Tag: chrysin

Foods

• • chamomile
  • honey

Studies

• Improving cisplatin chemotherapy in vivo by niosomal propolis and chrysin as nanoadjuvants Cite
  Mohamad EA, El-Garhy MR, Rageh MM. Improving cisplatin chemotherapy in vivo by niosomal propolis and chrysin as nanoadjuvants. Medical Oncology. Springer Science and Business Media LLC; 2025; 42 10.1007/s12032-025-03105-5
• Exploring honey-derived compounds as potential inhibitors of NDRG1 for breast cancer treatment under hypoxic conditions: a multiomics profiling, molecular docking, and molecular dynamics study Cite
  Putra WE, Hidayatullah A, Widiastuti D, Heikal MF, Sustiprijatno S. Exploring honey-derived compounds as potential inhibitors of NDRG1 for breast cancer treatment under hypoxic conditions: a multiomics profiling, molecular docking, and molecular dynamics study. Future Journal of Pharmaceutical Sciences. Springer Science and Business Media LLC; 2025; 11 10.1186/s43094-025-00854-y
• Identification of chrysin derivatives anticancer potential in MCF7 cells: biological insights and in silico evaluation Cite
  Abdullah S, Awan AN, Akhtar M, Ahmed K, Mohiuddin OA. Identification of chrysin derivatives anticancer potential in MCF7 cells: biological insights and in silico evaluation. Future Medicinal Chemistry. Informa UK Limited; 2025;:1-17 10.1080/17568919.2025.2559569
• Chrysin mitigates therapy-induced senescence in breast cancer via cGAS–STING pathway inhibition Cite
  Billimoria R, Bhatt P. Chrysin mitigates therapy-induced senescence in breast cancer via cGAS–STING pathway inhibition. Medical Oncology. Springer Science and Business Media LLC; 2025; 42 10.1007/s12032-025-02993-x
• Gold nanoparticles capped with inclusion complex for the delivery of Chrysin in triple-negative breast cancer Cite
  Velhal K, Sah P, Raut R, Patil S, Barage S, Lakkakula J, et al. Gold nanoparticles capped with inclusion complex for the delivery of Chrysin in triple-negative breast cancer. Medical Oncology. Springer Science and Business Media LLC; 2025; 42 10.1007/s12032-025-03011-w
• Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential Cite
  Kurkiewicz M, Moździerz A, Rzepecka-Stojko A, Stojko J. Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential. Pharmaceuticals. MDPI AG; 2025; 18:1162 10.3390/ph18081162
• Mechanistic Insights into Flavonoid Subclasses as Cardioprotective Agents Against Doxorubicin-Induced Cardiotoxicity: A Comprehensive Review Cite
  Shang W, Li X, Zeng L, Li Z, Hu Y, Wen H, et al. Mechanistic Insights into Flavonoid Subclasses as Cardioprotective Agents Against Doxorubicin-Induced Cardiotoxicity: A Comprehensive Review. Drug Design, Development and Therapy. Informa UK Limited; 2025; Volume 19:5553-5596 10.2147/dddt.s535517
• Network pharmacology unveils the intricate molecular landscape of Chrysin in breast cancer therapeutics Cite
  Ma J, Liu P, Pan L. Network pharmacology unveils the intricate molecular landscape of Chrysin in breast cancer therapeutics. Discover Oncology. Springer Science and Business Media LLC; 2025; 16 10.1007/s12672-025-01951-3
• Effect of quercetin and chrysin and its association on viability and cell cycle progression in MDA-MB-231 and MCF-7 human breast cancer cells Cite
  Ramos PS, Ferreira C, Passos CLA, Silva JL, Fialho E. Effect of quercetin and chrysin and its association on viability and cell cycle progression in MDA-MB-231 and MCF-7 human breast cancer cells. Biomedicine & Pharmacotherapy. Elsevier BV; 2024; 179:117276 10.1016/j.biopha.2024.117276
• Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review) Cite
  Raina R, Bhatt R, Hussain A. Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review). World Academy of Sciences Journal. Spandidos Publications; 2024; 6 10.3892/wasj.2024.260
