Tag: cucurbitacins

Cucurbitacins: Bitter triterpene compounds found most frequently in plants of the Cucurbitaceae family (cucumbers, pumpkins). Cucurbitacin B, cucurbitacin D and Cucurbitacin E are the most common.

Articles

Supplements with warnings for breast cancer

Foods

- cucumbers
- melons
- pumpkins
- watermelon
- zucchini

Studies

Cucurbitacin: Unveiling its Role as Phytomolecule in Health Benefits Cite
Paul R, Nag S, Mondal S, Panigrahi N, Roy P, Sahoo SK, et al. Cucurbitacin: Unveiling its Role as Phytomolecule in Health Benefits. Current Bioactive Compounds. Bentham Science Publishers Ltd.; 2024; 20 10.2174/0115734072316509240530044415
Anti-Cancer Potency of Cucurbitacin D through PI3K and AKT1: A Molecular Docking Studies Cite
Suprahman NY, Al-Bari R, Putri RA, Saputra MY, Sarmoko . Anti-Cancer Potency of Cucurbitacin D through PI3K and AKT1: A Molecular Docking Studies. Advances in Biological Sciences Research. Atlantis Press International BV; 2024;:4-10 10.2991/978-94-6463-431-0_2
Synthetic Modifications of Therapeutically Relevant Pre-assembled Cucurbitacins: Synthetic Strategies and Structure-Activity Relationships Cite
Sharma R, Thakur S, Natish , Kumar M, Vamsi K, Jachak S, et al. Synthetic Modifications of Therapeutically Relevant Pre-assembled Cucurbitacins: Synthetic Strategies and Structure-Activity Relationships. Journal of Molecular Structure. Elsevier BV; 2024;:138321 10.1016/j.molstruc.2024.138321
CUCURBITACIN: A COMPREHENSION OF NATURE'S THERAPEUTIC BIOACTIVE COMPOUND Cite
Rashid M, Ahmad FJ, Alam S, Iqbal MA, Sindhu RK. CUCURBITACIN: A COMPREHENSION OF NATURE'S THERAPEUTIC BIOACTIVE COMPOUND. PLANT ARCHIVES. Research Floor; 2023; 23 10.51470/plantarchives.2023.v23.no2.034
Potential of cucurbitacin as an anticancer drug Cite
Li Y, Li Y, Yao Y, Li H, Gao C, Sun C, et al. Potential of cucurbitacin as an anticancer drug. Biomedicine & Pharmacotherapy. Elsevier BV; 2023; 168:115707 10.1016/j.biopha.2023.115707
Recent Advances in the Application of Cucurbitacins as Anticancer Agents Cite
Zieniuk B, Pawełkowicz M. Recent Advances in the Application of Cucurbitacins as Anticancer Agents. Metabolites. MDPI AG; 2023; 13:1081 10.3390/metabo13101081
Purified Cucurbitacin D leads to alterations of apoptotic and autophagic genes expression in MDA-MB-468 and MCF-7 human breast cancer cells Cite
Zeinali E, Zargar SJ, Mozdoori N. Purified Cucurbitacin D leads to alterations of apoptotic and autophagic genes expression in MDA-MB-468 and MCF-7 human breast cancer cells. Research Square Platform LLC; 2023; 10.21203/rs.3.rs-2920606/v1
Apoptotic and antimetastatic effect of cucurbitacins in cancer: recent trends and advancement Cite
Kumar A, Sharma B, Sharma U, Parashar G, Parashar NC, Rani I, et al. Apoptotic and antimetastatic effect of cucurbitacins in cancer: recent trends and advancement. Naunyn-Schmiedeberg's Archives of Pharmacology. Springer Science and Business Media LLC; 2023; 10.1007/s00210-023-02471-z
Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms Cite
Varela C, Melim C, Neves BG, Sharifi-Rad J, Calina D, Mamurova A, et al. Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms. Journal of Translational Medicine. Springer Science and Business Media LLC; 2022; 20 10.1186/s12967-022-03828-3
Cytotoxicity and maternal toxicity attributed to exposure to Momordica charantia L. (Cucurbitaceae) dry leaf extract Cite
Trautenmuller AL, de Almeida Soares J, Behm KC, Guimarães LMM, Xavier-Silva KR, Monteiro de Melo A, et al. Cytotoxicity and maternal toxicity attributed to exposure to Momordica charantia L. (Cucurbitaceae) dry leaf extract. Journal of Toxicology and Environmental Health, Part A. Informa UK Limited; 2022; 86:36-50 10.1080/15287394.2022.2157354
Cucurbitacin B: A Review of its Pharmacology, Toxicity, and Pharmacokinetics Cite
Dai S, Wang C, Zhao X, Ma C, Fu K, Liu Y, et al. Cucurbitacin B: A Review of its Pharmacology, Toxicity, and Pharmacokinetics. Pharmacological Research. Elsevier BV; 2022;:106587 10.1016/j.phrs.2022.106587
