Tag: blackCumin

Black cumin: A spice made from the seeds of the black cumin plant (Nigella sativa). Black cumin is not related to cumin, which is a member of the parsley family.

News

08/09/19: Black cumin reduces resistance to paclitaxel chemotherapy
09/26/17: Black cumin enhances doxorubicin toxicity and reduces cardiomyopathy

Foods

- black cumin

Studies

Synergistic anti-breast cancer activity of simvastatin and thymoquinone encapsulated in nanostructured lipid carriers for enhanced therapeutic outcomes Cite
Kumari P, Ali J, Baboota S, Tyagi A, Dang S. Synergistic anti-breast cancer activity of simvastatin and thymoquinone encapsulated in nanostructured lipid carriers for enhanced therapeutic outcomes. Journal of Microencapsulation. Informa UK Limited; 2025;:1-20 10.1080/02652048.2025.2521077
Targeted delivery of thymoquinone-encapsulated polyethyleneimine/poly (lactic acid) nanoparticles into breast cancer cells Cite
Pandi JS, Pavadai P, Babkiewicz E, Panneerselvam T, Maszczyk P, Sankaranarayanan M, et al. Targeted delivery of thymoquinone-encapsulated polyethyleneimine/poly (lactic acid) nanoparticles into breast cancer cells. Springer Science and Business Media LLC; 2025; 10.21203/rs.3.rs-6858817/v1
Novel Thymoquinone Derivative TQFL28 Inhibits Triple-Negative Breast Cancer (TNBC) Invasiveness In Vitro and In Vivo Cite
He J, Zou H, Wei C, Du J, Xiao T, Li T, et al. Novel Thymoquinone Derivative TQFL28 Inhibits Triple-Negative Breast Cancer (TNBC) Invasiveness In Vitro and In Vivo. Current Issues in Molecular Biology. MDPI AG; 2025; 47:412 10.3390/cimb47060412
An updated review on the phytochemistry and pharmacological activity of black cumin (Nigella sativa L.) Cite
Pandey R, Pandey B, Bhargava A. An updated review on the phytochemistry and pharmacological activity of black cumin (Nigella sativa L.). Advanced Chinese Medicine. Wiley; 2025; 10.1002/acm4.33
Thymoquinone and cancer: Mechanisms and potential therapeutic applications Cite
Ilhan S, Oguz F, Atmaca H. Thymoquinone and cancer: Mechanisms and potential therapeutic applications. Studies in Natural Products Chemistry. Elsevier; 2025;:67-99 10.1016/b978-0-443-23752-2.00009-8
Anticancer Effects of Nigella sativa Seeds in Cell Line Cite
Khan I, JD Shaikh . Anticancer Effects of Nigella sativa Seeds in Cell Line. International Research Journal of Multidisciplinary Scope. Iquz Galaxy Publisher; 2025; 06:1198-1211 10.47857/irjms.2025.v0i01.02438
Thymoquinone-PLGA-PF68 Nanoparticles Induce S Phase Cell Cycle Arrest and Apoptosis, Leading to the Inhibition of Migration and Colony Formation in Tamoxifen-Resistant Breast Cancer Cells Cite
Noor NS, Hamid SBS. Thymoquinone-PLGA-PF68 Nanoparticles Induce S Phase Cell Cycle Arrest and Apoptosis, Leading to the Inhibition of Migration and Colony Formation in Tamoxifen-Resistant Breast Cancer Cells. Current Molecular Medicine. Bentham Science Publishers Ltd.; 2025; 25 10.2174/0115665240347014241203065055
Arginase Activity Inhibition With Thymoquinone Induces a Hybrid Type of Cell‐Death in MDA‐MB‐231 Cell Line Cite
Bday J, Souid M, Pires V, Gabbouj S, Véjux A, Lizard G, et al. Arginase Activity Inhibition With Thymoquinone Induces a Hybrid Type of Cell‐Death in MDA‐MB‐231 Cell Line. Journal of Biochemical and Molecular Toxicology. Wiley; 2025; 39 10.1002/jbt.70130
Nigella sativa (Black Seed) and Breast Cancer: A Systematic Review Cite
Esmaeli M, Ghanbari A, Barazesh M, Dehabadi MD. Nigella sativa (Black Seed) and Breast Cancer: A Systematic Review. Indian Journal of Gynecologic Oncology. Springer Science and Business Media LLC; 2024; 22 10.1007/s40944-024-00920-y
Tyrosine kinase inhibitors versus thymoquinone in management of cancer: A mechanistic approach Cite
Nath SK, Garg M, Babbar R. Tyrosine kinase inhibitors versus thymoquinone in management of cancer: A mechanistic approach. AIP Conference Proceedings. AIP Publishing; 2024; 3232:060014 10.1063/5.0227771
Systemic Codelivery of Thymoquinone and Doxorubicin by Targeted Mesoporous Silica Nanoparticle Sensitizes Doxorubicin-Resistant Breast Cancer by Interfering between the MDR1/P-gp and miR 298 Crosstalk Cite
Bhattacharjee M, Ghosh A, Das S, Sarker S, Bhattacharya S, Das A, et al. Systemic Codelivery of Thymoquinone and Doxorubicin by Targeted Mesoporous Silica Nanoparticle Sensitizes Doxorubicin-Resistant Breast Cancer by Interfering between the MDR1/P-gp and miR 298 Crosstalk. ACS Biomaterials Science & Engineering. American Chemical Society (ACS); 2024; 10.1021/acsbiomaterials.4c01081
Assessment of the Synergistic Effect of Thymoquinone and Cisplatin on MCF-7 Breast Cancer Cells Cite
Mousavinasab F, Hashemipour N, Soghala S, Talebi M, aghazadeh m, Baghalzadeh Salmasi E, et al. Assessment of the Synergistic Effect of Thymoquinone and Cisplatin on MCF-7 Breast Cancer Cells. Zenodo; 2024; 10.5281/ZENODO.13194610
Innovative approach against cancer: Thymoquinone-loaded PHEMA-based magnetic nanoparticles and their effects on MCF-7 breast cancer Cite
Yıldırım M, Acet Ö, Önal Acet B, Karakoç V, Odabaşı M. Innovative approach against cancer: Thymoquinone-loaded PHEMA-based magnetic nanoparticles and their effects on MCF-7 breast cancer. Biochemical and Biophysical Research Communications. Elsevier BV; 2024; 734:150464 10.1016/j.bbrc.2024.150464