• Abstract PO4-18-03: Combined Treatment with Pyrotinib and Chrysin Synergistically Improve the Autophagy Level in HER2-Positive Breast Cancer by Regulating the miR-16-5p/ZBTB16/G6PD Axis Cite
  Luo T, Zhong X, He P, Zheng D, Cheng Y, Zhu K. Abstract PO4-18-03: Combined Treatment with Pyrotinib and Chrysin Synergistically Improve the Autophagy Level in HER2-Positive Breast Cancer by Regulating the miR-16-5p/ZBTB16/G6PD Axis. Cancer Research. American Association for Cancer Research (AACR); 2024; 84:PO4-18-03-PO4-18-03 10.1158/1538-7445.sabcs23-po4-18-03
• Evaluating flavonoids as potential aromatase inhibitors for breast cancer treatment: In vitro studies and in silico predictions Cite
  Seo JI, Yu JS, Zhang Y, Yoo HH. Evaluating flavonoids as potential aromatase inhibitors for breast cancer treatment: In vitro studies and in silico predictions. Chemico-Biological Interactions. Elsevier BV; 2024;:110927 10.1016/j.cbi.2024.110927
• Optimizing Chrysin’s Anticancer Efficacy on MDA-MB-231 Cells: Synthesis and Characterization of Chrysin-Loaded Gold/Chitosan Nanoparticles Cite
  Dilfy SH, mubark NN, Ahad AA. Optimizing Chrysin’s Anticancer Efficacy on MDA-MB-231 Cells: Synthesis and Characterization of Chrysin-Loaded Gold/Chitosan Nanoparticles. Trends in Pharmaceutical Biotechnology. Nabea Al-Ajyal Foundation press; 2023; 10.57238/tpb.2023.144270.1001
• In Silico and In Vitro Evaluation of Selected Herbal Compounds as Robust HER-2 Inhibitors for Effective Treatment of Breast Cancer Cite
  Pourjafar M, Shirafkan N, Bakhtiari S, Afshar S, Saidijam M, Jalalvand A, et al. In Silico and In Vitro Evaluation of Selected Herbal Compounds as Robust HER-2 Inhibitors for Effective Treatment of Breast Cancer. Research Journal of Pharmacognosy. - The Iranian Society of Pharmacognosy - Shahid Beheshti University of Medical Sciences; 2023; 10 10.22127/rjp.2023.388090.2070
• Chrysin promotes Cisplatin-induced apoptosis via oxidative DNA damage in oral squamous cell carcinoma Cite
  Chen J, Li Q, Jiang Y. Chrysin promotes Cisplatin-induced apoptosis via oxidative DNA damage in oral squamous cell carcinoma. Biochemical Systematics and Ecology. Elsevier BV; 2023; 108:104623 10.1016/j.bse.2023.104623
• Synergistic effect of chrysin and radiotherapy against triple-negative breast cancer (TNBC) cell lines Cite
  Jafari S, Dabiri S, Mehdizadeh Aghdam E, Fathi E, Saeedi N, Montazersaheb S, et al. Synergistic effect of chrysin and radiotherapy against triple-negative breast cancer (TNBC) cell lines. Clinical and Translational Oncology. Springer Science and Business Media LLC; 2023; 10.1007/s12094-023-03141-5
• Effects of Chrysin and Its Major Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide on Cytochrome P450 Enzymes and on OATP, P-gp, BCRP, and MRP2 Transporters Cite
  Mohos V, Fliszár-Nyúl E, Ungvári O, Bakos É, Kuffa K, Bencsik T, et al. Effects of Chrysin and Its Major Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide on Cytochrome P450 Enzymes and on OATP, P-gp, BCRP, and MRP2 Transporters. Drug Metabolism and Disposition. Elsevier BV; 2020; 48:1064-1073 10.1124/dmd.120.000085
• Plant Secondary Metabolites: Therapeutic Potential and Pharmacological Properties Cite
  Zeeshan Bhatti M, Ismail H, Khan Kayani W. Plant Secondary Metabolites: Therapeutic Potential and Pharmacological Properties. Secondary Metabolites - Trends and Reviews [Working Title]. IntechOpen; 2022; 10.5772/intechopen.103698
• Protective Effect of Curcumin, Chrysin and Thymoquinone Injection on Trastuzumab-Induced Cardiotoxicity via Mitochondrial Protection Cite
  Shirmard LR, Shabani M, Moghadam AA, Zamani N, Ghanbari H, Salimi A. Protective Effect of Curcumin, Chrysin and Thymoquinone Injection on Trastuzumab-Induced Cardiotoxicity via Mitochondrial Protection. Cardiovascular Toxicology. Springer Science and Business Media LLC; 2022; 10.1007/s12012-022-09750-w
• Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review Cite
