Tag: rosemary

Articles

• Supplements with warnings for breast cancer

News

07/23/25

Rosmarinic acid can cause ER+/PR+ cell death by inhibiting integrin-linked kinase

Foods

• • rosemary

Studies

• Rosemary Reduced Estrogen Receptor (ESR1) Protein Mediated Cycle Arrest And Apoptosis: A Potential Hormonal Dependent Anticancer Mechanism Of The Plant In The MCF-7 Breast Cancer Cells Cite
  . Rosemary Reduced Estrogen Receptor (ESR1) Protein Mediated Cycle Arrest And Apoptosis: A Potential Hormonal Dependent Anticancer Mechanism Of The Plant In The MCF-7 Breast Cancer Cells. Pakistan Journal of Pharmaceutical Sciences. Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi; 2025; 10.36721/pjps.2025.38.4.reg.13514.1
• Rosmarinus officinalis suppresses cancer cell viability and inflammatory mediators in RAW 264.7 cells: in vitro and in silico analysis Cite
  Assaggaf H, Hachlafi NE, Mrabti NN, Taibi M, Elbouzidi A, Qasem A, et al. Rosmarinus officinalis suppresses cancer cell viability and inflammatory mediators in RAW 264.7 cells: in vitro and in silico analysis. Discover Oncology. Springer Science and Business Media LLC; 2025; 16 10.1007/s12672-025-02957-7
• In Vitro Therapeutic Potential and Morphological Effects of Rosmarinic Acid Derivatives on Triple‐Negative Breast Cancer Cell Line Cite
  Yesilay G, Bolat ZB, Hocaoglu G, Aydin ZB, Mermer A. In Vitro Therapeutic Potential and Morphological Effects of Rosmarinic Acid Derivatives on Triple‐Negative Breast Cancer Cell Line. ChemistrySelect. Wiley; 2025; 10 10.1002/slct.202404422
• Rosmarinus officinalis L. as Fascinating Source of Potential Anticancer Agents Targeting Aromatase and COX-2: An Overview Cite
  Gargano A, Greco I, Lupia C, Alcaro S, Ambrosio FA. Rosmarinus officinalis L. as Fascinating Source of Potential Anticancer Agents Targeting Aromatase and COX-2: An Overview. Molecules. MDPI AG; 2025; 30:1733 10.3390/molecules30081733
• Carvone: A Bioactive Monoterpene with Diverse Pharmacological Applications Cite
  Anjum R, Raza C. Carvone: A Bioactive Monoterpene with Diverse Pharmacological Applications. Current Pharmacology Reports. Springer Science and Business Media LLC; 2025; 11 10.1007/s40495-025-00402-5
• Toxicity and safety of rosemary (Rosmarinus officinalis): a comprehensive review Cite
  Ghasemzadeh Rahbardar M, Hosseinzadeh H. Toxicity and safety of rosemary (Rosmarinus officinalis): a comprehensive review. Naunyn-Schmiedeberg's Archives of Pharmacology. Springer Science and Business Media LLC; 2024; 398:9-23 10.1007/s00210-024-03336-9
• Rosmarinic acid promotes mitochondrial fission and induces ferroptosis in triple-negative breast cancer cells Cite
  Xie C, Chan L, Pang Y, Shang Y, Wang W, Zhao L. Rosmarinic acid promotes mitochondrial fission and induces ferroptosis in triple-negative breast cancer cells. Naunyn-Schmiedeberg's Archives of Pharmacology. Springer Science and Business Media LLC; 2025; 10.1007/s00210-025-03927-0
• Anti-proliferative effects of Rosmarinus officinalis L. (Rosemary) against human breast and liver carcinoma cells Cite
  Darra R, Majdalawieh AF, Mahasneh A, Rah B, Hamad M, Kanan SM. Anti-proliferative effects of Rosmarinus officinalis L. (Rosemary) against human breast and liver carcinoma cells. Food Bioscience. Elsevier BV; 2025; 65:106164 10.1016/j.fbio.2025.106164
• Evaluating the anticancer effects of carnosic acid against breast cancer: An In Vitro investigation Cite
