Tag: I3C

News

07/31/12

I3C in cruciferous vegetables inhibits proliferation of ER+ BC cells

02/20/12

Cruciferous vegetable consumption linked to reduced risk of cancer

Foods

• • broccoli
  • brussels sprouts
  • cabbage
  • cauliflower
  • greens
  • horseradish
  • kale
  • turnips and turnip greens
  • watercress

Studies

• Resveratrol and 3,3’-diindolylmethane differentially regulate aryl hydrocarbon receptor and estrogen receptor alpha to modulate diverse signalling pathways in MCF-7 human breast cancer cells Cite
  Das S, Ulven SM, Matthews J. Resveratrol and 3,3’-diindolylmethane differentially regulate aryl hydrocarbon receptor and estrogen receptor alpha to modulate diverse signalling pathways in MCF-7 human breast cancer cells. Research Square Platform LLC; 2023; 10.21203/rs.3.rs-3255817/v1
• The Interplay between Microbiota and Chemotherapy-Derived Metabolites in Breast Cancer Cite
  Plaza-Diaz J, Álvarez-Mercado AI. The Interplay between Microbiota and Chemotherapy-Derived Metabolites in Breast Cancer. Metabolites. MDPI AG; 2023; 13:703 10.3390/metabo13060703
• Indole-3-Carbinol: Occurrence, Health-Beneficial Properties, and Cellular/Molecular Mechanisms Cite
  Amarakoon D, Lee W, Tamia G, Lee S. Indole-3-Carbinol: Occurrence, Health-Beneficial Properties, and Cellular/Molecular Mechanisms. Annual Review of Food Science and Technology. Annual Reviews; 2023; 14:347-366 10.1146/annurev-food-060721-025531
• The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female Cite
  Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Military Medicine. Oxford University Press (OUP); 2022; 10.1093/milmed/usac367
• Regulation of micro-RNA, epigenetic factor by natural products for the treatment of cancers: Mechanistic insight and translational Association Cite
  Javaid A, Zahra D, Rashid F, Mashraqi M, Alzamami A, Khurshid M, et al. Regulation of micro-RNA, epigenetic factor by natural products for the treatment of cancers: Mechanistic insight and translational Association. Saudi Journal of Biological Sciences. Elsevier BV; 2022; 10.1016/j.sjbs.2022.03.005
• Role of Dietary Ingredients on Expression of Oncogenic and Tumour Suppressor miRNA Cite
  Gacche RN. Role of Dietary Ingredients on Expression of Oncogenic and Tumour Suppressor miRNA. Dietary Research and Cancer. Springer Singapore; 2021;:69-76 10.1007/978-981-16-6050-4_7
• Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis Cite
  Maroni P, Bendinelli P, Fulgenzi A, Ferraretto A. Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis. Biomolecules. MDPI AG; 2021; 11:1336 10.3390/biom11091336
• Biomedical application of Indole-3-carbinol: A mini-review Cite
  Singh AA, Patil MP, Kang M, Niyonizigiye I, Kim G. Biomedical application of Indole-3-carbinol: A mini-review. Phytochemistry Letters. Elsevier BV; 2020; 41:49-54 10.1016/j.phytol.2020.09.024
• 3, 3′-Diindolylmethane-encapsulated chitosan nanoparticles accelerate molecular events during chemical carcinogen-induced mammary cancer in Sprague Dawley rats Cite
  Isabella S, Mirunalini S. 3, 3′-Diindolylmethane-encapsulated chitosan nanoparticles accelerate molecular events during chemical carcinogen-induced mammary cancer in Sprague Dawley rats. Breast Cancer. Springer Science and Business Media LLC; 2019; 26:499-509 10.1007/s12282-019-00950-x
• Abstract 5800: Vorinostat and indole-3-carbinol modulate microRNAs and histone deacetylase activity in subtypes of triple-negative breast cancer Cite
