Milk thistle: ''Silybum marianum,'' a member of the thistle family that traditionally has been used for its liver-protective properties. A source of the complex flavonoid compound silymarin, which contains silibinin, silybin, silicristin, and silidianin.
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The Anticancer Properties of Silibinin: Its Molecular Mechanism and Therapeutic Effect in Breast Cancer.
Anti-Cancer Agents in Medicinal Chemistry. Bentham Science Publishers Ltd.;
SoleimaniV, DelghandiPS, MoallemSA, KarimiG.
Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review.
Phytotherapy Research. Wiley;
A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements.
In Silico Pharmacology. Springer Science and Business Media LLC;
SweetE, DowdF, ZhouM, StandishLJ, AndersenMR.
The Use of Complementary and Alternative Medicine Supplements of Potential Concern during Breast Cancer Chemotherapy.
Evidence-Based Complementary and Alternative Medicine. Hindawi Limited;
BayramD, ÇetinE, KaraM, ÖzgöçmenM, CandanI.
The apoptotic effects of silibinin on MDA-MB-231 and MCF-7 human breast carcinoma cells.
Human & Experimental Toxicology. SAGE Publications;
AbbasalipourkabirR, ZiamajidiN, NasiriA, BehroujH.
Effects of Aqueous Extracts of Chicory and Milk Thistle on Serum Concentrations of Copper, Zinc, and Manganese in Tamoxifen-Treated Rats.
Biological Trace Element Research. Springer Science and Business Media LLC;
JIANGK, WANGW, JINX, WANGZ, JIZ, MENGG.
Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells.
Oncology Reports. Spandidos Publications;
LuW, LinC, KingTD, ChenH, ReynoldsRC, LiY.
Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells.
Cellular Signalling. Elsevier BV;
AndersenMR, SweetE, LoweKA, StandishLJ, DrescherCW, GoffBA.
Dangerous Combinations: Ingestible CAM Supplement Use During Chemotherapy in Patients with Ovarian Cancer.
The Journal of Alternative and Complementary Medicine. Mary Ann Liebert Inc;