Tag: piperine

News

11/23/14

Black pepper compound inhibits TN cell growth and movement

05/31/13

Black pepper compound increases effectiveness of Taxol in HER2+ BC

03/15/12

Black pepper compound suppresses mammary cancer growth and metastasis

Foods

• • black pepper

Studies

• The novel Piperine derivative YL-1-9 exhibits anti-breast Cancer effects by inducing apoptosis via the p53/p21 pathway Cite
  Zhou C, Wang J, Zhou L, Li H, Liu X, Wang S, et al. The novel Piperine derivative YL-1-9 exhibits anti-breast Cancer effects by inducing apoptosis via the p53/p21 pathway. Bioorganic & Medicinal Chemistry Letters. Elsevier BV; 2025;:130231 10.1016/j.bmcl.2025.130231
• Harnessing the anticancer potential of Piper nigrum: a synergistic approach to chemotherapy enhancement and reduced side effects Cite
  Wiraswati HL, Ma’ruf IF, Hidayati NA, Ramadhanti J, Calina D, Sharifi-Rad J. Harnessing the anticancer potential of Piper nigrum: a synergistic approach to chemotherapy enhancement and reduced side effects. Discover Oncology. Springer Science and Business Media LLC; 2025; 16 10.1007/s12672-024-01716-4
• Fabrication and characterization of Curcumin and Piperine loaded CMTG/rGO Electrospun for breast cancer treatment Cite
  Orsu P, CH V. Fabrication and characterization of Curcumin and Piperine loaded CMTG/rGO Electrospun for breast cancer treatment. Springer Science and Business Media LLC; 2024; 10.21203/rs.3.rs-5356474/v1
• Piperine: an emerging biofactor with anticancer efficacy and therapeutic potential Cite
  Wiraswati HL, Ma'ruf IF, Sharifi‐Rad J, Calina D. Piperine: an emerging biofactor with anticancer efficacy and therapeutic potential. BioFactors. Wiley; 2024; 10.1002/biof.2134
• Impact of PEGylated liposomes on cytotoxicity of tamoxifen and piperine on MCF-7 human breast carcinoma cells Cite
  Vaiphei KK, Prabakaran A, Singh S, Murkute SL, Mohapatra P, Sahoo RK, et al. Impact of PEGylated liposomes on cytotoxicity of tamoxifen and piperine on MCF-7 human breast carcinoma cells. Journal of Drug Delivery Science and Technology. Elsevier BV; 2024;:106331 10.1016/j.jddst.2024.106331
• Black pepper extract reduces tumour incidence via suppressing tumour-promoted cytokines chemokines and modulating T cell subtype Cite
  Mad-adam N, Dokduang S, Taraporn S, Rattanaburee T, Saetang J, Nualla-ong A, et al. Black pepper extract reduces tumour incidence via suppressing tumour-promoted cytokines chemokines and modulating T cell subtype. Food and Agricultural Immunology. Informa UK Limited; 2024; 35 10.1080/09540105.2024.2408282
• Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment Cite
  Nguyen MH, Nguyen TYN, Le THN, Le TNT, Chau NTN, Le TMH, et al. Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment. Heliyon. Elsevier BV; 2024; 10:e39229 10.1016/j.heliyon.2024.e39229
• Exploring Piperine: Unleashing the multifaceted potential of a phytochemical in cancer therapy Cite
  Tripathi D, Gupta T, Pandey P. Exploring Piperine: Unleashing the multifaceted potential of a phytochemical in cancer therapy. Molecular Biology Reports. Springer Science and Business Media LLC; 2024; 51 10.1007/s11033-024-09978-5
• Design, synthesis, and in silico insights of novel N’-(2-oxoindolin-3-ylidene)piperidine-4-carbohydrazide derivatives as VEGFR-2 inhibitors Cite
  Eldehna WM, Habib YA, Mahmoud AE, Barghash MF, Elsayed ZM, Elsawi AE, et al. Design, synthesis, and in silico insights of novel N’-(2-oxoindolin-3-ylidene)piperidine-4-carbohydrazide derivatives as VEGFR-2 inhibitors. Bioorganic Chemistry. Elsevier BV; 2024;:107829 10.1016/j.bioorg.2024.107829
• Combination of resveratrol and piperine to target doxorubicin resistance in breast cancer: An in vitro and in vivo study Cite