Chemopreventive Agents from Nature: A Review of Apigenin, Rosmarinic Acid, and Thymoquinone Cite
Abutayeh RF, Altah M, Mehdawi A, Al-Ataby I, Ardakani A. Chemopreventive Agents from Nature: A Review of Apigenin, Rosmarinic Acid, and Thymoquinone. Current Issues in Molecular Biology. MDPI AG; 2024; 46:6600-6619 10.3390/cimb46070393
Recent advances on Nigella sativa – A Promising herb: Antihypertensive properties, thimoquinone nanoformulations, and health applications Cite
Raghavendra VB, Sagar N, Kusha LM, Krishna KL, Sharma M, Sridhar K, et al. Recent advances on Nigella sativa – A Promising herb: Antihypertensive properties, thimoquinone nanoformulations, and health applications. Pharmacological Research - Natural Products. Elsevier BV; 2024;:100052 10.1016/j.prenap.2024.100052
Determination of anti-cancer effects of Nigella sativa seed oil on MCF7 breast and AGS gastric cancer cells Cite
Çınar İ, Gıdık B, Dirican E. Determination of anti-cancer effects of Nigella sativa seed oil on MCF7 breast and AGS gastric cancer cells. Molecular Biology Reports. Springer Science and Business Media LLC; 2024; 51 10.1007/s11033-024-09453-1
Thymoquinone: A novel treatment option for triple negative breast cancer Cite
Mamillapalli V, Rallapalli V, Mohammed Z, Motukuru D, Sowgandhika Kosuri S, Kantamaneni P. Thymoquinone: A novel treatment option for triple negative breast cancer. Biomedicine. Indian Association of Biomedical Scientists; 2024; 44:13-20 10.51248/.v44i1.4155
Targeting cisplatin resistance in breast cancer using a combination of Thymoquinone and Silymarin: an in vitro and in vivo study Cite
Hamed RA, Talib WH. Targeting cisplatin resistance in breast cancer using a combination of Thymoquinone and Silymarin: an in vitro and in vivo study. Pharmacia. Pensoft Publishers; 2024; 71:1-19 10.3897/pharmacia.71.e117997
Thymoquinone Nanoparticle Induces Apoptosis and Cell Migration Retardation through Modulating of SUMOylation Process Genes in Breast Cancer Cell Line Cite
Sabouni F, Hamta A, Sohrabi B, Qadbeigi M. Thymoquinone Nanoparticle Induces Apoptosis and Cell Migration Retardation through Modulating of SUMOylation Process Genes in Breast Cancer Cell Line. Iranian Journal of Biotechnology. National Institute of Genetic Engineering and Biotechnology of Iran; 2024; 22 10.30498/ijb.2024.390400.3676
Computational and in vitro analyses on synergistic effects of paclitaxel and thymoquinone in suppressing invasive breast cancer cells Cite
Khazaei MR, Bozorgi M, Khazaei M, Moradi A, Bozorgi A. Computational and in vitro analyses on synergistic effects of paclitaxel and thymoquinone in suppressing invasive breast cancer cells. Molecular Biology Reports. Springer Science and Business Media LLC; 2024; 51 10.1007/s11033-024-09328-5
In Vitro and In Vivo Preventive Effects of Thymoquinone against Breast Cancer: Role of DNMT1 Cite
Kaleem M, Kayali A, Sheikh RA, Kuerban A, Hassan MA, Almalki NAR, et al. In Vitro and In Vivo Preventive Effects of Thymoquinone against Breast Cancer: Role of DNMT1. Molecules. MDPI AG; 2024; 29:434 10.3390/molecules29020434
Combination of Thymoquinone and Intermittent Fasting as a Treatment for Breast Cancer Implanted in Mice Cite
Haif SK, Al Kury LT, Talib WH. Combination of Thymoquinone and Intermittent Fasting as a Treatment for Breast Cancer Implanted in Mice. Plants. MDPI AG; 2023; 13:35 10.3390/plants13010035
Effectiveness of Nigella sativa Addition against TNF-Alpha in Stage III and IV Breast Cancer Undergoing Doxorubicin and Cyclophosphamide Chemotherapy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Cite
Friyoga Syahril , Wirdah A, Nur Qodir , Irfanuddin , Irsan Saleh , Yenny Dian Andayani , et al. Effectiveness of Nigella sativa Addition against TNF-Alpha in Stage III and IV Breast Cancer Undergoing Doxorubicin and Cyclophosphamide Chemotherapy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Bioscientia Medicina : Journal of Biomedicine and Translational Research. Hanif Medisiana Publisher; 2023; 8:4009-4014 10.37275/bsm.v8i2.924
A study on concurring effect of paclitaxel and thymoquinone on MCF-7 cell line – In vitro Cite
Anandan I, Gokul T, K N, Elango A, Vivekkumar P. A study on concurring effect of paclitaxel and thymoquinone on MCF-7 cell line – In vitro. National Journal of Physiology, Pharmacy and Pharmacology. ScopeMed; 2023;:1 10.5455/njppp.2023.13.09428202319092023
Anticancer activity of thymoquinone against breast cancer cells: Mechanisms of action and delivery approaches Cite
Shabani H, Karami MH, Kolour J, Sayyahi Z, Parvin MA, Soghala S, et al. Anticancer activity of thymoquinone against breast cancer cells: Mechanisms of action and delivery approaches. Biomedicine & Pharmacotherapy. Elsevier BV; 2023; 165:114972 10.1016/j.biopha.2023.114972
A mechanistic insight into the potential anti-cancerous property of Nigella sativa on breast cancer through micro-RNA regulation: An in vitro & in vivo study Cite
Das S, Ghosh A, Upadhyay P, Sarker S, Bhattacharjee M, Gupta P, et al. A mechanistic insight into the potential anti-cancerous property of Nigella sativa on breast cancer through micro-RNA regulation: An in vitro & in vivo study. Fitoterapia. Elsevier BV; 2023;:105601 10.1016/j.fitote.2023.105601
