Tag: asparagine

Asparagine: Asparagine (asparagine) - asparagine - A nonessential amino acid used in the biosynthesis of multiple proteins. It is also involved in regulating the uptake of other amino acids and is important for tumor mitochondrial respiration.

Foods

- asparagus

Studies

Down‐Regulation of Asparagine Synthetase Induces Cell Cycle Arrest and Inhibits Cell Proliferation of Breast Cancer Cite
Yang H, He X, Zheng Y, Feng W, Xia X, Yu X, et al. Down‐Regulation of Asparagine Synthetase Induces Cell Cycle Arrest and Inhibits Cell Proliferation of Breast Cancer. Chemical Biology & Drug Design. Wiley; 2014; 84:578-584 10.1111/cbdd.12348
Asparagine as a signal for glutamine sufficiency via asparagine synthetase: a fresh evidence-based framework in physiology and oncology Cite
Olawuni B, Bode BP. Asparagine as a signal for glutamine sufficiency via asparagine synthetase: a fresh evidence-based framework in physiology and oncology. American Journal of Physiology-Cell Physiology. American Physiological Society; 2024; 327:C1335-C1346 10.1152/ajpcell.00316.2024
Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer Cite
Morillo-Huesca M, G. López-Cepero I, Conesa-Bakkali R, Tomé M, Watts C, Huertas P, et al. Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer. Journal of Experimental & Clinical Cancer Research. Springer Science and Business Media LLC; 2025; 44 10.1186/s13046-025-03334-6
Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets Cite
Nan D, Yao W, Huang L, Liu R, Chen X, Xia W, et al. Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets. Cell Communication and Signaling. Springer Science and Business Media LLC; 2025; 23 10.1186/s12964-024-02018-6
Asparagine endopeptidase regulates lysosome homeostasis via modulating endomembrane phosphoinositide composition Cite
Yao L, Zi G, He M, Xu Y, Wang L, Peng B. Asparagine endopeptidase regulates lysosome homeostasis via modulating endomembrane phosphoinositide composition. Cell Death & Disease. Springer Science and Business Media LLC; 2025; 15 10.1038/s41419-024-07187-3
Asparagine endopeptidase promotes radioresistance in breast cancer through ATR pathway modulation Cite
Morillo-Huesca M, Tomé M, Watts C, Huertas P, Moreno-Bueno G, Durán RV, et al. Asparagine endopeptidase promotes radioresistance in breast cancer through ATR pathway modulation. Cold Spring Harbor Laboratory; 2025; 10.1101/2025.01.13.632704
Effective Targeting of Glutamine Synthetase with Amino Acid Analogs as a Novel Therapeutic Approach in Breast Cancer Cite
Abdesttar S, Al-Amodi HS, Kamel HF, Al-Eidan AA, Mahfouz MM, El khashab K, et al. Effective Targeting of Glutamine Synthetase with Amino Acid Analogs as a Novel Therapeutic Approach in Breast Cancer. International Journal of Molecular Sciences. MDPI AG; 2024; 26:78 10.3390/ijms26010078
Differential effect of asparagine and glutamine removal on three adenocarcinoma cell lines Cite
Pessino G, Lonati L, Scotti C, Calandra S, Cazzalini O, Iaria O, et al. Differential effect of asparagine and glutamine removal on three adenocarcinoma cell lines. Heliyon. Elsevier BV; 2024;:e35789 10.1016/j.heliyon.2024.e35789
Exploring the potential of asparagine restriction in solid cancer treatment: recent discoveries, therapeutic implications, and challenges Cite
Fontes MG, Silva C, Roldán WH, Monteiro G. Exploring the potential of asparagine restriction in solid cancer treatment: recent discoveries, therapeutic implications, and challenges. Medical Oncology. Springer Science and Business Media LLC; 2024; 41 10.1007/s12032-024-02424-3