  Lyn-Cook B, NouriEmamzaden F, Hawkins A, Hammons G, Word B. Abstract 5800: Vorinostat and indole-3-carbinol modulate microRNAs and histone deacetylase activity in subtypes of triple-negative breast cancer. Experimental and Molecular Therapeutics. American Association for Cancer Research; 2018; 10.1158/1538-7445.am2018-5800
• Indole-3-Carbinol (I3C) enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin (DOX) through inhibition of NF-κβ, blocking angiogenesis and regulation of mitochondrial apoptotic pathway Cite
  Hajra S, Patra AR, Basu A, Saha P, Bhattacharya S. Indole-3-Carbinol (I3C) enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin (DOX) through inhibition of NF-κβ, blocking angiogenesis and regulation of mitochondrial apoptotic pathway. Chemico-Biological Interactions. Elsevier BV; 2018; 290:19-36 10.1016/j.cbi.2018.05.005
• Effects of indole-3-carbinol on steroid hormone profile and tumor progression in a mice model of canine inflammatory mammarycancer Cite
  Martín-Ruiz A, Peña L, González-Gil A, Díez-Córdova LT, Cáceres S, Illera JC. Effects of indole-3-carbinol on steroid hormone profile and tumor progression in a mice model of canine inflammatory mammarycancer. BMC Cancer. Springer Science and Business Media LLC; 2018; 18 10.1186/s12885-018-4518-z
• Glucosinolate and isothiocyanate intakes are inversely associated with breast cancer risk: a case–control study in China Cite
  Zhang N, Ho SC, Mo X, Lin F, Huang W, Luo H, et al. Glucosinolate and isothiocyanate intakes are inversely associated with breast cancer risk: a case–control study in China. British Journal of Nutrition. Cambridge University Press (CUP); 2018; 119:957-964 10.1017/s0007114518000600
• Home food preparation techniques impacted the availability of natural antioxidants and bioactivities in kale and broccoli Cite
  Yu L, Gao B, Li Y, Wang TTY, Luo Y, Wang J, et al. Home food preparation techniques impacted the availability of natural antioxidants and bioactivities in kale and broccoli. Food & Function. Royal Society of Chemistry (RSC); 2018; 9:585-593 10.1039/c7fo00948h
• Inhibitory effects of 3,3′-diindolylmethane on epithelial-mesenchymal transition induced by endocrine disrupting chemicals in cellular and xenograft mouse models of breast cancer Cite
  Lee G, Hwang K, Choi K. Inhibitory effects of 3,3′-diindolylmethane on epithelial-mesenchymal transition induced by endocrine disrupting chemicals in cellular and xenograft mouse models of breast cancer. Food and Chemical Toxicology. Elsevier BV; 2017; 109:284-295 10.1016/j.fct.2017.08.037
• 3,3′-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice Cite
  Lu L, Dong J, Li D, Zhang J, Fan S. 3,3′-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice. Free Radical Biology and Medicine. Elsevier BV; 2016; 99:463-471 10.1016/j.freeradbiomed.2016.09.007
• Indole-3-carbinol protects against cisplatin-induced acute nephrotoxicity: role of calcitonin gene-related peptide and insulin-like growth factor-1 Cite
  El-Naga RN, Mahran YF. Indole-3-carbinol protects against cisplatin-induced acute nephrotoxicity: role of calcitonin gene-related peptide and insulin-like growth factor-1. Scientific Reports. Springer Science and Business Media LLC; 2016; 6 10.1038/srep29857
• The estrogenic effect of trigonelline and 3,3-diindolymethane on cell growth in non-malignant colonocytes Cite