Targeting Breast Cancer in Diabetic Mice Using a Combination of Thymoquinone and Metformin Cite
Talib WH, Aboulqassim NSS. Targeting Breast Cancer in Diabetic Mice Using a Combination of Thymoquinone and Metformin. The Natural Products Journal. Bentham Science Publishers Ltd.; 2023; 13 10.2174/2210315512666220615114025
Thymoquinone, piperine, and sorafenib combinations attenuate liver and breast cancers progression: epigenetic and molecular docking approaches Cite
El-Shehawy AA, Elmetwalli A, El-Far AH, Mosallam SAE, Salama AF, Babalghith AO, et al. Thymoquinone, piperine, and sorafenib combinations attenuate liver and breast cancers progression: epigenetic and molecular docking approaches. BMC Complementary Medicine and Therapies. Springer Science and Business Media LLC; 2023; 23 10.1186/s12906-023-03872-6
Thymoquinone may alleviate cisplatin-induced muscle atrophy in rats by regulating mitofusin 2 and meteorin-like levels Cite
Yalçın T, Kaya S. Thymoquinone may alleviate cisplatin-induced muscle atrophy in rats by regulating mitofusin 2 and meteorin-like levels. Comparative Clinical Pathology. Springer Science and Business Media LLC; 2023; 10.1007/s00580-023-03442-9
Thymoquinone-treated mouse mesenchymal stem cells-derived conditioned medium inhibits human breast cancer cells in vitro Cite
Hajmomeni P, Sisakhtnezhad S, Bidmeshkipour A. Thymoquinone-treated mouse mesenchymal stem cells-derived conditioned medium inhibits human breast cancer cells in vitro. Chemico-Biological Interactions. Elsevier BV; 2023; 369:110283 10.1016/j.cbi.2022.110283
Protective effect of short-term thymoquinone administration on the central nervous system in cisplatin-induced neurotoxicity Cite
Durak M, Ozhan O, Yildiz A, Durhan M, Vardi N, Cigremis Y, et al. Protective effect of short-term thymoquinone administration on the central nervous system in cisplatin-induced neurotoxicity. European Review for Medical and Pharmacological Sciences. Verduci Editore s.r.l.; 2022; 26:6935-6943. 10.26355/eurrev_202210_29874
Thymoquinone upregulates IL17RD in controlling the growth and metastasis of triple negative breast cancer cells in vitro Cite
Khan MA, Zheng M, Fu J, Tania M, Li J, Fu J. Thymoquinone upregulates IL17RD in controlling the growth and metastasis of triple negative breast cancer cells in vitro. BMC Cancer. Springer Science and Business Media LLC; 2022; 22 10.1186/s12885-022-09782-z
A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update Cite
Machado TQ, da Fonseca ACC, Duarte ABS, Robbs BK, de Sousa DP. A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update. BioMed Research International. Hindawi Limited; 2022; 2022:1-20 10.1155/2022/6317201
Protective Effect of Curcumin, Chrysin and Thymoquinone Injection on Trastuzumab-Induced Cardiotoxicity via Mitochondrial Protection Cite
Shirmard LR, Shabani M, Moghadam AA, Zamani N, Ghanbari H, Salimi A. Protective Effect of Curcumin, Chrysin and Thymoquinone Injection on Trastuzumab-Induced Cardiotoxicity via Mitochondrial Protection. Cardiovascular Toxicology. Springer Science and Business Media LLC; 2022; 10.1007/s12012-022-09750-w
Synergistic anti-cancer effects of Nigella sativa seed oil and conventional cytotoxic agent against human breast cancer Cite
Baig WA, Alwosaibai K, Al-Jubran KM, Chaudhry TM, Al-Dowish N, Alsaffar F, et al. Synergistic anti-cancer effects of Nigella sativa seed oil and conventional cytotoxic agent against human breast cancer. Drug Metabolism and Personalized Therapy. Walter de Gruyter GmbH; 2022; 0 10.1515/dmpt-2021-0229
Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis Cite
Homayoonfal M, Asemi Z, Yousefi B. Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis. Cellular & Molecular Biology Letters. Springer Science and Business Media LLC; 2022; 27 10.1186/s11658-022-00320-0
Prevention of doxorubicin-induced experimental cardiotoxicity by Nigella sativa in rats Cite
Adıyaman MŞ, Adıyaman ÖA, Dağlı AF, Karahan MZ, Dağlı MN. Prevention of doxorubicin-induced experimental cardiotoxicity by Nigella sativa in rats. Revista Portuguesa de Cardiologia. Elsevier BV; 2022; 10.1016/j.repc.2020.12.015
Insights into the Protective Effects of Thymoquinone against Toxicities Induced by Chemotherapeutic Agents Cite
Farooq J, Sultana R, Taj T, Asdaq SMB, Alsalman AJ, Mohaini MA, et al. Insights into the Protective Effects of Thymoquinone against Toxicities Induced by Chemotherapeutic Agents. Molecules. MDPI AG; 2021; 27:226 10.3390/molecules27010226
Therapeutic Potential of Thymoquinone in Triple-Negative Breast Cancer Prevention and Progression through the Modulation of the Tumor Microenvironment Cite
Adinew GM, Taka E, Mochona B, Badisa RB, Mazzio EA, Elhag R, et al. Therapeutic Potential of Thymoquinone in Triple-Negative Breast Cancer Prevention and Progression through the Modulation of the Tumor Microenvironment. Nutrients. MDPI AG; 2021; 14:79 10.3390/nu14010079
Thymoquinone and its pharmacological perspective: a review Cite