Traditional Food Processing and Acrylamide Formation: A Review Cite
Adimas MA, Abera BD, Adimas ZT, Woldemariam HW, Delele MA. Traditional Food Processing and Acrylamide Formation: A Review. Heliyon. Elsevier BV; 2024;:e30258 10.1016/j.heliyon.2024.e30258
Metabolism of asparagine in the physiological state and cancer Cite
Yuan Q, Yin L, He J, Zeng Q, Liang Y, Shen Y, et al. Metabolism of asparagine in the physiological state and cancer. Cell Communication and Signaling. Springer Science and Business Media LLC; 2024; 22 10.1186/s12964-024-01540-x
Glutamine transporter SLC38A3 promotes breast cancer metastasis via Gsk3β/β-catenin/EMT pathway Cite
Tan Z, Boyapati K, Tressler CM, Jenkinson N, Glunde K. Glutamine transporter SLC38A3 promotes breast cancer metastasis via Gsk3β/β-catenin/EMT pathway. Cancer Letters. Elsevier BV; 2024; 586:216653 10.1016/j.canlet.2024.216653
The Role of Amino Acids in the Diagnosis, Risk Assessment, and Treatment of Breast Cancer: A Review Cite
Bel’skaya LV, Gundyrev IA, Solomatin DV. The Role of Amino Acids in the Diagnosis, Risk Assessment, and Treatment of Breast Cancer: A Review. Current Issues in Molecular Biology. MDPI AG; 2023; 45:7513-7537 10.3390/cimb45090474
A prospective case–cohort analysis of plasma metabolites and breast cancer risk Cite
Stevens VL, Carter BD, Jacobs EJ, McCullough ML, Teras LR, Wang Y. A prospective case–cohort analysis of plasma metabolites and breast cancer risk. Breast Cancer Research. Springer Science and Business Media LLC; 2023; 25 10.1186/s13058-023-01602-x
Effect of 1H‐NMR serum lipoproteins on immunotherapy response in advanced triple‐negative breast cancer patients Cite
Tian Z, Rao Q, He Z, Zhao W, Chen L, Liu J, et al. Effect of 1H‐NMR serum lipoproteins on immunotherapy response in advanced triple‐negative breast cancer patients. Cancer Science. Wiley; 2023; 114:3924-3934 10.1111/cas.15937
Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort Cite
His M, Viallon V, Dossus L, Schmidt JA, Travis RC, Gunter MJ, et al. Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort. BMC Medicine. Springer Science and Business Media LLC; 2021; 19 10.1186/s12916-021-02183-2
Targeting Asparagine Synthetase in Tumorgenicity Using Patient-Derived Tumor-Initiating Cells Cite
Nishikawa G, Kawada K, Hanada K, Maekawa H, Itatani Y, Miyoshi H, et al. Targeting Asparagine Synthetase in Tumorgenicity Using Patient-Derived Tumor-Initiating Cells. Cells. MDPI AG; 2022; 11:3273 10.3390/cells11203273
High Expression of Asparagine Synthetase Is Associated with Poor Prognosis of Breast Cancer in Chinese Population Cite
Qin C, Yang X, Zhan Z. High Expression of Asparagine Synthetase Is Associated with Poor Prognosis of Breast Cancer in Chinese Population. Cancer Biotherapy and Radiopharmaceuticals. Mary Ann Liebert Inc; 2020; 35:581-585 10.1089/cbr.2019.3295
Asparagine bioavailability governs metastasis in a model of breast cancer Cite
Knott SRV, Wagenblast E, Khan S, Kim SY, Soto M, Wagner M, et al. Asparagine bioavailability governs metastasis in a model of breast cancer. Nature. Springer Science and Business Media LLC; 2018; 554:378-381 10.1038/nature25465
Dietary Acrylamide and Human Cancer: A Systematic Review of Literature Cite
Virk-Baker MK, Nagy TR, Barnes S, Groopman J. Dietary Acrylamide and Human Cancer: A Systematic Review of Literature. Nutrition and Cancer. Informa UK Limited; 2014; 66:774-790 10.1080/01635581.2014.916323