Daughters of women who have had a breast cancer diagnosis or who have a BRCA1 or BRCA2 mutation are at higher risk for breast cancer than the general population. While there are some breast cancer risk factors such as height and age at first period over which parents have limited control, there are other sources of risk that they can influence.
These generally fall under diet and lifestyle factors, although minimizing exposure to certain pollutants and ionizing radiation are also important.
This topic has been divided into three time periods: prenatal period and infancy; childhood and puberty; and teenage years and young adulthood.
Diet of mother and other factors during pregnancy
Birth weight and breast cancer risk
Low birth weight has been found to be associated with decreased risk of premenopausal breast cancer and high birth weight has been reported to be associated with increased risk of breast cancer in adulthood, although not all studies are in agreement. High birth weight is associated with dense breasts, a known risk factor for breast cancer. Older mothers (over age 39) are also more likely to have daughters with dense breasts. Women who weighed more than 8.8 lbs at birth have been found to have a significantly higher risk of breast cancer than women who weighed less than 5.5 lbs. However, one study reported that birth length, rather than birth weight, is positively associated with breast cancer risk, especially among daughters of tall women.
Note that it does not make sense to under nourish babies in the womb by greatly restricting the mother's calorie intake. Severe calorie restriction during pregnancy has been shown to dramatically increase the risk of breast cancer in adulthood. One study examined the effects of the famine that took place in the Netherlands at the end of World War II from November 1944 until liberation in May 1945. People were surviving on an estimated 400 to 800 calories per day and the diet lacked variety. Daughters of women who endured famine conditions during the first trimester of their pregnancies were found to have 8.3 times the risk of dying of breast cancer during adulthood than daughters not exposed to famine in the womb.
In summary, while there is some limited evidence that excessive weight gain during pregnancy could increase breast cancer risk in daughters, greatly restricting calories in an attempt to limit birth weight does not appear to be a safe or effective risk reduction strategy. On the other hand, one animal study suggested that exercise during pregnancy could reduce breast cancer risk in daughters.
Effect of high BMI before pregnancy
Are overweight women more likely to have daughters who eventually develop breast cancer? There is no clear answer. One study found that sex hormone binding globulin (which is associated with reduced breast cancer risk) was inversely related to pre-pregnancy BMI and weight gain during pregnancy, and positively related to vegetable and legume intake. The authors concluded that avoiding excess calorie intake and emphasizing plant foods might contribute to reducing the risk of breast cancer in daughters. Another study found that daughters of women who were obese while pregnant were more likely to experience early puberty, a breast cancer risk factor.
However, yet another study that included 814 mothers of nurses with breast cancer reported that the mothers' pre-pregnancy BMI was not associated with the daughters' breast cancer risk during adulthood. Weight gain during pregnancy also was not found to be associated with daughters' breast cancer risk. The authors of this study concluded that the known association between birth weight and breast cancer risk is likely due to factors independent of mothers' pre-pregnancy BMI or weight gain during pregnancy.
Folic acid supplementation during pregnancy and daughter's breast cancer
Currently, it is recommended that all women of childbearing age take 0.4 mg folic acid per day or to obtain this amount from fortified foods. This is because folic acid reduces the risk of neural tube defects such as spina bifida and anencephaly when taken before conception and during early pregnancy.
There are contradictory studies regarding the effect of folic acid supplementation of pregnant mice on the subsequent development of mammary tumors in offspring. Therefore, we suggest that women who plan to have children get their folate levels checked well before becoming pregnant. This will give them the opportunity to increase their circulating folate levels through their diets (see the list of foods below) and by eliminating alcohol consumption, if necessary. Women with folate levels in the high end of the normal range do not need folic acid supplementation during pregnancy. Those that are not able to achieve this level may need to take folic acid supplements.
The following foods are good sources of folate:
Note that both green and black tea reduce intestinal absorption of folate and should not be consumed with high-folate foods by those wishing to increase their circulating folate levels.
Some plastics contain endocrine disruptors such as bisphenol A (BPA), styrene, and phthalates that can leach into food when the plastics are heated, microwaved, put under pressure, or simply scuffed and worn. Prenatal exposure to BPA and phthalates has been shown to alter breast development in animal experiments and to increase the likelihood of early puberty in girls, thereby increasing the subsequent risk of breast cancer.
