Tag: cucurbitacins

Articles

• Supplements with warnings for breast cancer

News

02/25/18

Cucumber has anti-cancer activities in ER+, HER2+ and TN cells

Foods

• • cucumbers
  • melons
  • pumpkins
  • watermelon
  • zucchini

Studies

• Purified Cucurbitacin D leads to alterations of apoptotic and autophagic genes expression in MDA-MB-468 and MCF-7 human breast cancer cells Cite
  Zeinali E, Zargar SJ, Mozdoori N. Purified Cucurbitacin D leads to alterations of apoptotic and autophagic genes expression in MDA-MB-468 and MCF-7 human breast cancer cells. Research Square Platform LLC; 2023; 10.21203/rs.3.rs-2920606/v1
• Apoptotic and antimetastatic effect of cucurbitacins in cancer: recent trends and advancement Cite
  Kumar A, Sharma B, Sharma U, Parashar G, Parashar NC, Rani I, et al. Apoptotic and antimetastatic effect of cucurbitacins in cancer: recent trends and advancement. Naunyn-Schmiedeberg's Archives of Pharmacology. Springer Science and Business Media LLC; 2023; 10.1007/s00210-023-02471-z
• Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms Cite
  Varela C, Melim C, Neves BG, Sharifi-Rad J, Calina D, Mamurova A, et al. Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms. Journal of Translational Medicine. Springer Science and Business Media LLC; 2022; 20 10.1186/s12967-022-03828-3
• Cytotoxicity and maternal toxicity attributed to exposure to Momordica charantia L. (Cucurbitaceae) dry leaf extract Cite
  Trautenmuller AL, de Almeida Soares J, Behm KC, Guimarães LMM, Xavier-Silva KR, Monteiro de Melo A, et al. Cytotoxicity and maternal toxicity attributed to exposure to Momordica charantia L. (Cucurbitaceae) dry leaf extract. Journal of Toxicology and Environmental Health, Part A. Informa UK Limited; 2022; 86:36-50 10.1080/15287394.2022.2157354
• Cucurbitacin B: A Review of its Pharmacology, Toxicity, and Pharmacokinetics Cite
  Dai S, Wang C, Zhao X, Ma C, Fu K, Liu Y, et al. Cucurbitacin B: A Review of its Pharmacology, Toxicity, and Pharmacokinetics. Pharmacological Research. Elsevier BV; 2022;:106587 10.1016/j.phrs.2022.106587
• Pharmacokinetics and Biological Activity of Cucurbitacins Cite
  Delgado-Tiburcio EE, Cadena-Iñiguez J, Santiago-Osorio E, Ruiz-Posadas LdM, Castillo-Juárez I, Aguiñiga-Sánchez I, et al. Pharmacokinetics and Biological Activity of Cucurbitacins. Pharmaceuticals. MDPI AG; 2022; 15:1325 10.3390/ph15111325
• Effect of cucurbitacin on malignant biological behavior of breast cancer cells, and its possible underlying mechanism Cite
  Ren Y, Huang G, Huang G, Xue Q, Lv Q, Wu Y, et al. Effect of cucurbitacin on malignant biological behavior of breast cancer cells, and its possible underlying mechanism. Tropical Journal of Pharmaceutical Research. African Journals Online (AJOL); 2022; 22:297-302 10.4314/tjpr.v22i2.12
• Biosynthetic pathways of triterpenoids and strategies to improve their Biosynthetic Efficiency Cite
  Noushahi HA, Khan AH, Noushahi UF, Hussain M, Javed T, Zafar M, et al. Biosynthetic pathways of triterpenoids and strategies to improve their Biosynthetic Efficiency. Plant Growth Regulation. Springer Science and Business Media LLC; 2022; 10.1007/s10725-022-00818-9
• Regulation of micro-RNA, epigenetic factor by natural products for the treatment of cancers: Mechanistic insight and translational Association Cite
  Javaid A, Zahra D, Rashid F, Mashraqi M, Alzamami A, Khurshid M, et al. Regulation of micro-RNA, epigenetic factor by natural products for the treatment of cancers: Mechanistic insight and translational Association. Saudi Journal of Biological Sciences. Elsevier BV; 2022; 10.1016/j.sjbs.2022.03.005
• Identification of seven undescribed cucurbitacins in Cucumis sativus (cucumber) and their cytotoxic activity Cite
  Qing Z, Shi Y, Han L, Li P, Zha Z, Liu C, et al. Identification of seven undescribed cucurbitacins in Cucumis sativus (cucumber) and their cytotoxic activity. Phytochemistry. Elsevier BV; 2022; 197:113123 10.1016/j.phytochem.2022.113123
• Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer Cite
  Al-Bari MAA, Ito Y, Ahmed S, Radwan N, Ahmed HS, Eid N. Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer. International Journal of Molecular Sciences. MDPI AG; 2021; 22:9807 10.3390/ijms22189807
• Cucurbitacin I (JSI‐124)‐dependent inhibition of STAT3 permanently suppresses the pro‐carcinogenic effects of active breast cancer‐associated fibroblasts Cite
  Al‐Harbi B, Aboussekhra A. Cucurbitacin I (JSI‐124)‐dependent inhibition of STAT3 permanently suppresses the pro‐carcinogenic effects of active breast cancer‐associated fibroblasts. Molecular Carcinogenesis. Wiley; 2021; 10.1002/mc.23287
• Vegetables from the Cucurbitaceae family and their products: Positive effect on human health Cite
  Rolnik A, Olas B. Vegetables from the Cucurbitaceae family and their products: Positive effect on human health. Nutrition. Elsevier BV; 2020; 78:110788 10.1016/j.nut.2020.110788
• Encapsulation of cucurbitacin B into lipid polymer hybrid nanocarriers induced apoptosis of MDAMB231 cells through PARP cleavage Cite
