cite
  Zarrineh M, Ashrafian S, Jensen P, Nawrocki A, Ansari AM, Rezadoost H, et al. Comprehensive proteomics and sialiomics of the anti-proliferative activity of safranal on triple negative MDA-MB-231 breast cancer cell lines. Journal of Proteomics. Elsevier BV; 2022; 259:104539 10.1016/j.jprot.2022.104539
• 188P Amelioration of anxiety, depression, and chemotherapy related toxicity after crocin administration during chemotherapy of breast cancer: A double blind, randomized clinical trial Cite
  Javadinia S, Salek R, Dehghani M, Mohajeri S, Talaei A, Fanipakdel A. 188P Amelioration of anxiety, depression, and chemotherapy related toxicity after crocin administration during chemotherapy of breast cancer: A double blind, randomized clinical trial. Annals of Oncology. Elsevier BV; 2021; 32:S439-S440 10.1016/j.annonc.2021.08.469
• Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis Cite
  Maroni P, Bendinelli P, Fulgenzi A, Ferraretto A. Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis. Biomolecules. MDPI AG; 2021; 11:1336 10.3390/biom11091336
• Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats Cite
  Abdulkareem Aljumaily SA, Demir M, Elbe H, Yigitturk G, Bicer Y, Altinoz E. Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats. Environmental Science and Pollution Research. Springer Science and Business Media LLC; 2021; 10.1007/s11356-021-15409-w
• Antioxidant, anti-inflammatory and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats Cite
  ALJUMAILY SAA, Demir M, Elbe H, Yigitturk G, Bicer Y, Altinoz E. Antioxidant, anti-inflammatory and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats. Research Square Platform LLC; 2021; 10.21203/rs.3.rs-418902/v1
• Crocin and Metformin suppress metastatic breast cancer progression via VEGF and MMP9 downregulations: in vitro and in vivo studies Cite
  Farahi A, Abedini MR, Javdani H, Arzi L, Chamani E, Farhoudi R, et al. Crocin and Metformin suppress metastatic breast cancer progression via VEGF and MMP9 downregulations: in vitro and in vivo studies. Molecular and Cellular Biochemistry. Springer Science and Business Media LLC; 2021; 10.1007/s11010-020-04043-8
• Saffron anti-metastatic properties, ancient spice novel application Cite
  Arzi L, Hoshyar R. Saffron anti-metastatic properties, ancient spice novel application. null. Taylor & Francis; 2021;:1-12. 10.1080/10408398.2020.1871320
• Antioxidant and Anti-Inflammatory Effects of Crocin Ameliorate Doxorubicin-Induced Nephrotoxicity in Rats Cite
  Hussain MA, Abogresha NM, AbdelKader G, Hassan R, Abdelaziz EZ, Greish SM. Antioxidant and Anti-Inflammatory Effects of Crocin Ameliorate Doxorubicin-Induced Nephrotoxicity in Rats. Oxidative Medicine and Cellular Longevity. Hindawi Limited; 2021; 2021:1-12 10.1155/2021/8841726
• Evaluation of anti-tumor effects of crocin on a novel 3D tissue-engineered tumor model based on sodium alginate/gelatin microbead Cite
  Zhu J, Zheng S, Liu H, Wang Y, Jiao Z, Nie Y, et al. Evaluation of anti-tumor effects of crocin on a novel 3D tissue-engineered tumor model based on sodium alginate/gelatin microbead. International Journal of Biological Macromolecules. Elsevier BV; 2021; 174:339-351 10.1016/j.ijbiomac.2021.01.181
• Recent Advances on the Anticancer Properties of Saffron (Crocus sativus L.) and Its Major Constituents Cite
  Lambrianidou A, Koutsougianni F, Papapostolou I, Dimas K. Recent Advances on the Anticancer Properties of Saffron (Crocus sativus L.) and Its Major Constituents. Molecules. MDPI AG; 2020; 26:86 10.3390/molecules26010086
• Doxorubicin and Crocin Co-delivery by Polymeric Nanoparticles for Enhanced Anticancer Potential In Vitro and In Vivo Cite
  Khan I, Joshi G, Sarkar B, Nakhate KT, Ajazuddin , Mantha AK, et al. Doxorubicin and Crocin Co-delivery by Polymeric Nanoparticles for Enhanced Anticancer Potential In Vitro and In Vivo. ACS Applied Bio Materials. American Chemical Society (ACS); 2020; 3:7789-7799 10.1021/acsabm.0c00974
• Crocin protects against cardiotoxicity induced by doxorubicin through TLR-2/NF-κB signal pathway in vivo and vitro Cite