Plastics that may leach these substances include (1) polyvinyl chloride (PVC), which may be found in cling wrap, some plastic squeeze bottles, and cooking oil bottles; (2) polystyrene, which may be found in styrofoam food containers and disposable cups and bowls; and (3) polycarbonates, which may be found in soup and soda can linings, plastic baby bottles, water bottles, and clear plastic sippy cups. Pregnant and nursing women should avoid all but temporary, low temperature uses of these products. Plastic containers may be marked with a number in a triangle-like icon. Plastics marked 1, 2, 4 or 5 use less toxic additives in their manufacture. Products that use polyvinyl chloride should be marked with 3, polystyrene with a 6, and polycarbonate with a 7—these are the ones to avoid.
Exposure to pesticides
Girls whose mothers worked in greenhouses in the first trimester of pregnancy have been found to have earlier breast development than girls without such prenatal exposure. This appears to be because some currently approved pesticides possess endocrine disrupting properties.
Prenatal exposure to maternal smoking has been found to be associated with early first period, which in turn is linked to increased risk of breast cancer.
Omega-3 to omega-6 fatty acid ratio during pregnancy
There is also evidence that a relatively high omega-3 to omega-6 fatty acid ratio in the maternal diet may reduce the risk of subsequent breast cancer in daughters. This means emphasizing foods such as walnuts and walnut oil, as well as sources of marine fatty acids, and de-emphasizing corn oil, soybean oil and other high omega-6 vegetable oils. Flaxseed is another dietary source of omega-3 fatty acids, but flaxseed can accumulate unacceptable levels of cadmium (a known breast cancer promoter). We recommend that pregnant women consume only flaxseed that is stated to have low levels of cadmium. Refined flaxseed oil has negligible levels of cadmium and other heavy metals. In addition, while fatty fish are the best sources of marine omega-3 fatty acids, it may be best for pregnant women to consume high quality fish or krill oil supplements that have low levels of contaminants like mercury, PCBs and dioxins, instead of eating fatty fish.
Maternal consumption of whole grains during pregnancy has been found to be associated with lower risk of subsequent breast cancer in offspring, possibly by enhancing DNA damage repair mechanisms. There is also some evidence that adequate choline consumption during pregnancy is crucial.
However, it is important to avoid brown rice with high arsenic levels during pregnancy. Prenatal arsenic exposure has been shown to alter mammary gland development in ways that increase the risk of eventually developing breast cancer. Rice grown in California tends to have lower levels of arsenic than rice from the Louisiana, Arkansas, Missouri, Texas, or non-U.S. countries.
Foods to include during pregnancy and nursing
The following foods may reduce the subsequent risk of breast cancer in daughters when included in the mother's diet during pregnancy and while nursing:
Foods and supplements to limit or avoid during pregnancy and nursing
The following foods and supplements may increase the subsequent risk of breast cancer in daughters when consumed frequently during pregnancy or while nursing:
Prenatal exposure to cadmium or artificial sweeteners also has the potential to alter mammary gland development in unfavorable ways.
The following foods and other products may increase the risk of other cancers or birth defects in daughters or cause problems for the pregnancy when consumed regularly during pregnancy:
Exposure to oncogenic viruses
Certain viruses have been reported to be associated with breast cancer. These include mouse mammary tumor virus (MMTV), bovine leukemia virus (BLV), Epstein-Barr virus, human papilloma virus (HPV), human cytomegalovirus (Human Herpes virus 5), and measles virus. The topic is controversial, in part because of problems with methodology and inconsistent findings. In any case, it makes sense to reduce or avoid exposure to these viruses.
Steps should be taken to avoid transmitting herpes during pregnancy or childbirth. Children should be vaccinated against measles as young toddlers and HPV as older children.
Infancy and subsequent breast cancer
Parents should avoid using baby care products containing lavender or tea tree oil, which have been shown to produce estrogenic effects in children, and parabens, which are suspected to increase female breast cancer incidence. In addition, herbal treatments for colic containing fennel (Foeniculum vulgare) should not be used since they may cause premature breast development. Also to be avoided are clear plastic baby bottles, sippy cups, and toys containing polycarbonates, which have been shown to be carcinogenic. Plastic products containing polycarbonates may be marked on the base with a triangle containing the number 7.
Having been breastfed as an infant does not appear to influence the risk of breast cancer in adulthood. However, breastfeeding has other advantages for babies and it appears to reduce the risk of breast cancer in the mother, even if undertaken only for a short period of time. The more difficult question is whether infant formula made from cow's milk or soy is safer for our high risk daughters (little evidence is available for other types of infant formula). This is a topic that can lead to highly emotional reactions. We summarize the available scientific evidence in the following two sections.
Cow's milk formula
Although milk consumption during adulthood has been found to be associated with higher risk of breast cancer, milk has been found to protect against breast cancer when consumed in infancy and childhood. A partial explanation for this finding is the fact that milk is a very good source of calcium, which is known to protect against breast cancer.
