Melatonin is a hormone that communicates information concerning environmental light conditions to various parts of the body and plays a vital role in the synchronization of circadian rhythms (the body clock). Melatonin has also been shown to have anti-cancer properties, especially in breast cancer. Low levels of melatonin as a result of excessive exposure to light at night is associated with increased risk of breast cancer. Now a new study has demonstrated that melatonin reduces estrogen production in normal breast cells near malignant cells, in addition to reducing tumor angiogenesis (new blood vessel formation).
Latest research shows that melatonin reduces VEGF
The study referenced at the beginning of this news article was designed to investigate the role of melatonin in the regulation of vascular endothelial growth factor (VEGF) in breast cancer cells. VEGF is vital for tumor blood vessel formation. To conduct the study, the authors co-cultured hormone receptor positive (ER+/PR+) MCF-7 human breast cancer cells with human umbilical vein endothelial cells (HUVECs).
VEGF was found to stimulate the proliferation of HUVECs when VEGF was added to the culture, whereas melatonin counteracted this effect. Furthermore, melatonin was found to inhibit VEGF production and VEGF mRNA expression in MCF-7 cells. The co-culturing of breast cancer cells with umbilical endothelial cells stimulated the proliferation of the endothelial cells and heightened VEGF levels in the culture media. In addition, conditioned media from MCF-7 cells stimulated the proliferation of HUVECs. Melatonin was shown to counteracted all three effects.
Taken together, the findings indicate that melatonin might play a role in the interactions between malignant cells and nearby endothelial cells by down regulating VEGF expression in the cancer cells. The authors conclude that lower levels of VEGF induced by melatonin could be important in reducing the number of estrogen-producing normal cells in local proximity to malignant cells, in addition to reducing tumor angiogenesis.
Please see our article on how to optimize your breast cancer diet for information on what to eat during all stages of treatment and recovery.