  Salari N, Faraji F, Jafarpour S, Faraji F, Rasoulpoor S, Dokaneheifard S, et al. Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review. Indian Journal of Surgical Oncology. Springer Science and Business Media LLC; 2022; 10.1007/s13193-022-01550-6
• Chrysin attenuates estradiol-induced endometrial hyperplasia in rats via enhancing PPARα activity Cite
  Eid BG. Chrysin attenuates estradiol-induced endometrial hyperplasia in rats via enhancing PPARα activity. Environmental Science and Pollution Research. Springer Science and Business Media LLC; 2022; 10.1007/s11356-022-19206-x
• Chrysin impairs genomic stability by suppressing DNA double-strand break repair in breast cancer cells Cite
  Geng A, Xu S, Yao Y, Qian Z, Wang X, Sun J, et al. Chrysin impairs genomic stability by suppressing DNA double-strand break repair in breast cancer cells. Cell Cycle. Informa UK Limited; 2022;:1-13 10.1080/15384101.2021.2020434
• Targeting allosteric sites of human aromatase: a comprehensive in-silico and in-vitro workflow to find potential plant-based anti-breast cancer therapeutics Cite
  Alhadrami HA, Sayed AM, Melebari SA, Khogeer AA, Abdulaal WH, Al-Fageeh MB, et al. Targeting allosteric sites of human aromatase: a comprehensive in-silico and in-vitro workflow to find potential plant-based anti-breast cancer therapeutics. Journal of Enzyme Inhibition and Medicinal Chemistry. Informa UK Limited; 2021; 36:1333-1344 10.1080/14756366.2021.1937145
• Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer Cite
  Al-Bari MAA, Ito Y, Ahmed S, Radwan N, Ahmed HS, Eid N. Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer. International Journal of Molecular Sciences. MDPI AG; 2021; 22:9807 10.3390/ijms22189807
• Phytochemicals from Honey as MAP-Kinase Inhibitors: Current Therapeutic Standing and Future Prospects Cite
  Wani HA, Majid S, Wani RA, Khan MS, Qureshi W, Bhat AA, et al. Phytochemicals from Honey as MAP-Kinase Inhibitors: Current Therapeutic Standing and Future Prospects. Therapeutic Applications of Honey and its Phytochemicals. Springer Singapore; 2020;:141-164 10.1007/978-981-15-7305-7_7
• Inhibitory effect of chrysin on estrogen biosynthesis by suppression of enzyme aromatase (CYP19): A systematic review Cite
  Balam FH, Ahmadi ZS, Ghorbani A. Inhibitory effect of chrysin on estrogen biosynthesis by suppression of enzyme aromatase (CYP19): A systematic review. Heliyon. Elsevier BV; 2020; 6:e03557 10.1016/j.heliyon.2020.e03557
• Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein (BCRP): From library screening to biological evaluation to structure-activity relationship Cite
  Fan X, Bai J, Zhao S, Hu M, Sun Y, Wang B, et al. Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein (BCRP): From library screening to biological evaluation to structure-activity relationship. Toxicology in Vitro. Elsevier BV; 2019; 61:104642 10.1016/j.tiv.2019.104642
• Inhibition of Tyrosine-Phosphorylated STAT3 in Human Breast and Lung Cancer Cells by Manuka Honey is Mediated by Selective Antagonism of the IL-6 Receptor Cite
  Aryappalli P, Shabbiri K, Masad RJ, Al-Marri RH, Haneefa SM, Mohamed YA, et al. Inhibition of Tyrosine-Phosphorylated STAT3 in Human Breast and Lung Cancer Cells by Manuka Honey is Mediated by Selective Antagonism of the IL-6 Receptor. International Journal of Molecular Sciences. MDPI AG; 2019; 20:4340 10.3390/ijms20184340
• Chrysin Increases the Therapeutic Efficacy of Docetaxel and Mitigates Docetaxel-Induced Edema Cite
  Lim H, Kim KM, Jeong S, Choi EK, Jung J. Chrysin Increases the Therapeutic Efficacy of Docetaxel and Mitigates Docetaxel-Induced Edema. Integrative Cancer Therapies. SAGE Publications; 2016; 16:496-504 10.1177/1534735416645184
• Synergistic Anticancer Effects of Silibinin and Chrysin in T47D Breast Cancer Cells Cite