  AlHur MJ, Barakova N, Talib WH. Combination of resveratrol and piperine to target doxorubicin resistance in breast cancer: An in vitro and in vivo study. Pharmacia. Pensoft Publishers; 2024; 71:1-10 10.3897/pharmacia.71.e122171
• Piperine enhances doxorubicin sensitivity in triple-negative breast cancer by targeting the PI3K/Akt/mTOR pathway and cancer stem cells Cite
  Hakeem AN, El-Kersh DM, Hammam O, Elhosseiny A, Zaki A, Kamel K, et al. Piperine enhances doxorubicin sensitivity in triple-negative breast cancer by targeting the PI3K/Akt/mTOR pathway and cancer stem cells. Scientific Reports. Springer Science and Business Media LLC; 2024; 14 10.1038/s41598-024-65508-0
• Synergistic enhancement: Exploring the potential of piperine in cancer therapeutics through chemosensitization and combination therapies Cite
  Manickasamy MK, Kumar A, BharathwajChetty B, Alqahtani MS, Abbas M, Alqahtani A, et al. Synergistic enhancement: Exploring the potential of piperine in cancer therapeutics through chemosensitization and combination therapies. Life Sciences. Elsevier BV; 2024;:122943 10.1016/j.lfs.2024.122943
• Hand-in-glove effect of Piperine in anti-cancer formulations Cite
  Kumar J, Kriplani P, Guarve K. Hand-in-glove effect of Piperine in anti-cancer formulations. Current Functional Foods. Bentham Science Publishers Ltd.; 2023; 01 10.2174/2666862901666230727104158
• Molecular Targets of Plant-based Alkaloids and Polyphenolics in Liver and Breast Cancer- An Insight into Anticancer Drug Development Cite
  Batool S, Asim L, Raffaq Qureshi F, Masood A, Mushtaq M, Saleem RSZ. Molecular Targets of Plant-based Alkaloids and Polyphenolics in Liver and Breast Cancer- An Insight into Anticancer Drug Development. Anti-Cancer Agents in Medicinal Chemistry. Bentham Science Publishers Ltd.; 2024; 24 10.2174/0118715206302216240628072554
• Harnessing Micronutrient Power: Vitamins, Antioxidants and Probiotics in Breast Cancer Prevention Cite
  MOKBEL K, MOKBEL K. Harnessing Micronutrient Power: Vitamins, Antioxidants and Probiotics in Breast Cancer Prevention. Anticancer Research. Anticancer Research USA Inc.; 2024; 44:2287-2295 10.21873/anticanres.17036
• Triple Negative Breast Cancer (TNBC): Signalling pathways-Role of plant-based inhibitors Cite
  Ravindra B. Malabadi , Sadiya MR , Kiran P. Kolkar , Simuzar S. Mammadova , Raju K. Chalannavar , Himansu Baijnath , et al. Triple Negative Breast Cancer (TNBC): Signalling pathways-Role of plant-based inhibitors. Open Access Research Journal of Biology and Pharmacy. Open Access Research Journals Publication; 2024; 10:028-071 10.53022/oarjbp.2024.10.2.0013
• Anticancer Potential of the Principal Constituent of Piper nigrum, Piperine: A Comprehensive Review Cite
  Umapathy VR, Dhanavel A, Kesavan R, Natarajan PM, S B, P V. Anticancer Potential of the Principal Constituent of Piper nigrum, Piperine: A Comprehensive Review. Cureus. Springer Science and Business Media LLC; 2024; 10.7759/cureus.54425
• Phytochemicals and Their Usefulness in the Maintenance of Health Cite
  Rodríguez-Negrete EV, Morales-González Á, Madrigal-Santillán EO, Sánchez-Reyes K, Álvarez-González I, Madrigal-Bujaidar E, et al. Phytochemicals and Their Usefulness in the Maintenance of Health. Plants. MDPI AG; 2024; 13:523 10.3390/plants13040523
• Chitosan-coated MIL-100(Fe) nanoparticles for enhanced piperine release in breast cancer treatment Cite
  Quijia CR, Ocaña A, Alonso‑Moreno C, Galvão Frem RC, Chorilli M. Chitosan-coated MIL-100(Fe) nanoparticles for enhanced piperine release in breast cancer treatment. Journal of Molecular Structure. Elsevier BV; 2024; 1305:137801 10.1016/j.molstruc.2024.137801