  Borhan A, Bagherlou A, Ghayour MB. Evaluating the anticancer effects of carnosic acid against breast cancer: An In Vitro investigation. Tissue and Cell. Elsevier BV; 2025; 93:102718 10.1016/j.tice.2024.102718
• The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity Cite
  Kowalczyk A, Tuberoso CIG, Jerković I. The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity. Antioxidants. MDPI AG; 2024; 13:1313 10.3390/antiox13111313
• Pomolic Acid: Cancer Molecular Targets, Plant Extraction Yields and Availability Cite
  Fernandes J. Pomolic Acid: Cancer Molecular Targets, Plant Extraction Yields and Availability. Drugs and Drug Candidates. MDPI AG; 2024; 3:723-735 10.3390/ddc3040041
• Review on effects and mechanisms of plant-derived natural products against breast cancer bone metastasis Cite
  Zhang X, Miao J, Song Y, Zhang J, Miao M. Review on effects and mechanisms of plant-derived natural products against breast cancer bone metastasis. Heliyon. Elsevier BV; 2024;:e37894 10.1016/j.heliyon.2024.e37894
• Carnosic acid: an effective phenolic diterpenoid for prevention and management of cancers via targeting multiple signaling pathways Cite
  Chen X, Wei C, Zhao J, Zhou D, Wang Y, Zhang S, et al. Carnosic acid: an effective phenolic diterpenoid for prevention and management of cancers via targeting multiple signaling pathways. Pharmacological Research. Elsevier BV; 2024;:107288 10.1016/j.phrs.2024.107288
• Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy Cite
  Khan F, Pandey P, Verma M, Ramniwas S, Lee D, Moon S, et al. Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy. Biomedicine & Pharmacotherapy. Elsevier BV; 2024; 173:116363 10.1016/j.biopha.2024.116363
• Green Tea Leaves and Rosemary Extracts Selectively Induce Cell Death in Triple-Negative Breast Cancer Cells and Cancer Stem Cells and Enhance the Efficacy of Common Chemotherapeutics Cite
  Raad C, Raad A, Pandey S. Green Tea Leaves and Rosemary Extracts Selectively Induce Cell Death in Triple-Negative Breast Cancer Cells and Cancer Stem Cells and Enhance the Efficacy of Common Chemotherapeutics. Evidence-Based Complementary and Alternative Medicine. Hindawi Limited; 2024; 2024:1-21 10.1155/2024/9458716
• Exploring the anti-cancer properties of essential oils from some Lamiaceae species against human cancer cells with multivariate analysis Cite
  Gezici S, Turkmen M, Karahan F. Exploring the anti-cancer properties of essential oils from some Lamiaceae species against human cancer cells with multivariate analysis. South African Journal of Botany. Elsevier BV; 2024; 166:287-296 10.1016/j.sajb.2023.10.057
• Exploring the Potential of Rosemary Derived Compounds (Rosmarinic and Carnosic Acids) as Cancer Therapeutics: Current Knowledge and Future Perspectives Cite
  Sirajudeen F, Bou Malhab LJ, Bustanji Y, Shahwan M, Alzoubi KH, Semreen MH, et al. Exploring the Potential of Rosemary Derived Compounds (Rosmarinic and Carnosic Acids) as Cancer Therapeutics: Current Knowledge and Future Perspectives. Biomolecules & Therapeutics. The Korean Society of Applied Pharmacology; 2024; 32:38-55 10.4062/biomolther.2023.054
• Use of [18F]FLT/PET for assessing the tumor evolution and monitoring the antitumor activity of rosmarinic acid in a mouse 4T1 breast tumor model Cite
  Pereira JM, Schirmer BGdA, Araujo MR, Nascimento LTC, Ferreira AV, Gonçalves AdBB, et al. Use of [18F]FLT/PET for assessing the tumor evolution and monitoring the antitumor activity of rosmarinic acid in a mouse 4T1 breast tumor model. Brazilian Journal of Radiation Sciences. Sociedade Brasilieira de Protecao Radiologica - SBPR; 2023; 11:01-23 10.15392/2319-0612.2023.2300