Tabassum S, Rosli N, Ichwan SJA, Mishra P. Thymoquinone and its pharmacological perspective: a review. Pharmacological Research - Modern Chinese Medicine. Elsevier BV; 2021;:100020 10.1016/j.prmcm.2021.100020
PIK3CA hotspot mutations p. H1047R and p. H1047L sensitize breast cancer cells to thymoquinone treatment by regulating the PI3K/Akt1 pathway Cite
Zhou J, Imani S, Shasaltaneh MD, Liu S, Lu T, Fu J. PIK3CA hotspot mutations p. H1047R and p. H1047L sensitize breast cancer cells to thymoquinone treatment by regulating the PI3K/Akt1 pathway. Molecular Biology Reports. Springer Science and Business Media LLC; 2021; 10.1007/s11033-021-06990-x
Impact of Nigella Sativa on body weight, volume and weight of ovary in Letrozole Induced POS in Mice Cite
Anwar N, Nadeem A, Naheed K, Arshad Jarral S, Saad Abdullah M, Asad A, et al. Impact of Nigella Sativa on body weight, volume and weight of ovary in Letrozole Induced POS in Mice. Pakistan Journal of Medical and Health Sciences. Lahore Medical and Dental College; 2021; 15:2355-2357 10.53350/pjmhs211592355
Targeting microRNAs with thymoquinone: a new approach for cancer therapy Cite
Homayoonfal M, Asemi Z, Yousefi B. Targeting microRNAs with thymoquinone: a new approach for cancer therapy. Cellular & Molecular Biology Letters. Springer Science and Business Media LLC; 2021; 26 10.1186/s11658-021-00286-5
Thymoquinone upregulates miR‐125a‐5p, attenuates STAT3 activation, and potentiates doxorubicin antitumor activity in murine solid Ehrlich carcinoma Cite
Atteia HH, Arafa MH, Mohammad NS, Amin DM, Sakr AT. Thymoquinone upregulates miR‐125a‐5p, attenuates STAT3 activation, and potentiates doxorubicin antitumor activity in murine solid Ehrlich carcinoma. Journal of Biochemical and Molecular Toxicology. Wiley; 2021; 10.1002/jbt.22924
1764P A dose and time-dependent inhibitory effect of thymoquinone on inflammasome pathway in hormone receptor positive breast cancer: A novel personalized adjuvant therapy Cite
Elgohary S, Abdeltawab R, El Tayebi H. 1764P A dose and time-dependent inhibitory effect of thymoquinone on inflammasome pathway in hormone receptor positive breast cancer: A novel personalized adjuvant therapy. Annals of Oncology. Elsevier BV; 2021; 32:S1212 10.1016/j.annonc.2021.08.1708
Thymoquinone and its derivatives against breast cancer with HER2 positive: in silico studies of ADMET, docking and QSPR Cite
Wulandari AA, Choiri AA, Fitria , Widiandani T. Thymoquinone and its derivatives against breast cancer with HER2 positive: in silico studies of ADMET, docking and QSPR. Journal of Basic and Clinical Physiology and Pharmacology. Walter de Gruyter GmbH; 2021; 32:393-401 10.1515/jbcpp-2020-0431
Synergistic Role of Thymoquinone on Anticancer Activity of 5-fluorouracil in Triple-Negative Breast Cancer Cells Cite
Zheng M, Mei Z, Junaid M, Tania M, Fu J, Chen H, et al. Synergistic Role of Thymoquinone on Anticancer Activity of 5-fluorouracil in Triple-Negative Breast Cancer Cells. Anti-Cancer Agents in Medicinal Chemistry. Bentham Science Publishers Ltd.; 2021; 21 10.2174/1871520621666210624111613
Thymoquinone and its nanoformulation attenuate colorectal and breast cancers and alleviate doxorubicin-induced cardiotoxicity Cite
El-Far AH, Salaheldin TA, Godugu K, Darwish NH, Mousa SA. Thymoquinone and its nanoformulation attenuate colorectal and breast cancers and alleviate doxorubicin-induced cardiotoxicity. Nanomedicine. Future Medicine Ltd; 2021; 10.2217/nnm-2021-0103
A review on pharmacological activities and anti-microbial properties of Nigella sativa and isolated Thymoquinone Cite
Perera W, Liyanage J, Dissanayake K, Chandrasiri W, Gunathilaka H. A review on pharmacological activities and anti-microbial properties of Nigella sativa and isolated Thymoquinone. Journal of Medicinal Plants Studies. AkiNik Publications; 2021; 9:118-122 10.22271/plants.2021.v9.i3b.1277
Effect of thymoquinone-loaded lipid–polymer nanoparticles as an oral delivery system on anticancer efficiency of doxorubicin Cite
Moghaddam FA, Ebrahimian M, Oroojalian F, Yazdian-Robati R, Kalalinia F, Tayebi L, et al. Effect of thymoquinone-loaded lipid–polymer nanoparticles as an oral delivery system on anticancer efficiency of doxorubicin. Journal of Nanostructure in Chemistry. Springer Science and Business Media LLC; 2021; 10.1007/s40097-021-00398-6
Low Doses of Thymoquinone and Ferulic Acid in Combination Effectively Inhibit Proliferation of Cultured MDA-MB 231 Breast Adenocarcinoma Cells Cite
Al-Mutairi A, Rahman A, Rao MS. Low Doses of Thymoquinone and Ferulic Acid in Combination Effectively Inhibit Proliferation of Cultured MDA-MB 231 Breast Adenocarcinoma Cells. Nutrition and Cancer. Informa UK Limited; 2020; 73:282-289 10.1080/01635581.2020.1743869
Thymoquinone inhibited vasculogenic capacity and promoted mesenchymal-epithelial transition of human breast cancer stem cells Cite
Haiaty S, Rashidi M, Akbarzadeh M, Bazmany A, Mostafazadeh M, Nikanfar S, et al. Thymoquinone inhibited vasculogenic capacity and promoted mesenchymal-epithelial transition of human breast cancer stem cells. BMC Complementary Medicine and Therapies. Springer Science and Business Media LLC; 2021; 21 10.1186/s12906-021-03246-w
