Tag: kaempferol

News

03/29/15

Kaempferol reduces ER+/PR+ breast cancer proliferation

04/26/14

Kaempferol reduces ER+/PR+ growth and protects against triclosan

12/15/11

Kaempferol protects against Adriamycin-induced heart damage

Foods

• • dill
  • fennel
  • greens
  • kale
  • saffron
  • watercress

Studies

• Abstract 504: Anticancer effects of kaempferol through cell cycle arrest and the inhibition of proliferation in genetically distinct triple-negative breast cancer cells Cite
  Kaur S, Mendonca P, Soliman KFA. Abstract 504: Anticancer effects of kaempferol through cell cycle arrest and the inhibition of proliferation in genetically distinct triple-negative breast cancer cells. Cancer Research. American Association for Cancer Research (AACR); 2024; 84:504-504 10.1158/1538-7445.am2024-504
• Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling Cite
  Kubatka P, Koklesova L, Mazurakova A, Brockmueller A, Büsselberg D, Kello M, et al. Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling. Cancer and Metastasis Reviews. Springer Science and Business Media LLC; 2023; 10.1007/s10555-023-10134-x
• Green synthesis of chitosan/silver nanocomposite using kaempferol for triple negative breast cancer therapy and antibacterial activity Cite
  Bharathi D, Ranjithkumar R, Nandagopal JGT, Djearamane S, Lee J, Wong LS. Green synthesis of chitosan/silver nanocomposite using kaempferol for triple negative breast cancer therapy and antibacterial activity. Environmental Research. Elsevier BV; 2023;:117109 10.1016/j.envres.2023.117109
• Phytochemicals Modify the Action of Cancer Cells Mitochondrial Drug-Resistance Mechanism Cite
  Das S. Phytochemicals Modify the Action of Cancer Cells Mitochondrial Drug-Resistance Mechanism. Sciences of Pharmacy. Etflin; 2023; 2:79-105 10.58920/sciphar02030079
• The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC) Cite
  Farghadani R, Naidu R. The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC). Biomedicine & Pharmacotherapy. Elsevier BV; 2023; 165:115170 10.1016/j.biopha.2023.115170
• Insights on the Role of Polyphenols in Combating Cancer Drug Resistance Cite
  Farhan M. Insights on the Role of Polyphenols in Combating Cancer Drug Resistance. Biomedicines. MDPI AG; 2023; 11:1709 10.3390/biomedicines11061709
• Kaempferol induces mitochondrial dysfunction and mitophagy by activating the LKB1/AMPK/MFF pathway in breast precancerous lesions Cite
  Cao J, Ma X, Yan X, Zhang G, Hong S, Ma R, et al. Kaempferol induces mitochondrial dysfunction and mitophagy by activating the LKB1/AMPK/MFF pathway in breast precancerous lesions. Phytotherapy Research. Wiley; 2023; 10.1002/ptr.7838
• Kaempferol, a Phytoprogestin, Induces a Subset of Progesterone-Regulated Genes in the Uterus Cite
  Bergsten TM, Li K, Lantvit DD, Murphy BT, Burdette JE. Kaempferol, a Phytoprogestin, Induces a Subset of Progesterone-Regulated Genes in the Uterus. Nutrients. MDPI AG; 2023; 15:1407 10.3390/nu15061407
• Association of Dietary Intake of Flavonols With Changes in Global Cognition and Several Cognitive Abilities Cite
  Holland TM, Agarwal P, Wang Y, Dhana K, Leurgans SE, Shea K, et al. Association of Dietary Intake of Flavonols With Changes in Global Cognition and Several Cognitive Abilities. Neurology. Ovid Technologies (Wolters Kluwer Health); 2022;:10.1212/WNL.0000000000201541 10.1212/wnl.0000000000201541
• A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound Cite
  Amjad E, Sokouti B, Asnaashari S. A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound. Cancer Cell International. Springer Science and Business Media LLC; 2022; 22 10.1186/s12935-022-02673-0
• Kaempferol attenuates viability of ex-vivo cultured post-NACT breast tumorexplants through downregulation of p53 induced stemness, inflammation and apoptosis evasion pathways Cite
  Nandi SK, Pradhan A, Das B, Das B, Basu S, Dutta A, et al. Kaempferol attenuates viability of ex-vivo cultured post-NACT breast tumorexplants through downregulation of p53 induced stemness, inflammation and apoptosis evasion pathways. Pathology - Research and Practice. Elsevier BV; 2022;:154029 10.1016/j.prp.2022.154029