• Piperine: Chemistry and Biology Cite
  Han J, Zhang S, He J, Li T. Piperine: Chemistry and Biology. Toxins. MDPI AG; 2023; 15:696 10.3390/toxins15120696
• Enhancing Paclitaxel Efficacy with Piperine-Paclitaxel Albumin Nanoparticles in Multidrug-Resistant Triple-Negative Breast Cancer by Inhibiting P-Glycoprotein Cite
  Xu W, Xiao Y, Zheng L, Xu M, Jiang X, Wang L. Enhancing Paclitaxel Efficacy with Piperine-Paclitaxel Albumin Nanoparticles in Multidrug-Resistant Triple-Negative Breast Cancer by Inhibiting P-Glycoprotein. Pharmaceutics. MDPI AG; 2023; 15:2703 10.3390/pharmaceutics15122703
• Development of Statistically Optimized Piperine-Loaded Polymeric Nanoparticles for Breast Cancer: In Vitro Evaluation and Cell Culture Studies Cite
  Gilani SJ, Bin-Jumah MN, Fatima F. Development of Statistically Optimized Piperine-Loaded Polymeric Nanoparticles for Breast Cancer: In Vitro Evaluation and Cell Culture Studies. ACS Omega. American Chemical Society (ACS); 2023; 10.1021/acsomega.3c06605
• Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer Cite
  da Silva FC, Brandão DC, Ferreira EA, Siqueira RP, Ferreira HSV, Da Silva Filho AA, et al. Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer. Pharmaceuticals. MDPI AG; 2023; 16:1466 10.3390/ph16101466
• A Systematic Review on Chemical Actives from Plant Sources, Targets and Chemotherapy for Triple-Negative Breast Cancer Cite
  Varne AA, Bhatia MS, Ashtek SS. A Systematic Review on Chemical Actives from Plant Sources, Targets and Chemotherapy for Triple-Negative Breast Cancer. Pharmaceutical Chemistry Journal. Springer Science and Business Media LLC; 2023; 57:694-702 10.1007/s11094-023-02940-y
• Breast Cancer Cells are Sensitized by Piperine to Radiotherapy through Estrogen Receptor-α mediated modulation of a Key NHEJ repair protein- DNA-PK Cite
  Shaheer K, Prabhu BS, Ali HS, Lakshmanan-M D. Breast Cancer Cells are Sensitized by Piperine to Radiotherapy through Estrogen Receptor-α mediated modulation of a Key NHEJ repair protein- DNA-PK. Phytomedicine. Elsevier BV; 2023;:155126 10.1016/j.phymed.2023.155126
• Enhanced anticancer activity of piperine: Structural optimization and chitosan-based microgels with boosted drug delivery Cite
  Wang X, Wang J, Li H. Enhanced anticancer activity of piperine: Structural optimization and chitosan-based microgels with boosted drug delivery. International Journal of Biological Macromolecules. Elsevier BV; 2023;:127019 10.1016/j.ijbiomac.2023.127019
• Piper nigrum extract retards tumor growth by reducing tumor-promoted cytokines/chemokines and modulating immune cells in blood circulation Cite
  Mad-adam N, Dokduang S, Taraporn S, Saetang J, Nualla-ong A, Rattanaburee T, et al. Piper nigrum extract retards tumor growth by reducing tumor-promoted cytokines/chemokines and modulating immune cells in blood circulation. Research Square Platform LLC; 2023; 10.21203/rs.3.rs-3209274/v1
• Piper nigrum extract suppresses tumor growth and enhances the antitumor immune response in murine models of breast cancer and melanoma Cite
  Lasso P, Rojas L, Arévalo C, Urueña C, Murillo N, Nossa P, et al. Piper nigrum extract suppresses tumor growth and enhances the antitumor immune response in murine models of breast cancer and melanoma. Cancer Immunology, Immunotherapy. Springer Science and Business Media LLC; 2023; 10.1007/s00262-023-03487-3
• Nutritional Metabolomics in Diet–Breast Cancer Relations: Current Research, Challenges, and Future Directions—A Review Cite
  Vahid F, Hajizadeghan K, Khodabakhshi A. Nutritional Metabolomics in Diet–Breast Cancer Relations: Current Research, Challenges, and Future Directions—A Review. Biomedicines. MDPI AG; 2023; 11:1845 10.3390/biomedicines11071845