  Javan-Maasomi Z, Pilehvar-Soltanahmadi Y, Dadashpour M, Alipour S, Abolhasani S, Zarghami N. Synergistic Anticancer Effects of Silibinin and Chrysin in T47D Breast Cancer Cells. Asian Pacific Journal of Cancer Prevention. Asian Pacific Organization for Cancer Prevention; 2017; 18 10.22034/APJCP.2017.18.5.1283
• Plant‐Derived Agents for Counteracting Cisplatin‐Induced Nephrotoxicity Cite
  Ojha S, Venkataraman B, Kurdi A, Mahgoub E, Sadek B, Rajesh M. Plant‐Derived Agents for Counteracting Cisplatin‐Induced Nephrotoxicity. Oxidative Medicine and Cellular Longevity. Wiley; 2016; 2016 10.1155/2016/4320374
• Inhibitory and cytotoxic activities of chrysin on human breast adenocarcinoma cells by induction of apoptosis Cite
  Hasanzadeh M, Samarghandian S, Azimi-Nezhad M, Borji A, Jabbari F, Farkhondeh T, et al. Inhibitory and cytotoxic activities of chrysin on human breast adenocarcinoma cells by induction of apoptosis. Pharmacognosy Magazine. Medknow; 2016; 12:436 10.4103/0973-1296.191453
• Neuroprotective effects of chrysin: From chemistry to medicine Cite
  Nabavi SF, Braidy N, Habtemariam S, Orhan IE, Daglia M, Manayi A, et al. Neuroprotective effects of chrysin: From chemistry to medicine. Neurochemistry International. Elsevier BV; 2015; 90:224-231 10.1016/j.neuint.2015.09.006
• Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives Cite
  Kasala ER, Bodduluru LN, Madana RM, V AK, Gogoi R, Barua CC. Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives. Toxicology Letters. Elsevier BV; 2015; 233:214-225 10.1016/j.toxlet.2015.01.008
• Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway Cite
  Yang B, Huang J, Xiang T, Yin X, Luo X, Huang J, et al. Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway. Journal of Applied Toxicology. Wiley; 2013; 34:105-112 10.1002/jat.2941
• A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells Cite
  LIRDPRAPAMONGKOL K, SAKURAI H, ABDELHAMED S, YOKOYAMA S, MARUYAMA T, ATHIKOMKULCHAI S, et al. A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells. Oncology Reports. Spandidos Publications; 2013; 30:2357-2364 10.3892/or.2013.2667
• Chrysin: A Histone Deacetylase 8 Inhibitor with Anticancer Activity and a Suitable Candidate for the Standardization of Chinese Propolis Cite
  Sun L, Chen A, Hung H, Chien Y, Huang J, Huang C, et al. Chrysin: A Histone Deacetylase 8 Inhibitor with Anticancer Activity and a Suitable Candidate for the Standardization of Chinese Propolis. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2012; 60:11748-11758 10.1021/jf303261r
• Chrysin enhances doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: The role of glutathione Cite
  Brechbuhl HM, Kachadourian R, Min E, Chan D, Day BJ. Chrysin enhances doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: The role of glutathione. Toxicology and Applied Pharmacology. Elsevier BV; 2012; 258:1-9 10.1016/j.taap.2011.08.004
• Induction of apoptosis by 5,7-dihydroxy-8-nitrochrysin in breast cancer cells: The role of reactive oxygen species and Akt Cite
  Cao . Induction of apoptosis by 5,7-dihydroxy-8-nitrochrysin in breast cancer cells: The role of reactive oxygen species and Akt. International Journal of Oncology. Spandidos Publications; 2010; 37 10.3892/ijo_00000787
• Differential modulation of cisplatin and doxorubicin efficacies in leukemia cells by flavonoids Cite
  Čipák L, Novotný L, Čipáková I, Rauko P. Differential modulation of cisplatin and doxorubicin efficacies in leukemia cells by flavonoids. Nutrition Research. Elsevier BV; 2003; 23:1045-1057 10.1016/s0271-5317(03)00078-2
• (Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture Cite
  van Meeuwen J, Korthagen N, de Jong P, Piersma A, van den Berg M. (Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture. Toxicology and Applied Pharmacology. Elsevier BV; 2007; 221:372-383 10.1016/j.taap.2007.03.016