• Plant Secondary Metabolites: Therapeutic Potential and Pharmacological Properties Cite
  Zeeshan Bhatti M, Ismail H, Khan Kayani W. Plant Secondary Metabolites: Therapeutic Potential and Pharmacological Properties. Secondary Metabolites - Trends and Reviews [Working Title]. IntechOpen; 2022; 10.5772/intechopen.103698
• Virtual Screening and Molecular Docking Studies with Organosulfur and Flavonoid Compounds of Garlic Targeting the Estrogen Receptor Protein for the Therapy of Breast Cancer Cite
  . Virtual Screening and Molecular Docking Studies with Organosulfur and Flavonoid Compounds of Garlic Targeting the Estrogen Receptor Protein for the Therapy of Breast Cancer. Biointerface Research in Applied Chemistry. AMG Transcend Association; 2022; 13:49 10.33263/briac131.049
• Molecular mechanisms of flavonoids and their modulatory effects against breast cancer: A scoping review Cite
  Murithi M, Wambugu E, Nyanjom S, Mobegi V, Shahin S, Makokha F. Molecular mechanisms of flavonoids and their modulatory effects against breast cancer: A scoping review. F1000Research. F1000 Research Ltd; 2022; 11:293 10.12688/f1000research.108908.1
• The Anti-Cancer Effects of Red-Pigmented Foods: Biomarker Modulation and Mechanisms Underlying Cancer Progression Cite
  Chung M, Hwang J, Lee J, Choi H. The Anti-Cancer Effects of Red-Pigmented Foods: Biomarker Modulation and Mechanisms Underlying Cancer Progression. Applied Sciences. MDPI AG; 2022; 12:2584 10.3390/app12052584
• Apigenin and kaempferol as novel renoprotective agent against cisplatin-induced toxicity: an in vitro study Cite
  Sharma A, Sinha S, Shrivastava N. Apigenin and kaempferol as novel renoprotective agent against cisplatin-induced toxicity: an in vitro study. Natural Product Research. Informa UK Limited; 2022;:1-6 10.1080/14786419.2022.2045603
• Protective Effect of Kaempferol and Its Nanoparticles on 5-Fluorouracil-Induced Cardiotoxicity in Rats Cite
  Safarpour S, Pirzadeh M, Ebrahimpour A, Shirafkan F, Madani F, Hosseini M, et al. Protective Effect of Kaempferol and Its Nanoparticles on 5-Fluorouracil-Induced Cardiotoxicity in Rats. BioMed Research International. Hindawi Limited; 2022; 2022:1-13 10.1155/2022/2273000
• Anti-inflammatory Effects of Different Dietary Antioxidants Cite
  Roy A, Das S, Chatterjee I, Roy S, Chakraborty R. Anti-inflammatory Effects of Different Dietary Antioxidants. Plant Antioxidants and Health. Springer International Publishing; 2022;:1-25 10.1007/978-3-030-45299-5_20-1
• Kaempferol and Apigenin suppresses the stemness properties of TNBC cells by modulating Sirtuins Cite
  Sharma A, Sinha S, Keswani H, Shrivastava N. Kaempferol and Apigenin suppresses the stemness properties of TNBC cells by modulating Sirtuins. Molecular Diversity. Springer Science and Business Media LLC; 2022; 10.1007/s11030-022-10384-x
• Kaempferol attenuates doxorubicin-mediated nephropathy in rats by activating SIRT1 signaling Cite
  Alagal RI, AlFaris NA, Alshammari GM, ALTamimi JZ, AlMousa LA, Yahya MA. Kaempferol attenuates doxorubicin-mediated nephropathy in rats by activating SIRT1 signaling. Journal of Functional Foods. Elsevier BV; 2022; 89:104918 10.1016/j.jff.2021.104918
• Natural Products Targeting Cancer Stem Cells for Augmenting Cancer Therapeutics Cite
  Meerson A, Khatib S, Mahajna J. Natural Products Targeting Cancer Stem Cells for Augmenting Cancer Therapeutics. International Journal of Molecular Sciences. MDPI AG; 2021; 22:13044 10.3390/ijms222313044
• Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy Cite
  Fatima N, Baqri SSR, Bhattacharya A, Koney NK, Husain K, Abbas A, et al. Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy. Frontiers in Genetics. Frontiers Media SA; 2021; 12 10.3389/fgene.2021.758733
• Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer Cite
  Al-Bari MAA, Ito Y, Ahmed S, Radwan N, Ahmed HS, Eid N. Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer. International Journal of Molecular Sciences. MDPI AG; 2021; 22:9807 10.3390/ijms22189807
• Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis Cite
  Maroni P, Bendinelli P, Fulgenzi A, Ferraretto A. Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis. Biomolecules. MDPI AG; 2021; 11:1336 10.3390/biom11091336
• Kaempferol protects mitochondria and alleviates damages against endotheliotoxicity induced by doxorubicin Cite
  Wu W, Yang B, Qiao Y, Zhou Q, He H, He M. Kaempferol protects mitochondria and alleviates damages against endotheliotoxicity induced by doxorubicin. Biomedicine & Pharmacotherapy. Elsevier BV; 2020; 126:110040 10.1016/j.biopha.2020.110040
• Flavonoid-induced apoptotic cell death in human cancer cells and its mechanisms Cite
  Bhosale PB, Ha SE, Vetrivel P, Kim HH, Kim J, Park K, et al. Flavonoid-induced apoptotic cell death in human cancer cells and its mechanisms. Journal of Biomedical Translational Research. Research Institute of Veterinary Medicine; 2020; 21:50-58 10.12729/jbtr.2020.21.2.050
• Flavonoids in Cancer Metastasis Cite
  Liskova A, Koklesova L, Samec M, Smejkal K, Samuel SM, Varghese E, et al. Flavonoids in Cancer Metastasis. Cancers. MDPI AG; 2020; 12:1498 10.3390/cancers12061498
• Kaempferol blocks neutrophil extracellular traps formation and reduces tumour metastasis by inhibiting ROS‐PAD4 pathway Cite
  Zeng J, Xu H, Fan P, Xie J, He J, Yu J, et al. Kaempferol blocks neutrophil extracellular traps formation and reduces tumour metastasis by inhibiting ROS‐PAD4 pathway. Journal of Cellular and Molecular Medicine. Wiley; 2020; 24:7590-7599 10.1111/jcmm.15394
• Association between flavonoids, flavonoid subclasses intake and breast cancer risk: a case-control study in China Cite
  Feng X, Ho SC, Mo X, Lin F, Zhang N, Luo H, et al. Association between flavonoids, flavonoid subclasses intake and breast cancer risk: a case-control study in China. European Journal of Cancer Prevention. Ovid Technologies (Wolters Kluwer Health); 2019; 29:493-500 10.1097/cej.0000000000000561
• Kaempferol as a Potential PAK4 Inhibitor in Triple Negative Breast Cancer: Extra Precision Glide Docking and Free Energy Calculation Cite
  Arowosegbe MA, Amusan OT, Adeola SA, Adu OB, Akinola IA, Ogungbe BF, et al. Kaempferol as a Potential PAK4 Inhibitor in Triple Negative Breast Cancer: Extra Precision Glide Docking and Free Energy Calculation. Current Drug Discovery Technologies. Bentham Science Publishers Ltd.; 2020; 17:682-695 10.2174/1570163816666190823135948
• In Vivo Exposure of Kaempferol Is Driven by Phase II Metabolic Enzymes and Efflux Transporters Cite
  Zheng L, Zhu L, Zhao M, Shi J, Li Y, Yu J, et al. In Vivo Exposure of Kaempferol Is Driven by Phase II Metabolic Enzymes and Efflux Transporters. The AAPS Journal. Springer Science and Business Media LLC; 2016; 18:1289-1299 10.1208/s12248-016-9951-9
• Epigenetic activities of flavonoids in the prevention and treatment of cancer Cite
  Busch C, Burkard M, Leischner C, Lauer UM, Frank J, Venturelli S. Epigenetic activities of flavonoids in the prevention and treatment of cancer. Clinical Epigenetics. Springer Science and Business Media LLC; 2015; 7 10.1186/s13148-015-0095-z
• The Chemopreventive Effect of the Dietary Compound Kaempferol on the MCF-7 Human Breast Cancer Cell Line Is Dependent on Inhibition of Glucose Cellular Uptake Cite
  Azevedo C, Correia-Branco A, Araújo JR, Guimarães JT, Keating E, Martel F. The Chemopreventive Effect of the Dietary Compound Kaempferol on the MCF-7 Human Breast Cancer Cell Line Is Dependent on Inhibition of Glucose Cellular Uptake. Nutrition and Cancer. Informa UK Limited; 2015; 67:504-513 10.1080/01635581.2015.1002625
• Treatment with kaempferol resulted in the regulation of cell cycle-related and apoptosis-related genes in cancer cell growth caused by triclosan in MCF-7 breast cancer cells Cite
  Kim S, Choi K. Treatment with kaempferol resulted in the regulation of cell cycle-related and apoptosis-related genes in cancer cell growth caused by triclosan in MCF-7 breast cancer cells. Endocrine Abstracts. Bioscientifica; 2014; 10.1530/endoabs.35.p504