Effect of cucurbitacin on malignant biological behavior of breast cancer cells, and its possible underlying mechanism Cite
Ren Y, Huang G, Huang G, Xue Q, Lv Q, Wu Y, et al. Effect of cucurbitacin on malignant biological behavior of breast cancer cells, and its possible underlying mechanism. Tropical Journal of Pharmaceutical Research. African Journals Online (AJOL); 2022; 22:297-302 10.4314/tjpr.v22i2.12
Identification of seven undescribed cucurbitacins in Cucumis sativus (cucumber) and their cytotoxic activity Cite
Qing Z, Shi Y, Han L, Li P, Zha Z, Liu C, et al. Identification of seven undescribed cucurbitacins in Cucumis sativus (cucumber) and their cytotoxic activity. Phytochemistry. Elsevier BV; 2022; 197:113123 10.1016/j.phytochem.2022.113123
Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer Cite
Al-Bari MAA, Ito Y, Ahmed S, Radwan N, Ahmed HS, Eid N. Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer. International Journal of Molecular Sciences. MDPI AG; 2021; 22:9807 10.3390/ijms22189807
Cucurbitacin I (JSI‐124)‐dependent inhibition of STAT3 permanently suppresses the pro‐carcinogenic effects of active breast cancer‐associated fibroblasts Cite
Al‐Harbi B, Aboussekhra A. Cucurbitacin I (JSI‐124)‐dependent inhibition of STAT3 permanently suppresses the pro‐carcinogenic effects of active breast cancer‐associated fibroblasts. Molecular Carcinogenesis. Wiley; 2021; 10.1002/mc.23287
Encapsulation of cucurbitacin B into lipid polymer hybrid nanocarriers induced apoptosis of MDAMB231 cells through PARP cleavage Cite
Bakar-Ates F, Ozkan E, Sengel-Turk CT. Encapsulation of cucurbitacin B into lipid polymer hybrid nanocarriers induced apoptosis of MDAMB231 cells through PARP cleavage. International Journal of Pharmaceutics. Elsevier BV; 2020; 586:119565 10.1016/j.ijpharm.2020.119565
Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells Cite
Saeed ME, Boulos JC, Elhaboub G, Rigano D, Saab A, Loizzo MR, et al. Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells. Phytomedicine. Elsevier BV; 2019; 62:152945 10.1016/j.phymed.2019.152945
Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells Cite
Dittharot K, Dakeng S, Suebsakwong P, Suksamrarn A, Patmasiriwat P, Promkan M. Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells. Planta Medica. Georg Thieme Verlag KG; 2018; 85:370-378 10.1055/a-0791-1591
Abstract 2934: Cucurbitacin D enhances the therapeutic efficacy of docetaxel via targeting cancer stem cells and miR-145 Cite
Sikander M, Malik S, Hafeez BB, Mandil H, Halaweish FT, Jaggi M, et al. Abstract 2934: Cucurbitacin D enhances the therapeutic efficacy of docetaxel via targeting cancer stem cells and miR-145. Experimental and Molecular Therapeutics. American Association for Cancer Research; 2018; 10.1158/1538-7445.am2018-2934
Cucurbitacin D exhibits its anti-cancer effect in human breast cancer cells by inhibiting Stat3 and Akt signaling Cite
Ku JM, Hong SH, Kim HI, Lim YS, Lee SJ, Kim M, et al. Cucurbitacin D exhibits its anti-cancer effect in human breast cancer cells by inhibiting Stat3 and Akt signaling. European Journal of Inflammation. SAGE Publications; 2018; 16:1721727X1775180 10.1177/1721727x17751809
Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells Cite
LUO W, ZHAO W, LU J, WANG Y, CHEN X. Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells. Chinese Journal of Natural Medicines. Elsevier BV; 2018; 16:10-19 10.1016/s1875-5364(18)30025-6
Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein Cite
Lu J, Zhang Y, Sun M, Liu M, Wang X. Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein. Phytomedicine. Elsevier BV; 2017; 26:1-10 10.1016/j.phymed.2017.01.004
Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis Cite
Sinha S, Khan S, Shukla S, Lakra AD, Kumar S, Das G, et al. Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis. The International Journal of Biochemistry & Cell Biology. Elsevier BV; 2016; 77:41-56 10.1016/j.biocel.2016.05.014
Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells Cite
Ku JM, Kim SR, Hong SH, Choi H, Seo HS, Shin YC, et al. Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells. Molecular and Cellular Biochemistry. Springer Science and Business Media LLC; 2015; 409:33-43 10.1007/s11010-015-2509-9
Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells Cite
Ren G, Sha T, Guo J, Li W, Lu J, Chen X. Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells. Journal of Natural Medicines. Springer Science and Business Media LLC; 2015; 69:522-530 10.1007/s11418-015-0918-4
Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery Cite
Hall JA, Seedarala S, Rice N, Kopel L, Halaweish F, Blagg BSJ. Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery. Journal of Natural Products. American Chemical Society (ACS); 2015; 78:873-879 10.1021/acs.jnatprod.5b00054
Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer Cite
Kong Y, Chen J, Zhou Z, Xia H, Qiu M, Chen C. Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer. PLoS ONE. Public Library of Science (PLoS); 2014; 9:e103760 10.1371/journal.pone.0103760
Abstract 286: Cucurbitacin B inhibits epithelial-to-mesenchymal transition in breast cancer cells through Snail downregulation. Cite
Gupta P, Srivastava SK. Abstract 286: Cucurbitacin B inhibits epithelial-to-mesenchymal transition in breast cancer cells through Snail downregulation.. Cancer Research. American Association for Cancer Research (AACR); 2013; 73:286-286 10.1158/1538-7445.am2013-286
The Effectiveness of Cucurbitacin B in BRCA1 Defective Breast Cancer Cells Cite
Promkan M, Dakeng S, Chakrabarty S, Bögler O, Patmasiriwat P. The Effectiveness of Cucurbitacin B in BRCA1 Defective Breast Cancer Cells. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e55732 10.1371/journal.pone.0055732
The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer Cite
Aribi A, Gery S, Lee DH, Thoennissen NH, Thoennissen GB, Alvarez R, et al. The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer. International Journal of Cancer. Wiley; 2012; 132:2730-2737 10.1002/ijc.27950
Curcuminoids Block TGF-β Signaling in Human Breast Cancer Cells and Limit Osteolysis in a Murine Model of Breast Cancer Bone Metastasis Cite
Wright LE, Frye JB, Lukefahr AL, Timmermann BN, Mohammad KS, Guise TA, et al. Curcuminoids Block TGF-β Signaling in Human Breast Cancer Cells and Limit Osteolysis in a Murine Model of Breast Cancer Bone Metastasis. Journal of Natural Products. American Chemical Society (ACS); 2012; 76:316-321 10.1021/np300663v
Screening of biochemical modulator by tumor cell permeability of doxorubicin Cite
Sadzuka Y, Hatakeyama H, Daimon T, Sonobe T. Screening of biochemical modulator by tumor cell permeability of doxorubicin. International Journal of Pharmaceutics. Elsevier BV; 2008; 354:63-69 10.1016/j.ijpharm.2007.10.015
Cucurbitacin E inhibits breast tumor metastasis by suppressing cell migration and invasion Cite
Zhang T, Li J, Dong Y, Zhai D, Lai L, Dai F, et al. Cucurbitacin E inhibits breast tumor metastasis by suppressing cell migration and invasion. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2012; 135:445-458 10.1007/s10549-012-2175-5
Abstract 769: Effect of cucurbitacin B, a medicinal herb extract from Trichosanthes cucumerina on Wnt signaling pathway in breast cancer cells Cite
Dakeng S, Duangmano S, Jiratchariyakul W, Bögler O, Patmasiriwat P. Abstract 769: Effect of cucurbitacin B, a medicinal herb extract from Trichosanthes cucumerina on Wnt signaling pathway in breast cancer cells. Cancer Research. American Association for Cancer Research (AACR); 2010; 70:769-769 10.1158/1538-7445.am10-769
Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo Cite
Wakimoto N, Yin D, O’Kelly J, Haritunians T, Karlan B, Said J, et al. Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo. Cancer Science. Wiley; 2008; 99:1793-1797 10.1111/j.1349-7006.2008.00899.x