• Efficient synergistic combination effect of curcumin with piperine by polymeric magnetic nanoparticles for breast cancer treatment Cite
  Ahmadi F, Akbari J, Saeedi M, Seyedabadi M, Ebrahimnejad P, Ghasemi S, et al. Efficient synergistic combination effect of curcumin with piperine by polymeric magnetic nanoparticles for breast cancer treatment. Journal of Drug Delivery Science and Technology. Elsevier BV; 2023; 86:104624 10.1016/j.jddst.2023.104624
• Co‐administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets Cite
  Ghobadi N, Asoodeh A. Co‐administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets. Phytotherapy Research. Wiley; 2023; 10.1002/ptr.7794
• Thymoquinone, piperine, and sorafenib combinations attenuate liver and breast cancers progression: epigenetic and molecular docking approaches Cite
  El-Shehawy AA, Elmetwalli A, El-Far AH, Mosallam SAE, Salama AF, Babalghith AO, et al. Thymoquinone, piperine, and sorafenib combinations attenuate liver and breast cancers progression: epigenetic and molecular docking approaches. BMC Complementary Medicine and Therapies. Springer Science and Business Media LLC; 2023; 23 10.1186/s12906-023-03872-6
• Characterization and in vitro cytotoxicity of piperine-loaded nanoemulsion in breast cancer cells Cite
  Vitor LC, Filippo LDD, Duarte J, Brito LD, Luiz MT, Dutra J, et al. Characterization and in vitro cytotoxicity of piperine-loaded nanoemulsion in breast cancer cells. Research Square Platform LLC; 2023; 10.21203/rs.3.rs-3352243/v1
• Estrogen Receptor-positive Breast Cancer Cells are Sensitized by Piperine to Chemo/Radio Therapy through Lowering the expression of a NHEJ repair protein DNA-PK Cite
  Shaheer K, Prabhu S, Ali HS, Lakshmanan D. Estrogen Receptor-positive Breast Cancer Cells are Sensitized by Piperine to Chemo/Radio Therapy through Lowering the expression of a NHEJ repair protein DNA-PK. Research Square Platform LLC; 2022; 10.21203/rs.3.rs-2401099/v1
• Immunomodulatory effects of low piperine fractional Piper nigrum extract on breast cancer prevention Cite
  Mad-Adam N, Graidist P, Saetang J, Rattanaburee T, Tanawattanasuntorn T, Dokduang S, et al. Immunomodulatory effects of low piperine fractional Piper nigrum extract on breast cancer prevention. European Journal of Cancer. Elsevier BV; 2022; 174:S45 10.1016/s0959-8049(22)00921-2
• Dietary Piperine Suppresses Obesity-Associated Breast Cancer Growth and Metastasis by Regulating the miR-181c-3p/PPARα Axis Cite
  Rajarajan D, Natesh J, Penta D, Meeran SM. Dietary Piperine Suppresses Obesity-Associated Breast Cancer Growth and Metastasis by Regulating the miR-181c-3p/PPARα Axis. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2021; 10.1021/acs.jafc.1c05670
• Antioxidant and Cytotoxicity Potential of Piperine and Sorafenib combination in human MDA-MB-231 Breast Cancer cells Cite
  Mohany H, Mahmoud MA, El-Shehawy AA, Gaber M, Elmetwalli A, Salama AF, et al. Antioxidant and Cytotoxicity Potential of Piperine and Sorafenib combination in human MDA-MB-231 Breast Cancer cells. Biochemistry Letters. Egypts Presidential Specialized Council for Education and Scientific Research; 2021; 17:108-116 10.21608/blj.2021.200558
• Antitumoral Activities of Curcumin and Recent Advances to ImProve Its Oral Bioavailability Cite
  Nocito MC, De Luca A, Prestia F, Avena P, La Padula D, Zavaglia L, et al. Antitumoral Activities of Curcumin and Recent Advances to ImProve Its Oral Bioavailability. Biomedicines. MDPI AG; 2021; 9:1476 10.3390/biomedicines9101476
