Tag: cucurbitacins

Cucurbitacins: Bitter triterpene compounds found most frequently in plants of the Cucurbitaceae family (cucumbers, pumpkins). Cucurbitacin B, cucurbitacin D and Cucurbitacin E are the most common.

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02/25/18
Cucumber compound exhibits anti-cancer activities in ER+, HER2+ and triple negative cells

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  • Vegetables from the Cucurbitaceae family and their products: Positive effect on human health Cite
    Rolnik A, Olas B. Vegetables from the Cucurbitaceae family and their products: Positive effect on human health. Nutrition. Elsevier BV; 2020; 78:110788 10.1016/j.nut.2020.110788
  • Encapsulation of cucurbitacin B into lipid polymer hybrid nanocarriers induced apoptosis of MDAMB231 cells through PARP cleavage Cite
    Bakar-Ates F, Ozkan E, Sengel-Turk CT. Encapsulation of cucurbitacin B into lipid polymer hybrid nanocarriers induced apoptosis of MDAMB231 cells through PARP cleavage. International Journal of Pharmaceutics. Elsevier BV; 2020; 586:119565 10.1016/j.ijpharm.2020.119565
  • Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells Cite
    Saeed ME, Boulos JC, Elhaboub G, Rigano D, Saab A, Loizzo MR, et al. Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells. Phytomedicine. Elsevier BV; 2019; 62:152945 10.1016/j.phymed.2019.152945
  • Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells Cite
    Dittharot K, Dakeng S, Suebsakwong P, Suksamrarn A, Patmasiriwat P, Promkan M. Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells. Planta Medica. Georg Thieme Verlag KG; 2018; 85:370-378 10.1055/a-0791-1591
  • Abstract 2934: Cucurbitacin D enhances the therapeutic efficacy of docetaxel via targeting cancer stem cells and miR-145 Cite
    Sikander M, Malik S, Hafeez BB, Mandil H, Halaweish FT, Jaggi M, et al. Abstract 2934: Cucurbitacin D enhances the therapeutic efficacy of docetaxel via targeting cancer stem cells and miR-145. Experimental and Molecular Therapeutics. American Association for Cancer Research; 2018; 10.1158/1538-7445.am2018-2934
  • Bioactive profile of pumpkin: an overview on terpenoids and their health-promoting properties Cite
    Montesano D, Rocchetti G, Putnik P, Lucini L. Bioactive profile of pumpkin: an overview on terpenoids and their health-promoting properties. Current Opinion in Food Science. Elsevier BV; 2018; 22:81-87 10.1016/j.cofs.2018.02.003
  • Cucurbitacin D exhibits its anti-cancer effect in human breast cancer cells by inhibiting Stat3 and Akt signaling Cite
    Ku JM, Hong SH, Kim HI, Lim YS, Lee SJ, Kim M, et al. Cucurbitacin D exhibits its anti-cancer effect in human breast cancer cells by inhibiting Stat3 and Akt signaling. European Journal of Inflammation. SAGE Publications; 2018; 16:1721727X1775180 10.1177/1721727x17751809
  • Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells Cite
    LUO W, ZHAO W, LU J, WANG Y, CHEN X. Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells. Chinese Journal of Natural Medicines. Elsevier BV; 2018; 16:10-19 10.1016/s1875-5364(18)30025-6
  • Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein Cite
    Lu J, Zhang Y, Sun M, Liu M, Wang X. Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein. Phytomedicine. Elsevier BV; 2017; 26:1-10 10.1016/j.phymed.2017.01.004
  • Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis Cite
    Sinha S, Khan S, Shukla S, Lakra AD, Kumar S, Das G, et al. Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis. The International Journal of Biochemistry & Cell Biology. Elsevier BV; 2016; 77:41-56 10.1016/j.biocel.2016.05.014
  • Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells Cite
    Ku JM, Kim SR, Hong SH, Choi H, Seo HS, Shin YC, et al. Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells. Molecular and Cellular Biochemistry. Springer Science and Business Media LLC; 2015; 409:33-43 10.1007/s11010-015-2509-9
  • Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells Cite
    Ren G, Sha T, Guo J, Li W, Lu J, Chen X. Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells. Journal of Natural Medicines. Springer Science and Business Media LLC; 2015; 69:522-530 10.1007/s11418-015-0918-4
  • Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery Cite
    Hall JA, Seedarala S, Rice N, Kopel L, Halaweish F, Blagg BSJ. Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery. Journal of Natural Products. American Chemical Society (ACS); 2015; 78:873-879 10.1021/acs.jnatprod.5b00054
  • Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer Cite
    Kong Y, Chen J, Zhou Z, Xia H, Qiu M, Chen C. Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer. PLoS ONE. Public Library of Science (PLoS); 2014; 9:e103760 10.1371/journal.pone.0103760
  • The Effectiveness of Cucurbitacin B in BRCA1 Defective Breast Cancer Cells Cite
    Promkan M, Dakeng S, Chakrabarty S, Bögler O, Patmasiriwat P. The Effectiveness of Cucurbitacin B in BRCA1 Defective Breast Cancer Cells. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e55732 10.1371/journal.pone.0055732
  • The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer Cite
    Aribi A, Gery S, Lee DH, Thoennissen NH, Thoennissen GB, Alvarez R, et al. The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer. International Journal of Cancer. Wiley; 2012; 132:2730-2737 10.1002/ijc.27950
  • Screening of biochemical modulator by tumor cell permeability of doxorubicin Cite
    Sadzuka Y, Hatakeyama H, Daimon T, Sonobe T. Screening of biochemical modulator by tumor cell permeability of doxorubicin. International Journal of Pharmaceutics. Elsevier BV; 2008; 354:63-69 10.1016/j.ijpharm.2007.10.015