• Kaempferol Reduces Matrix Metalloproteinase-2 Expression by Down-Regulating ERK1/2 and the Activator Protein-1 Signaling Pathways in Oral Cancer Cells Cite
  Lin C, Chen P, Chen M, Yang W, Tang C, Yang S, et al. Kaempferol Reduces Matrix Metalloproteinase-2 Expression by Down-Regulating ERK1/2 and the Activator Protein-1 Signaling Pathways in Oral Cancer Cells. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e80883 10.1371/journal.pone.0080883
• Influence of Berry Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention Cite
  Aiyer HS, Warri AM, Woode DR, Hilakivi-Clarke L, Clarke R. Influence of Berry Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2012; 60:5693-5708 10.1021/jf204084f
• New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals Cite
  Souček P, Kondrová E, Heřmánek J, Stopka P, Boumendjel A, Ueng Y, et al. New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals. Anti-Cancer Drugs. Ovid Technologies (Wolters Kluwer Health); 2011; 22:176-184 10.1097/cad.0b013e328341a17b
• Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro Cite
  Xiao J, Sun G, Sun B, Wu Y, He L, Wang X, et al. Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro. Toxicology. Elsevier BV; 2012; 292:53-62 10.1016/j.tox.2011.11.018
• Is there any difference between the phenolic content of organic and conventional tomato juices? Cite
  Vallverdú-Queralt A, Medina-Remón A, Casals-Ribes I, Lamuela-Raventos RM. Is there any difference between the phenolic content of organic and conventional tomato juices?. Food Chemistry. Elsevier BV; 2012; 130:222-227 10.1016/j.foodchem.2011.07.017
• Potential interaction of natural dietary bioactive compounds with COX-2 Cite
  Maldonado-Rojas W, Olivero-Verbel J. Potential interaction of natural dietary bioactive compounds with COX-2. Journal of Molecular Graphics and Modelling. Elsevier BV; 2011; 30:157-166 10.1016/j.jmgm.2011.07.002
• Flavonoids, Proanthocyanidins, and Cancer Risk: A Network of Case-Control Studies From Italy Cite
  Rossi M, Bosetti C, Negri E, Lagiou P, Vecchia CL. Flavonoids, Proanthocyanidins, and Cancer Risk: A Network of Case-Control Studies From Italy. Nutrition and Cancer. Informa UK Limited; 2010; 62:871-877 10.1080/01635581.2010.509534
• Influence of Domestic Processing and Storage on Flavonol Contents in Berries Cite
  Häkkinen SH, Kärenlampi SO, Mykkänen HM, Törrönen AR. Influence of Domestic Processing and Storage on Flavonol Contents in Berries. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2000; 48:2960-2965 10.1021/jf991274c
• Phenolic compound profile of selected vegetables frequently consumed by African Americans in the southeast United States Cite
  Huang Z, Wang B, Eaves DH, Shikany JM, Pace RD. Phenolic compound profile of selected vegetables frequently consumed by African Americans in the southeast United States. Food Chemistry. Elsevier BV; 2007; 103:1395-1402 10.1016/j.foodchem.2006.10.077
• Antiproliferative Effects of Honey and of Its Polyphenols: A Review Cite
  Jaganathan SK, Mandal M. Antiproliferative Effects of Honey and of Its Polyphenols: A Review. Journal of Biomedicine and Biotechnology. Hindawi Limited; 2009; 2009:1-13 10.1155/2009/830616
• Flavonoids and Breast Cancer Risk in Italy Cite
  Bosetti C. Flavonoids and Breast Cancer Risk in Italy. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2005; 14:805-808 10.1158/1055-9965.epi-04-0838
• Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells Cite
  Lee W, Chen W, Wang C, Lin W, Tseng T. Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells. Toxicology and Applied Pharmacology. Elsevier BV; 2008; 226:178-191 10.1016/j.taap.2007.09.013
• Dietary flavonols and flavonol-rich foods intake and the risk of breast cancer Cite
  Adebamowo CA, Cho E, Sampson L, Katan MB, Spiegelman D, Willett WC, et al. Dietary flavonols and flavonol-rich foods intake and the risk of breast cancer. International Journal of Cancer. Wiley; 2005; 114:628-633 10.1002/ijc.20741