Tag: crocin

News

04/01/17

Saffron carotenoid crocin inhibits breast cancer cell division

Foods

• • saffron

Studies

• Inhibitory effects of crocin on breast cancer cell proliferation and apoptosis: Mediation via downregulation of ERα and suppression of p38 MAPK/Akt signaling pathways Cite
  Jiang X, Jia Y, Zhang B, Yang k, Yang L, Li Y. Inhibitory effects of crocin on breast cancer cell proliferation and apoptosis: Mediation via downregulation of ERα and suppression of p38 MAPK/Akt signaling pathways. Springer Science and Business Media LLC; 2025; 10.21203/rs.3.rs-6338876/v1
• Carotenoids Modulate FoxO‐Induced Cell Cycle Arrest in Human Cancer Cell Lines: A Scoping Review Cite
  Lee ZX, Guo H, Looi AD, Bhuvanendran S, Magalingam KB, Lee WL, et al. Carotenoids Modulate FoxO‐Induced Cell Cycle Arrest in Human Cancer Cell Lines: A Scoping Review. Food Science & Nutrition. Wiley; 2025; 13 10.1002/fsn3.70100
• Cardioprotective effect of crocin in patients with breast cancer receiving anthracycline-based chemotherapy: A randomized, double-blind, placebo-controlled study Cite
  Li X, Su X, Liang W, Wang L, Yuan C, Xu J, et al. Cardioprotective effect of crocin in patients with breast cancer receiving anthracycline-based chemotherapy: A randomized, double-blind, placebo-controlled study. Pharmacological Research. Elsevier BV; 2025; 213:107630 10.1016/j.phrs.2025.107630
• The Antitumour Mechanisms of Carotenoids: A Comprehensive Review Cite
  Baeza-Morales A, Medina-García M, Martínez-Peinado P, Pascual-García S, Pujalte-Satorre C, López-Jaén AB, et al. The Antitumour Mechanisms of Carotenoids: A Comprehensive Review. Antioxidants. MDPI AG; 2024; 13:1060 10.3390/antiox13091060
• Crocin Induces Apoptosis in Primary Cancer Epithelial Cells Isolated from Human Breast Tumors via Different Mechanisms in HER2- Negative or Positive Cells: A Preliminary Study Cite
  Bathaie SZ, Faridi N, Hydrazideh H, Hashemi SA, Abroun S, Tamanoi F, et al. Crocin Induces Apoptosis in Primary Cancer Epithelial Cells Isolated from Human Breast Tumors via Different Mechanisms in HER2- Negative or Positive Cells: A Preliminary Study. Springer Science and Business Media LLC; 2024; 10.21203/rs.3.rs-4711052/v1
• Folic acid-modified nanocrystalline cellulose for enhanced delivery and anti-cancer effects of crocin Cite
  Soltani M, Farhadi A, Rajabi S, Homayouni‐Tabrizi M, Hussein FS, Mohammadian N. Folic acid-modified nanocrystalline cellulose for enhanced delivery and anti-cancer effects of crocin. Scientific Reports. Springer Science and Business Media LLC; 2024; 14 10.1038/s41598-024-64758-2
• Exploring the therapeutic efficacy of crocetin in oncology: an evidence-based review Cite
  Koch W, Wawruszak A, Kukula-Koch W, Zdziebło M, Helon P, Almarhoon ZM, et al. Exploring the therapeutic efficacy of crocetin in oncology: an evidence-based review. Naunyn-Schmiedeberg's Archives of Pharmacology. Springer Science and Business Media LLC; 2023; 10.1007/s00210-023-02714-z
• Advances on the anti-tumor mechanisms of the carotenoid Crocin Cite
  Bao X, Hu J, Zhao Y, Jia R, Zhang H, Xia L. Advances on the anti-tumor mechanisms of the carotenoid Crocin. PeerJ. PeerJ; 2023; 11:e15535 10.7717/peerj.15535
• Crocin-loaded liposomes sensitize MDA-MB 231 breast cancer cells to doxorubicin by inducing apoptosis Cite
  Chavoshi H, Taheri M, Wan MLY, Sabzichi M. Crocin-loaded liposomes sensitize MDA-MB 231 breast cancer cells to doxorubicin by inducing apoptosis. Process Biochemistry. Elsevier BV; 2023; 10.1016/j.procbio.2023.04.012
• Crocin suppresses breast cancer cell proliferation by down‐regulating tumor promoter miR-122-5p and up‐regulating tumor suppressors FOXP2 and SPRY2 Cite
  Jia Y, Yang H, Yu J, Li Z, Jia G, Ding B, et al. Crocin suppresses breast cancer cell proliferation by down‐regulating tumor promoter miR-122-5p and up‐regulating tumor suppressors FOXP2 and SPRY2. Environmental Toxicology. Wiley; 2023; 10.1002/tox.23789