• Modulation of interaction of BRCA1-RAD51 and BRCA1-AURKA protein complexes by natural metabolites using as possible therapeutic intervention toward cardiotoxic effects of cancer drugs: an in-silico approach Cite
  Tiwari S, Pandey VP, Yadav K, Dwivedi UN. Modulation of interaction of BRCA1-RAD51 and BRCA1-AURKA protein complexes by natural metabolites using as possible therapeutic intervention toward cardiotoxic effects of cancer drugs: an in-silico approach. Journal of Biomolecular Structure and Dynamics. Informa UK Limited; 2021;:1-17 10.1080/07391102.2021.1976278
• Piperine for treating breast cancer: A review of molecular mechanisms, combination with anticancer drugs, and nanosystems Cite
  Quijia CR, Chorilli M. Piperine for treating breast cancer: A review of molecular mechanisms, combination with anticancer drugs, and nanosystems. Phytotherapy Research. Wiley; 2021; 10.1002/ptr.7291
• Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women Cite
  Zeleznik OA, Balasubramanian R, Zhao Y, Frueh L, Jeanfavre S, Avila-Pacheco J, et al. Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women. npj Breast Cancer. Springer Science and Business Media LLC; 2021; 7 10.1038/s41523-021-00262-4
• Diet-Related Metabolomic Signature of Long-Term Breast Cancer Risk Using Penalized Regression: An Exploratory Study in the SU.VI.MAX Cohort Cite
  Lécuyer L, Dalle C, Lefevre-Arbogast S, Micheau P, Lyan B, Rossary A, et al. Diet-Related Metabolomic Signature of Long-Term Breast Cancer Risk Using Penalized Regression: An Exploratory Study in the SU.VI.MAX Cohort. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2019; 29:396-405 10.1158/1055-9965.epi-19-0900
• Delivery of Apoptosis-inducing Piperine to Triple-negative Breast Cancer Cells via Co-polymeric Nanoparticles Cite
  RAD JG, HOSKIN DW. Delivery of Apoptosis-inducing Piperine to Triple-negative Breast Cancer Cells via Co-polymeric Nanoparticles. Anticancer Research. Anticancer Research USA Inc.; 2020; 40:689-694 10.21873/anticanres.13998
• Two Natural Alkaloids Synergistically Induce Apoptosis in Breast Cancer Cells by Inhibiting STAT3 Activation Cite
  Chen D, Ma Y, Guo Z, Liu L, Yang Y, Wang Y, et al. Two Natural Alkaloids Synergistically Induce Apoptosis in Breast Cancer Cells by Inhibiting STAT3 Activation. Molecules. MDPI AG; 2020; 25:216 10.3390/molecules25010216
• Impact of curcumin with and without (+/-) piperine on tamoxifen exposure. Cite
  Hussaarts G, Hurkmans D, De Hoop EO, van Harten LJ, Berghuis S, van Alphen RJ, et al. Impact of curcumin with and without (+/-) piperine on tamoxifen exposure.. Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2018; 36:2572-2572 10.1200/jco.2018.36.15_suppl.2572
• Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone Cite
  Aumeeruddy MZ, Mahomoodally MF. Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone. Cancer. Wiley; 2019; 125:1600-1611 10.1002/cncr.32022
• A Comparative Study On Viability Of Mcf-7 Human Breast Cancer Cell Lines Using Piperine And Tamoxifen – An In Vitro Study With A Novel Mishmash Cite
  Gokul T, Anusha D, David DC. A Comparative Study On Viability Of Mcf-7 Human Breast Cancer Cell Lines Using Piperine And Tamoxifen – An In Vitro Study With A Novel Mishmash. Biomedical and Pharmacology Journal. Oriental Scientific Publishing Company; 2018; 11:1955-1959 10.13005/bpj/1568
• Capsaicin and Piperine Can Overcome Multidrug Resistance in Cancer Cells to Doxorubicin Cite
  Li H, Krstin S, Wang S, Wink M. Capsaicin and Piperine Can Overcome Multidrug Resistance in Cancer Cells to Doxorubicin. Molecules. MDPI AG; 2018; 23:557 10.3390/molecules23030557
• Regressions of Breast Carcinoma Syngraft Following Treatment with Piperine in Combination with Thymoquinone Cite
