Tag: crocin

News

04/01/17

Saffron carotenoid crocin inhibits breast cancer cell division

Studies

• Crocin molecular signaling pathways at a glance: A comprehensive review Cite
  Boozari M, Hosseinzadeh H. Crocin molecular signaling pathways at a glance: A comprehensive review. Phytotherapy Research. Wiley; 2022; 10.1002/ptr.7583
• An evaluation on potential anti-oxidant and anti-inflammatory effects of Crocin Cite
  Bastani S, Vahedian V, Rashidi M, Mir A, Mirzaei S, Alipourfard I, et al. An evaluation on potential anti-oxidant and anti-inflammatory effects of Crocin. Biomedicine & Pharmacotherapy. Elsevier BV; 2022; 153:113297 10.1016/j.biopha.2022.113297
• Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ Cite
  Xu Q, Yu J, Jia G, Li Z, Xiong H. Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ. Cytokine. Elsevier BV; 2022; 154:155888 10.1016/j.cyto.2022.155888
• Crocin Inhibit the Metastasis of MDA-MB-231 cell line by Suppressing Epithelial to Mesenchymal Transition through WNT/β-catenin Signaling Pathway Cite
  Dariushnejad H, ALJAF KAH, Wasman HM, Pirzeh L, Ghorbanzadeh V. Crocin Inhibit the Metastasis of MDA-MB-231 cell line by Suppressing Epithelial to Mesenchymal Transition through WNT/β-catenin Signaling Pathway. Research Square Platform LLC; 2022; 10.21203/rs.3.rs-1539821/v1
• Crocetin Alleviates Ovariectomy-Induced Metabolic Dysfunction through Regulating Estrogen Receptor β Cite
  Liu X, Wang Z, Song X, Chang X, Zu E, Ma X, et al. Crocetin Alleviates Ovariectomy-Induced Metabolic Dysfunction through Regulating Estrogen Receptor β. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2021; 10.1021/acs.jafc.1c04570
• 188P Amelioration of anxiety, depression, and chemotherapy related toxicity after crocin administration during chemotherapy of breast cancer: A double blind, randomized clinical trial Cite
  Javadinia S, Salek R, Dehghani M, Mohajeri S, Talaei A, Fanipakdel A. 188P Amelioration of anxiety, depression, and chemotherapy related toxicity after crocin administration during chemotherapy of breast cancer: A double blind, randomized clinical trial. Annals of Oncology. Elsevier BV; 2021; 32:S439-S440 10.1016/j.annonc.2021.08.469
• Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis Cite
  Maroni P, Bendinelli P, Fulgenzi A, Ferraretto A. Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis. Biomolecules. MDPI AG; 2021; 11:1336 10.3390/biom11091336
• Effectiveness of crocin of saffron (Crocus sativus L.) against chemotherapy-induced peripheral neuropathy: A randomized, double-blind, placebo-controlled clinical trial Cite
  Bozorgi H, Ghahremanfard F, Motaghi E, Zamaemifard M, Zamani M, Izadi A. Effectiveness of crocin of saffron (Crocus sativus L.) against chemotherapy-induced peripheral neuropathy: A randomized, double-blind, placebo-controlled clinical trial. Journal of Ethnopharmacology. Elsevier BV; 2021; 281:114511 10.1016/j.jep.2021.114511
• Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats Cite
  Abdulkareem Aljumaily SA, Demir M, Elbe H, Yigitturk G, Bicer Y, Altinoz E. Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats. Environmental Science and Pollution Research. Springer Science and Business Media LLC; 2021; 10.1007/s11356-021-15409-w
• Crocins: A comprehensive review of structural characteristics, pharmacokinetics and therapeutic effects Cite
  Song Y, Wang Y, Zheng Y, Liu T, Zhang C. Crocins: A comprehensive review of structural characteristics, pharmacokinetics and therapeutic effects. Fitoterapia. Elsevier BV; 2021;:104969 10.1016/j.fitote.2021.104969
• Antioxidant, anti-inflammatory and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats Cite