• Crocin Inhibit the Metastasis of MDA-MB-231 cell line by Suppressing Epithelial to Mesenchymal Transition through WNT/β-catenin Signaling Pathway Cite
  Dariushnejad H, ALJAF KAH, Wasman HM, Pirzeh L, Ghorbanzadeh V. Crocin Inhibit the Metastasis of MDA-MB-231 cell line by Suppressing Epithelial to Mesenchymal Transition through WNT/β-catenin Signaling Pathway. Research Square Platform LLC; 2022; 10.21203/rs.3.rs-1539821/v1
• 188P Amelioration of anxiety, depression, and chemotherapy related toxicity after crocin administration during chemotherapy of breast cancer: A double blind, randomized clinical trial Cite
  Javadinia S, Salek R, Dehghani M, Mohajeri S, Talaei A, Fanipakdel A. 188P Amelioration of anxiety, depression, and chemotherapy related toxicity after crocin administration during chemotherapy of breast cancer: A double blind, randomized clinical trial. Annals of Oncology. Elsevier BV; 2021; 32:S439-S440 10.1016/j.annonc.2021.08.469
• Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis Cite
  Maroni P, Bendinelli P, Fulgenzi A, Ferraretto A. Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis. Biomolecules. MDPI AG; 2021; 11:1336 10.3390/biom11091336
• Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats Cite
  Abdulkareem Aljumaily SA, Demir M, Elbe H, Yigitturk G, Bicer Y, Altinoz E. Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats. Environmental Science and Pollution Research. Springer Science and Business Media LLC; 2021; 10.1007/s11356-021-15409-w
• Antioxidant, anti-inflammatory and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats Cite
  ALJUMAILY SAA, Demir M, Elbe H, Yigitturk G, Bicer Y, Altinoz E. Antioxidant, anti-inflammatory and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats. Research Square Platform LLC; 2021; 10.21203/rs.3.rs-418902/v1
• Crocin and Metformin suppress metastatic breast cancer progression via VEGF and MMP9 downregulations: in vitro and in vivo studies Cite
  Farahi A, Abedini MR, Javdani H, Arzi L, Chamani E, Farhoudi R, et al. Crocin and Metformin suppress metastatic breast cancer progression via VEGF and MMP9 downregulations: in vitro and in vivo studies. Molecular and Cellular Biochemistry. Springer Science and Business Media LLC; 2021; 10.1007/s11010-020-04043-8
• Saffron anti-metastatic properties, ancient spice novel application Cite
  Arzi L, Hoshyar R. Saffron anti-metastatic properties, ancient spice novel application. null. Taylor & Francis; 2021;:1-12. 10.1080/10408398.2020.1871320
• Antioxidant and Anti-Inflammatory Effects of Crocin Ameliorate Doxorubicin-Induced Nephrotoxicity in Rats Cite
  Hussain MA, Abogresha NM, AbdelKader G, Hassan R, Abdelaziz EZ, Greish SM. Antioxidant and Anti-Inflammatory Effects of Crocin Ameliorate Doxorubicin-Induced Nephrotoxicity in Rats. Oxidative Medicine and Cellular Longevity. Hindawi Limited; 2021; 2021:1-12 10.1155/2021/8841726
• Evaluation of anti-tumor effects of crocin on a novel 3D tissue-engineered tumor model based on sodium alginate/gelatin microbead Cite
  Zhu J, Zheng S, Liu H, Wang Y, Jiao Z, Nie Y, et al. Evaluation of anti-tumor effects of crocin on a novel 3D tissue-engineered tumor model based on sodium alginate/gelatin microbead. International Journal of Biological Macromolecules. Elsevier BV; 2021; 174:339-351 10.1016/j.ijbiomac.2021.01.181
• Recent Advances on the Anticancer Properties of Saffron (Crocus sativus L.) and Its Major Constituents Cite
  Lambrianidou A, Koutsougianni F, Papapostolou I, Dimas K. Recent Advances on the Anticancer Properties of Saffron (Crocus sativus L.) and Its Major Constituents. Molecules. MDPI AG; 2020; 26:86 10.3390/molecules26010086
• Doxorubicin and Crocin Co-delivery by Polymeric Nanoparticles for Enhanced Anticancer Potential In Vitro and In Vivo Cite
