Tag: Indole-3-carbinol

News

• Brassica compound DIM inhibits breast cancer cell growth synergistically with Taxotere

Foods

• broccoli  brussels sprouts  cabbage  cauliflower  genistein and daidzein  greens  kale 

Studies

• 3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice
• Differences in the hepatic P450-dependent metabolism of estrogen and tamoxifen in response to treatment of rats with 3,3′-diindolylmethane and its parent compound indole-3-carbinol
• Expression profile of CYP19 in human breast cancer cell lines treated with indole-3-carbinol, 3,3'-diindolylmethane, and sulforaphane
• Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity
• Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment
• Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner
• Post-initiation treatment of Indole-3-carbinol did not suppress N-methyl-N-nitrosourea induced mammary carcinogenesis in rats
• The effect of 3,3’-diindolylmethane (DIM) on plasma cytokine levels in healthy human subjects