Tag: cucurbitacins

Articles

• Supplements with warnings for breast cancer

Foods

• • cucumbers
  • melons
  • pumpkins
  • watermelon
  • zucchini

Studies

• Cucurbitacin‐E‐Glucoside Augments Tamoxifen's Anticancer Efficacy by Targeting PPARγ and NF‐kB: In Vivo and In Silico Studies Cite
  Sabry Y, Hussein MA, Elshal MF. Cucurbitacin‐E‐Glucoside Augments Tamoxifen's Anticancer Efficacy by Targeting PPARγ and NF‐kB: In Vivo and In Silico Studies. Journal of Biochemical and Molecular Toxicology. Wiley; 2025; 39 10.1002/jbt.70540
• Ursolic acid inhibits the proliferation of triple‑negative breast cancer stem‑like cells through NRF2‑mediated ferroptosis Cite
  Yang X, Liang B, Zhang L, Zhang M, Ma M, Qing L, et al. Ursolic acid inhibits the proliferation of triple‑negative breast cancer stem‑like cells through NRF2‑mediated ferroptosis. Oncology Reports. Spandidos Publications; 2024; 52 10.3892/or.2024.8753
• Anti-Cancer Potency of Cucurbitacin D through PI3K and AKT1: A Molecular Docking Studies Cite
  Suprahman NY, Al-Bari R, Putri RA, Saputra MY, Sarmoko . Anti-Cancer Potency of Cucurbitacin D through PI3K and AKT1: A Molecular Docking Studies. Advances in Biological Sciences Research. Atlantis Press International BV; 2024;:4-10 10.2991/978-94-6463-431-0_2
• Synthetic Modifications of Therapeutically Relevant Pre-assembled Cucurbitacins: Synthetic Strategies and Structure-Activity Relationships Cite
  Sharma R, Thakur S, Natish , Kumar M, Vamsi K, Jachak S, et al. Synthetic Modifications of Therapeutically Relevant Pre-assembled Cucurbitacins: Synthetic Strategies and Structure-Activity Relationships. Journal of Molecular Structure. Elsevier BV; 2024;:138321 10.1016/j.molstruc.2024.138321
• CUCURBITACIN: A COMPREHENSION OF NATURE'S THERAPEUTIC BIOACTIVE COMPOUND Cite
  Rashid M, Ahmad FJ, Alam S, Iqbal MA, Sindhu RK. CUCURBITACIN: A COMPREHENSION OF NATURE'S THERAPEUTIC BIOACTIVE COMPOUND. PLANT ARCHIVES. Research Floor; 2023; 23 10.51470/plantarchives.2023.v23.no2.034
• Potential of cucurbitacin as an anticancer drug Cite
  Li Y, Li Y, Yao Y, Li H, Gao C, Sun C, et al. Potential of cucurbitacin as an anticancer drug. Biomedicine & Pharmacotherapy. Elsevier BV; 2023; 168:115707 10.1016/j.biopha.2023.115707
• Recent Advances in the Application of Cucurbitacins as Anticancer Agents Cite
  Zieniuk B, Pawełkowicz M. Recent Advances in the Application of Cucurbitacins as Anticancer Agents. Metabolites. MDPI AG; 2023; 13:1081 10.3390/metabo13101081
• Purified Cucurbitacin D leads to alterations of apoptotic and autophagic genes expression in MDA-MB-468 and MCF-7 human breast cancer cells Cite
  Zeinali E, Zargar SJ, Mozdoori N. Purified Cucurbitacin D leads to alterations of apoptotic and autophagic genes expression in MDA-MB-468 and MCF-7 human breast cancer cells. Research Square Platform LLC; 2023; 10.21203/rs.3.rs-2920606/v1
• Apoptotic and antimetastatic effect of cucurbitacins in cancer: recent trends and advancement Cite
  Kumar A, Sharma B, Sharma U, Parashar G, Parashar NC, Rani I, et al. Apoptotic and antimetastatic effect of cucurbitacins in cancer: recent trends and advancement. Naunyn-Schmiedeberg's Archives of Pharmacology. Springer Science and Business Media LLC; 2023; 10.1007/s00210-023-02471-z
• The involvement of the noradrenergic system in the antinociceptive effect of cucurbitacin D on mice with paclitaxel-induced neuropathic pain Cite
  Park K, Kim S, Choi I, Han I, Bae H, Kim W. The involvement of the noradrenergic system in the antinociceptive effect of cucurbitacin D on mice with paclitaxel-induced neuropathic pain. Frontiers in Pharmacology. Frontiers Media SA; 2023; 13 10.3389/fphar.2022.1055264
• Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms Cite
  Varela C, Melim C, Neves BG, Sharifi-Rad J, Calina D, Mamurova A, et al. Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms. Journal of Translational Medicine. Springer Science and Business Media LLC; 2022; 20 10.1186/s12967-022-03828-3
• Cytotoxicity and maternal toxicity attributed to exposure to Momordica charantia L. (Cucurbitaceae) dry leaf extract Cite
  Trautenmuller AL, de Almeida Soares J, Behm KC, Guimarães LMM, Xavier-Silva KR, Monteiro de Melo A, et al. Cytotoxicity and maternal toxicity attributed to exposure to Momordica charantia L. (Cucurbitaceae) dry leaf extract. Journal of Toxicology and Environmental Health, Part A. Informa UK Limited; 2022; 86:36-50 10.1080/15287394.2022.2157354
• Cucurbitacin B: A Review of its Pharmacology, Toxicity, and Pharmacokinetics Cite