  Khan I, Joshi G, Sarkar B, Nakhate KT, Ajazuddin , Mantha AK, et al. Doxorubicin and Crocin Co-delivery by Polymeric Nanoparticles for Enhanced Anticancer Potential In Vitro and In Vivo. ACS Applied Bio Materials. American Chemical Society (ACS); 2020; 3:7789-7799 10.1021/acsabm.0c00974
• Crocin protects against cardiotoxicity induced by doxorubicin through TLR-2/NF-κB signal pathway in vivo and vitro Cite
  Chu X, Zhang Y, Xue Y, Li Z, Shi J, Wang H, et al. Crocin protects against cardiotoxicity induced by doxorubicin through TLR-2/NF-κB signal pathway in vivo and vitro. International Immunopharmacology. Elsevier BV; 2020; 84:106548 10.1016/j.intimp.2020.106548
• Saffron carotenoids change the superoxide dismutase activity in breast cancer: In vitro, in vivo and in silico studies Cite
  Hashemi SA, Karami M, Bathaie SZ. Saffron carotenoids change the superoxide dismutase activity in breast cancer: In vitro, in vivo and in silico studies. International Journal of Biological Macromolecules. Elsevier BV; 2020; 158:845-853 10.1016/j.ijbiomac.2020.04.063
• Anti-metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer Cite
  Arzi L, Hoshyar R, Jafarzadeh N, Riazi G, Sadeghizadeh M. Anti-metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer. Life Sciences. Elsevier BV; 2020; 243:117245 10.1016/j.lfs.2019.117245
• Antiangiogenic effect of crocin on breast cancer cell MDA-MB-231 Cite
  Chen S, Gu Y, Lu F, Qian D, Dong T, Ding Z, et al. Antiangiogenic effect of crocin on breast cancer cell MDA-MB-231. Journal of Thoracic Disease. AME Publishing Company; 2019; 11:4464-4473 10.21037/jtd.2019.11.18
• Role of crocin in several cancer cell lines: An updated review Cite
  Veisi A, Akbari G, Mard A, Badfar G, Zarezade V, Mirshekar MA. Role of crocin in several cancer cell lines: An updated review. Iranian Journal of Basic Medical Sciences. Mashhad University of Medical Sciences; 2020; 23 10.22038/ijbms.2019.37821.8995
• Crocin, a carotenoid, suppresses spindle microtubule dynamics and activates the mitotic checkpoint by binding to tubulin Cite
  Sawant AV, Srivastava S, Prassanawar SS, Bhattacharyya B, Panda D. Crocin, a carotenoid, suppresses spindle microtubule dynamics and activates the mitotic checkpoint by binding to tubulin. Biochemical Pharmacology. Elsevier BV; 2019; 163:32-45 10.1016/j.bcp.2019.01.023
• Inhibitory Effect of Crocin on Metastasis of Triple-Negative Breast Cancer by Interfering with Wnt/β-Catenin Pathway in Murine Model Cite
  Arzi L, Farahi A, Jafarzadeh N, Riazi G, Sadeghizadeh M, Hoshyar R. Inhibitory Effect of Crocin on Metastasis of Triple-Negative Breast Cancer by Interfering with Wnt/β-Catenin Pathway in Murine Model. DNA and Cell Biology. Mary Ann Liebert Inc; 2018; 37:1068-1075 10.1089/dna.2018.4351
• A Comparative Study on Anti-Invasion, Antimigration, and Antiadhesion Effects of the Bioactive Carotenoids of Saffron on 4T1 Breast Cancer Cells Through Their Effects on Wnt/β-Catenin Pathway Genes Cite
  Arzi L, Riazi G, Sadeghizadeh M, Hoshyar R, Jafarzadeh N. A Comparative Study on Anti-Invasion, Antimigration, and Antiadhesion Effects of the Bioactive Carotenoids of Saffron on 4T1 Breast Cancer Cells Through Their Effects on Wnt/β-Catenin Pathway Genes. DNA and Cell Biology. Mary Ann Liebert Inc; 2018; 37:697-707 10.1089/dna.2018.4248
• Antiproliferative Activity of Crocin Involves Targeting of Microtubules in Breast Cancer Cells Cite
  Hire RR, Srivastava S, Davis MB, Kumar Konreddy A, Panda D. Antiproliferative Activity of Crocin Involves Targeting of Microtubules in Breast Cancer Cells. Scientific Reports. Springer Science and Business Media LLC; 2017; 7 10.1038/srep44984
• Crocin Suppresses Constitutively Active STAT3 Through Induction of Protein Tyrosine Phosphatase SHP-1 Cite
