Newsletter November 2016

Dear subscriber:

Researchers at the National Cancer Institute and the Babraham Institute in the UK have discovered that tumor cells release potassium into the extracellular space as they are dying, which serves to inhibit the actions of immune cells against other tumor cells in the area. Potassium normally is found in abundance within cells, not outside them. Excess potassium was shown to block T cell activation.

To understand this process more completely, the researchers engineered T cells to contain more molecular pumps designed to expel potassium, thus preventing its high intracellular accumulation. Altering T cells in this way was shown to improve the survival of mice with melanoma. This research identifies a new target for new immune system-based treatments of cancer.

Below are links to new topics covered last month in our website.

Best wishes,

Sarah

Below are links to new topics covered last month in our website.

Factors affecting breast cancer risk, treatment and prognosis

Being overweight increases breast cancer risk associated with exposure to PAHs

BPA promotes tumor development in mice by binding to estrogen receptor

Food, diet & supplements

Anthocyanin found primarily in red and black fruits inhibits triple negative breast cancer

Melatonin reduces the viability of both ER+ and ER- breast cancer stem cells

Click on reference for the more information on the study described in this month's newsletter.

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