Tag: redClover

Red clover: A herb (Trifolium pratense) used for a variety of conditions, including menopausal symptoms such as hot flashes. Isoflavones are the most important active compounds in red clover, which is a legume.

Articles

Supplements with warnings for breast cancer

News

12/06/11: Red clover compound biochanin A reduces potency of tamoxifen in rats

Studies

Endogenous estrogens—breast cancer and chemoprevention Cite
Starek-Świechowicz B, Budziszewska B, Starek A. Endogenous estrogens—breast cancer and chemoprevention. Pharmacological Reports. Springer Science and Business Media LLC; 2021; 10.1007/s43440-021-00317-0
Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy Cite
Sabo AA, Dudau M, Constantin GL, Pop TC, Geilfus C, Naccarati A, et al. Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy. Frontiers in Pharmacology. Frontiers Media SA; 2021; 12 10.3389/fphar.2021.652074
Inhibitory Effects of Coumestrol in Triple‐Negative Inflammatory Breast Cancer Cite
Rodriguez‐Martir K, Colon A, Peterson E. Inhibitory Effects of Coumestrol in Triple‐Negative Inflammatory Breast Cancer. The FASEB Journal. Wiley; 2021; 35 10.1096/fasebj.2021.35.s1.01858
Disposition of Dietary Polyphenols in Breast Cancer Patients’ Tumors, and their Associated Anticancer Activity: the Particular Case of Curcumin Cite
Ávila‐Gálvez MÁ, González‐Sarrías A, Martínez‐Díaz F, Abellán B, Martínez‐Torrano AJ, Fernández‐López AJ, et al. Disposition of Dietary Polyphenols in Breast Cancer Patients’ Tumors, and their Associated Anticancer Activity: the Particular Case of Curcumin. Molecular Nutrition & Food Research. Wiley; 2021;:2100163 10.1002/mnfr.202100163
No Clinically Relevant Pharmacokinetic Interactions of a Red Clover Dietary Supplement with Cytochrome P450 Enzymes in Women Cite
Chen L, Choi J, Leonard SW, Banuvar S, Barengolts E, Viana M, et al. No Clinically Relevant Pharmacokinetic Interactions of a Red Clover Dietary Supplement with Cytochrome P450 Enzymes in Women. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2020; 68:13929-13939 10.1021/acs.jafc.0c05856
Red clover and lifestyle changes to contrast menopausal symptoms in premenopausal patients with hormone-sensitive breast cancer receiving tamoxifen Cite
Ferraris C, Ballestra B, Listorti C, Cappelletti V, Reduzzi C, Scaperrotta GP, et al. Red clover and lifestyle changes to contrast menopausal symptoms in premenopausal patients with hormone-sensitive breast cancer receiving tamoxifen. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2020; 180:157-165 10.1007/s10549-020-05534-4
Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation Cite
Hüser S, Guth S, Joost HG, Soukup ST, Köhrle J, Kreienbrock L, et al. Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation. Archives of Toxicology. Springer Science and Business Media LLC; 2018; 92:2703-2748 10.1007/s00204-018-2279-8
Dietary isoflavones or isoflavone-rich food intake and breast cancer risk: A meta-analysis of prospective cohort studies Cite
Zhao T, Jin F, Li J, Xu Y, Dong H, Liu Q, et al. Dietary isoflavones or isoflavone-rich food intake and breast cancer risk: A meta-analysis of prospective cohort studies. Clinical Nutrition. Elsevier BV; 2019; 38:136-145 10.1016/j.clnu.2017.12.006
Evaluation of estrogenic activity of red clover (Trifolium pratense L.) sprouts cultivated under different conditions by content of isoflavones, calorimetric study and molecular modelling Cite
Budryn G, Gałązka-Czarnecka I, Brzozowska E, Grzelczyk J, Mostowski R, Żyżelewicz D, et al. Evaluation of estrogenic activity of red clover (Trifolium pratense L.) sprouts cultivated under different conditions by content of isoflavones, calorimetric study and molecular modelling. Food Chemistry. Elsevier BV; 2018; 245:324-336 10.1016/j.foodchem.2017.10.100