  Kim B, Lee KY, Park B. Crocin Suppresses Constitutively Active STAT3 Through Induction of Protein Tyrosine Phosphatase SHP-1. Journal of Cellular Biochemistry. Wiley; 2017; 118:3290-3298 10.1002/jcb.25980
• Comparative study on preventive effect of saffron carotenoids, crocin and crocetin, in NMU-induced breast cancer in rat Cite
  Bathaie S, Sajjadi M. Comparative study on preventive effect of saffron carotenoids, crocin and crocetin, in NMU-induced breast cancer in rat. Cell J (Yakhteh). Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR); 2017; 19 10.22074/cellj.2016.3901
• Effect of crocin and doxorubicin / radiation on the breast cancer cell line, Michigan Cancer Foundation-7 Cite
  Fanayi AR, Changizi V, Safa M. Effect of crocin and doxorubicin / radiation on the breast cancer cell line, Michigan Cancer Foundation-7. Bioscience Biotechnology Research Communications. Society for Science and Nature; 2016; 9:428-434 10.21786/bbrc/9.3/13
• Neuroprotective Activities of Saffron and Crocin Cite
  Soeda S, Aritake K, Urade Y, Sato H, Shoyama Y. Neuroprotective Activities of Saffron and Crocin. Advances in Neurobiology. Springer International Publishing; 2016;:275-292 10.1007/978-3-319-28383-8_14
• Crocin treatment prevents doxorubicin-induced cardiotoxicity in rats Cite
  Razmaraii N, Babaei H, Mohajjel Nayebi A, Assadnassab G, Ashrafi Helan J, Azarmi Y. Crocin treatment prevents doxorubicin-induced cardiotoxicity in rats. Life Sciences. Elsevier BV; 2016; 157:145-151 10.1016/j.lfs.2016.06.012
• Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation Cite
  Bakshi HA, Hakkim FL, Sam S. Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation. Asian Pacific Journal of Cancer Prevention. Asian Pacific Organization for Cancer Prevention; 2016; 17:1499-1506 10.7314/apjcp.2016.17.3.1499
• Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters Cite
  Eid SY, El-Readi MZ, Wink M. Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. Elsevier BV; 2012; 19:977-987 10.1016/j.phymed.2012.05.010
• The toxicity of saffron (Crocus sativus L.) and its constituents against normal and cancer cells Cite
  Milajerdi A, Djafarian K, Hosseini B. The toxicity of saffron (Crocus sativus L.) and its constituents against normal and cancer cells. Journal of Nutrition & Intermediary Metabolism. Elsevier BV; 2016; 3:23-32 10.1016/j.jnim.2015.12.332
• Synergistic Apoptotic Effect of Crocin and Paclitaxel or Crocin and Radiation on MCF-7 Cells, a Type of Breast Cancer Cell Line Cite
  Vali F, Changizi V, Safa M. Synergistic Apoptotic Effect of Crocin and Paclitaxel or Crocin and Radiation on MCF-7 Cells, a Type of Breast Cancer Cell Line. International Journal of Breast Cancer. Hindawi Limited; 2015; 2015:1-7 10.1155/2015/139349
• Effect of Crocin on Cell Cycle Regulators in N-Nitroso-N-Methylurea-Induced Breast Cancer in Rats Cite
  Ashrafi M, Bathaie SZ, Abroun S, Azizian M. Effect of Crocin on Cell Cycle Regulators in N-Nitroso-N-Methylurea-Induced Breast Cancer in Rats. DNA and Cell Biology. Mary Ann Liebert Inc; 2015; 34:684-691 10.1089/dna.2015.2951
• Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol Cite
  Zeka K, Ruparelia KC, Continenza MA, Stagos D, Vegliò F, Arroo RR. Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol. Fitoterapia. Elsevier BV; 2015; 107:128-134 10.1016/j.fitote.2015.05.014
• Crocus sativus L. (saffron) for cancer chemoprevention: A mini review Cite
  Bhandari PR. Crocus sativus L. (saffron) for cancer chemoprevention: A mini review. Journal of Traditional and Complementary Medicine. Elsevier BV; 2015; 5:81-87 10.1016/j.jtcme.2014.10.009
• Saffron and natural carotenoids: Biochemical activities and anti-tumor effects Cite
  Bolhassani A, Khavari A, Bathaie SZ. Saffron and natural carotenoids: Biochemical activities and anti-tumor effects. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. Elsevier BV; 2014; 1845:20-30 10.1016/j.bbcan.2013.11.001