  Yoo G, Allred CD. The estrogenic effect of trigonelline and 3,3-diindolymethane on cell growth in non-malignant colonocytes. Food and Chemical Toxicology. Elsevier BV; 2016; 87:23-30 10.1016/j.fct.2015.11.015
• Anti-cancer and cardioprotective effects of indol-3-carbinol in doxorubicin-treated mice Cite
  Adwas AA, Elkhoely AA, Kabel AM, Abdel-Rahman MN, Eissa AA. Anti-cancer and cardioprotective effects of indol-3-carbinol in doxorubicin-treated mice. Journal of Infection and Chemotherapy. Elsevier BV; 2016; 22:36-43 10.1016/j.jiac.2015.10.001
• Low levels of 3,3′-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol Cite
  Marques M, Laflamme L, Benassou I, Cissokho C, Guillemette B, Gaudreau L. Low levels of 3,3′-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol. BMC Cancer. Springer Science and Business Media LLC; 2014; 14 10.1186/1471-2407-14-524
• Cruciferous vegetables intake is inversely associated with risk of breast cancer: A meta-analysis Cite
  Liu X, Lv K. Cruciferous vegetables intake is inversely associated with risk of breast cancer: A meta-analysis. The Breast. Elsevier BV; 2013; 22:309-313 10.1016/j.breast.2012.07.013
• Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3′-diindolylmethene in human breast epithelial cell lines Cite
  Licznerska BE, Szaefer H, Murias M, Bartoszek A, Baer-Dubowska W. Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3′-diindolylmethene in human breast epithelial cell lines. European Journal of Nutrition. Springer Science and Business Media LLC; 2012; 52:1483-1492 10.1007/s00394-012-0455-9
• Indole-3-Carbinol disrupts Estrogen Receptor-alpha dependent expression of Insulin-like Growth Factor-1 Receptor and Insulin Receptor Substrate-1 and proliferation of human breast cancer cells Cite
  Marconett CN, Singhal AK, Sundar SN, Firestone GL. Indole-3-Carbinol disrupts Estrogen Receptor-alpha dependent expression of Insulin-like Growth Factor-1 Receptor and Insulin Receptor Substrate-1 and proliferation of human breast cancer cells. Molecular and Cellular Endocrinology. Elsevier BV; 2012; 363:74-84 10.1016/j.mce.2012.07.008
• Modulation of CYP1A1, CYP1A2 and CYP1B1 Expression by Cabbage Juices and Indoles in Human Breast Cell Lines Cite
  Szaefer H, Licznerska B, Krajka-Kuźniak V, Bartoszek A, Baer-Dubowska W. Modulation of CYP1A1, CYP1A2 and CYP1B1 Expression by Cabbage Juices and Indoles in Human Breast Cell Lines. Nutrition and Cancer. Informa UK Limited; 2012; 64:879-888 10.1080/01635581.2012.690928
• Diindolilmethane (DIM) selectively inhibits cancer stem cells Cite
  Semov A, Iourtchenco L, Lin Fang L, Shengmin L, Xu Y, Su X, et al. Diindolilmethane (DIM) selectively inhibits cancer stem cells. Biochemical and Biophysical Research Communications. Elsevier BV; 2012; 424:45-51 10.1016/j.bbrc.2012.06.062
• Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling Cite
  Aronchik I, Chen T, Durkin KA, Horwitz MS, Preobrazhenskaya MN, Bjeldanes LF, et al. Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling. Molecular Carcinogenesis. Wiley; 2011; 51:881-894 10.1002/mc.20857
• 3,3′-Diindolylmethane induces immunotoxicity via splenocyte apoptosis in neonatal mice Cite
  Roh YS, Cho A, Islam MR, Cho S, Kim J, Kim JH, et al. 3,3′-Diindolylmethane induces immunotoxicity via splenocyte apoptosis in neonatal mice. Toxicology Letters. Elsevier BV; 2011; 206:218-228 10.1016/j.toxlet.2011.07.021
• A Novel Mechanism of Indole-3-Carbinol Effects on Breast Carcinogenesis Involves Induction of Cdc25A Degradation Cite