  Chu X, Zhang Y, Xue Y, Li Z, Shi J, Wang H, et al. Crocin protects against cardiotoxicity induced by doxorubicin through TLR-2/NF-κB signal pathway in vivo and vitro. International Immunopharmacology. Elsevier BV; 2020; 84:106548 10.1016/j.intimp.2020.106548
• Saffron carotenoids change the superoxide dismutase activity in breast cancer: In vitro, in vivo and in silico studies Cite
  Hashemi SA, Karami M, Bathaie SZ. Saffron carotenoids change the superoxide dismutase activity in breast cancer: In vitro, in vivo and in silico studies. International Journal of Biological Macromolecules. Elsevier BV; 2020; 158:845-853 10.1016/j.ijbiomac.2020.04.063
• Anti-metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer Cite
  Arzi L, Hoshyar R, Jafarzadeh N, Riazi G, Sadeghizadeh M. Anti-metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer. Life Sciences. Elsevier BV; 2020; 243:117245 10.1016/j.lfs.2019.117245
• Antiangiogenic effect of crocin on breast cancer cell MDA-MB-231 Cite
  Chen S, Gu Y, Lu F, Qian D, Dong T, Ding Z, et al. Antiangiogenic effect of crocin on breast cancer cell MDA-MB-231. Journal of Thoracic Disease. AME Publishing Company; 2019; 11:4464-4473 10.21037/jtd.2019.11.18
• Role of crocin in several cancer cell lines: An updated review Cite
  Veisi A, Akbari G, Mard A, Badfar G, Zarezade V, Mirshekar MA. Role of crocin in several cancer cell lines: An updated review. Iranian Journal of Basic Medical Sciences. Mashhad University of Medical Sciences; 2020; 23 10.22038/ijbms.2019.37821.8995
• Comparative anticancer activity analysis of saffron extracts and a principle component, crocetin for prevention and treatment of human malignancies Cite
  Gezici S. Comparative anticancer activity analysis of saffron extracts and a principle component, crocetin for prevention and treatment of human malignancies. Journal of Food Science and Technology. Springer Science and Business Media LLC; 2019; 56:5435-5443 10.1007/s13197-019-04014-y
• Crocin, a carotenoid, suppresses spindle microtubule dynamics and activates the mitotic checkpoint by binding to tubulin Cite
  Sawant AV, Srivastava S, Prassanawar SS, Bhattacharyya B, Panda D. Crocin, a carotenoid, suppresses spindle microtubule dynamics and activates the mitotic checkpoint by binding to tubulin. Biochemical Pharmacology. Elsevier BV; 2019; 163:32-45 10.1016/j.bcp.2019.01.023
• Inhibitory Effect of Crocin on Metastasis of Triple-Negative Breast Cancer by Interfering with Wnt/β-Catenin Pathway in Murine Model Cite
  Arzi L, Farahi A, Jafarzadeh N, Riazi G, Sadeghizadeh M, Hoshyar R. Inhibitory Effect of Crocin on Metastasis of Triple-Negative Breast Cancer by Interfering with Wnt/β-Catenin Pathway in Murine Model. DNA and Cell Biology. Mary Ann Liebert Inc; 2018; 37:1068-1075 10.1089/dna.2018.4351
• A Comparative Study on Anti-Invasion, Antimigration, and Antiadhesion Effects of the Bioactive Carotenoids of Saffron on 4T1 Breast Cancer Cells Through Their Effects on Wnt/β-Catenin Pathway Genes Cite
  Arzi L, Riazi G, Sadeghizadeh M, Hoshyar R, Jafarzadeh N. A Comparative Study on Anti-Invasion, Antimigration, and Antiadhesion Effects of the Bioactive Carotenoids of Saffron on 4T1 Breast Cancer Cells Through Their Effects on Wnt/β-Catenin Pathway Genes. DNA and Cell Biology. Mary Ann Liebert Inc; 2018; 37:697-707 10.1089/dna.2018.4248
• Antioxidant Activity of Spices and Their Impact on Human Health: A Review Cite
  Yashin A, Yashin Y, Xia X, Nemzer B. Antioxidant Activity of Spices and Their Impact on Human Health: A Review. Antioxidants. MDPI AG; 2017; 6:70 10.3390/antiox6030070
• Anti-tumor effects of crocetin and related molecular targets Cite
  Moradzadeh M, Sadeghnia HR, Tabarraei A, Sahebkar A. Anti-tumor effects of crocetin and related molecular targets. Journal of Cellular Physiology. Wiley; 2017; 233:2170-2182 10.1002/jcp.25953
• Crocetin shifts autophagic cell survival to death of breast cancer cells in chemotherapy Cite
  Zhang A, Li J. Crocetin shifts autophagic cell survival to death of breast cancer cells in chemotherapy. Tumor Biology. SAGE Publications; 2017; 39:101042831769453 10.1177/1010428317694536