• Ursolic acid: a pentacyclic triterpenoid that exhibits anticancer therapeutic potential by modulating multiple oncogenic targets Cite
  Sandhu SS, Rouz SK, Kumar S, Swamy N, Deshmukh L, Hussain A, et al. Ursolic acid: a pentacyclic triterpenoid that exhibits anticancer therapeutic potential by modulating multiple oncogenic targets. Biotechnology and Genetic Engineering Reviews. Informa UK Limited; 2023;:1-31 10.1080/02648725.2022.2162257
• Targeting Triple-Negative Breast Cancer by the Phytopolyphenol Carnosol: ROS-Dependent Mechanisms Cite
  Alsamri H, Al Dhaheri Y, Iratni R. Targeting Triple-Negative Breast Cancer by the Phytopolyphenol Carnosol: ROS-Dependent Mechanisms. Antioxidants. MDPI AG; 2023; 12:1349 10.3390/antiox12071349
• Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications Cite
  Ijaz S, Iqbal J, Abbasi BA, Ullah Z, Yaseen T, Kanwal S, et al. Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications. Biomedicine & Pharmacotherapy. Elsevier BV; 2023; 162:114687 10.1016/j.biopha.2023.114687
• Study on Standardized Rosemary Extract Induce Apoptotic Events, Enhances the Anticancer Effects in Breast Cancer Cite
  Gouthamchandra K, Sudeep HV, Lingaraju HB, Prasad KS. Study on Standardized Rosemary Extract Induce Apoptotic Events, Enhances the Anticancer Effects in Breast Cancer. Issues and Developments in Medicine and Medical Research Vol. 9. Book Publisher International (a part of SCIENCEDOMAIN International); 2021;:104-111 10.9734/bpi/idmmr/v9/3204e
• Essential oils as anticancer agents: Potential role in malignancies, drug delivery mechanisms, and immune system enhancement Cite
  Sharma M, Grewal K, Jandrotia R, Batish DR, Singh HP, Kohli RK. Essential oils as anticancer agents: Potential role in malignancies, drug delivery mechanisms, and immune system enhancement. Biomedicine & Pharmacotherapy. Elsevier BV; 2022; 146:112514 10.1016/j.biopha.2021.112514
• Zn, Cu, and Fe Concentrations in Dehydrated Herbs (Thyme, Rosemary, Cloves, Oregano, and Basil) and the Correlation with the Microbial Counts of Listeria monocytogenes and Other Foodborne Pathogens Cite
  García-Galdeano JM, Villalón-Mir M, Medina-Martínez J, Vázquez-Foronda LM, Zamora-Bustillos JG, Agil A, et al. Zn, Cu, and Fe Concentrations in Dehydrated Herbs (Thyme, Rosemary, Cloves, Oregano, and Basil) and the Correlation with the Microbial Counts of Listeria monocytogenes and Other Foodborne Pathogens. Foods. MDPI AG; 2020; 9:1658 10.3390/foods9111658
• Evaluate the inhibition of cytochrome P450 1A1 for enhancing breast cancer chemotherapy with a turn-on fluorescent probe Cite
  Huang Y, Yu L, Lu P, Wei Y, Wang X, Chen L. Evaluate the inhibition of cytochrome P450 1A1 for enhancing breast cancer chemotherapy with a turn-on fluorescent probe. Sensors and Actuators B: Chemical. Elsevier BV; 2021; 344:130233 10.1016/j.snb.2021.130233
• Herb-drug interactions and toxicity: Underscoring potential mechanisms and forecasting clinically relevant interactions induced by common phytoconstituents via data mining and computational approaches Cite
  Suroowan S, Abdallah HH, Mahomoodally MF. Herb-drug interactions and toxicity: Underscoring potential mechanisms and forecasting clinically relevant interactions induced by common phytoconstituents via data mining and computational approaches. Food and Chemical Toxicology. Elsevier BV; 2021;:112432 10.1016/j.fct.2021.112432