  Dai S, Wang C, Zhao X, Ma C, Fu K, Liu Y, et al. Cucurbitacin B: A Review of its Pharmacology, Toxicity, and Pharmacokinetics. Pharmacological Research. Elsevier BV; 2022;:106587 10.1016/j.phrs.2022.106587
• Effect of cucurbitacin on malignant biological behavior of breast cancer cells, and its possible underlying mechanism Cite
  Ren Y, Huang G, Huang G, Xue Q, Lv Q, Wu Y, et al. Effect of cucurbitacin on malignant biological behavior of breast cancer cells, and its possible underlying mechanism. Tropical Journal of Pharmaceutical Research. African Journals Online (AJOL); 2022; 22:297-302 10.4314/tjpr.v22i2.12
• Identification of seven undescribed cucurbitacins in Cucumis sativus (cucumber) and their cytotoxic activity Cite
  Qing Z, Shi Y, Han L, Li P, Zha Z, Liu C, et al. Identification of seven undescribed cucurbitacins in Cucumis sativus (cucumber) and their cytotoxic activity. Phytochemistry. Elsevier BV; 2022; 197:113123 10.1016/j.phytochem.2022.113123
• Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer Cite
  Al-Bari MAA, Ito Y, Ahmed S, Radwan N, Ahmed HS, Eid N. Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer. International Journal of Molecular Sciences. MDPI AG; 2021; 22:9807 10.3390/ijms22189807
• Cucurbitacin I (JSI‐124)‐dependent inhibition of STAT3 permanently suppresses the pro‐carcinogenic effects of active breast cancer‐associated fibroblasts Cite
  Al‐Harbi B, Aboussekhra A. Cucurbitacin I (JSI‐124)‐dependent inhibition of STAT3 permanently suppresses the pro‐carcinogenic effects of active breast cancer‐associated fibroblasts. Molecular Carcinogenesis. Wiley; 2021; 10.1002/mc.23287
• Encapsulation of cucurbitacin B into lipid polymer hybrid nanocarriers induced apoptosis of MDAMB231 cells through PARP cleavage Cite
  Bakar-Ates F, Ozkan E, Sengel-Turk CT. Encapsulation of cucurbitacin B into lipid polymer hybrid nanocarriers induced apoptosis of MDAMB231 cells through PARP cleavage. International Journal of Pharmaceutics. Elsevier BV; 2020; 586:119565 10.1016/j.ijpharm.2020.119565
• Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells Cite
  Saeed ME, Boulos JC, Elhaboub G, Rigano D, Saab A, Loizzo MR, et al. Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells. Phytomedicine. Elsevier BV; 2019; 62:152945 10.1016/j.phymed.2019.152945
• Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells Cite
  Dittharot K, Dakeng S, Suebsakwong P, Suksamrarn A, Patmasiriwat P, Promkan M. Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells. Planta Medica. Georg Thieme Verlag KG; 2018; 85:370-378 10.1055/a-0791-1591
• Abstract 2934: Cucurbitacin D enhances the therapeutic efficacy of docetaxel via targeting cancer stem cells and miR-145 Cite
  Sikander M, Malik S, Hafeez BB, Mandil H, Halaweish FT, Jaggi M, et al. Abstract 2934: Cucurbitacin D enhances the therapeutic efficacy of docetaxel via targeting cancer stem cells and miR-145. Experimental and Molecular Therapeutics. American Association for Cancer Research; 2018; 10.1158/1538-7445.am2018-2934
• Cucurbitacin D exhibits its anti-cancer effect in human breast cancer cells by inhibiting Stat3 and Akt signaling Cite
  Ku JM, Hong SH, Kim HI, Lim YS, Lee SJ, Kim M, et al. Cucurbitacin D exhibits its anti-cancer effect in human breast cancer cells by inhibiting Stat3 and Akt signaling. European Journal of Inflammation. SAGE Publications; 2018; 16:1721727X1775180 10.1177/1721727x17751809
• Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells Cite
  LUO W, ZHAO W, LU J, WANG Y, CHEN X. Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells. Chinese Journal of Natural Medicines. Elsevier BV; 2018; 16:10-19 10.1016/s1875-5364(18)30025-6
• Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein Cite
  Lu J, Zhang Y, Sun M, Liu M, Wang X. Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein. Phytomedicine. Elsevier BV; 2017; 26:1-10 10.1016/j.phymed.2017.01.004
• Cucurbitacin B reverses multidrug resistance by targeting CIP2A to reactivate protein phosphatase 2A in MCF-7/Adriamycin cells Cite
  Cai F, Zhang L, Xiao X, Duan C, Huang Q, Fan C, et al. Cucurbitacin B reverses multidrug resistance by targeting CIP2A to reactivate protein phosphatase 2A in MCF-7/Adriamycin cells. Oncology Reports. Spandidos Publications; 2016; 36:1180-1186 10.3892/or.2016.4892
• Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis Cite
  Sinha S, Khan S, Shukla S, Lakra AD, Kumar S, Das G, et al. Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis. The International Journal of Biochemistry & Cell Biology. Elsevier BV; 2016; 77:41-56 10.1016/j.biocel.2016.05.014
• Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells Cite
  Ku JM, Kim SR, Hong SH, Choi H, Seo HS, Shin YC, et al. Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells. Molecular and Cellular Biochemistry. Springer Science and Business Media LLC; 2015; 409:33-43 10.1007/s11010-015-2509-9
• Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells Cite
  Ren G, Sha T, Guo J, Li W, Lu J, Chen X. Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells. Journal of Natural Medicines. Springer Science and Business Media LLC; 2015; 69:522-530 10.1007/s11418-015-0918-4
• Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery Cite
  Hall JA, Seedarala S, Rice N, Kopel L, Halaweish F, Blagg BSJ. Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery. Journal of Natural Products. American Chemical Society (ACS); 2015; 78:873-879 10.1021/acs.jnatprod.5b00054
• Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer Cite
  Kong Y, Chen J, Zhou Z, Xia H, Qiu M, Chen C. Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer. PLoS ONE. Public Library of Science (PLoS); 2014; 9:e103760 10.1371/journal.pone.0103760
• Abstract 286: Cucurbitacin B inhibits epithelial-to-mesenchymal transition in breast cancer cells through Snail downregulation. Cite
  Gupta P, Srivastava SK. Abstract 286: Cucurbitacin B inhibits epithelial-to-mesenchymal transition in breast cancer cells through Snail downregulation.. Cancer Research. American Association for Cancer Research (AACR); 2013; 73:286-286 10.1158/1538-7445.am2013-286
• The Effectiveness of Cucurbitacin B in BRCA1 Defective Breast Cancer Cells Cite
  Promkan M, Dakeng S, Chakrabarty S, Bögler O, Patmasiriwat P. The Effectiveness of Cucurbitacin B in BRCA1 Defective Breast Cancer Cells. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e55732 10.1371/journal.pone.0055732
• The Effectiveness of Cucurbitacin B in BRCA1 Defective Breast Cancer Cells Cite
  Promkan M, Dakeng S, Chakrabarty S, Bögler O, Patmasiriwat P. The Effectiveness of Cucurbitacin B in BRCA1 Defective Breast Cancer Cells. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e55732 10.1371/journal.pone.0055732
• The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer Cite
  Aribi A, Gery S, Lee DH, Thoennissen NH, Thoennissen GB, Alvarez R, et al. The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer. International Journal of Cancer. Wiley; 2012; 132:2730-2737 10.1002/ijc.27950
• Curcuminoids Block TGF-β Signaling in Human Breast Cancer Cells and Limit Osteolysis in a Murine Model of Breast Cancer Bone Metastasis Cite
  Wright LE, Frye JB, Lukefahr AL, Timmermann BN, Mohammad KS, Guise TA, et al. Curcuminoids Block TGF-β Signaling in Human Breast Cancer Cells and Limit Osteolysis in a Murine Model of Breast Cancer Bone Metastasis. Journal of Natural Products. American Chemical Society (ACS); 2012; 76:316-321 10.1021/np300663v
• Screening of biochemical modulator by tumor cell permeability of doxorubicin Cite
  Sadzuka Y, Hatakeyama H, Daimon T, Sonobe T. Screening of biochemical modulator by tumor cell permeability of doxorubicin. International Journal of Pharmaceutics. Elsevier BV; 2008; 354:63-69 10.1016/j.ijpharm.2007.10.015
• Cucurbitacin E inhibits breast tumor metastasis by suppressing cell migration and invasion Cite
  Zhang T, Li J, Dong Y, Zhai D, Lai L, Dai F, et al. Cucurbitacin E inhibits breast tumor metastasis by suppressing cell migration and invasion. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2012; 135:445-458 10.1007/s10549-012-2175-5
• Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest Cite
  Duangmano S, Sae-lim P, Suksamrarn A, Patmasiriwat P, Domann FE. Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest. Journal of Oncology. Wiley; 2012; 2012:1-8 10.1155/2012/601682
• Abstract 769: Effect of cucurbitacin B, a medicinal herb extract from Trichosanthes cucumerina on Wnt signaling pathway in breast cancer cells Cite
  Dakeng S, Duangmano S, Jiratchariyakul W, Bögler O, Patmasiriwat P. Abstract 769: Effect of cucurbitacin B, a medicinal herb extract from Trichosanthes cucumerina on Wnt signaling pathway in breast cancer cells. Cancer Research. American Association for Cancer Research (AACR); 2010; 70:769-769 10.1158/1538-7445.am10-769
• Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo Cite
  Wakimoto N, Yin D, O’Kelly J, Haritunians T, Karlan B, Said J, et al. Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo. Cancer Science. Wiley; 2008; 99:1793-1797 10.1111/j.1349-7006.2008.00899.x