  ALJUMAILY SAA, Demir M, Elbe H, Yigitturk G, Bicer Y, Altinoz E. Antioxidant, anti-inflammatory and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats. Research Square Platform LLC; 2021; 10.21203/rs.3.rs-418902/v1
• Crocin and Metformin suppress metastatic breast cancer progression via VEGF and MMP9 downregulations: in vitro and in vivo studies Cite
  Farahi A, Abedini MR, Javdani H, Arzi L, Chamani E, Farhoudi R, et al. Crocin and Metformin suppress metastatic breast cancer progression via VEGF and MMP9 downregulations: in vitro and in vivo studies. Molecular and Cellular Biochemistry. Springer Science and Business Media LLC; 2021; 10.1007/s11010-020-04043-8
• Saffron anti-metastatic properties, ancient spice novel application Cite
  Arzi L, Hoshyar R. Saffron anti-metastatic properties, ancient spice novel application. null. Taylor & Francis; 2021;:1-12. 10.1080/10408398.2020.1871320
• Antioxidant and Anti-Inflammatory Effects of Crocin Ameliorate Doxorubicin-Induced Nephrotoxicity in Rats Cite
  Hussain MA, Abogresha NM, AbdelKader G, Hassan R, Abdelaziz EZ, Greish SM. Antioxidant and Anti-Inflammatory Effects of Crocin Ameliorate Doxorubicin-Induced Nephrotoxicity in Rats. Oxidative Medicine and Cellular Longevity. Hindawi Limited; 2021; 2021:1-12 10.1155/2021/8841726
• Evaluation of anti-tumor effects of crocin on a novel 3D tissue-engineered tumor model based on sodium alginate/gelatin microbead Cite
  Zhu J, Zheng S, Liu H, Wang Y, Jiao Z, Nie Y, et al. Evaluation of anti-tumor effects of crocin on a novel 3D tissue-engineered tumor model based on sodium alginate/gelatin microbead. International Journal of Biological Macromolecules. Elsevier BV; 2021; 174:339-351 10.1016/j.ijbiomac.2021.01.181
• Saffron bioactives crocin, crocetin and safranal: effect on oxidative stress and mechanisms of action Cite
  Cerdá-Bernad D, Valero-Cases E, Pastor J, Frutos MJ. Saffron bioactives crocin, crocetin and safranal: effect on oxidative stress and mechanisms of action. Critical Reviews in Food Science and Nutrition. Informa UK Limited; 2020;:1-18 10.1080/10408398.2020.1864279
• Recent Advances on the Anticancer Properties of Saffron (Crocus sativus L.) and Its Major Constituents Cite
  Lambrianidou A, Koutsougianni F, Papapostolou I, Dimas K. Recent Advances on the Anticancer Properties of Saffron (Crocus sativus L.) and Its Major Constituents. Molecules. MDPI AG; 2020; 26:86 10.3390/molecules26010086
• Toxicity of Saffron Extracts on Cancer and Normal Cells: A Review Article Cite
  Shakeri M, Hashemi Tayer A, Shakeri H, Sotoodeh Jahromi A, Moradzadeh M, Hojjat-Farsangi M. Toxicity of Saffron Extracts on Cancer and Normal Cells: A Review Article. Asian Pacific Journal of Cancer Prevention. EpiSmart Science Vector Ltd; 2020; 21:1867-1875 10.31557/apjcp.2020.21.7.1867
• Doxorubicin and Crocin Co-delivery by Polymeric Nanoparticles for Enhanced Anticancer Potential In Vitro and In Vivo Cite
  Khan I, Joshi G, Sarkar B, Nakhate KT, Ajazuddin , Mantha AK, et al. Doxorubicin and Crocin Co-delivery by Polymeric Nanoparticles for Enhanced Anticancer Potential In Vitro and In Vivo. ACS Applied Bio Materials. American Chemical Society (ACS); 2020; 3:7789-7799 10.1021/acsabm.0c00974
• Crocin protects against cardiotoxicity induced by doxorubicin through TLR-2/NF-κB signal pathway in vivo and vitro Cite
  Chu X, Zhang Y, Xue Y, Li Z, Shi J, Wang H, et al. Crocin protects against cardiotoxicity induced by doxorubicin through TLR-2/NF-κB signal pathway in vivo and vitro. International Immunopharmacology. Elsevier BV; 2020; 84:106548 10.1016/j.intimp.2020.106548