Isoflavone content and estrogenic activity of different batches of red clover (Trifolium pratense L.) extracts: An in vitro study in MCF-7 cells Cite
Spagnuolo P, Rasini E, Luini A, Legnaro M, Luzzani M, Casareto E, et al. Isoflavone content and estrogenic activity of different batches of red clover (Trifolium pratense L.) extracts: An in vitro study in MCF-7 cells. Fitoterapia. Elsevier BV; 2014; 94:62-69 10.1016/j.fitote.2014.01.027
Adverse effects of herbal medicines: an overview of systematic reviews Cite
Posadzki P, Watson LK, Ernst E. Adverse effects of herbal medicines: an overview of systematic reviews. Clinical Medicine. Royal College of Physicians; 2013; 13:7-12 10.7861/clinmedicine.13-1-7
Effect of oral phytoestrogen on androgenicity and insulin sensitivity in postmenopausal women Cite
Lee CC, Bloem CJ, Kasa-Vubu JZ, Liang L. Effect of oral phytoestrogen on androgenicity and insulin sensitivity in postmenopausal women. Diabetes, Obesity and Metabolism. Wiley; 2011; 14:315-319 10.1111/j.1463-1326.2011.01532.x
Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms Cite
Geller SE, Shulman LP, van Breemen RB, Banuvar S, Zhou Y, Epstein G, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms. Menopause. Ovid Technologies (Wolters Kluwer Health); 2009; 16:1156-1166 10.1097/gme.0b013e3181ace49b
Effect of biochanin A on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells Cite
Han EH, Kim JY, Jeong HG. Effect of biochanin A on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells. Archives of Pharmacal Research. Springer Science and Business Media LLC; 2006; 29:570-576 10.1007/bf02969267
The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression Cite
Wang Y, Man Gho W, Chan FL, Chen S, Leung LK. The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression. British Journal of Nutrition. Cambridge University Press (CUP); 2008; 99:303-310 10.1017/s0007114507811974
Reduced Bioavailability of Tamoxifen and its Metabolite 4-Hydroxytamoxifen After Oral Administration with Biochanin A (an Isoflavone) in Rats Cite
Singh SP, Wahajuddin , Raju KSR, Ali MM, Kohli K, Jain GK. Reduced Bioavailability of Tamoxifen and its Metabolite 4-Hydroxytamoxifen After Oral Administration with Biochanin A (an Isoflavone) in Rats. Phytotherapy Research. Wiley; 2011; 26:303-307 10.1002/ptr.3652
A dietary supplement for female sexual dysfunction, Avlimil, stimulates the growth of estrogen-dependent breast tumors (MCF-7) implanted in ovariectomized athymic nude mice Cite
Ju YH, Doerge DR, Helferich WG. A dietary supplement for female sexual dysfunction, Avlimil, stimulates the growth of estrogen-dependent breast tumors (MCF-7) implanted in ovariectomized athymic nude mice. Food and Chemical Toxicology. Elsevier BV; 2008; 46:310-320 10.1016/j.fct.2007.08.006
Evaluation of the Estrogenic Effects of Legume Extracts Containing Phytoestrogens Cite
Boué SM, Wiese TE, Nehls S, Burow ME, Elliott S, Carter-Wientjes CH, et al. Evaluation of the Estrogenic Effects of Legume Extracts Containing Phytoestrogens. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2003; 51:2193-2199 10.1021/jf021114s
Effect of Red Clover Isoflavones on Cox-2 Activity in Murine and Human Monocyte/Macrophage Cells Cite
Lam ANC, Demasi M, James MJ, Husband AJ, Walker C. Effect of Red Clover Isoflavones on Cox-2 Activity in Murine and Human Monocyte/Macrophage Cells. Nutrition and Cancer. Informa UK Limited; 2004; 49:89-93 10.1207/s15327914nc4901_12