Soy infant formula contains phytoestrogens, which have been shown to accelerate puberty in female rats and delay puberty in male rats. However, female rats fed soy protein isolate (the principal ingredient of soy formula) have been found to have reduced incidence of carcinogen-induced mammary tumors. Soy formula could adversely affect thyroid function and, based on animal studies, might increase body weight and reduce eventual fertility. Nevertheless, the few studies that have compared the health of milk formula-fed children with soy formula fed children have not found any adverse effects for soy. Based on the available evidence, boys fed soy formula could suffer from subtle demasculinization effects. In addition, while isoflavone-rich diets in mice during pregnancy and lactation reduce breast cancer in offspring, soy formula may have unforeseen and unintended long-term effects.
Pregnant women who themselves have an elevated risk of breast cancer should eat a wide variety of the foods on our recommended food list and limit or avoid those on our avoid list, in addition to paying particular attention to the foods and other products on the lists above.
Below are links to recent studies on this topic. For a more complete list of studies, please click on prenatal exposure or protecting our children.
Selected breast cancer studies
Isoflavones alter male and female fertility in different development windows
Sleiman HK, de Oliveira JM, Langoni de Freitas GB. Isoflavones alter male and female fertility in different development windows. Biomedicine & Pharmacotherapy. Elsevier BV; 2021; 140:111448 10.1016/j.biopha.2021.111448
Aluminum Content of Human Milk and Antiperspirant Use
Rochman M, Mangel L, Mandel D, Berkovitch M, Kohn E, Abu Hamad R, et al. Aluminum Content of Human Milk and Antiperspirant Use. Breastfeeding Medicine. Mary Ann Liebert Inc; 2021; 10.1089/bfm.2020.0408
Maternal fish oil consumption has a negative impact on mammary gland tumorigenesis in C3(1) Tag mice offspring
Ion G, Akinsete JA, Witte TR, Bostan M, Hardman WE. Maternal fish oil consumption has a negative impact on mammary gland tumorigenesis in C3(1) Tag mice offspring. European Journal of Nutrition. Springer Science and Business Media LLC; 2021; 10.1007/s00394-021-02546-8
Early-life Exposures and Age at Breast Development in the Sister Study Cohort
Goldberg M, D'Aloisio A, O'Brien K, Zhao S, Sandler D. Early-life Exposures and Age at Breast Development in the Sister Study Cohort. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2021; 30:802.3-803 10.1158/1055-9965.epi-21-0202
The association of women’s birth size with risk of molecular breast cancer subtypes: a cohort study
Sandvei MS, Opdahl S, Valla M, Lagiou P, Vesterfjell EV, Rise TV, et al. The association of women’s birth size with risk of molecular breast cancer subtypes: a cohort study. BMC Cancer. Springer Science and Business Media LLC; 2021; 21 10.1186/s12885-021-08027-9
Early-life risk factors for breast cancer - prospective follow-up in the Northern Finland Birth Cohort 1966
Tastula A, Jukkola A, Alakokkare A, Nordström T, Eteläinen S, Karihtala P, et al. Early-life risk factors for breast cancer - prospective follow-up in the Northern Finland Birth Cohort 1966. Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2021;:cebp.1442.2020 10.1158/1055-9965.epi-20-1442
Commercial Artificial Sweeteners Might Affect Pregnant and Nursing Mice Mammary Gland. A Histological Study
Al-Hasan MM, Al-Qudsi F. Commercial Artificial Sweeteners Might Affect Pregnant and Nursing Mice Mammary Gland. A Histological Study. Journal of Biosciences and Medicines. Scientific Research Publishing, Inc.; 2020; 08:95-108 10.4236/jbm.2020.812010
In Utero and Lactational Exposure to an Environmentally Relevant Mixture of Brominated Flame Retardants Induces a Premature Development of the Mammary Glands
Gouesse R, Dianati E, McDermott A, Wade MG, Hales B, Robaire B, et al. In Utero and Lactational Exposure to an Environmentally Relevant Mixture of Brominated Flame Retardants Induces a Premature Development of the Mammary Glands. Toxicological Sciences. Oxford University Press (OUP); 2020; 179:206-219 10.1093/toxsci/kfaa176