• Saffron carotenoids change the superoxide dismutase activity in breast cancer: In vitro, in vivo and in silico studies Cite
  Hashemi SA, Karami M, Bathaie SZ. Saffron carotenoids change the superoxide dismutase activity in breast cancer: In vitro, in vivo and in silico studies. International Journal of Biological Macromolecules. Elsevier BV; 2020; 158:845-853 10.1016/j.ijbiomac.2020.04.063
• Anti-metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer Cite
  Arzi L, Hoshyar R, Jafarzadeh N, Riazi G, Sadeghizadeh M. Anti-metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer. Life Sciences. Elsevier BV; 2020; 243:117245 10.1016/j.lfs.2019.117245
• Antiangiogenic effect of crocin on breast cancer cell MDA-MB-231 Cite
  Chen S, Gu Y, Lu F, Qian D, Dong T, Ding Z, et al. Antiangiogenic effect of crocin on breast cancer cell MDA-MB-231. Journal of Thoracic Disease. AME Publishing Company; 2019; 11:4464-4473 10.21037/jtd.2019.11.18
• Role of crocin in several cancer cell lines: An updated review Cite
  Veisi A, Akbari G, Mard A, Badfar G, Zarezade V, Mirshekar MA. Role of crocin in several cancer cell lines: An updated review. Iranian Journal of Basic Medical Sciences. Mashhad University of Medical Sciences; 2020; 23 10.22038/ijbms.2019.37821.8995
• Crocin, a carotenoid, suppresses spindle microtubule dynamics and activates the mitotic checkpoint by binding to tubulin Cite
  Sawant AV, Srivastava S, Prassanawar SS, Bhattacharyya B, Panda D. Crocin, a carotenoid, suppresses spindle microtubule dynamics and activates the mitotic checkpoint by binding to tubulin. Biochemical Pharmacology. Elsevier BV; 2019; 163:32-45 10.1016/j.bcp.2019.01.023
• Inhibitory Effect of Crocin on Metastasis of Triple-Negative Breast Cancer by Interfering with Wnt/β-Catenin Pathway in Murine Model Cite
  Arzi L, Farahi A, Jafarzadeh N, Riazi G, Sadeghizadeh M, Hoshyar R. Inhibitory Effect of Crocin on Metastasis of Triple-Negative Breast Cancer by Interfering with Wnt/β-Catenin Pathway in Murine Model. DNA and Cell Biology. Mary Ann Liebert Inc; 2018; 37:1068-1075 10.1089/dna.2018.4351
• A Comparative Study on Anti-Invasion, Antimigration, and Antiadhesion Effects of the Bioactive Carotenoids of Saffron on 4T1 Breast Cancer Cells Through Their Effects on Wnt/β-Catenin Pathway Genes Cite
  Arzi L, Riazi G, Sadeghizadeh M, Hoshyar R, Jafarzadeh N. A Comparative Study on Anti-Invasion, Antimigration, and Antiadhesion Effects of the Bioactive Carotenoids of Saffron on 4T1 Breast Cancer Cells Through Their Effects on Wnt/β-Catenin Pathway Genes. DNA and Cell Biology. Mary Ann Liebert Inc; 2018; 37:697-707 10.1089/dna.2018.4248
• A comprehensive review on anticancer mechanisms of the main carotenoid of saffron, crocin Cite
  Hoshyar R, Mollaei H. A comprehensive review on anticancer mechanisms of the main carotenoid of saffron, crocin. Journal of Pharmacy and Pharmacology. Wiley; 2017; 69:1419-1427 10.1111/jphp.12776
• Antiproliferative Activity of Crocin Involves Targeting of Microtubules in Breast Cancer Cells Cite
  Hire RR, Srivastava S, Davis MB, Kumar Konreddy A, Panda D. Antiproliferative Activity of Crocin Involves Targeting of Microtubules in Breast Cancer Cells. Scientific Reports. Springer Science and Business Media LLC; 2017; 7 10.1038/srep44984
• Crocin Suppresses Constitutively Active STAT3 Through Induction of Protein Tyrosine Phosphatase SHP-1 Cite
  Kim B, Lee KY, Park B. Crocin Suppresses Constitutively Active STAT3 Through Induction of Protein Tyrosine Phosphatase SHP-1. Journal of Cellular Biochemistry. Wiley; 2017; 118:3290-3298 10.1002/jcb.25980