Abstract PS19-28: Thymoquinone and tamoxifen co-treatment synergistically inhibit proliferation, invasion and induce apoptosis in human breast cancer cell lines in vitro and in vivo Cite
Yahiya I, Helmy H, Sultan A. Abstract PS19-28: Thymoquinone and tamoxifen co-treatment synergistically inhibit proliferation, invasion and induce apoptosis in human breast cancer cell lines in vitro and in vivo. Poster Session Abstracts. American Association for Cancer Research; 2021; 10.1158/1538-7445.sabcs20-ps19-28
Molecular Mechanisms of Thymoquinone as Anticancer agent Cite
Alhmied FI, Alammar AH, Alsultan BM, Alshehri M, Pottoo FH. Molecular Mechanisms of Thymoquinone as Anticancer agent. Combinatorial Chemistry & High Throughput Screening. Bentham Science Publishers Ltd.; 2020; 23 10.2174/1386207323999201027225305
Incorporation of docetaxel and thymoquinone in borage nanoemulsion potentiates their antineoplastic activity in breast cancer cells Cite
Alkhatib MH, Bawadud RS, Gashlan HM. Incorporation of docetaxel and thymoquinone in borage nanoemulsion potentiates their antineoplastic activity in breast cancer cells. Scientific Reports. Springer Science and Business Media LLC; 2020; 10 10.1038/s41598-020-75017-5
Abstract 6558: Thymoquinone and epicatechin ameliorate the anticancer properties of tafuramycin-A against naïve and resistant breast cancer cells Cite
Alshehri OY, Henidi HA, Alabbasi FA, El-Deeb IM, Halwani MA, Al-Abd AM. Abstract 6558: Thymoquinone and epicatechin ameliorate the anticancer properties of tafuramycin-A against naïve and resistant breast cancer cells. Clinical Research (Excluding Clinical Trials). American Association for Cancer Research; 2020; 10.1158/1538-7445.am2020-6558
Combinatorial therapy of Thymoquinone and Emodin synergistically enhances apoptosis, attenuates cell migration and reduces stemness efficiently in breast cancer Cite
Bhattacharjee M, Upadhyay P, Sarker S, Basu A, Das S, Ghosh A, et al. Combinatorial therapy of Thymoquinone and Emodin synergistically enhances apoptosis, attenuates cell migration and reduces stemness efficiently in breast cancer. Biochimica et Biophysica Acta (BBA) - General Subjects. Elsevier BV; 2020; 1864:129695 10.1016/j.bbagen.2020.129695
Combination of Docetaxel with Thymoquinone in Nanoemulsion Impedes the Migration of Breast Cancer Stem Cells Cite
Bawadud RS B, Alkhatib MH, Gashlan HM G. Combination of Docetaxel with Thymoquinone in Nanoemulsion Impedes the Migration of Breast Cancer Stem Cells. International Journal of Pharmaceutical Investigation. EManuscript Services; 2020; 10:211-216 10.5530/ijpi.2020.2.39
Evidence-Based Review on Clinical Potential of Thymoquinone in Breast Cancer Cite
Barkat MA, Harshita , Pottoo FH, Beg S, Rahman M, Ahmad FJ. Evidence-Based Review on Clinical Potential of Thymoquinone in Breast Cancer. Nanomedicine for Bioactives. Springer Singapore; 2020;:471-486 10.1007/978-981-15-1664-1_19
Antiproliferative Effects of Thymoquinone in MCF-7 Breast and HepG2 Liver Cancer Cells: Possible Role of Ceramide and ER Stress Cite
Aslan M, Afşar E, Kırımlıoglu E, Çeker T, Yılmaz Ç. Antiproliferative Effects of Thymoquinone in MCF-7 Breast and HepG2 Liver Cancer Cells: Possible Role of Ceramide and ER Stress. Nutrition and Cancer. Informa UK Limited; 2020;:1-13 10.1080/01635581.2020.1751216
The Effect of Fennel and Black Seed, on Breast milk, Prolactin Levels and Anthropometric Index in Human and Animal Samples: A Review Cite
Barkhordari Ahmadi F, Pourghorban A, Kharghani S, Rezaei Shahmirzadi A, Haghjoyan SM, Heydari O, et al. The Effect of Fennel and Black Seed, on Breast milk, Prolactin Levels and Anthropometric Index in Human and Animal Samples: A Review. International Journal of Pediatrics. Mashhad University of Medical Sciences; 2020; 8 10.22038/ijp.2020.46722.3790
Senescent Colon and Breast Cancer Cells Induced by Doxorubicin Exhibit Enhanced Sensitivity to Curcumin, Caffeine, and Thymoquinone Cite
El-Far AH, Darwish NHE, Mousa SA. Senescent Colon and Breast Cancer Cells Induced by Doxorubicin Exhibit Enhanced Sensitivity to Curcumin, Caffeine, and Thymoquinone. Integrative Cancer Therapies. SAGE Publications; 2020; 19:153473541990116 10.1177/1534735419901160
Thymoquinone Enhances Paclitaxel Anti-Breast Cancer Activity via Inhibiting Tumor-Associated Stem Cells Despite Apparent Mathematical Antagonism Cite
Bashmail HA, Alamoudi AA, Noorwali A, Hegazy GA, Ajabnoor GM, Al-Abd AM. Thymoquinone Enhances Paclitaxel Anti-Breast Cancer Activity via Inhibiting Tumor-Associated Stem Cells Despite Apparent Mathematical Antagonism. Molecules. MDPI AG; 2020; 25:426 10.3390/molecules25020426
Antiproliferative and apoptotic effects of proteins from black seeds (Nigella sativa) on human breast MCF-7 cancer cell line Cite
Khurshid Y, Syed B, Simjee SU, Beg O, Ahmed A. Antiproliferative and apoptotic effects of proteins from black seeds (Nigella sativa) on human breast MCF-7 cancer cell line. BMC Complementary Medicine and Therapies. Springer Science and Business Media LLC; 2020; 20 10.1186/s12906-019-2804-1
Thymoquinone and pentoxifylline enhance the chemotherapeutic effect of cisplatin by targeting Notch signaling pathway in mice Cite