  Talib W. Regressions of Breast Carcinoma Syngraft Following Treatment with Piperine in Combination with Thymoquinone. Scientia Pharmaceutica. MDPI AG; 2017; 85:27 10.3390/scipharm85030027
• Evidences for Piperine inhibiting cancer by targeting human G-quadruplex DNA sequences Cite
  Tawani A, Amanullah A, Mishra A, Kumar A. Evidences for Piperine inhibiting cancer by targeting human G-quadruplex DNA sequences. Scientific Reports. Springer Science and Business Media LLC; 2016; 6 10.1038/srep39239
• Resveratrol-piperine loaded mixed micelles: formulation, characterization, bioavailability, safety and in vitro anticancer activity Cite
  Jadhav P, Bothiraja C, Pawar A. Resveratrol-piperine loaded mixed micelles: formulation, characterization, bioavailability, safety and in vitro anticancer activity. RSC Advances. Royal Society of Chemistry (RSC); 2016; 6:112795-112805 10.1039/c6ra24595a
• Transcriptomic profiling of curcumin-treated human breast stem cells identifies a role for stearoyl-coa desaturase in breast cancer prevention Cite
  Colacino JA, McDermott SP, Sartor MA, Wicha MS, Rozek LS. Transcriptomic profiling of curcumin-treated human breast stem cells identifies a role for stearoyl-coa desaturase in breast cancer prevention. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2016; 158:29-41 10.1007/s10549-016-3854-4
• Piper nigrum ethanolic extract rich in piperamides causes ROS overproduction, oxidative damage in DNA leading to cell cycle arrest and apoptosis in cancer cells Cite
  de Souza Grinevicius VMA, Kviecinski MR, Santos Mota NSR, Ourique F, Porfirio Will Castro LSE, Andreguetti RR, et al. Piper nigrum ethanolic extract rich in piperamides causes ROS overproduction, oxidative damage in DNA leading to cell cycle arrest and apoptosis in cancer cells. Journal of Ethnopharmacology. Elsevier BV; 2016; 189:139-147 10.1016/j.jep.2016.05.020
• Anti-cancer effects of Piper nigrum via inducing multiple molecular signaling in vivo and in vitro Cite
  Deng Y, Sriwiriyajan S, Tedasen A, Hiransai P, Graidist P. Anti-cancer effects of Piper nigrum via inducing multiple molecular signaling in vivo and in vitro. Journal of Ethnopharmacology. Elsevier BV; 2016; 188:87-95 10.1016/j.jep.2016.04.047
• Piperine loaded PEG-PLGA nanoparticles: Preparation, characterization and targeted delivery for adjuvant breast cancer chemotherapy Cite
  Pachauri M, Gupta ED, Ghosh PC. Piperine loaded PEG-PLGA nanoparticles: Preparation, characterization and targeted delivery for adjuvant breast cancer chemotherapy. Journal of Drug Delivery Science and Technology. Elsevier BV; 2015; 29:269-282 10.1016/j.jddst.2015.08.009
• Piperine derivatives as potential inhibitors of Survivin: An in silico molecular docking Cite
  Sattarinezhad E, Bordbar A, Fani N. Piperine derivatives as potential inhibitors of Survivin: An in silico molecular docking. Computers in Biology and Medicine. Elsevier BV; 2015; 63:219-227 10.1016/j.compbiomed.2015.05.016
• Combined effect of paclitaxel and piperine on a MCF-7 breast cancer cell line in vitro: Evidence of a synergistic interaction Cite
  Motiwala M, Rangari V. Combined effect of paclitaxel and piperine on a MCF-7 breast cancer cell line in vitro: Evidence of a synergistic interaction. Synergy. Elsevier BV; 2015; 2:1-6 10.1016/j.synres.2015.04.001
• Piperine inhibits the growth and motility of triple-negative breast cancer cells Cite
  Greenshields AL, Doucette CD, Sutton KM, Madera L, Annan H, Yaffe PB, et al. Piperine inhibits the growth and motility of triple-negative breast cancer cells. Cancer Letters. Elsevier BV; 2015; 357:129-140 10.1016/j.canlet.2014.11.017
• Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells Cite