  Wu Y, Feng X, Jin Y, Wu Z, Hankey W, Paisie C, et al. A Novel Mechanism of Indole-3-Carbinol Effects on Breast Carcinogenesis Involves Induction of Cdc25A Degradation. Cancer Prevention Research. American Association for Cancer Research (AACR); 2010; 3:818-828 10.1158/1940-6207.capr-09-0213
• Direct Inhibition of Elastase Activity by Indole-3-Carbinol Triggers a CD40-TRAF Regulatory Cascade That Disrupts NF-κB Transcriptional Activity in Human Breast Cancer Cells Cite
  Aronchik I, Bjeldanes LF, Firestone GL. Direct Inhibition of Elastase Activity by Indole-3-Carbinol Triggers a CD40-TRAF Regulatory Cascade That Disrupts NF-κB Transcriptional Activity in Human Breast Cancer Cells. Cancer Research. American Association for Cancer Research (AACR); 2010; 70:4961-4971 10.1158/0008-5472.can-09-3349
• Differences in the hepatic P450-dependent metabolism of estrogen and tamoxifen in response to treatment of rats with 3,3′-diindolylmethane and its parent compound indole-3-carbinol Cite
  Parkin DR, Malejka-Giganti D. Differences in the hepatic P450-dependent metabolism of estrogen and tamoxifen in response to treatment of rats with 3,3′-diindolylmethane and its parent compound indole-3-carbinol. Cancer Detection and Prevention. Elsevier BV; 2004; 28:72-79 10.1016/j.cdp.2003.11.006
• Low Concentrations of Diindolylmethane, a Metabolite of Indole-3-Carbinol, Protect against Oxidative Stress in a BRCA1-Dependent Manner Cite
  Fan S, Meng Q, Saha T, Sarkar FH, Rosen EM. Low Concentrations of Diindolylmethane, a Metabolite of Indole-3-Carbinol, Protect against Oxidative Stress in a BRCA1-Dependent Manner. Cancer Research. American Association for Cancer Research (AACR); 2009; 69:6083-6091 10.1158/0008-5472.can-08-3309
• 3,3′-Diindolylmethane and Paclitaxel Act Synergistically to Promote Apoptosis in HER2/Neu Human Breast Cancer Cells Cite
  McGuire K, Ngoubilly N, Neavyn M, Lanza-Jacoby S. 3,3′-Diindolylmethane and Paclitaxel Act Synergistically to Promote Apoptosis in HER2/Neu Human Breast Cancer Cells. Journal of Surgical Research. Elsevier BV; 2006; 132:208-213 10.1016/j.jss.2006.02.008
• Ligand-independent activation of estrogen receptor function by 3,3′-diindolylmethane in human breast cancer cells Cite
  Riby JE, Chang GH, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3′-diindolylmethane in human breast cancer cells. Biochemical Pharmacology. Elsevier BV; 2000; 60:167-177 10.1016/s0006-2952(00)00307-5
• Estrogen receptor α as a target for indole-3-carbinol Cite
  WANG T, MILNER M, MILNER J, KIM Y. Estrogen receptor α as a target for indole-3-carbinol. The Journal of Nutritional Biochemistry. Elsevier BV; 2006; 17:659-664 10.1016/j.jnutbio.2005.10.012
• Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment Cite
  Moiseeva EP, Fox LH, Howells LM, Temple LAF, Manson MM. Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment. Apoptosis. Springer Science and Business Media LLC; 2006; 11:799-812 10.1007/s10495-006-5877-5
• Expression profile ofCYP19in human breast cancer cell lines treated with indole-3-carbinol, 3,3'-diindolylmethane, and sulforaphane. Cite
  Licznerska B, Matuszak I, Baer-Dubowska W. Expression profile ofCYP19in human breast cancer cell lines treated with indole-3-carbinol, 3,3'-diindolylmethane, and sulforaphane.. Poster Session Abstracts. American Association for Cancer Research; 2009; 10.1158/0008-5472.sabcs-1113