Newsletter October 2016

Dear subscriber:

Researchers led by Stefan Offermanns at Frankfurt University have discovered a mechanism by which cancer cells can exit blood vessels and move into adjacent tissues. Cells that separate from the primary tumor in order to form tumors in distant locations typically travel through the bloodstream. Eventually, they must pass through the walls of small blood vessels.

Offermanns and his team have demonstrated that tumor cells can kill cells in the vascular wall in order to move into tissues where they can establish metastases. The surfaces of vascular wall endothelial cells have a receptor molecule called Death Receptor 6 (DR6) which can trigger a form of programmed cell death. Some tumor cells are capable of activing DR6, starting the process of degrading the blood vessel cell walls. “This mechanism could be a promising starting point for treatments to prevent the formation of metastases,” according to Offermanns.

Below are links to new topics covered last month in our website.

Best wishes,


Below are links to new topics covered last month in our website.

Factors affecting breast cancer risk, treatment and prognosis

Radiation exposure associated with childhood scoliosis increases breast cancer risk

Psychological traits not likely to influence breast cancer risk

Elevated insulin levels worsen prognosis even among women without type 2 diabetes

Food, diet & supplements

Garlic compound diallyl trisulfide inhibits triple negative breast cancer metastasis

Click on reference for the more information on the study described in this month's newsletter.

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