Newsletter December 2016

Dear subscriber:

Recently, it has been determined that the composition of bacteria in the gut (the gut "microbiome") affects health in multiple ways. However, some less-studied organs, including the breast, also are populated by bacteria, albeit at far lower levels. Bacteria can enter the breast through the nipple and ductal systems and also through other avenues such as skin wounds. Breast-feeding, which is associated with reduced breast cancer risk, appears to support the growth of beneficial microbes. Now researchers led by Gregor Reid at Western University in Ontario have discovered that the breast microbiome of women with breast cancer differs from that of women with healthy breasts.

Reid's team analyzed bacterial DNA in breast tissue from 58 women with benign or cancerous breast tumors and 23 healthy women who had undergone cosmetic surgeries. The breast cancer patients tended to have greater representations of bacteria in the Bacillus, Enterobacteriaceae (including E. coli) and Staphylococcus families. In fact, E. coli and Staphylococcus epidermidis derived from breast cancer patients were found to induce DNA double-stranded breaks in HeLa cells (a cancer cell line derived from cervical cancer). The results “suggest that microbes in the breast, even in low amounts, may be playing a role in breast cancer; increasing the risk in some cases and decreasing the risk in other cases,” according to Reid.

Below are links to new topics covered last month in our website.

Best wishes,

Sarah

Below are links to new topics covered last month in our website.

Factors affecting breast cancer risk, treatment and prognosis

Treatment can cause long-term fatigue in breast cancer survivors

Food, diet & supplements

Proinflammatory diet is linked to increased risk of breast cancer

Enterolactone increases radiation-induced breast cancer cell death

Low vitamin D level at diagnosis linked to aggressive disease and poor prognosis

Click on reference for the more information on the study described in this month's newsletter.

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