  Do MT, Kim HG, Choi JH, Khanal T, Park BH, Tran TP, et al. Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells. Food Chemistry. Elsevier BV; 2013; 141:2591-2599 10.1016/j.foodchem.2013.04.125
• Effects of Piperine, Cinnamic Acid and Gallic Acid on Rosuvastatin Pharmacokinetics in Rats Cite
  Basu S, Jana S, Patel VB, Patel H. Effects of Piperine, Cinnamic Acid and Gallic Acid on Rosuvastatin Pharmacokinetics in Rats. Phytotherapy Research. Wiley; 2012;:n/a-n/a 10.1002/ptr.4894
• A plausible explanation for enhanced bioavailability of P-gp substrates in presence of piperine: simulation for next generation of P-gp inhibitors Cite
  Singh DV, Godbole MM, Misra K. A plausible explanation for enhanced bioavailability of P-gp substrates in presence of piperine: simulation for next generation of P-gp inhibitors. Journal of Molecular Modeling. Springer Science and Business Media LLC; 2012; 19:227-238 10.1007/s00894-012-1535-8
• Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-κB, C/EBP and AP-1 signaling pathways in murine macrophages Cite
  Kim HG, Han EH, Jang W, Choi JH, Khanal T, Park BH, et al. Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-κB, C/EBP and AP-1 signaling pathways in murine macrophages. Food and Chemical Toxicology. Elsevier BV; 2012; 50:2342-2348 10.1016/j.fct.2012.04.024
• Comparative efficacy of piperine, curcumin and picroliv against Cd immunotoxicity in mice Cite
  Pathak N, Khandelwal S. Comparative efficacy of piperine, curcumin and picroliv against Cd immunotoxicity in mice. BioMetals. Springer Science and Business Media LLC; 2008; 21:649-661 10.1007/s10534-008-9150-y
• Piperine protects cisplatin-induced apoptosis via heme oxygenase-1 induction in auditory cells Cite
  Choi B, Kim S, Park T, Li G, Hong S, Park R, et al. Piperine protects cisplatin-induced apoptosis via heme oxygenase-1 induction in auditory cells. The Journal of Nutritional Biochemistry. Elsevier BV; 2007; 18:615-622 10.1016/j.jnutbio.2006.11.012
• Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model Cite
  Lai L, Fu Q, Liu Y, Jiang K, Guo Q, Chen Q, et al. Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model. Acta Pharmacologica Sinica. Springer Science and Business Media LLC; 2012; 33:523-530 10.1038/aps.2011.209
• Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells Cite
  Li S, Lei Y, Jia Y, Li N, Wink M, Ma Y. Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells. Phytomedicine. Elsevier BV; 2011; 19:83-87 10.1016/j.phymed.2011.06.031
• Co-administration of piperine and docetaxel results in improved anti-tumor efficacy via inhibition of CYP3A4 activity Cite
  Makhov P, Golovine K, Canter D, Kutikov A, Simhan J, Corlew MM, et al. Co-administration of piperine and docetaxel results in improved anti-tumor efficacy via inhibition of CYP3A4 activity. The Prostate. Wiley; 2011; 72:661-667 10.1002/pros.21469
• Piperine, a dietary phytochemical, inhibits angiogenesis Cite
  Doucette CD, Hilchie AL, Liwski R, Hoskin DW. Piperine, a dietary phytochemical, inhibits angiogenesis. The Journal of Nutritional Biochemistry. Elsevier BV; 2013; 24:231-239 10.1016/j.jnutbio.2012.05.009
• Targeting breast stem cells with the cancer preventive compounds curcumin and piperine Cite
  Kakarala M, Brenner DE, Korkaya H, Cheng C, Tazi K, Ginestier C, et al. Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2009; 122:777-785 10.1007/s10549-009-0612-x
• Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects Cite
  Srinivasan K. Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects. Critical Reviews in Food Science and Nutrition. Informa UK Limited; 2007; 47:735-748 10.1080/10408390601062054