• In Vivo and In Vitro Protective Effects of Rosmarinic Acid against Doxorubicin-Induced Cardiotoxicity Cite
  Rahbardar MG, Eisvand F, Rameshrad M, Razavi BM, Hosseinzadeh H. In Vivo and In Vitro Protective Effects of Rosmarinic Acid against Doxorubicin-Induced Cardiotoxicity. Nutrition and Cancer. Informa UK Limited; 2021;:1-15 10.1080/01635581.2021.1931362
• Anticancer Properties of Carnosol: A Summary of In Vitro and In Vivo Evidence Cite
  O’Neill EJ, Den Hartogh DJ, Azizi K, Tsiani E. Anticancer Properties of Carnosol: A Summary of In Vitro and In Vivo Evidence. Antioxidants. MDPI AG; 2020; 9:961 10.3390/antiox9100961
• Anticancer Properties of Carnosol: A Summary of In Vitro and In Vivo Evidence Cite
  O’Neill EJ, Den Hartogh DJ, Azizi K, Tsiani E. Anticancer Properties of Carnosol: A Summary of In Vitro and In Vivo Evidence. Antioxidants. MDPI AG; 2020; 9:961 10.3390/antiox9100961
• Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells Cite
  Messeha SS, Zarmouh NO, Asiri A, Soliman KF. Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells. European Journal of Pharmacology. Elsevier BV; 2020; 885:173419 10.1016/j.ejphar.2020.173419
• Rosmarinic Acid Exhibits Anticancer Effects via MARK4 Inhibition Cite
  Anwar S, Shamsi A, Shahbaaz M, Queen A, Khan P, Hasan GM, et al. Rosmarinic Acid Exhibits Anticancer Effects via MARK4 Inhibition. Scientific Reports. Springer Science and Business Media LLC; 2020; 10 10.1038/s41598-020-65648-z
• Anticancer Activity of Rosmarinus officinalis L.: Mechanisms of Action and Therapeutic Potentials Cite
  Allegra A, Tonacci A, Pioggia G, Musolino C, Gangemi S. Anticancer Activity of Rosmarinus officinalis L.: Mechanisms of Action and Therapeutic Potentials. Nutrients. MDPI AG; 2020; 12:1739 10.3390/nu12061739
• Transfer rate of pesticide residues from medicinal plants in different types of extractive solutions Cite
  Florea AM, Drumea V, Nita RA, Bicu A, Olariu L, Dutu LE, et al. Transfer rate of pesticide residues from medicinal plants in different types of extractive solutions. Toxicological & Environmental Chemistry. Informa UK Limited; 2020; 102:37-61 10.1080/02772248.2020.1773466
• Rosemary Extract Inhibits Proliferation, Survival, Akt, and mTOR Signaling in Triple-Negative Breast Cancer Cells Cite
  Jaglanian A, Tsiani E. Rosemary Extract Inhibits Proliferation, Survival, Akt, and mTOR Signaling in Triple-Negative Breast Cancer Cells. International Journal of Molecular Sciences. MDPI AG; 2020; 21:810 10.3390/ijms21030810
• Expression profiling of genes modulated by rosmarinic acid (RA) in MCF-7 breast cancer cells Cite
  Juskowiak B, Bogacz A, Wolek M, Kamiński A, Uzar I, Seremak-Mrozikiewicz A, et al. Expression profiling of genes modulated by rosmarinic acid (RA) in MCF-7 breast cancer cells. Ginekologia Polska. VM Media SP. zo.o VM Group SK; 2018; 89:541-545 10.5603/gp.a2018.0092
• Antioxidant Activity of Spices and Their Impact on Human Health: A Review Cite
  Yashin A, Yashin Y, Xia X, Nemzer B. Antioxidant Activity of Spices and Their Impact on Human Health: A Review. Antioxidants. MDPI AG; 2017; 6:70 10.3390/antiox6030070
• Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cells Cite
  D’Alesio C, Bellese G, Gagliani MC, Aiello C, Grasselli E, Marcocci G, et al. Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cells. Journal of Experimental & Clinical Cancer Research. Springer Science and Business Media LLC; 2017; 36 10.1186/s13046-017-0615-0
• Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin-induced neurotoxicity in rats Cite
  Rizk HA, Masoud MA, Maher OW. Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin-induced neurotoxicity in rats. Journal of Biochemical and Molecular Toxicology. Wiley; 2017; 31:e21977 10.1002/jbt.21977
• Carnosic acid cooperates with tamoxifen to induce apoptosis associated with Caspase-3 activation in breast cancer cells in vitro and in vivo Cite
  Han N, Zhou Q, Huang Q, Liu K. Carnosic acid cooperates with tamoxifen to induce apoptosis associated with Caspase-3 activation in breast cancer cells in vitro and in vivo. Biomedicine & Pharmacotherapy. Elsevier BV; 2017; 89:827-837 10.1016/j.biopha.2017.01.084
• Cytotoxic responses of carnosic acid and doxorubicin on breast cancer cells in butterfly-shaped microchips in comparison to 2D and 3D culture Cite
  Yildiz-Ozturk E, Gulce-Iz S, Anil M, Yesil-Celiktas O. Cytotoxic responses of carnosic acid and doxorubicin on breast cancer cells in butterfly-shaped microchips in comparison to 2D and 3D culture. Cytotechnology. Springer Science and Business Media LLC; 2017; 69:337-347 10.1007/s10616-016-0062-3
• A comprehensive study on the phenolic profile of widely used culinary herbs and spices: Rosemary, thyme, oregano, cinnamon, cumin and bay Cite
  Vallverdú-Queralt A, Regueiro J, Martínez-Huélamo M, Rinaldi Alvarenga JF, Leal LN, Lamuela-Raventos RM. A comprehensive study on the phenolic profile of widely used culinary herbs and spices: Rosemary, thyme, oregano, cinnamon, cumin and bay. Food Chemistry. Elsevier BV; 2014; 154:299-307 10.1016/j.foodchem.2013.12.106
• Characterization of in vitro and in vivo metabolites of carnosic acid, a natural antioxidant, by high performance liquid chromatography coupled with tandem mass spectrometry Cite
  Song Y, Yan H, Chen J, Wang Y, Jiang Y, Tu P. Characterization of in vitro and in vivo metabolites of carnosic acid, a natural antioxidant, by high performance liquid chromatography coupled with tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. Elsevier BV; 2014; 89:183-196 10.1016/j.jpba.2013.11.001
• Antitumor effect of 5-fluorouracil is enhanced by rosemary extract in both drug sensitive and resistant colon cancer cells Cite
  González-Vallinas M, Molina S, Vicente G, de la Cueva A, Vargas T, Santoyo S, et al. Antitumor effect of 5-fluorouracil is enhanced by rosemary extract in both drug sensitive and resistant colon cancer cells. Pharmacological Research. Elsevier BV; 2013; 72:61-68 10.1016/j.phrs.2013.03.010
• Carnosic acid inhibits the growth of ER-negative human breast cancer cells and synergizes with curcumin Cite
  Einbond LS, Wu H, Kashiwazaki R, He K, Roller M, Su T, et al. Carnosic acid inhibits the growth of ER-negative human breast cancer cells and synergizes with curcumin. Fitoterapia. Elsevier BV; 2012; 83:1160-1168 10.1016/j.fitote.2012.07.006
• Identification and quantification of a major anti-oxidant and anti-inflammatory phenolic compound found in basil, lemon thyme, mint, oregano, rosemary, sage, and thyme Cite
  Park JB. Identification and quantification of a major anti-oxidant and anti-inflammatory phenolic compound found in basil, lemon thyme, mint, oregano, rosemary, sage, and thyme. International Journal of Food Sciences and Nutrition. Informa UK Limited; 2011; 62:577-584 10.3109/09637486.2011.562882