• Antiproliferative Activity of Crocin Involves Targeting of Microtubules in Breast Cancer Cells Cite
  Hire RR, Srivastava S, Davis MB, Kumar Konreddy A, Panda D. Antiproliferative Activity of Crocin Involves Targeting of Microtubules in Breast Cancer Cells. Scientific Reports. Springer Science and Business Media LLC; 2017; 7 10.1038/srep44984
• Crocin Suppresses Constitutively Active STAT3 Through Induction of Protein Tyrosine Phosphatase SHP-1 Cite
  Kim B, Lee KY, Park B. Crocin Suppresses Constitutively Active STAT3 Through Induction of Protein Tyrosine Phosphatase SHP-1. Journal of Cellular Biochemistry. Wiley; 2017; 118:3290-3298 10.1002/jcb.25980
• Comparative study on preventive effect of saffron carotenoids, crocin and crocetin, in NMU-induced breast cancer in rat Cite
  Bathaie S, Sajjadi M. Comparative study on preventive effect of saffron carotenoids, crocin and crocetin, in NMU-induced breast cancer in rat. Cell J (Yakhteh). Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR); 2017; 19 10.22074/cellj.2016.3901
• Neuroprotective Activities of Saffron and Crocin Cite
  Soeda S, Aritake K, Urade Y, Sato H, Shoyama Y. Neuroprotective Activities of Saffron and Crocin. Advances in Neurobiology. Springer International Publishing; 2016;:275-292 10.1007/978-3-319-28383-8_14
• Crocin treatment prevents doxorubicin-induced cardiotoxicity in rats Cite
  Razmaraii N, Babaei H, Mohajjel Nayebi A, Assadnassab G, Ashrafi Helan J, Azarmi Y. Crocin treatment prevents doxorubicin-induced cardiotoxicity in rats. Life Sciences. Elsevier BV; 2016; 157:145-151 10.1016/j.lfs.2016.06.012
• Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation Cite
  Bakshi HA, Hakkim FL, Sam S. Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation. Asian Pacific Journal of Cancer Prevention. Asian Pacific Organization for Cancer Prevention; 2016; 17:1499-1506 10.7314/apjcp.2016.17.3.1499
• The toxicity of saffron (Crocus sativus L.) and its constituents against normal and cancer cells Cite
  Milajerdi A, Djafarian K, Hosseini B. The toxicity of saffron (Crocus sativus L.) and its constituents against normal and cancer cells. Journal of Nutrition & Intermediary Metabolism. Elsevier BV; 2016; 3:23-32 10.1016/j.jnim.2015.12.332
• Synergistic Apoptotic Effect of Crocin and Paclitaxel or Crocin and Radiation on MCF-7 Cells, a Type of Breast Cancer Cell Line Cite
  Vali F, Changizi V, Safa M. Synergistic Apoptotic Effect of Crocin and Paclitaxel or Crocin and Radiation on MCF-7 Cells, a Type of Breast Cancer Cell Line. International Journal of Breast Cancer. Hindawi Limited; 2015; 2015:1-7 10.1155/2015/139349
• Effect of Crocin on Cell Cycle Regulators in N-Nitroso-N-Methylurea-Induced Breast Cancer in Rats Cite
  Ashrafi M, Bathaie SZ, Abroun S, Azizian M. Effect of Crocin on Cell Cycle Regulators in N-Nitroso-N-Methylurea-Induced Breast Cancer in Rats. DNA and Cell Biology. Mary Ann Liebert Inc; 2015; 34:684-691 10.1089/dna.2015.2951
• Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol Cite
  Zeka K, Ruparelia KC, Continenza MA, Stagos D, Vegliò F, Arroo RR. Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol. Fitoterapia. Elsevier BV; 2015; 107:128-134 10.1016/j.fitote.2015.05.014
• Saffron extracts alleviate cardiomyocytes injury induced by doxorubicin and ischemia-reperfusionin vitro Cite
  Chahine N, Nader M, Duca L, Martiny L, Chahine R. Saffron extracts alleviate cardiomyocytes injury induced by doxorubicin and ischemia-reperfusionin vitro. Drug and Chemical Toxicology. Informa UK Limited; 2015; 39:87-96 10.3109/01480545.2015.1036281
• Crocus sativus L. (saffron) for cancer chemoprevention: A mini review Cite
  Bhandari PR. Crocus sativus L. (saffron) for cancer chemoprevention: A mini review. Journal of Traditional and Complementary Medicine. Elsevier BV; 2015; 5:81-87 10.1016/j.jtcme.2014.10.009
• Saffron and natural carotenoids: Biochemical activities and anti-tumor effects Cite
  Bolhassani A, Khavari A, Bathaie SZ. Saffron and natural carotenoids: Biochemical activities and anti-tumor effects. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. Elsevier BV; 2014; 1845:20-30 10.1016/j.bbcan.2013.11.001