Mosalam EM, Zidan AA, Mehanna ET, Mesbah NM, Abo-Elmatty DM. Thymoquinone and pentoxifylline enhance the chemotherapeutic effect of cisplatin by targeting Notch signaling pathway in mice. Life Sciences. Elsevier BV; 2020; 244:117299 10.1016/j.lfs.2020.117299
Co-encapsulation of docetaxel and thymoquinone in mPEG-DSPE-vitamin E TPGS-lipid nanocapsules for breast cancer therapy: Formulation optimization and implications on cellular and in vivo toxicity Cite
Zafar S, Akhter S, Garg N, Selvapandiyan A, Kumar Jain G, Ahmad FJ. Co-encapsulation of docetaxel and thymoquinone in mPEG-DSPE-vitamin E TPGS-lipid nanocapsules for breast cancer therapy: Formulation optimization and implications on cellular and in vivo toxicity. European Journal of Pharmaceutics and Biopharmaceutics. Elsevier BV; 2020; 148:10-26 10.1016/j.ejpb.2019.12.016
Co-encapsulation of thymoquinone with docetaxel enhances the encapsulation efficiency into PEGylated liposomes and the chemosensitivity of MCF7 breast cancer cells to docetaxel Cite
Odeh F, Naffa R, Azzam H, Mahmoud IS, Alshaer W, Al Bawab A, et al. Co-encapsulation of thymoquinone with docetaxel enhances the encapsulation efficiency into PEGylated liposomes and the chemosensitivity of MCF7 breast cancer cells to docetaxel. Heliyon. Elsevier BV; 2019; 5:e02919 10.1016/j.heliyon.2019.e02919
Improved chemotherapeutic efficacy against resistant human breast cancer cells with co-delivery of Docetaxel and Thymoquinone by Chitosan grafted lipid nanocapsules: Formulation optimization, in vitro and in vivo studies Cite
Zafar S, Akhter S, Ahmad I, Hafeez Z, Alam Rizvi MM, Jain GK, et al. Improved chemotherapeutic efficacy against resistant human breast cancer cells with co-delivery of Docetaxel and Thymoquinone by Chitosan grafted lipid nanocapsules: Formulation optimization, in vitro and in vivo studies. Colloids and Surfaces B: Biointerfaces. Elsevier BV; 2020; 186:110603 10.1016/j.colsurfb.2019.110603
Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects Cite
Ahmad A, Mishra RK, Vyawahare A, Kumar A, Rehman MU, Qamar W, et al. Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects. Saudi Pharmaceutical Journal. Elsevier BV; 2019; 27:1113-1126 10.1016/j.jsps.2019.09.008
Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics Cite
Khan MA, Tania M, Fu J. Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics. Drug Discovery Today. Elsevier BV; 2019; 24:2315-2322 10.1016/j.drudis.2019.09.007
Abstract 2995: Thymoquinone attenuates breast cancer cell resistance to paclitaxel via targeting tumor associated stem cell population Cite
Bashmail HA, Alamoudi AA, Hegazy GA, Agabnoor GM, Noorwali A, Al-Abd AM. Abstract 2995: Thymoquinone attenuates breast cancer cell resistance to paclitaxel via targeting tumor associated stem cell population. Experimental and Molecular Therapeutics. American Association for Cancer Research; 2019; 10.1158/1538-7445.am2019-2995
Abstract 3876: Thymoquinone induces the expression of clock genes in breast cancer cells Cite
Alamoudi AA, Bashmail HA, Ajabnoor GM, Choudhry H, Hassan MA, Aldahlawi AM, et al. Abstract 3876: Thymoquinone induces the expression of clock genes in breast cancer cells. Experimental and Molecular Therapeutics. American Association for Cancer Research; 2019; 10.1158/1538-7445.am2019-3876
Abstract 3834: Epigenetic modification of oncogenes or tumor suppressor genes by thymoquinone in triple negative breast cancer Cite
Khan MA, Zheng M, Fu J. Abstract 3834: Epigenetic modification of oncogenes or tumor suppressor genes by thymoquinone in triple negative breast cancer. Experimental and Molecular Therapeutics. American Association for Cancer Research; 2019; 10.1158/1538-7445.am2019-3834
Thymoquinone Augments Cyclophosphamide-Mediated Inhibition of Cell Proliferation in Breast Cancer Cells Cite
Khan A, Aldebasy YH, Alsuhaibani SA, Khan MA. Thymoquinone Augments Cyclophosphamide-Mediated Inhibition of Cell Proliferation in Breast Cancer Cells. Asian Pacific Journal of Cancer Prevention. EpiSmart Science Vector Ltd; 2019; 20:1153-1160 10.31557/apjcp.2019.20.4.1153
Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms Cite
Qadi SA, Hassan MA, Sheikh RA, Baothman OA, Zamzami MA, Choudhry H, et al. Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms. Epigenetics Insights. SAGE Publications; 2019; 12:251686571983901 10.1177/2516865719839011
Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone Cite
Aumeeruddy MZ, Mahomoodally MF. Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone. Cancer. Wiley; 2019; 125:1600-1611 10.1002/cncr.32022
Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis Cite
Shanmugam MK, Ahn KS, Hsu A, Woo CC, Yuan Y, Tan KHB, et al. Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis. Frontiers in Pharmacology. Frontiers Media SA; 2018; 9 10.3389/fphar.2018.01294
Abstract 5813: Thymoquinone influences the anticancer properties of paclitaxel and gemcitabine against breast cancer cells Cite
Bashmil HA, Alamoudi AA, Noorwali A, Hegazy GA, Ajabnoor G, Al-Abd AM. Abstract 5813: Thymoquinone influences the anticancer properties of paclitaxel and gemcitabine against breast cancer cells. Experimental and Molecular Therapeutics. American Association for Cancer Research; 2018; 10.1158/1538-7445.am2018-5813