Associations of prenatal exposure to polycyclic aromatic hydrocarbons with pubertal timing and body composition in adolescent girls: Implications for breast cancer risk
Kehm RD, Oskar S, Tehranifar P, Zeinomar N, Rundle AG, Herbstman JB, et al. Associations of prenatal exposure to polycyclic aromatic hydrocarbons with pubertal timing and body composition in adolescent girls: Implications for breast cancer risk. Environmental Research. Elsevier BV; 2020;:110369 10.1016/j.envres.2020.110369
Birth Weight and Incidence of Breast Cancer: Dose-Response Meta-analysis of Prospective Studies
Zhou W, Chen X, Huang H, Liu S, Xie A, Lan L. Birth Weight and Incidence of Breast Cancer: Dose-Response Meta-analysis of Prospective Studies. Clinical Breast Cancer. Elsevier BV; 2020; 20:e555-e568 10.1016/j.clbc.2020.04.011
Neonatal exposure to genistein affects reproductive physiology and behavior in female and male Long-Evans rats
Ali M, Broyles TM, Davis LK, Gonzalez CM, Lucero D, Stary L, et al. Neonatal exposure to genistein affects reproductive physiology and behavior in female and male Long-Evans rats. Behavioural Pharmacology. Ovid Technologies (Wolters Kluwer Health); 2020; 31:610-621 10.1097/fbp.0000000000000569
Perinatal and postnatal exposures and risk of young-onset breast cancer
Diaz-Santana MV, O’Brien KM, D’Aloisio AA, Regalado G, Sandler DP, Weinberg CR. Perinatal and postnatal exposures and risk of young-onset breast cancer. Breast Cancer Research. Springer Science and Business Media LLC; 2020; 22 10.1186/s13058-020-01317-3
Impact of perinatal bisphenol A and 17β estradiol exposure: Comparing hormone receptor response
Leonel ECR, Campos SGP, Guerra LHA, Bedolo CM, Vilamaior PSL, Calmon MF, et al. Impact of perinatal bisphenol A and 17β estradiol exposure: Comparing hormone receptor response. Ecotoxicology and Environmental Safety. Elsevier BV; 2020; 188:109918 10.1016/j.ecoenv.2019.109918
Parabens in breast milk and possible sources of exposure among lactating women in Korea
Park N, Cho YH, Choi K, Lee E, Kim YJ, Kim JH, et al. Parabens in breast milk and possible sources of exposure among lactating women in Korea. Environmental Pollution. Elsevier BV; 2019; 255:113142 10.1016/j.envpol.2019.113142
Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms
da Cruz RS, Andrade FdO, Carioni VMdO, Rosim MP, Miranda MLP, Fontelles CC, et al. Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms. Food and Chemical Toxicology. Elsevier BV; 2019; 134:110813 10.1016/j.fct.2019.110813
Birth weight, weight over the adult life course and risk of breast cancer
Luo J, Chen X, Manson JE, Shadyab AH, Wactawski‐Wende J, Vitolins M, et al. Birth weight, weight over the adult life course and risk of breast cancer. International Journal of Cancer. Wiley; 2019; 147:65-75 10.1002/ijc.32710
Sanitary pads and diapers contain higher phthalate contents than those in common commercial plastic products
Park CJ, Barakat R, Ulanov A, Li Z, Lin P, Chiu K, et al. Sanitary pads and diapers contain higher phthalate contents than those in common commercial plastic products. Reproductive Toxicology. Elsevier BV; 2019; 84:114-121 10.1016/j.reprotox.2019.01.005
DDT and Breast Cancer: Prospective Study of Induction Time and Susceptibility Windows
Cohn BA, Cirillo PM, Terry MB. DDT and Breast Cancer: Prospective Study of Induction Time and Susceptibility Windows. JNCI: Journal of the National Cancer Institute. Oxford University Press (OUP); 2019; 111:803-810 10.1093/jnci/djy198
Maternal exposure to an n-3 polyunsaturated fatty acid diet decreases mammary cancer risk of female offspring in adulthood
Li J, Li K, Gao J, Guo X, Lu M, Li Z, et al. Maternal exposure to an n-3 polyunsaturated fatty acid diet decreases mammary cancer risk of female offspring in adulthood. Food & Function. Royal Society of Chemistry (RSC); 2018; 9:5768-5777 10.1039/c8fo01006d
Temporal Efficacy of a Sulforaphane-Based Broccoli Sprout Diet in Prevention of Breast Cancer through Modulation of Epigenetic Mechanisms
Li Y, Buckhaults P, Li S, Tollefsbol T. Temporal Efficacy of a Sulforaphane-Based Broccoli Sprout Diet in Prevention of Breast Cancer through Modulation of Epigenetic Mechanisms. Cancer Prevention Research. American Association for Cancer Research (AACR); 2018; 11:451-464 10.1158/1940-6207.capr-17-0423