• Comparative study on preventive effect of saffron carotenoids, crocin and crocetin, in NMU-induced breast cancer in rat Cite
  Bathaie S, Sajjadi M. Comparative study on preventive effect of saffron carotenoids, crocin and crocetin, in NMU-induced breast cancer in rat. Cell J (Yakhteh). Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR); 2017; 19 10.22074/cellj.2016.3901
• Main chemical compounds and pharmacological activities of stigmas and tepals of ‘red gold’; saffron Cite
  Shahi T, Assadpour E, Jafari SM. Main chemical compounds and pharmacological activities of stigmas and tepals of ‘red gold’; saffron. Trends in Food Science & Technology. Elsevier BV; 2016; 58:69-78 10.1016/j.tifs.2016.10.010
• Neuroprotective Activities of Saffron and Crocin Cite
  Soeda S, Aritake K, Urade Y, Sato H, Shoyama Y. Neuroprotective Activities of Saffron and Crocin. Advances in Neurobiology. Springer International Publishing; 2016;:275-292 10.1007/978-3-319-28383-8_14
• Crocin treatment prevents doxorubicin-induced cardiotoxicity in rats Cite
  Razmaraii N, Babaei H, Mohajjel Nayebi A, Assadnassab G, Ashrafi Helan J, Azarmi Y. Crocin treatment prevents doxorubicin-induced cardiotoxicity in rats. Life Sciences. Elsevier BV; 2016; 157:145-151 10.1016/j.lfs.2016.06.012
• Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation Cite
  Bakshi HA, Hakkim FL, Sam S. Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation. Asian Pacific Journal of Cancer Prevention. Asian Pacific Organization for Cancer Prevention; 2016; 17:1499-1506 10.7314/apjcp.2016.17.3.1499
• Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters Cite
  Eid SY, El-Readi MZ, Wink M. Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. Elsevier BV; 2012; 19:977-987 10.1016/j.phymed.2012.05.010
• The toxicity of saffron (Crocus sativus L.) and its constituents against normal and cancer cells Cite
  Milajerdi A, Djafarian K, Hosseini B. The toxicity of saffron (Crocus sativus L.) and its constituents against normal and cancer cells. Journal of Nutrition & Intermediary Metabolism. Elsevier BV; 2016; 3:23-32 10.1016/j.jnim.2015.12.332
• Synergistic Apoptotic Effect of Crocin and Paclitaxel or Crocin and Radiation on MCF-7 Cells, a Type of Breast Cancer Cell Line Cite
  Vali F, Changizi V, Safa M. Synergistic Apoptotic Effect of Crocin and Paclitaxel or Crocin and Radiation on MCF-7 Cells, a Type of Breast Cancer Cell Line. International Journal of Breast Cancer. Hindawi Limited; 2015; 2015:1-7 10.1155/2015/139349
• Effect of Crocin on Cell Cycle Regulators in N-Nitroso-N-Methylurea-Induced Breast Cancer in Rats Cite
  Ashrafi M, Bathaie SZ, Abroun S, Azizian M. Effect of Crocin on Cell Cycle Regulators in N-Nitroso-N-Methylurea-Induced Breast Cancer in Rats. DNA and Cell Biology. Mary Ann Liebert Inc; 2015; 34:684-691 10.1089/dna.2015.2951
• Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol Cite
  Zeka K, Ruparelia KC, Continenza MA, Stagos D, Vegliò F, Arroo RR. Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol. Fitoterapia. Elsevier BV; 2015; 107:128-134 10.1016/j.fitote.2015.05.014
• Crocus sativus L. (saffron) for cancer chemoprevention: A mini review Cite
  Bhandari PR. Crocus sativus L. (saffron) for cancer chemoprevention: A mini review. Journal of Traditional and Complementary Medicine. Elsevier BV; 2015; 5:81-87 10.1016/j.jtcme.2014.10.009
• Saffron and natural carotenoids: Biochemical activities and anti-tumor effects Cite
  Bolhassani A, Khavari A, Bathaie SZ. Saffron and natural carotenoids: Biochemical activities and anti-tumor effects. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. Elsevier BV; 2014; 1845:20-30 10.1016/j.bbcan.2013.11.001