Thymoquinone inhibits cell proliferation, migration, and invasion by regulating the elongation factor 2 kinase (eEF-2K) signaling axis in triple-negative breast cancer Cite
Kabil N, Bayraktar R, Kahraman N, Mokhlis HA, Calin GA, Lopez-Berestein G, et al. Thymoquinone inhibits cell proliferation, migration, and invasion by regulating the elongation factor 2 kinase (eEF-2K) signaling axis in triple-negative breast cancer. Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2018; 171:593-605 10.1007/s10549-018-4847-2
Loading of doxorubicin and thymoquinone with F2 gel nanofibers improves the antitumor activity and ameliorates doxorubicin-associated nephrotoxicity Cite
Zidan AA, El-Ashmawy NE, Khedr EG, Ebeid EM, Salem ML, Mosalam EM. Loading of doxorubicin and thymoquinone with F2 gel nanofibers improves the antitumor activity and ameliorates doxorubicin-associated nephrotoxicity. Life Sciences. Elsevier BV; 2018; 207:461-470 10.1016/j.lfs.2018.06.008
Crude Flavonoid Extract of the Medicinal Herb Nigella sativa Inhibits Proliferation and Induces Apoptosis in Breast Cancer Cells Cite
Elkady AI, Abu-Zinadah OA, El Hamid Hussein RA. Crude Flavonoid Extract of the Medicinal Herb Nigella sativa Inhibits Proliferation and Induces Apoptosis in Breast Cancer Cells. Journal of Biomaterials and Tissue Engineering. American Scientific Publishers; 2017; 7:1235-1249 10.1166/jbt.2017.1695
ID:2024 Synthesis and Characterization of PLGA-PEG Thymoquinone Nanoparticle and its Cytotoxicity Effects in Tamoxifen-resistant Breast Cancer Cells Cite
Ahmad R, Kaus NHM, Hamid S. ID:2024 Synthesis and Characterization of PLGA-PEG Thymoquinone Nanoparticle and its Cytotoxicity Effects in Tamoxifen-resistant Breast Cancer Cells. Biomedical Research and Therapy. Biomedical Research and Therapy; 2017; 4:55 10.15419/bmrat.v4is.248
Enhanced anticancer effect and reduced toxicity of doxorubicin in combination with thymoquinone released from poly- N -acetyl glucosamine nanomatrix in mice bearing solid Ehrlish carcinoma Cite
El-Ashmawy NE, Khedr EG, Ebeid EM, Salem ML, Zidan AA, Mosalam EM. Enhanced anticancer effect and reduced toxicity of doxorubicin in combination with thymoquinone released from poly- N -acetyl glucosamine nanomatrix in mice bearing solid Ehrlish carcinoma. European Journal of Pharmaceutical Sciences. Elsevier BV; 2017; 109:525-532 10.1016/j.ejps.2017.09.012
Abstract 3249: Thymoquinone inhibits elongation factor 2 kinase signaling axis by inducing tumor suppressor miR-603 in triple negative breast cancer cells Cite
Kabil NN, Bayraktar R, Kahraman N, Ozpolat B. Abstract 3249: Thymoquinone inhibits elongation factor 2 kinase signaling axis by inducing tumor suppressor miR-603 in triple negative breast cancer cells. Cancer Chemistry. American Association for Cancer Research; 2017; 10.1158/1538-7445.am2017-3249
Regressions of Breast Carcinoma Syngraft Following Treatment with Piperine in Combination with Thymoquinone Cite
Talib W. Regressions of Breast Carcinoma Syngraft Following Treatment with Piperine in Combination with Thymoquinone. Scientia Pharmaceutica. MDPI AG; 2017; 85:27 10.3390/scipharm85030027
Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer Cite
Alobaedi OH, Talib WH, Basheti IA. Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer. Asian Pacific Journal of Tropical Medicine. Medknow; 2017; 10:400-408 10.1016/j.apjtm.2017.03.026
Abstract 4123: Thymoquinone inhibits bone metastasis in a breast cancer mouse model by modulating CXCR4/CXCL12 signaling axis Cite
Shanmugam MK, Hsu A, Hui KM, Tan BK, Sethi G. Abstract 4123: Thymoquinone inhibits bone metastasis in a breast cancer mouse model by modulating CXCR4/CXCL12 signaling axis. Tumor Biology. American Association for Cancer Research; 2016; 10.1158/1538-7445.am2016-4123
Abstract 2176: Targeting eEF-2Kinase by thymoquinone in triple negative breast cancer Cite
Kabil NN, Bayraktar R, Kahraman N, Ozpolat B. Abstract 2176: Targeting eEF-2Kinase by thymoquinone in triple negative breast cancer. Cancer Chemistry. American Association for Cancer Research; 2016; 10.1158/1538-7445.am2016-2176
Uptake, delivery, and anticancer activity of thymoquinone nanoparticles in breast cancer cells Cite
Fakhoury I, Saad W, Bouhadir K, Nygren P, Schneider-Stock R, Gali-Muhtasib H. Uptake, delivery, and anticancer activity of thymoquinone nanoparticles in breast cancer cells. Journal of Nanoparticle Research. Springer Science and Business Media LLC; 2016; 18 10.1007/s11051-016-3517-8
Ameliorative Potential of Tamoxifen/Thymoquinone Combination in Patients with Breast Cancer: A Biochemical and Immunohistochemical Study Cite
Kabel AM, Rashidy MAE, Omar MS. Ameliorative Potential of Tamoxifen/Thymoquinone Combination in Patients with Breast Cancer: A Biochemical and Immunohistochemical Study. Journal of Cancer Science and Research. OMICS Publishing Group; 2018; 01 10.4172/2576-1447.1000102
Anticancer activity of an ultrasonic nanoemulsion formulation of Nigella sativa L. essential oil on human breast cancer cells Cite