  Bakar-Ates F, Ozkan E, Sengel-Turk CT. Encapsulation of cucurbitacin B into lipid polymer hybrid nanocarriers induced apoptosis of MDAMB231 cells through PARP cleavage. International Journal of Pharmaceutics. Elsevier BV; 2020; 586:119565 10.1016/j.ijpharm.2020.119565
• Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells Cite
  Saeed ME, Boulos JC, Elhaboub G, Rigano D, Saab A, Loizzo MR, et al. Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells. Phytomedicine. Elsevier BV; 2019; 62:152945 10.1016/j.phymed.2019.152945
• Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells Cite
  Dittharot K, Dakeng S, Suebsakwong P, Suksamrarn A, Patmasiriwat P, Promkan M. Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells. Planta Medica. Georg Thieme Verlag KG; 2018; 85:370-378 10.1055/a-0791-1591
• Abstract 2934: Cucurbitacin D enhances the therapeutic efficacy of docetaxel via targeting cancer stem cells and miR-145 Cite
  Sikander M, Malik S, Hafeez BB, Mandil H, Halaweish FT, Jaggi M, et al. Abstract 2934: Cucurbitacin D enhances the therapeutic efficacy of docetaxel via targeting cancer stem cells and miR-145. Experimental and Molecular Therapeutics. American Association for Cancer Research; 2018; 10.1158/1538-7445.am2018-2934
• Bioactive profile of pumpkin: an overview on terpenoids and their health-promoting properties Cite
  Montesano D, Rocchetti G, Putnik P, Lucini L. Bioactive profile of pumpkin: an overview on terpenoids and their health-promoting properties. Current Opinion in Food Science. Elsevier BV; 2018; 22:81-87 10.1016/j.cofs.2018.02.003
• Cucurbitacin D exhibits its anti-cancer effect in human breast cancer cells by inhibiting Stat3 and Akt signaling Cite
  Ku JM, Hong SH, Kim HI, Lim YS, Lee SJ, Kim M, et al. Cucurbitacin D exhibits its anti-cancer effect in human breast cancer cells by inhibiting Stat3 and Akt signaling. European Journal of Inflammation. SAGE Publications; 2018; 16:1721727X1775180 10.1177/1721727x17751809
• Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells Cite
  LUO W, ZHAO W, LU J, WANG Y, CHEN X. Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells. Chinese Journal of Natural Medicines. Elsevier BV; 2018; 16:10-19 10.1016/s1875-5364(18)30025-6
• Cucurbitacin B and cancer intervention: Chemistry, biology and mechanisms (Review) Cite
  Garg S, Kaul S, Wadhwa R. Cucurbitacin B and cancer intervention: Chemistry, biology and mechanisms (Review). International Journal of Oncology. Spandidos Publications; 2017; 10.3892/ijo.2017.4203
• Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein Cite
  Lu J, Zhang Y, Sun M, Liu M, Wang X. Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein. Phytomedicine. Elsevier BV; 2017; 26:1-10 10.1016/j.phymed.2017.01.004
• Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis Cite
  Sinha S, Khan S, Shukla S, Lakra AD, Kumar S, Das G, et al. Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis. The International Journal of Biochemistry & Cell Biology. Elsevier BV; 2016; 77:41-56 10.1016/j.biocel.2016.05.014
• Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells Cite
  Ku JM, Kim SR, Hong SH, Choi H, Seo HS, Shin YC, et al. Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells. Molecular and Cellular Biochemistry. Springer Science and Business Media LLC; 2015; 409:33-43 10.1007/s11010-015-2509-9
• Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells Cite
  Ren G, Sha T, Guo J, Li W, Lu J, Chen X. Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells. Journal of Natural Medicines. Springer Science and Business Media LLC; 2015; 69:522-530 10.1007/s11418-015-0918-4
• Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery Cite
  Hall JA, Seedarala S, Rice N, Kopel L, Halaweish F, Blagg BSJ. Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery. Journal of Natural Products. American Chemical Society (ACS); 2015; 78:873-879 10.1021/acs.jnatprod.5b00054
• Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer Cite
  Kong Y, Chen J, Zhou Z, Xia H, Qiu M, Chen C. Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer. PLoS ONE. Public Library of Science (PLoS); 2014; 9:e103760 10.1371/journal.pone.0103760
• The Effectiveness of Cucurbitacin B in BRCA1 Defective Breast Cancer Cells Cite
  Promkan M, Dakeng S, Chakrabarty S, Bögler O, Patmasiriwat P. The Effectiveness of Cucurbitacin B in BRCA1 Defective Breast Cancer Cells. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e55732 10.1371/journal.pone.0055732
• The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer Cite
  Aribi A, Gery S, Lee DH, Thoennissen NH, Thoennissen GB, Alvarez R, et al. The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer. International Journal of Cancer. Wiley; 2012; 132:2730-2737 10.1002/ijc.27950
• Screening of biochemical modulator by tumor cell permeability of doxorubicin Cite
  Sadzuka Y, Hatakeyama H, Daimon T, Sonobe T. Screening of biochemical modulator by tumor cell permeability of doxorubicin. International Journal of Pharmaceutics. Elsevier BV; 2008; 354:63-69 10.1016/j.ijpharm.2007.10.015