Periasamy VS, Athinarayanan J, Alshatwi AA. Anticancer activity of an ultrasonic nanoemulsion formulation of Nigella sativa L. essential oil on human breast cancer cells. Ultrasonics Sonochemistry. Elsevier BV; 2016; 31:449-455 10.1016/j.ultsonch.2016.01.035
Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin Cite
Effenberger-Neidnicht K, Schobert R. Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin. Cancer Chemotherapy and Pharmacology. Springer Science and Business Media LLC; 2010; 67:867-874 10.1007/s00280-010-1386-x
Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-γ pathway Cite
Woo CC, Loo SY, Gee V, Yap CW, Sethi G, Kumar AP, et al. Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-γ pathway. Biochemical Pharmacology. Elsevier BV; 2011; 82:464-475 10.1016/j.bcp.2011.05.030
NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis Cite
Sutton KM, Doucette CD, Hoskin DW. NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis. Biochemical and Biophysical Research Communications. Elsevier BV; 2012; 426:421-426 10.1016/j.bbrc.2012.08.111
Radiosensitization in human breast carcinoma cells by thymoquinone: role of cell cycle and apoptosis Cite
Velho‑Pereira R, Kumar A, Pandey BN, Jagtap AG, Mishra KP. Radiosensitization in human breast carcinoma cells by thymoquinone: role of cell cycle and apoptosis. Cell Biology International. Wiley; 2011; 35:1025-1029 10.1042/cbi20100701
Thymoquinone: Potential cure for inflammatory disorders and cancer Cite
Woo CC, Kumar AP, Sethi G, Tan KHB. Thymoquinone: Potential cure for inflammatory disorders and cancer. Biochemical Pharmacology. Elsevier BV; 2012; 83:443-451 10.1016/j.bcp.2011.09.029
Targeted Apoptotic Effects of Thymoquinone and Tamoxifen on XIAP Mediated Akt Regulation in Breast Cancer Cite
Rajput S, Kumar BNP, Sarkar S, Das S, Azab B, Santhekadur PK, et al. Targeted Apoptotic Effects of Thymoquinone and Tamoxifen on XIAP Mediated Akt Regulation in Breast Cancer. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e61342 10.1371/journal.pone.0061342
Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS Cite
Woo CC, Hsu A, Kumar AP, Sethi G, Tan KHB. Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS. PLoS ONE. Public Library of Science (PLoS); 2013; 8:e75356 10.1371/journal.pone.0075356
Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells Cite
Rajput S, Kumar BP, Dey KK, Pal I, Parekh A, Mandal M. Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells. Life Sciences. Elsevier BV; 2013; 93:783-790 10.1016/j.lfs.2013.09.009
Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells Cite
MOTAGHED M, AL-HASSAN FM, HAMID SS. Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells. International Journal of Molecular Medicine. Spandidos Publications; 2013; 33:8-16 10.3892/ijmm.2013.1563
P0051 Immunomodulator effect of black cumin seed oil (BCO) in the inhibition of breast cancer carcinogenesis in Dimenthylbenzantracene (DMBA)-induced SD rats Cite
Akrom A, Marstyawan H, Mustofa M. P0051 Immunomodulator effect of black cumin seed oil (BCO) in the inhibition of breast cancer carcinogenesis in Dimenthylbenzantracene (DMBA)-induced SD rats. European Journal of Cancer. Elsevier BV; 2014; 50:e22 10.1016/j.ejca.2014.03.095
Thymoquinone, A Bioactive Component of Black Caraway Seeds, Causes G1 Phase Cell Cycle Arrest and Apoptosis in Triple-Negative Breast Cancer Cells with Mutant p53 Cite
Sutton KM, Greenshields AL, Hoskin DW. Thymoquinone, A Bioactive Component of Black Caraway Seeds, Causes G1 Phase Cell Cycle Arrest and Apoptosis in Triple-Negative Breast Cancer Cells with Mutant p53. Nutrition and Cancer. Informa UK Limited; 2014; 66:408-418 10.1080/01635581.2013.878739
Proapoptotic and Antimetastatic Properties of Supercritical CO2 Extract of Nigella sativa Linn. Against Breast Cancer Cells Cite
Baharetha HM, Nassar ZD, Aisha AF, Ahamed MBK, Al-Suede FSR, Kadir MOA, et al. Proapoptotic and Antimetastatic Properties of Supercritical CO2 Extract of Nigella sativa Linn. Against Breast Cancer Cells. Journal of Medicinal Food. Mary Ann Liebert Inc; 2013; 16:1121-1130 10.1089/jmf.2012.2624
Antiradical and antimicrobial properties of cold-pressed black cumin and cumin oils Cite
Ramadan MF, Asker MMS, Tadros M. Antiradical and antimicrobial properties of cold-pressed black cumin and cumin oils. European Food Research and Technology. Springer Science and Business Media LLC; 2012; 234:833-844 10.1007/s00217-012-1696-9
Antioxidant potency of cumin varieties—cumin, black cumin and bitter cumin—on antioxidant systems Cite
Thippeswamy NB, Naidu KA. Antioxidant potency of cumin varieties—cumin, black cumin and bitter cumin—on antioxidant systems. European Food Research and Technology. Springer Science and Business Media LLC; 2005; 220:472-476 10.1007/s00217-004-1087-y
Radical Scavenging Activity of Black Cumin (Nigella sativaL.), Coriander (Coriandrum sativumL.), and Niger (Guizotia abyssinicaCass.) Crude Seed Oils and Oil Fractions Cite
Ramadan MF, Kroh LW, Mörsel J. Radical Scavenging Activity of Black Cumin (Nigella sativaL.), Coriander (Coriandrum sativumL.), and Niger (Guizotia abyssinicaCass.) Crude Seed Oils and Oil Fractions. Journal of Agricultural and Food Chemistry. American Chemical Society (ACS); 2003; 51:6961-6969 10.1021/jf0346713